• The Journal of Korean Medical History
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• v.22 no.2
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• pp.15-22
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• 2009

In this thesis, the emphasis is laid especially on the culture & structure of Huizhou Province, China as the prime mover of the specifically-regional Huizhou $X{\bar{i}}n^{\prime}{\bar{a}}n$ medicine. Huizhou was the home town & stronghold of Neo-coufucian masters Cheng-Zhu (Cheng brothers and Zhu-hsi)". The tradition of the region as "The arts province" resulted in the flourishing trend of nurturing prominent Confucian-doctors. The remarkable all round activities of Huizhou Merchants (新安商人 $X{\bar{i}}n^{\prime}{\bar{a}}nsh{\bar{a}}ngr{\acute{e}}n$), as the reigning power merchant at the period were the second mover of the Zeitgeist. Their nation-wide network all over China made it possible to gain valuable inlormation and access to news including the field of medicine in time. Some merchants actually have "abandoned their own jobs to become doctors of medicine". This Confucian-Merchant culture was one of intrinsic characteristics of Huizhou region, inducing "Pragmatic Scholarship". With the enlargement of the population of Confucian-tumed doctors and improvement of the societal status of doctors, the resultant occupational triad of local Confucian govemment officials, local $X{\bar{i}}n^{\prime}{\bar{a}}nsh{\bar{a}}ngr{\acute{e}}n$ merchants, and local doctors was established after the Middle-Ming Dynasty. Ultimately, the two prime movers of the concomitant development of medicine in the Province Huizhou in this study are concluded to be the synergy effects of the Neo-Confucian tradition and economic power of the prevalent Huizhou Merchants ($X{\bar{i}}n^{\prime}{\bar{a}}nsh{\bar{a}}ngr{\acute{e}}n$).

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.16 no.11
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• pp.3507-3522
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• 2022

Model pruning methods have attracted huge attention owing to the increasing demand of deploying models on low-resource devices recently. Most existing methods use the weight norm of filters to represent their importance, and discard the ones with small value directly to achieve the pruning target, which ignores the contribution of the small norm filters. This is not only results in filter contribution waste, but also gives comparable performance to training with the random initialized weights [1]. In this paper, we point out that the small norm filters can harm the performance of the pruned model greatly, if they are discarded directly. Therefore, we propose a novel filter contribution recycle (FCR) method for structured model pruning to resolve the fore-mentioned problem. FCR collects and reassembles contribution from the small norm filters to obtain a mixed contribution collector, and then assigns the reassembled contribution to other filters with higher probability to be preserved. To achieve the target FLOPs, FCR also adopts a weight decay strategy for the small norm filters. To explore the effectiveness of our approach, extensive experiments are conducted on ImageNet2012 and CIFAR-10 datasets, and superior results are reported when comparing with other methods under the same or even more FLOPs reduction. In addition, our method is flexible to be combined with other different pruning criterions.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.5
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• pp.3139-3142
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• 2013

Associations of P16, MGMT, hMLH1 and hMLH2 with gastric cancer and their relation with MTHFR status in gastric patients who were confirmed with pathological diagnosis were assessed. Aberrant DNA methylation of P16, MGMT, hMLH1 and hMLH2 and polymorphisms of MTHFR C677T were assayed. The proportional DNA hypermethylation in P16, MGMT, hMLH1 and hMLH2 in cancer tissues was significantly higher than in remote normal-appearing tissues. DNA hypermethylation of P16 and MGMT was correlated with the T and N stages. Individuals with homozygotes (TT) of MTHFR C677T had significant risk of hypermethylation of MGMT in cancer tissues [OR (95% CI)= 3.47(1.41-7.93)]. However, we did not find association between polymorphism in MTHFR C677T and risk of hypermethylation in P16, MGMT, hMLH1 and hMLH2 genes either in cancer or remote normal-appearing tissues. Aberrant hypermethylation of P16, MGMT, hMLH1 and hMLH2 could be predictive of gastric cancer.

