Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Aberrant DNA Methylation of P16, MGMT, hMLH1 and hMSH2 Genes in Combination with the MTHFR C677T Genetic Polymorphism in Gastric Cancer

  • Xiong, Hai-Lin (Department of Medical Oncology, Huizhou Municipal Central Hospital) ;
  • Liu, Xun-Qi (Department of Medical Oncology, Huizhou Municipal Central Hospital) ;
  • Sun, Ai-Hua (Department of Medical Oncology, Huizhou Municipal Central Hospital) ;
  • He, Ying (Department of Medical Oncology, Huizhou Municipal Central Hospital) ;
  • Li, Jun (Department of Medical Oncology, Huizhou Municipal Central Hospital) ;
  • Xia, Yuan (Department of Medical Oncology, Huizhou Municipal Central Hospital)
  • Published : 2013.05.30
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Abstract

Associations of P16, MGMT, hMLH1 and hMLH2 with gastric cancer and their relation with MTHFR status in gastric patients who were confirmed with pathological diagnosis were assessed. Aberrant DNA methylation of P16, MGMT, hMLH1 and hMLH2 and polymorphisms of MTHFR C677T were assayed. The proportional DNA hypermethylation in P16, MGMT, hMLH1 and hMLH2 in cancer tissues was significantly higher than in remote normal-appearing tissues. DNA hypermethylation of P16 and MGMT was correlated with the T and N stages. Individuals with homozygotes (TT) of MTHFR C677T had significant risk of hypermethylation of MGMT in cancer tissues [OR (95% CI)= 3.47(1.41-7.93)]. However, we did not find association between polymorphism in MTHFR C677T and risk of hypermethylation in P16, MGMT, hMLH1 and hMLH2 genes either in cancer or remote normal-appearing tissues. Aberrant hypermethylation of P16, MGMT, hMLH1 and hMLH2 could be predictive of gastric cancer.

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References

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