• Korean Journal of Radiology
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• 제25권7호
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• pp.623-633
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• 2024

This study systematically reviewed the role of diffusion-weighted imaging (DWI) in the assessment of molecular prognostic biomarkers in breast cancer, focusing on the correlation of apparent diffusion coefficient (ADC) with hormone receptor status and prognostic biomarkers. Our meta-analysis includes data from 52 studies examining ADC values in relation to estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (HER2), and Ki-67 status. The results indicated significant differences in ADC values among different receptor statuses, with ER-positive, PgR-positive, HER2-negative, and Ki-67-positive tumors having lower ADC values compared to their negative counterparts. This study also highlights the potential of advanced DWI techniques such as intravoxel incoherent motion and non-Gaussian DWI to provide additional insights beyond ADC. Despite these promising findings, the high heterogeneity among the studies underscores the need for standardized DWI protocols to improve their clinical utility in breast cancer management.

• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.1665-1667
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• 2013

Background: Ten to 30% of early breast cancer (EBC) patients develop brain metastasis (BM) during their follow-up. In this study, we aimed to evaluate importance of the lymph node ratio (LNR) in development of BM in EBC cases. Materials and Methods: Ninety patients whom had axillary metastases in lymph nodes at their initial diagnosis and developed BM during 5-year follow-up were detected in 950 EBC patients. LNR values were calculated for all patients and after categorization into 4 molecular sub-types as luminal A, luminal B HER-2 (+), HER-2 overexpressing and basal- like. Comparison was with control group patients who had similar characteristics. Results: In the comparison of all molecular sub-types of LNR, 54.9% and 28.4% values were found in patients with and without BM respectively (p<0.001). In the comparison of the LNR with control groups, a statistically significant differences were found with luminal A with BM (p=0.001), luminal B HER-2 (p=0.001), HER-2 overexpressing (p=0.027) and basal-like groups (p<0.001). In the evaluation of patients with BM, the highest ratio was found in the basal-like group (67.9%) and there was a statistically significant difference between this group and the others (p=0.048). Conclusions: EBC patients developing BM within 5 years follow-up had significantly higher LNRs for all molecular sub-types, especially in the basal-like group. Larger scale studies are now needed for evaluating LNR prognostic importance for EBC regarding BM development.

• Asian Pacific Journal of Cancer Prevention
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• 제13권3호
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• pp.873-877
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• 2012

MicroRNAs (miRNAs) are short non-coding RNA molecules characterized by their regulatory roles in cancer and gene expression. We analyzed the expression of miR-21, miR-205, and miR-342 in 59 patients with breast cancer. Samples were divided into three different groups according to their immunohistochemistry (IHC) classification: ER- positive and/or PR-positive group ($ER^+$ and/or $PR^+$; group I); HER2-positive group ($HER^{2+}$; group II); and ER/ PR/ HER2- negative ($ER^-$/ $PR^-$/ $HER^{2-}$; group III) as the triple negative group. The expression levels of the 3 miRNAs were analyzed in the tumor samples and the compared with the normal neighboring dissected tumor (NNDT) samples in all three groups. The expression of miR-21 was similar in all three groups. In patients positive for P53 by IHC, positive for axillary lymph node metastasis and higher tumor stages, it appeared to have significantly elevated. However, significant increase was not found among the 18 fibroadenoma samples. Both miR-205 and miR-342 expressions were significantly down regulated in group III. We conclude that miR-21 does not discriminate between different breast cancer groups. In contrast, miR-205 and miR-342 may be used as potential biomarkers for diagnosis of triple negative breast cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.1881-1886
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• 2012

Breast cancer is a heterogeneous disease that is affected by ethnicity of patients. According to hormone receptor status and gene expression profiling, breast cancers are classified into four molecular subtypes, each showing distinct clinical behavior. Lack of sufficient data on molecular subtypes of breast cancer in Iran, prompted us to investigate the prevalence and the clinicopathological features of each subtype among Iranian women. A total of 428 women diagnosed with breast cancer from 2002 to 2011 were included and categorized into four molecular subtypes using immunohistochemistry. Prevalence of each subtype and its association with patients' demographics and tumor characteristics, such as size, grade, lymph-node involvement and vascular invasion, were investigated using Chi-square, analysis of variance and multivariate logistic regression. Luminal A was the most common molecular subtype (63.8%) followed by Luminal B (8.4%), basal-like (15.9%) and HER-2 (11.9%). Basal-like and HER-2 subtypes were mostly of higher grades while luminal A tumors were more of grade 1 (P<0.001). Vascular invasion was more prevalent in HER-2 subtype, and HER-2 positive tumors were significantly associated with vascular invasion (P=0.013). Using muti-variate analysis, tumor size greater than 5 cm and vascular invasion were significant predictors of 3 or more nodal metastases. Breast cancer was most commonly diagnosed in women around 50 years of age and the majority of patients had lymph node metastasis at the time of diagnosis. This points to the necessity for devising an efficient screening program for breast cancer in Iran. Further, prospective surveys are suggested to evaluate prognosis of different subtypes in Iranian patients.

• 패션비즈니스
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• 제14권2호
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• pp.73-80
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• 2010

This research examined the design characteristics of Madeleine Vionnet, a female fashion designer who left an enormous legacy and made a great contribution to the high added-value fashion industry. Her techniques can be dividing in to three types: the bias cutting, the design by geometrical methods, and the classical style of ancient Greek clothing. This research also intended to study the design cases in which Vionnet's drapery images are applied to modern fashion, mainly the haute couture works that have appeared at Dior collections since 2000. In terms of the characteristics of Madeleine Vionnet's design, First, she produced the best achievement in dress and ornament history by developing a new technique called bias cutting. Second, her work was groundbreaking because it changed the previously planar approach to the female body into a solid conception by cutting and connecting geometrical pieces in the form of quadrangle, triangle, and a quarter-circle. As a result, her works depicted feminine beauty to the fullest extent through the combination of the human body, excellent materials, and the most sophisticated technology and personal skill. Third, her approach was a classical style tinged with the Greek costume image. With this style, which was born by reinterpreting the key tone of the Greek epoch in a modern way, and transcending and even changing tradition, she created a form of beauty that only she could.

