• 척추신경추나의학회지
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• 제10권1호
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• pp.117-127
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• 2015

Objectives : Most of pains are important symptoms caused by cancer transpered to spine. Harpagophyti Radix Pharmacopuncture is highly effective in reducing fever, pain, inflammation but was never used to reduce pain from cancer transpered to spine. So I intended to use Harpagophyti Radix Pharmacopuncture to control pain. The purpose of this study is to evaluate the clinical application of Harpagophyti Radix Pharmacopuncture for Bone Metastasis of Breast Cancer and Spinal Stenosis. Methods : We examined patient with Bone Metastasis of Breast Cancer and Spinal Stenosis who admitted Jaseng Korean Medicine Hospital. The patient was treated by Korean Medicine treatment and Harpagophyti Radix Pharmacopuncture. This case was assessed by Numerical Rating Scale(NRS), Oswestry Low Back Pain Disability Index(ODI), Short-Form 36 Health Survey(SF-36), ROM(Range of Movement) and Special Test. Results : In this study, the patient's pain was controlled and NRS, ODI were decreased. I could identify the improvement in life quality from the positive change of SF-36 and also found out that treatment was successful from the improvement of ROM, Special test. Conclusions : Harpagophyti Radix Pharmacopuncture with Korean Medicine treatment for Bone Metastasis of Breast Cancer and Spinal Stenosis was proved to be useful to the pain relief and function recovery, but further research should take place for clear understanding of the exact amount of dosage and safety. Moreover it must be accompanied by long term follow up research.

• Journal of Yeungnam Medical Science
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• 제24권1호
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• pp.1-10
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• 2007

만성 피로증후군은 인지능력 감소, 근골격 및 수면 장애증상을 가지며 심한 피로감을 특징으로 하는 증상군을 말한다. 아직 명확한 진단기법이나 확립된 표식자가 없으며, 타질환을 배제한 후 증상기준에 따라 진단하고 있다. 병태생리도 명확한 인과관계가 증명되지 않고 있으며 치료 역시 환자의 증상개선과 삶의 질 향상을 목표로 여러 방법을 동원하고 있는 실정이다. 그러나 대조군과 비교한 많은 연구들에서 중추신경계, 신경호르몬 조절 시스템 및 만성 면역 활성 등의 이상이 보고되고 있으며, 이러한 결과들을 근거로 현재 다양한 치료방법이 동원되고 있다. 또한 이 증후군은 가족력의 가능성이 크므로 향후 유전 및 환경적 요인에 관한 연구가 활발해질 것으로 보인다. 대부분의 환자들은 우울증이나 범불안 장애 등을 동반하고 있으며, 이들이 병태생리와 관련 있을 가능성도 크다고 볼 수 있다. 결론적으로 이 증후군은 개인의 유전적 요소에 생리학적, 정신적 요인과 더불어 영양, 생활습관, 스트레스, 호르몬 등의 다양한 요인들이 복합적으로 상호 작용하여 만성적인 피로감과 다양한 증상을 나타내는 것으로 볼 수 있다. 환자-의사간 긴밀한 관계를 바탕으로 약물 및 비약물요법과 인지요법, 단계적 운동요법 등 효과가 인정된 치료방법을 꾸준히 사용하면 증상개선과 삶의 질 향상에 도움이 될 것으로 생각한다.

• 대한간호학회지
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• 제31권2호
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• pp.206-220
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• 2001

