• Clinical and Experimental Pediatrics
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• 제62권7호
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• pp.274-280
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• 2019

Purpose: To analyze the growth response to growth hormone (GH) therapy in prepubertal patients with Noonan syndrome (NS) harboring different genetic mutations. Methods: Twenty-three patients with prepubertal NS treated at Pusan National University Children's Hospital between March 2009 and July 2017 were enrolled. According to the disease-causing genes identified, the patients with NS were divided into 4 groups. Three groups were positive for mutations of the PTPN11, RAF1, and SOS1 genes. The five genes undetected (FGU) group was negative for PTPN11, RAF1, SOS1, KRAS, and BRAF gene mutations. The influence of genotype was retrospectively analyzed by comparing the growth parameters after GH therapy. Results: The mean chronological age at the start of GH treatment was $5.85{\pm}2.67years$. At the beginning of the GH treatment, the height standard deviation score (SDS), growth velocity (GV), and lower levels of insulin-like growth factor-1 (IGF)-1 levels were not statistically different among the groups. All the 23 NS patients had significantly increased height SDS and serum IGF-1 level during the 3 years of treatment. GV was highest during the first year of treatment. During the 3 years of GH therapy, the PTPN11, RAF1, and SOS1 groups showed less improvement in height SDS, IGF-1 SDS, and GV, and less increase in bone age-to-chronological age ratio than the FGU group. Conclusion: The 3-year GH therapy in the 23 prepubertal patients with NS was effective in improving height SDS, GV, and serum IGF-1 levels. The FGU group showed a better response to recombinant human GH therapy than the PTPN11, RAF1, and SOS1 groups.

• KOREAN JOURNAL OF CROP SCIENCE
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• 제65권4호
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• pp.399-405
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• 2020

The objective of this study was to identify the effect of zebularine soaking on the early growth stage of barley (Hordeum vulgare L.). Hence, root elongation was measured daily according to the different concentrations of zebularine (1.0, 2.5, 5.0, and 10.0 μM) for 4 days. On the first day, root length at 2.5 and 5.0 μM was significantly longer than that in the non-treated control. On the second day, root length was not significantly different among all concentrations and controls. On the third day, root elongation was suppressed by the effect of zebularine, except at 2.5 μM. The treatment time of zebularine accounted for the largest proportion of the variation in root elongation. After transplanting, plant growth velocity was similar to that of the control; however, plants at 2.5 μM showed faster growth velocity than that of the other concentrations and the control. In the metaphase of mitosis, most chromosomes of cells under zebularine treatment were ordinary regardless of the concentration, while some cells with short chromosomes were investigated at around 2%. The short chromosome showed a centromere. In addition, it showed short and long arms based on the centromere. The lengths of the short and long arms were different for each short chromosome. It is necessary to study the effect of the short chromosome as a chromosomal function on plant growth and phenotype through investigation of meiosis and fertilization at the chromosome level.

• Journal of The Korean Astronomical Society
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• 제37권5호
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• pp.547-551
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• 2004

We showed that magnetic fields are generated in the plasma which have the temperature inhomogeneities. The mechanism is the same as the Weibel instability because the velocity distribution functions are at non-equilibrium and anisotropic under the temperature gradients. The growth timescale is much shorter than the dynamical time of structure formation. The coherence length of magnetic fields at the saturated time is much shorter than kpc scale and then, at nonlinear phase, become longer by inverse-cascade process. We report the application of our results to clusters of galaxies, not including hydrodynamic effects.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 한국해양공학회 2003년도 춘계학술대회 논문집
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• pp.257-261
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• 2003

A free stream vortical disturbance generated by a single axial vortex of periodically modulated strength was used to investigate vortical receptivity of a flat plate boundary layer to low-frequency spatially localized free-stream disturbances. It was found that the boundary-layer response was dominated by stream-wise velocity perturbation (streak). However, in contrast to the stationary streaks considered by Boiko (2002), its intensity showed no pronounced growth along the flat plate.

• Journal of applied mathematics & informatics
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• 제42권1호
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• pp.105-121
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• 2024

We consider incompressible, inviscid, stratified shear flows in β plane. First, we obtained an unbounded instability region intersect with semi-ellipse region. Second, we obtained a bounded instability regions depending on Coriolis, stratification parameters and basic velocity profile. Third, we obtained a criterion for wave stability. This has been illustrated with standard examples. Also, we obtained upper bound for growth rate.