• Journal of architectural history
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• v.21 no.6
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• pp.19-34
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• 2012

This paper focuses on the spatial analysis of traditional houses in Huizhou during the Ming and Qing period in China. It first reviews the spatial characteristics of the houses in Huizhou. Typical configurations, spatial elements and spatial compositions of the houses are briefly examined. It then discusses how those spatial characteristics are applied to the houses. To do so, the review of existing research and literature on the houses was conducted. For a detailed analysis of the houses, a field survey was performed to collect research materials of the houses and to assess the application of the characteristics in the houses. At times, the plans of the houses were redrawn for a further analysis of the spatial compositions of the houses. Attempts have been made to understand the underlying principles of their spatial organization. For example, Jin (2010) examined the spatial organization of unit plans. Boyd (1989), Berliner (2003) and Dan (2005) similarly categorized the organizational typology of its varying designs. Son(1995) further interpreted the spatial relations of the variety of houses in a comprehensive manner. Nevertheless, their analytic methodology falls short of a complete explanation of the spatial expansion and transformation in the houses. Therefore, this paper examines the basic principles behind the spatial expansion and transformation of a variety of traditional houses in Huizhou. In doing so, it strives to make logical sense of design variations in the houses and reveal the theory behind them.

• Journal of the Korean housing association
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• v.26 no.6
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• pp.147-155
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• 2015

The purpose of this study is to understand the characteristic elements of interior space which effects the basic floor plan of traditional houses, in Huizhou, CHINA. The field study for the content analysis of a interior space of traditional houses were conducted from August 16 to 21, 2015, in Xidicun & Hongcun village. The major characteristics of 'tang' interior were as follows; Firstly, all of traditional houses in a skylight that front of 'tang'. Several types of floor plan were fixed by a combination of the space layout and numbers between 'tang' and skylights. Secondly, 'Tang' is from 3,250 to 6,000 mm in width, from 3,800 to 7,800 mm in depth. All skylights are more length than 'tang' in width. So all of spacious 'tang' were very bright without any lighting fixtutes. Thirdly, the patterns of woodcuts were the major settings of interior decorations. All of a window and door, capital has a detail woodcuts that are flowers, animals, plants, peoples, vases, and geometric patterns. In the last analysis, the traditional housing designs in Huizhoui old villages were planned for family that everlasting life, made a functional and rational decision.

• Molecules and Cells
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• v.39 no.8
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• pp.619-624
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• 2016

Glioblastoma stem cells (GBM-SCs) are believed to be a subpopulation within all glioblastoma (GBM) cells that are in large part responsible for tumor growth and the high grade of therapeutic resistance that is so characteristic of GBM. MicroRNAs (miR) have been implicated in regulating the expression of oncogenes and tumor suppressor genes in cancer stem cells, including GBM-SCs, and they are a potential target for cancer therapy. In the current study, miR-203 expression was reduced in $CD133^+$ GBM-SCs derived from six human GBM biopsies. MicroRNA-203 transfected GBM-SCs had reduced capacity for self-renewal in the cell sphere assay and increased expression of glial and neuronal differentiation markers. In addition, a reduced proliferation rate and an increased rate of apoptosis were observed. Therefore, miR-203 has the potential to reduce features of stemness, specifically in GBM-SCs, and is a logical target for GBM gene therapy.

• Korean Journal of Materials Research
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• v.30 no.8
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• pp.383-392
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• 2020

In this paper, AgCl/Ag₃PO₄/diatomite photocatalyst is successfully synthesized by microemulsion method and anion in situ substitution method. X-ray diffraction (XRD), photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), transmission electron microscopy (TEM), and ultraviolet-visible spectroscopy (UV-Vis) are used to study the structural and physicochemical characteristics of the AgCl/Ag₃PO₄/diatomite composite. Using rhodamine B (RhB) as a simulated pollutant, the photocatalytic activity and stability of the AgCl/Ag₃PO₄/diatomite composite under visible light are evaluated. In the AgCl/Ag₃PO₄/diatomite visible light system, RhB is nearly 100 % degraded within 15 minutes. And, after five cycles of operation, the photocatalytic activity of AgCl/Ag₃PO₄/diatomite remains at 95 % of the original level, much higher than that of pure Ag₃PO₄ (40 %). In addition, the mechanism of enhanced catalytic performance is discussed. The high photocatalytic performance of AgCl/Ag₃PO₄/diatomite composites can be attributed to the synergistic effect of Ag₃PO₄, diatomite and AgCl nanoparticles. Free radical trapping experiments are used to show that holes and oxygen are the main active species. This material can quickly react with dye molecules adsorbed on the surface of diatomite to degrade RhB dye to CO₂ and H₂O. Even more remarkably, AgCl/Ag₃PO₄/diatomite can maintain above 95 % photo-degradation activity after five cycles.

