• The Korea Journal of Herbology
• /
• v.28 no.3
• /
• pp.7-15
• /
• 2013

Objectives : Interruption and subsequent restoration of blood flow into the kidney result in renal injury. As an approach to preventing the renal injury, we determined the optimal conditions and the underlying mechanisms by which supernatant of hot water extract of ground Triticum aestivum L. (extract) attenuated ischemia/reperfusion (I/R) injury. Methods : One hour after administration of the extract (400 mg/kg) by intraperitoneal injection, renal I/R injury was generated by clamping the left renal artery in rats after surgical removal of the right kidney, followed by reperfusion. The maximal difference between the vehicle-treated and the extract-treated group under ketamine/xylazine or enflurane anesthetization was assessed at varying periods of ischemia (30-45 min) and reperfusion (3-48 hr), based on the renal function assessed with serum creatinine levels, tissue injury with hematoxylin/eosin staining, and apoptosis with terminal deoxynucleotidyltransferase-mediated dUTP nick-end labeling staining. Results : Enflurane anesthetization with 40 min of ischemia and 24 hr of reperfusion was identified to be the optimal condition, under which condition serum creatinine levels and tubular damage in the extract-treated group were significantly reduced compared with those in the vehicle-treated group ($1.3{\pm}0.2$ versus $2.7{\pm}0.3$ mg/dL, P < 0.01, and average score $1.8{\pm}0.1$ versus $3.5{\pm}0.3$, P < 0.01, respectively). These beneficial effects were mediated by inhibition of apoptotic cascades through attenuation of renal tissue malondialdehyde levels, Bax/Bcl-2 ratio and caspase-3 levels. Conclusions : The extract conferred renal protection against ischemia/reperfusion injury in rats by scavenging reactive oxygen species and consequently blocking apoptotic cascades, plausibly augmented by enflurane protection.

• Journal of Drive and Control
• /
• v.18 no.4
• /
• pp.77-83
• /
• 2021

With the progress in virtual reality technology, various virtual objects can be displayed using head-mounted displays (HMD). However, force feedback sensations such as pushing against a virtual object are not possible with an HMD only. Focusing on force feedback, desktop-type devices are generally used, but the user cannot move in a virtual space because such devices are fixed on a desk. With a wearable force feedback device, users can move around while experiencing force feedback. Therefore, the authors have developed a wearable force feedback device using a magnetorheological fluid clutch and pneumatic rubber artificial muscle, aiming at presenting the elasticity, friction, and viscosity of an object. To date, we have developed a wearable four-degree-of-freedom (4-DOF) force feedback device and have quantitatively evaluated that it can present commanded elastic, frictional, and viscous forces to the end effector. However, sensory evaluation with a human has not been performed. In this paper, therefore, we conduct a sensory evaluation of the proposed method. In the experiment, frictional and viscous forces are rendered in a virtual space using a 4-DOF force feedback device. Subjects are asked to answer questions on a 1- to 7-point scale, from 1 (not at all) to 4 (neither) to 7 (strongly). The Wilcoxon signed rank test was used for all data, and answer 4 (neither) was used as compared standard data. The experimental results confirmed that the user could feel the presence or absence of viscous and frictional forces. However, the magnitude of those forces was not sensed correctly.

• Journal of the Korea Society of Computer and Information
• /
• v.27 no.11
• /
• pp.115-121
• /
• 2022

In surface mount technology (SMT), the screen printer, which is an equipment for applying solder cream, has a lot of poor coating as the pad becomes smaller. To solve this problem, a jet printer is being used recently. However, if the nozzle at the end of the valve applied to the jet printer head is not cleaned, solder cream remains or an error occurs. To prevent this, the nozzles should be cleaned periodically. In this paper, a more stable cleaning method than the existing technology is presented for the stable application of solder cream on a jet printer. In this method, cut a 35mm wide mujin cloth, wrap it in a roll, and rotate it with a DC geared motor on the other side to clean it. As a result, it was confirmed that the solder paste was not left on the nozzle surface and was well wiped when cleaning with about 2,000 dotting cycles.

• Journal of the Korean Geotechnical Society
• /
• v.22 no.10
• /
• pp.69-76
• /
• 2006

A reliability-groundwater flow analysis is performed and the influence of flow parameters on the probability of exceeding the threshold value is examined. For this study, the 3-D numerical groundwater flow program, DGU-FLOW, is developed by extending the 2-D flow program and is coupled to the first and second order reliability program. The 3-D flow program is verified by solving the examples of groundwater flow through the underground excavation and comparing the results from commercial MODFLOW program. Reliability routine of the program is also verified by comparing the probability of failure with that of Monte-Carlo Simulation. The reliability analysis of the groundwater flow showed that the probability of failure from the first and second order reliability method are quite close to that of Monte-Carlo Simulation. from the parametric study of hydraulic conductivity of soil layers, the increase of both mean and variance of hydraulic conductivity results in the increase of probability of exceeding the threshold flow quantity. The probability of failure was more sensitive to constant head located at the end of the flow domain than the other parameters.

