• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.1
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• pp.9-14
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• 2010

The purpose of this study was to review the direction of Korean medicine treatment in hyperlipidemia, focusing on Korean herbal medicine and to suggest sources for drug development in treatment of hyperlipidemia. We searched 115 articles which had been published from 1997 to 2009 in journals in Korean Oriental Medical Society and its sub-societies. Those articles were selected from the search engine of web site of each journal with the key words 'hyperlipidemia'. Excluding 21 articles in no relation to herbs, we finally reviewed 94 articles. There are many studies of 'hyperlipidemia' in Korean Medicine. Analyzing the articles, we found that the medicinal effects of the herbs used in recent studies and patents coincides with treatment of hyperlipidemia in Korean medicine. Although many herbs in articles is granted patent, it doesn't proceeds to develop herbal drug. It requires to study in treatment of hyperlipidemia in Korean medicine and then to develop herbal drug.

• Herbal Formula Science
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• v.12 no.2
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• pp.213-220
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• 2004

Background: We had treatment for two cases of Hyperemesis Gravidarum . they had difficulty in taking herbal medcine(Gamibosengtang), because of bitter taste and increased nausea and vomiting. So We used acupuncture treatment for increasing of taking herbal medicine and reduction of nausea and vomiting. Methods: The patients estimated their dgree of chief complain on a visual analogue scale and change of oral intake and change of frequency of vomiting. Result: Herbal treatment andacupuncture treatment was efficacious for Hyperemesis Gravidarum. Conclusion: More study fo herbal medicine is needed because of bitter taste.

• The Journal of Pediatrics of Korean Medicine
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• v.33 no.3
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• pp.15-29
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• 2019

Objectives The purpose of this study is to investigate the clinical studies on the effect of herbal medicine in type 1 diabetes in children and to seek better approach of herbal medicine to treat type 1 diabetes in children. Methods This study researched randomized controlled trials through various databases in the world about herbal medicine treatments in type 1 diabetes in children. Results 10 out of 337 studies were selected and analyzed. All studies were conducted in China. All studies were using herbal medicines, as an adjunctive treatment to the main regimen. As a result, the integrated Chinese medicine and western medicine lowered FPG by -1.56 mmol/L and 2hPG by -1.94 mmol/L on average, respectively. The HbA1c also decreased by -1.11% in the treatment group compared to the control group. Total efficacy of the treatment was 1.21 times more effective in the treatment group than in the control group. Conclusions Based on the results of the studies, it seems that the herbal medicine for the treatment of type 1 diabetes in children will be effective as a combination with conventional medicines. Further research is needed to prove the findings of this observatoional studies.

• Journal of Society of Preventive Korean Medicine
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• v.24 no.1
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• pp.27-35
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• 2020

Objectives : The purpose of study was estimation of adverse events [AEs] scale relating herbal medicine in Korea using Korean Medicine Utilization and Herbal Medicine Consumption Survey (National statistics No. 117087). Methods : Using microdata of Korean Medicine Utilization and Herbal Medicine Consumption Survey 2017, the number of inpatients and outpatients who experienced AEs was calculated. The microdata included AEs of all treatment methods that have been performed by visiting Korean medical institutions for one year, so set up the data into three models; model A (in case all treatments were only herbal medicine for one year), model B (in case herbal medicines were a part of all treatment methods in 1 year), model C (in case herbal medicines were a part of treatment methods at least one time in 1 year). The proportion of patients who experienced AEs during the last 1 year was calculated and then, the number of AEs relating herbal medicine was estimated. Results : A total of 1,010 outpatients and 904 inpatients were included in Korean Medicine Utilization and Herbal Medicine Consumption Survey 2017. The number of patients who had experienced AEs in the past 1 year was 0 in the model A, 9 in the model B (5 for outpatients, 4 for inpatients), and 19 in the model C (10 for outpatients, 9 for inpatients). By consideration for the complex sample survey, estimating the number of AEs relating herbal medicine, the model A was 0, the model B was 36,457 patients (0 to 75,526 patients), and the model C was 84,830 patients (26,314 to 143,347 patients). Conclusion : From the results of this study, it was possible to estimate the scale of AEs relating herbal medicines in Korea, suggesting that it is necessary to understand the actual condition of AEs and establish its management system.

• The Journal of Internal Korean Medicine
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• v.40 no.1
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• pp.38-57
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• 2019

Objective: This study reviewed recent clinical research trends regarding the effects of herbal medicine treatment containing diuretic herbs on nonalcoholic fatty liver disease (NAFLD) in China. Methods: We reviewed clinical studies on NAFLD from the China Academic Journal of the China National Knowledge Infrastructure from January 1, 2016, to September 10, 2018. Results: Thirty-nine papers from 86 studies were reviewed. The most commonly used herbal prescriptions included Alismatis Rhizoma(澤瀉), Salviae miltiorrhizae Radix (丹蔘), Crataegii Fructus (山査), Polia Sclerotium (茯?), Bupleuri Radix (柴胡), and Cassiae Semen (決明子). The treatment effective rate, liver function test, serum lipid test, radiological examination, and symptom comparisons were used to analyze the treatments. In 32 of the papers, the effective treatment rate was 76.9%-100%, and the effectiveness in the experimental group was significantly higher than that in the control group (p<0.05). The risk ratio for the treatment effective rate was 1.26. The mean difference of ALT was -13.44 U/L (95% confidential interval, -24.45 U/L, -2.44 U/L, p=0.0166). Conclusion: Herbal medicine containing diuretic herbs has been demonstrated to be an effective and useful treatment for NAFLD. Clinical studies that are more scientific and systematic should be actively conducted in the future, and the results of the current study could be used as basic data in future clinical studies on herbal medicine treatment for NAFLD.