• Journal of Information Processing Systems
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• v.13 no.1
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• pp.83-94
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• 2017

Near-field source localization algorithms are very sensitive to sensor gain/phase response errors, and so it is important to calibrate the errors. We took into consideration the uniform linear array and are proposing a blind calibration algorithm that can estimate the directions-of-arrival and range parameters of incident signals and sensor gain/phase responses jointly, without the need for any reference source. They are estimated separately by using an iterative approach, but without the need for good initial guesses. The ambiguities in the estimations of 2-D electric angles and sensor gain/phase responses are also analyzed in this paper. We show that the ambiguities can be remedied by assuming that two sensor phase responses of the array have been previously calibrated. The behavior of the proposed method is illustrated through simulation experiments. The simulation results show that the convergent rate is fast and that the convergent precision is high.

• Journal of the Korean Institute of Rural Architecture
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• v.21 no.3
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• pp.69-75
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• 2019

The purpose of this study is to provide the conservation management direction about cultural landscape of the traditional villages in the area of Huizhou through the importance-performance analysis. The results of the survey on the importance - performance of 261 people who had many visits to various cultural landscapes of Huizhou villages such as Hongchun, Sidichun etc. are as follows. It was appeared that the item of 'good air' is the highest level of importance and satisfaction and is best condition. The item of 'historical conservation' is the high level of importance, but the level of satisfaction is low, so continuous improvement is necessary. The item of 'Old garden conservation' has high satisfaction but low importance, so it needs to improve its importance through subsequent improvement. The item of 'Keeping of old cemetary and old tower' has low importance and satisfaction but it is above average, so continuous maintenance is needed. The items of 'Preservation of stone gate' and 'Preservation of famous man's birth house' all have slightly higher satisfaction and lower importance. Both items are highly satisfied with their importance, so they should avoid excessive efforts and maintain the present status. Satisfaction with the item of 'water environment and water quality' was the lowest, and the problem of the present condition is the most serious, and a major improvement is needed. The importance and satisfaction of 'Commercial development of old villages' was the lowest among all items. This item is causing serious problems and should provide an overall improvement way to drastically improve the importance and satisfaction. Concentration is necessary to improve the environment of the whole villages, to protect the ecological plants and animals in old villages, to transfer and improve the culture of old villages, to maintain sustainability of the villages, and to protect old temple and old rock in old villages. As the level of satisfaction with sustainability is the lowest in the part of 'Concentrate here', there is a great concern about sustainability. Therefore, it is necessary to focus on sustainability and concentrate on sustainable development.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.14 no.7
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• pp.2769-2784
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• 2020

This paper aims to compare the scenic images of four ancient Chinese cities including Lijiang, Pingyao, Huizhou and Langzhong, so as to provide specific development strategies for the ancient cities. In this paper, the ancient cities' scenic images are divided into three sub-indexes and eight evaluation dimensions. Based on this, the study first uses Python software to collect tourists' online comments on the four ancient cities. Then, the social network analysis method is used to build a high-frequency keywords matrix of tourist comments and the R language is used to generate a visual network graph. After this, the entropy weight method is used to determine the weights and values of eight evaluation dimensions. Finally, the tourists' overall satisfaction indexes of the four ancient cities are calculated accordingly. The results show that (1) the overall satisfaction of Lijiang is the highest, while that of Huizhou is the lowest; (2) from the weight of each evaluation dimension, it can be seen that tourists care more about the national culture and historical culture; (3) from tourists' satisfaction index on each evaluation dimension of the four ancient cities, we can find that the four ancient cities has their own advantages and disadvantages in tourism development. (4) local tourism-related institutions should strengthen their advantages and improve their deficiencies so as to enhance tourists' overall image of the ancient city.