• Journal of the Korean Geotechnical Society
• /
• v.22 no.12
• /
• pp.33-43
• /
• 2006

Driving tests using model plastic piles with different hammer cushion materials were performed in order to evaluate the efficiency of energy transfer ratio from the hammer, degree of vibration of the surrounding ground and noise due to impacting. A small pile driving analyzer (PDA) was composed using straingages and Hopkinson bar which is measuring force signal and pile-head velocity. The hammer cushion (cap block) materials used for the model driving tests were commercial Micarta, plywood, polyurethane, rubber (SBR) and silicone rubber. The highest energy transfer ratio was obtained from Micarta in the same soil and driving conditions. Micarta was followed by polyurethane, plywood, rubber and silicone in descending order. The more efficient energy transfdr ratio of the hammer cushion materials became, the bigger average noisy (sound) level was found. In addition, Micarta and polyurethane provided bigger bearing capacities than other materials compared in the same soil and driving conditions in which the static loading tests were performed at the end of driving.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.26 no.6D
• /
• pp.985-993
• /
• 2006

The use of prefabricated concrete piles have been gradually increased in many construction sites. One of main works for building a concrete pile foundation is to crush a part of pile head which is compressed with more than $800kg/cm^2$. A pile cutting work is usually performed by a crusher and three to four skilled workers. Recent reports on the pile cutting work reveal that a lot of cracks which significantly reduce the strength of the pile and are frequently made during pile cutting operations and it is very repetitive and labor intensive work. To improve productivity, safety, and quality of the conventional concrete pile cutting work, the research on developing an automated concrete pile cutter has been performed. In this paper, sensing methods for detecting a pile cutting line are suggested with operation process algorithms. The suggested methods are very important to develop the automated pile cutter. A pilot-type of the automated pile cutter that adopt one of the suggested sensing methods, is developed and tested in a construction site.

• Anatomy and Cell Biology
• /
• v.56 no.4
• /
• pp.552-561
• /
• 2023

The endocrinology of type 2 diabetes (T2D) and its predisposing factors have been studied extensively while its skeletal effects have received negligible research despite this being a global disease. The cellular and molecular association between proximal humeral fractures and T2D has not been fully elucidated. We aimed to study bone cell quantities and immunolabel osteogenic and antiosteogenic cytokines. The study used 12-week-old rats (23 males) consisting of 8 Sprague Dawley (SD) and 15 Zucker Diabetic Sprague Dawley (ZDSD). Weekly mass measurements were taken while fasting blood glucose levels were recorded every 2 weeks with oral glucose tolerance tests conducted once every 4 weeks. Upon termination at the age of 28 weeks, humeri were fixed in 10% buffered formalin, prior to decalcification in ethylenediaminetetraacetic acid. The bone samples were then processed in ascending grades of alcohol using an automatic processor before embedding in paraffin wax. Sections were cut at 5 ㎛ thickness in a series for Haematoxylin and Eosin stain, and immunohistochemistry was performed with the anti-tartrate-resistant acid phosphatase (TRAP), anti-alkaline phosphatase (ALP), anti-bone morphogenetic protein 3 (BMP3), anti-transforming growth factor beta 1 (TGFβ1), anti-aged glycation end product (AGE) antibodies in the sequence. ZDSD rats had more adipocytes, BMP3 and AGEs expression with higher numbers of TRAP positive osteocytes and fewer ALP cells although no differences were found in TGFβ1 immunopositivity. We also found that T2D increases the number of AGEs immuno-positive cells, as well as its extracellular expression, thus providing a conducive environment for the interaction of the osteogenic cytokine and its antagonist to suppress osteoblastogenesis. ZDSD groups had higher adipocyte numbers therefore increased marrow adiposity in T2D.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
• /
• v.30 no.1
• /
• pp.51-60
• /
• 2024