• The Journal of Korean Obstetrics and Gynecology
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• v.32 no.4
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• pp.67-86
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• 2019

Objectives: The purpose of this study is to investigate the effect of herbal medicine treatment for glucose and lipid metabolic abnormalities caused by polycystic ovary syndrome (PCOS). Methods: We searched for randomized controlled clinical trials (RCTs) in 6 electronic databases and search key words were 'PCOS' and 'chinese medicine' or 'herbal medicine' and 'Metabolic syndrome' or 'glucose' or 'lipid'. The results of the studies were analyzed and the risk of bias was assessed by using Cochrane risk of bias (RoB) tool. Results: We finally selected 7 studies. In 3 of selected studies, herbal medicine was more effective than western medicine in all outcomes and in other 3 selected studies, herbal medicine was partially more effective than western medicine. Conclusions: The study provides a basis for applying herbal medicine treatment to patients with metabolic syndrome caused by PCOS and helps developing a treatment protocol of caring patients with PCOS. But the limitation of this study is that the number of studies included is small and lack of uniformity of outcome indicators made it difficult to observe overall interrelationship between indicators.

• The Journal of Pediatrics of Korean Medicine
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• v.35 no.4
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• pp.56-74
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• 2021

Objectives The purpose of this study is to analyze the trend of herbal medicine treatment, treatment's effect and stability for Crohn's disease by reviewing clinical studies published over the past 5 years. Methods 22 articles which were published from 2017 to August, 2021 were obtained from the ScienceON, Research information sharing service (RISS), Koreanstudies Information Service System (KISS), Oriental medicine advanced searching integrated system (OASIS), China national knowledge infrastructure (CNKI), Pubmed. We analyzed the literature in regards to the treatment methods and results. Results There were 6 case reports, 1 controlled clinical trial, and 15 randomized controlled trial and in most cases, herbal medicines and Western medicines were administered in combination. The pathology of damp-heat due to spleen deficiency was the most common, and Sijunzi-tang and Shenling Baishu san were the most commonly used. As a result of the treatment, it was found that the combined administration of the herbal medicine and the Western medicine was more effective than the administration of the Western medicine alone. Conclusions Herbal treatment of Crohn's disease induced high cure rate safely than when only western treatment was applied. Future studies on safety and studies that can suggest specific guidelines for the combined administration of western and herbal medicines are needed.

• The Journal of Korean Obstetrics and Gynecology
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• v.34 no.3
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• pp.49-64
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• 2021

Objectives: This study analyzed medical records and online survey of mothers who received herbal medicine treatment using the Jeollabuk-do Postpartum Health Support Project. Through this, we would like to discuss the proposal of a postpartum questionnaire of korean medicine for the initial examination, and the project direction. Methods: This study investigated the medical records of 46 mothers who received herbal medicine treatment using the Jeollabuk-do Postpartum Health Support Program at one korean medical hospital. The mother's general characteristics, past history, symptoms, and herbal medicine prescription were analyzed. In addition, through the 33 mothers who responded to the online survey questionnaire, 13 items including medication satisfaction, lactation, and side effects were investigated. Results: The average age of the subjects was 34.46±4.27 years. Musculo-skeletal pain was the most common in both medical records and online surveys. The date of visit from the date of delivery was 47.56±57.15 days. Boheo-tang was prescribed the most, and 84.8% of mothers answered positively about their health after taking herbal medicine. Conclusions: The satisfaction of mothers who received herbal medicine treatment through this project was very high. There were no significant side effects on the mother and the breastfeeding baby who took herbal medicine. In the future, support projects for postpartum korean medical treatment at the national or local level will be necessary.

• Journal of Korean Medicine for Obesity Research
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• v.21 no.2
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• pp.105-111
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• 2021

This study is reporting the clinical effect of herbal medicine for Class III obesity. A 34-year-old man with body mass index (BMI) 44.1 kg/m² was diagnosed to Class III obesity. We prescribed herbal medicine (Gambi-hwan) for 60 days. Self controlled low calorie diet and slight aerobic exercise were concomitantly performed during the treatment period. Body weight decreased from 152.4 kg to 128.1 kg. BMI decreased from 44.1 kg/m² to 37.0 kg/m². Visceral fat area decreased from 276 cm² to 195 cm². Percent of excess weight loss was 58.40% after treatment. A Class III obesity patient showed significant weight loss with herbal medicine as single Korean medicine treatment.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.37 no.3
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• pp.29-48
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• 2024

Objectives : The purpose of this study is to investigate recent trends in herbal medicine treatment for xerostomia. Methods : We searched for Randomized Controlled Trial(RCT) studies on xerostomia published after 2015 in the China National Knowledge Infrastructure(CNKI). Studies were analyzed based on the year of publication, characteristics of patient groups, herbal medicine treatments and assessment scales. Results : A total of 16 RCT studies were selected. The most frequently used herbal prescription was Zengye Decoction(增液湯). Liriope Tuber(麥門冬), Rehmanniae Radix(生地黃), Glycyrrhizae Radix(甘草), Schisandrae Fructus(五味子), Scrophulariae Radix(玄蔘), Dendrobii Herba(石斛) and Gypsum Fibrosum(石膏) were commonly used herbs. Herbal medicine treatment demonstrated effectiveness in treating xerostomia across all the studies, and this effect was statistically significant. Conclusions : Herbal medicine treatment is effective in treating xerostomia. We anticipate that more high quality studies will be conducted in the future.