The purpose of this study was to investigate the impact of depression, discomfort, spirituality, physical care, and opioid use on pain with terminally ill cancer patients residing in hospice units. The convenient sample of this study consisted of 41 terminally ill cancer patients at three hospice units in university affiliated hospitals. Patients were interviewed with structured questionnaires three times at predetermined intervals: admission to the hospice unit (Time 1), one week later (Time 2), and two weeks later (Time 3). The data was collected from January 1998 to January 1999 and was analyzed using ANOVA, Pearson correlation coefficient, and multivariate multiple regression. 1. The mean age of the participants was approximately 55 years old. In terms of diagnosis, lung cancer showed the highest frequency (19.5%), followed by stomach cancer and rectal cancer (17.1%). The motive of seeking hospice unit admission was control (72. 2%), followed by spiritual care (50%), and symptom relief (38.9%). 2. Regarding the type of pain felt, the highest pain frequency the participants experienced was deep pain (55%), followed by multiple pain (25%), intestinal pain (10%), then superficial (5%) and neurogenic pain (5%). For the level of pain measured by VAS, there was no significant difference among the three time points; Time 1 (5.04$\pm$2.21), Time 2 (4.82$\pm$2.58) and Time 3(4.73$\pm$2.51). 3. There was significant change seen in spirituality and physical care in each time interval. Namely, the longer the length of admission at the hospice unit, the higher the importance of spirituality (p=0.0001) and the more the physical care the participants received (p=0.01). The opioid use at the three time points showed the following frequencies : Time 1 (75.6%), Time 2 (85.4%) and Time 3 (75.6%). 4. Regarding factors influencing pain, the pain level was significantly affected by the depression level (p〈0.01) and the opioid use (p〈0.1). These results were the most significant at the two time points (Time 1 and Time 2). At Time 3 (two weeks later), the pain level was significantly affected by the depression level (p〈0.05) and the amount of physical care the participants received (p〈0.1). In conclusion, the terminally ill cancer patients had moderate pain, were generally depressed, and were treated with opioid analgesics. As approaching death, the patients received more physical care due to increased physical symptoms experienced and they had a higher perception of the importance of spirituality. Thus, health care professionals need to provide continuous care for each of them to die comfortably physically, psycho- logically, and spiritually.

• Journal of Nutrition and Health
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• 제12권1호
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• pp.51-58
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• 1979

It is a general trend everywhere that the uses of vegetable oils are increasing due to the fact that they are effective in curing and preventing symptoms of high blood pressure and various heart failure conditions. At the same time the concept that oxidative rancidity is caused by the oxidation of unsaturated fatty acid moieties whose subsequent decomposition gives rise to various undesirable, sometimes toxic compounds is now well accepted. Linolenic acid (C, 18:3) is one of highly unsaturated and readily oxidizable fatty acid. The content of this essential polyunsaturated fatty acid in perilla seed oil (PSO) was found to be as high as 48% while only 1.5% in sesame seed oil (SSO). In this experiment the oxidative stability of PSO was compared with that of SSO. The experimental test group were as follows: A) Stored at different temperatures, namely $4^{\circ}C,\;30^{\circ}C,$ and $60^{\circ}C,$ B) Stored at room temperature $(20{\pm}5^{\circ}C)$ ; a. protected from sunlight and air, b. exposed to air without sunlight c. exposed to sunlight but protected front air, d. completely exposed to both air and sunlight. The following results were obtained; 1) It was found to be most stable against oxidation to store both PSO and SSO under the low temperature $(4^{\circ}C)$ condition. According to P.V. measurements it was found to be safe to keep both oils up to $30^{\circ}C$ for at least 8 weeks. When exposed to air, sunlight and high temperature $(60^{\circ}C)$, P.V. of PSO reached there peak values, which were much higher than those of SSO. This explains much of its instability as compared to SSO against oxidation. 2) The effect of high temperature $(60^{\circ}C)$ on A.V. was found to be more striking than those of all the other storage conditions. The condition of refrigeration was most effective in keeping A.V. low for both oils as was the case in P.V. 3) For both oils, I.V. decreased throughout the experimental period (8 weeks). The range of decrement was larger for PSO than SSO. 4) There was no significant change in the compositions of fatty acids of SSO caused by various experimental storage conditions. But for PSO the compositions of stearic, oleic and linoleic acid were decreased, whereas linolenic acid was increased proportionally.

• Journal of Nutrition and Health
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• 제47권1호
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• pp.45-50
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• 2014

생강 건조 분말의 임신 또는 멀미로 인해 발생하는 오심, 구토 개선 기능성을 평가하기 위하여 체계적 고찰을 실시하였다. 2013년 3월 기준으로 DB 검색을 통해 870건의 자료를 수집하여, 선정/제외 기준에 따라 선별한 결과 총 12건의 연구가 평가되었다. 12건 (2,694명) 중 11건 (2,630명)의 연구에서 통계적으로 유의한 개선 효과 나타났으며 (p < 0.05), 효과를 보이는 일일 섭취량은 0.25~2.5 g이었다. 특히 임신부 대상 연구 9건에서는 모두 유의한 개선 효과를 보였고, 멀미에 대한 효과를 관찰한 3건의 연구 중 1,741명을 대상으로 한 대규모 연구 1건을 포함한 2건에서 구토를 유의하게 개선시키는 것으로 보고되었다. 해당 연구에서 모두 생강섭취로 인한 이상 반응은 없는 것으로 확인되었다.