Background: Ankle sprains are a common clinical ankle disorder and alternations in tibiofibular joint biomechanics along with the talus are thought to contribute to its occurrence. During ankle joint dorsi flexion, proper movement requires the talus to glide posteriorly. Due to the wider front of the talus head, achieving the end range of dorsi flexion necessitates both superior and posterior glide of the distal fibula and anterior glide of the proximal fibula. The purpose of this study was to investigate the effects of tibiofibular joint mobilization on pain, range of motion, and balance in patients with lateral ankle sprains. Methods: Participants were randomly assigned to a control group (n=33) or an experimental group (n=31). Both groups underwent ankle joint mobilization three times a week for two weeks. Additionally, the experimental group received proximal and distal tibiofibular joint mobilization three times a week for two weeks. Measurements were obtained pre-intervention and post-intervention (after 2 weeks). Results: Evaluation parameters included the visual analog scale score (VAS), range of motion (ROM), and one-leg standing test (OLS). Post-intervention, both groups demonstrated significantly improved results for all assessments (p<.01). A significant intergroup difference was observed only in the ROM (p<.01) and OLS (p<.05). Conclusion: Our findings suggest that tibiofibular joint mobilization, combined with ankle joint mobilization, may be beneficial in enhancing outcomes for individuals with lateral ankle sprains.

• Korean Circulation Journal
• /
• v.54 no.5
• /
• pp.233-252
• /
• 2024

Background and Objectives: Myocardial ischemia-reperfusion injury (MIRI) refers to the damage of cardiac function caused by restoration of blood flow perfusion in ischemic myocardium. However, long non-coding RNA prostate androgen regulated transcript 1 (PART1)'s role in MIRI remain unclear. Methods: Immunofluorescence detected LC3 expression. Intermolecular relationships were verified by dual luciferase reporter assay. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, flow cytometry and transferase-mediated dUTP nick-end labeling (TUNEL) assays analyzed cell viability and apoptosis. The release of lactate dehydrogenase was tested via enzyme-linked immunosorbent assay (ELISA). Left anterior descending coronary artery surgery induced a MIRI mouse model. Infarct area was detected by 2,3,5-triphenyltetrazolium chloride staining. Hematoxylin and eosin staining examined myocardial injury. ELISA evaluated myocardial marker (creatine kinase MB) level. Results: PART1 was decreased in hypoxia/reoxygenation (H/R) induced AC16 cells and MIRI mice. PART1 upregulation attenuated the increased levels of Bax, beclin-1 and the ratio of LC3II/I, and enhanced the decrease of Bcl-2 and p62 expression in H/R-treated cells. PART1 upregulation alleviated H/R-triggered autophagy and apoptosis via miR-302a-3p. Mechanically, PART1 targeted miR-302a-3p to upregulate transcription factor activating enhancer-binding protein 2C (TFAP2C). TFAP2C silencing reversed the protected effects of miR-302a-3p inhibitor on H/R treated AC16 cells. We further established TFAP2C combined to dual-specificity phosphatase 5 (DUSP5) promoter and activated DUSP5. TFAP2C upregulation suppressed H/R-stimulated autophagy and apoptosis through upregulating DUSP5. Overexpressed PART1 reduced myocardial infarction area and attenuated MIRI in mice. Conclusion: PART1 improved the autophagy and apoptosis in H/R-exposed AC16 cells through miR-302a-3p/TFAP2C/DUSP5 axis, which might provide novel targets for MIRI treatment.

• Progress in Medical Physics
• /
• v.26 no.4
• /
• pp.193-200
• /
• 2015

The aim of this study is to present commissioning results of the ViewRay system. We verified safety functions of the ViewRay system. For imaging system, we acquired signal to noise ratio (SNR) and image uniformity. In addition, we checked spatial integrity of the image. Couch movement accuracy and coincidence of isocenters (radiation therapy system, imaging system and virtual isocneter) was verified. Accuracy of MLC positioing was checked. We performed reference dosimetry according to American Association of Physicists in Medicine (AAPM) Task Group 51 (TG-51) in water phantom for head 1 and 3. The deviations between measurements and calculation of percent depth dose (PDD) and output factor were evaluated. Finally, we performed gamma evaluations with a total of 8 IMRT plans as an end-to-end (E2E) test of the system. Every safety system of ViewRay operated properly. The values of SNR and Uniformity met the tolerance level. Every point within 10 cm and 17.5 cm radii about the isocenter showed deviations less than 1 mm and 2 mm, respectively. The average couch movement errors in transverse (x), longitudinal (y) and vertical (z) directions were 0.2 mm, 0.1 mm and 0.2 mm, respectively. The deviations between radiation isocenter and virtual isocenter in x, y and z directions were 0 mm, 0 mm and 0.3 mm, respectively. Those between virtual isocenter and imaging isocenter were 0.6 mm, 0.5 mm and 0.2 mm, respectively. The average MLC positioning errors were less than 0.6 mm. The deviations of output, PDDs between mesured vs. BJR supplement 25, PDDs between measured and calculated and output factors of each head were less than 0.5%, 1%, 1% and 2%, respectively. For E2E test, average gamma passing rate with 3%/3 mm criterion was $99.9%{\pm}0.1%$.