• Proceedings of the Korea Association of Crystal Growth Conference
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• 한국결정성장학회 2000년도 Proceedings of 2000 International Nano Crystals/Ceramics Forum and International Symposium on Intermaterials
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• pp.165-177
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• 2000

Ceramic on ceramic total hip prostheses are developed to apply to young patients because lifetime of polyethylene joint prostheses is limited by loosening due to biological response. As mating faces of all-ceramic joint must be highly conformed to reduce stress concentration, wear properties of flat surfaces are investigated in this study. Through wear tests at 2 MPa of contact pressure and 36 mm/s of sliding velocity, alumina and silicon carbide keep low wear rate, high hardness and smooth surface. Soft surface film was detected after the test in bovine serum. This suggests that boundary lubrication is effective to reduce wear in all-ceramic joint.

• Proceedings of the Korea Association of Crystal Growth Conference
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• 한국결정성장학회 1997년도 Proceedings of the 12th KACG Technical Meeting and the 4th Korea-Japan EMGS (Electronic Materials Growth Symposium)
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• pp.223-228
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• 1997

The gas dynamics in a stagnation point upflow OMVPE reactor were studied by Raman spectroscopy. The gas temperature was measured as a function of inlet gas velocity and aspect ratio for both H$_2$ and N$_2$ carrier gases. The centerline temperature gradient was latger at higher inlet velocities and with the use of N$_2$, and only weakly dependent on the aspect ratio. a tracer molecule, CH$_4$, was used to investigate the steady state behavior of reactants in the reactor, and the use of a sweeping flow was found to be a suitable method for preventing wall deposition. The transient switching response of the gas manifold was also investigated. Under certain conditions (low velocities, unmatched flows) recirculation flows were apparent. Numerical calculations of the reactor gas dynamics gave reasonable agreement with experimental results when detailed thermal boundary conditions were included.

• Proceedings of the Korea Association of Crystal Growth Conference
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• 한국결정성장학회 1997년도 Proceedings of the 13th KACG Technical Meeting `97 Industrial Crystallization Symposium(ICS)-Doosan Resort, Chunchon, October 30-31, 1997
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• pp.39-43
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• 1997

Mercurous chloride (Hg$_2$Cl$_2$) has many advantages in its applications to acousto-optic, and opto-electronic devices because it has the unique properties of a broad transmisson range, well into the far infra-red, a low acoustic velocity, a large birefringence, and a high acousto-optic figure of merit[1]. Hg$_2$Cl$_2$ has a high vapor pressure, hence single crystals are usually grown by physical vapor transport(PVT) method in closed silica glass ampoules. We discuss the application of the laser Doppler velocimetry to measure the flow field inside a closed ampoule. The experimental results, are discussed its relationship to computational model and compared to their expectations.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2009년 춘계학술대회논문집
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• pp.355-362
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• 2009

Most material of engineering interest undergoes solidification process from liquid to solid state. Identifying the underlying mechanism during solidification process is essential to determine the microstructure of material which governs the physical properties of final product. In this paper, we expand our previous two-dimensional numerical technique to three-dimensional simulation for computing dendritic solidification process with fluid convection. We used Level Contour Reconstruction Method to track the moving liquid-solid interface and Sharp Interface Technique to correctly implement phase changing boundary condition. Three-dimensional results showed clear difference compared to two-dimensional simulation on tip growth rate and velocity.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 한국소음진동공학회 2008년도 추계학술대회논문집
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• pp.82-83
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• 2008

In the cases of high speed railway bridge, dynamic behavior analysis is important because of high passing velocity and moving load at the regular intervals, and the damping ratio is a major element in dynamic behavior analysis. In this paper, damping ratios were estimated by two methods and vibration type sections, and relationship between estimated damping ratio and representative value of bridge vibration. At the results, estimated damping ratio using all time of vibration were more stable then using only free vibration section. And in the case of using extended Kalman filter, estimated damping ratio were trend of growth by growth of representative value of bridge vibration. At last, it was shown that study about reliabilities of estimated damping ratios were need.