• Journal of Nutrition and Health
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• 제41권1호
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• pp.22-30
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• 2008

사철쑥 (Artemisia capillaris Thunberg)이 암세포의 세포고사에 미치는 영향을 보기 위하여 인체 자국경부 상피암 세포주인 HeLa 세포를 이용하여 사철쑥의 메탄올, 에틸아세테이트, 부탄올 추출물의 농도를 각각 0, 100, 500, 1,000 및 $2,000{\mu}g/ml$로 처리하여 세포활성도, 세포형태 변화, DNA분절, DNA 함량을 알아보았다. 세포활성도는 사철쑥의 메탄올, 에틸아세테이트 추출물이 농도에 비례하여 HeLa세포생존율을 감소시켰지만 부탄올 추출물에서는 그 정도가 약하였고 물 추출물에서는 거의 관찰되지 않았다. 사철쑥의 메탄올, 에틸아세테이트, 부탄올과 물 추출물은 각 추출물의 농도에 의존적으로 배양된 HeLa 세포에 세포부착을 방해하고 세포막의 blobbing 및 핵의 분절화 등 세포고사의 특징들을 나타냈다. 사다리형 DNA 분절현상은 사철쑥의 메탄올 추출물 $1,000{\mu}g/ml$, $2,000{\mu}g/ml$ 처리군에서 관찰되었다. 유세포분석기 (FACS)를 이용하여 측정한 고사세포의 DNA 함량은 메탄올과 에틸아세테이트, 부탄올 추출물이 농도 의존적으로 증가하였다. 이상의 결과는 사철쑥이 암세포의 세포고사를 증가시킴으로서 암 억제 작용이 있을 것을 시사해 준다고 할 수 있다.

• 미생물학회지
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• 제48권4호
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• pp.309-313
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• 2012

본 연구는 multiplex PCR 방법을 적용하여 질 내부에 서식하는 유산균을 동시에 그리고 신속하게 검출하는 방법을 개발하는 것을 목적으로 수행되었다. 세균의 감염에 의한 질염 증상이 없는 건강한 20대 여성 166명으로부터 질 분비물을 채취하였다. 건강한 여성의 질 내부에 서식하는 것으로 확인된 Lactobacillus 속에 속하는 6종의 유산균을 종 특이 multiplex PCR primer를 제작하기 위해 선정하였다. Multiplex primer I은 L. iners, L. crispatus, L. gasseri를 선택적으로 검출하기 위해 특성화하였고 multiplex primer II는 L. acidophilus, L. jensenii, L. fermentum를 선택적으로 검출하기 위해 특성화하였다. Multiplex PCR 기술을 이용하여 분석한 결과 L. crispatus (77%)가 가장 높은 빈도로 검출되었고 L. acidophilus (57%)과 L. jensenii (57%)는 상대적으로 높은 빈도로 검출되었다. L. iners (59%)는 L. acidophilus (57%)와 L. jensenii (57%) 보다 높은 빈도로 검출되었지만 항생제 치료 과정 후 또는 세균성 질염의 경우에도 발견되는 균종으로 건강한 여성에게서 주로 서식하는 종이라고 결론 내리기는 어렵다. 결론적으로, 특정 유산균의 특이적인 primer를 이용한 multiplex PCR 기술은 질의 건강상태의 변화 또는 질의 질병으로부터 회복 과정을 예측할 수 있는 도구로서 유용할 것으로 생각된다.

• 정신신체의학
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• 제27권2호
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• pp.85-89
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• 2019

연구목적 본 연구는 후기청소년기에서 중증근무력증이 정신건강에 영향을 미치는 정도를 다면적 인성검사인 군인성 검사 결과를 통해 정량적으로 확인하고자 하였다. 방 법 우리는 2007년 2월부터 2010년 1월까지 병무청으로 군 신체검사를 받으러 방문한 19세 남성 중 다른 내외과 및 정신건강의학과 질환이 없는 건강한 대상자들 104명과 중증근무력증으로 확진 된 대상자들 26명의 군인성 검사 결과를 수집하고 분석하였다. 군인성검사는 미네소타 다면적 인성 검사와 비슷한 점수 체계를 가지고 있으며 한국의 징병 검사를 위해 개발되었다. 결 과 군인성검사 결과 중 타당도 척도인 긍정왜곡, 부정왜곡 및 희귀도 하위척도는 중증근무력증 환자 및 정상 대상자 간에 유의미한 차이를 보이지 않았다(t=-0.51, p=0.607 ; t=0.11, p=0.913 ; t=1.41, p=0.158). 신경증 척도에서는 신체화 하위척도 점수가 중증근무력증 환자에서 정상 대상자들에 비해 유의하게 높았다(t=2.29, p=0.023). 정신증 척도에서는 정신분열 하위척도 점수가 중증근무력증 환자에서 정상 대상자들에 비해 더 낮았다(t=-2.38, p=0.018). 결 론 MPI 결과로 미루어 볼 때 후기 청소년기 중증근무력증 환자는 본인의 신체증상에 다소 예민한 상태이며 질병을 관리하는 과정에서 다른 정상 대상자에 비하여 규칙을 더 잘 지키려고 하고 더욱 관습적으로 행동하려는 경향이 있을 것으로 유추해 볼 수 있다.