• 패션비즈니스
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• 제11권4호
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• pp.111-119
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• 2007

This research analyzes how female college students' perception of somatotype-self and their satisfactions with their somatotype-self affect their appearance-management behaviors. The result is as follows: 1)An analysis of subjects' physical characteristics revealed that the average figures of their body sizes were within the normal boundaries. The average Quetelet Index of the subjects, which determines obesity of adults, was slightly below the nationwide physical standard of Korea. 2)The subjects' satisfaction with their each body part shows that the women were unsatisfied with every body-part measurement; height, bust size, waist size, hips size and particularly weight. 3)While most of the respondents recognized that sizes of their body parts were average, they were not happy with their body sizes. 4)Three factors were recognized from the study of appearance-management behaviors of the subjects; we defined them as 'Appearance Management', 'Weight Management', and 'Satisfaction with one's Appearance.' The study showed that the fatter, the more a subject controlled her weight. 5)A correlation study between one's perception of her body and her appearance-management behavior found that the more obese a subject was, the harder the subject was controlling her weight.

• 대한수학교육학회지:학교수학
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• 제12권2호
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• pp.97-111
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• 2010

이 연구의 목적은 예비수학교사의 수학교수학습에 대한 신념체계와 수학교수법 중에 시행하는 예비실습을 하는 동안 기록한 활동지의 기술된 수업행동을 분석하여 예비교사가 어떻게 새로운 신념체계를 내재화하는 지 살펴보는 것이다. 연구 결과, 연구에 참여한 예비교사는 일대일 학생과의 예비실습활동을 통하여, 초등학생들의 수학학습 사고과정에 대한 지식을 더 확실하게 자신의 신념체계로 통합하는 것으로 보인다. 그 과정에서 예비교사는 기존의 신념체계와의 심리적 갈등을 겪고 해소해 나가는 것으로 나타났다. 또한, 그 과정을 통하여, 예비교사는 자신의 수학교수학습에 대한 신념체계를 보다 더 분명하고 명확하게 표현하는 것으로 나타났다.

• 대한간호학회지
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• 제14권1호
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• pp.50-59
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• 1984

The purpose of this study was to evaluate the maternal perception of her newborn and identify the risk of mother-infant relationship. Broussard's Neonatal Perception Inventories were completed by 113 mothers on the first or second postpartum day (Time I ) while they were still in the University Hospital. These inventories were again administered when the infants were approximately one month of age (Time Ⅱ). The data was analyzed by S.P.S.S. program and the results were as follows: 1) There were differences between the mothers' exportations of the average baby and perceptions of their babies at Time I and Time Ⅱ (p<0.01). 2) The maternal perception of her newborn at Time I was not related with the education, the parity, the experience of abortion, the type of delivery and the sex of baby but related with the method of feeding (p<0.05). 3) The maternal perception of her newborn at Time Ⅱ was not related with the education, the parity, the experience of abortion, the type of delivery and the method of feeding but related with the sex of baby (p<0.05). 4) The changes of maternal perception between Time I and Time Ⅱ were not related with the education, the parity, the experience of abortion, the method of delivery and the sex of baby but related with the method of feeding (p<0.1). 5) The maternal perception of the newborn was not correlated with the age and the duration of labor.

• Journal of Chest Surgery
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• 제48권4호
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• pp.281-284
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• 2015

We present the case of a 38-year-old woman admitted to our outpatient clinic with accelerating back pain and fatigue following a kick to her back by her husband. Upon arrival, we detected ST segment elevation in the D1, aVL, and V2 leads and accelerated idioventricular rhythm. She had pallor and hypotension consistent with cardiogenic shock. We immediately performed coronary angiography and found a long dissection starting from the mid-left main coronary artery and progressing into the mid-left anterior descending (LAD) and circumflex arteries. She was then transferred to the operating room for surgery. A saphenous vein was grafted to the distal LAD. Since the patient was hypotensive under noradrenaline and dopamine infusions, she was transferred to the cardiovascular surgery intensive care unit on an extracorporeal membrane oxygenator and intra-aortic balloon pump. During follow-up, her blood pressure remained low, at approximately 60/40 mmHg, despite aggressive inotropic and mechanical support. On the second postoperative day, asystole and cardiovascular arrest quickly developed, and despite aggressive cardiopulmonary resuscitation, she died.

• Parasites, Hosts and Diseases
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• 제46권4호
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• pp.269-271
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• 2008

A healthy 30-yr-old woman carrying an insect that had been caught in her living room visited the International Clinic at Severance Hospital, Seoul, in December 2007. The insect she brought was identified to be a nymph of a bedbug, Cimex lectularius, and her skin rashes looked typical bedbug's bites. Her apartment was investigated, and a dead body of a bedbug, cast skins, and hatched eggs were found in her rooms and neighbors' rooms in the same building. She was living in that apartment in Seoul for 9 months since she had moved from New Jersey, USA. We assume that the bedbugs were introduced from abroad, since there had been no report on bedbugs in Seoul for more than 2 decades at least. This is a report of a reemergence of the common bedbug, C. lectularius in Seoul, Korea.