• Journal of Preventive Medicine and Public Health
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• 제33권1호
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• pp.25-30
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• 2000

Objectives : This study was performed to evaluate the effect of stage shift according to screening of stomach cancer. Methods : Total 840 cases of stomach cancer patients, undergone a surgical operation at Department of Surgery, Kangnam St. Mary's Hospital, The Catholic University of Korea from Jan. 1989 to Dec. 1995, were reviewed by stomach cancer working sheet, and classified as asymptomatic and symptomatic group based on the presence of subjective symptoms on their hospital visit. Their histopathologic stages were analysed. We compared the histopathologic stages of asymptomatic stomach cancer patients with those of symptomatic patients. Results : From the total of 840 patients, asymptomatic patients group comprised 28 cases (3.3%). Proportion of asymptomatic patients tended to increase from 1.9% in 1990, 0.9% in 1991 to 8.6% in 1995. Proportions of asymptomatic patients by stages were 78.6% (stage I), 3.6% (stage III), 17.9% (stage IV) and that of symptomatic patients by stages were 38.2% (stage I), 16.5% (stage II), 24.8% (stage III), 19.1% (stage IV). In less than 40 years old, 50.5% of symptomatic patients were diagnosed as stage I. With increment of ages, proportions of stage I were makedly decreased. It was significantly different between proportion of early gastric cancer in asymptomatic patients (60.1%) and that in symptomatic patients (25.0%). Conclusions : We confirmed stage shift according to screening of stomach cancer. And proportion of early gastric cancer in asymptomatic patients was higher than that in symptomatic patients. This results suggest that screening of gastric cancer be important to reduce mortality and if be indirectly started from 40 years old.

• 대한임상검사과학회지
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• 제39권2호
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• pp.141-146
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• 2007

Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) is a disorder characterized by the repetitive collapse of the pharyngeal airway during sleep, which leads to oxygen desaturation, sleep fragmentation, daytime sleepiness, and increased risk for hypertension and stroke. We investigated the clinical factors related to the severity of OSAHS. Polysomnography was performed in three hundred and ninety five consecutive adult patients with clinical symptoms of obstructive sleep apnea syndrome. All patients completed the sleep questionnaire and the Epworth Sleepiness Scale before polysomnography. Patients were classified into four groups based on the severity of their polysomnographic data: Non-OSA group, characterized by Apnea-Hypopnea Index (AHI) < 5; mild OSA group, by AHI 5-15; moderate OSA group, by AHI 16-30; and severe OSA group, by AHI > 30. Neck circumference was also measured at the cricothyroid level. A total of 395 patients (336 men and 59 women) were studied. In the non-OSA group, there were 55 patients; their mean neck circumference was $39.63{\pm}4.24cm$ and mean BMI was $24.48{\pm}3.53$. In the mild group, there were 101 patients; their mean neck circumference was $41.93{\pm}3.75cm$ and mean BMI was $25.33{\pm}2.94$. In the moderated group, there were 93 patients; their mean neck circumference was $43.27{\pm}3.50cm$ and BMI was $25.90{\pm}2.88$. In the severe group, there were 146 patients; their mean neck circumference was $44.94{\pm}3.93cm$ and mean BMI was $26.81{\pm}3.76$. Men had significantly larger neck circumference than women ($Mean{\pm}SD$, $43.72{\pm}3.83$ vs $39.17{\pm}4.30$, p < 0.001), and higher AHI than women ($29.12{\pm}22.65$ vs $14.63{\pm}14.11$, p < 0.001). Multiple regression analysis revealed that neck circumference was the most significant predictor of AHI. Neck circumference and BMI were positively correlated with the severity of OSAHS. The severity of OSAHS was greater in men than in women.