• Journal of Periodontal and Implant Science
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• 제23권1호
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• pp.135-143
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• 1993

The investigation was undertaken to determin the altered function and structure of granulation tissue fibroblasts. Human granulation-tissue fibroblasts were cultured from periodontal chronic inflammatory lesions (SBI index : above 3) and compared with healthy gingival connective tissues fibroblasts a control(SBI index : below 1). Granulation tissue fibroblasts proliferated with a slower growth rate and exhibited larger cell size than control cells. Total protein profile of granulation tissue fibroblasts was almost identical to that of control cells with some exception. These results support tha theory that granulation tissue fibroblasts represent a distinct phenotype of fibrotic cells.

• 한국환경과학회지
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• 제5권3호
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• pp.387-398
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• 1996

Granular sludge formation and it's activity change are the most important factors in achieving successful start-up and operation of UASB reactor. Nevertheless, the detailed mechanism is still unknown. On the basic of the experiments in laboratory-scale UASB reactor, the effect of hydrogen partial pressure on sludge granulation was evaluated. Size distribution method and specific metabolic activity of the sludge with the operation time were used as a means for estimating the degree of the sludge granulation. At the constant hydrogen loading, the granulation increased as starvation periods in hydrogen supply increased, resulting in high organic removal efficiency. It was evidient that hydrogen play very important role in granulation and sludge granulation was achieved through mutual symbiosis between hydrogen utilizing bacteria and hydrogen producing bacteria under the hydrogen dificient conditions. Key words : granular sludge, UASB reactor, hydrogen partial pressure.

• 대한기관식도과학회지
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• 제7권2호
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• pp.174-177
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• 2001

Previously, we used a rigid bronchoscope in removal of endotracheal granulation tissue and foreign body. But these method has poor visual field and difficulty in handling of the instruments, therefore there were restriction in removing the endotracheal granulation tissue and foreign body. Recently we underwent one case each of endotracheal granulation tissue and foreign body causing dyspnea and removed them by right angled forceps under visualization via nasal rigid endoscope inserted through the tracheal stoma. We suggest this method for removal of tracheal foreign body, granulation tissue and excision of tumorous condition in patients with tracheocutaneous fistula.

• 대한기관식도과학회지
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• 제4권2호
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• pp.165-170
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• 1998

Background and Objectives : Decannulation failure may result from factors such as inadequate ability 0 clear secretion, mucosal induration, granulation tissue, restenosis, tracheal wall depression and vocal cord palsy. We were to evaluate the effectiveness of surgical treatment on the basis of site and type of stenosis. Materials and Method : A series of 44 cases of decannulation difficulty between 1993 and 1997 were reviewed. The following data were collected on each of these patients : primary disease, indication for tracheostomy, site of stenosis, endoscopic findings of stenosis, surgical techniques used for treatment. Results : Primary diseases were 30 head trauma, 4 neck injury, 10 other diseases. Indication for tracheostomy were 37 prolonged intubation, 4 emergency tracheostomy, 3 laryngeal trauma. Endoscopic findings of stenosis were 24 granulation tissue, 16 laryngotracheal collapse, 4 combined with granulation tissue and collapse. Site of stenosis were 3 glottic, 9 subglottic, 24 stomal, 1 substomal, 7 mixed. 22 of 24 cases were decannulation using endoscopic treatment. Conclusion : The most common cause of failed decannulation was sternal granulation tissue. The most effective treatment of granulation tissue was endoscopic technique.

• 한방안이비인후피부과학회지
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• 제14권2호
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• pp.89-111
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• 2001

In order to investigate the effects of GamiTakliSodocyum(GTS) on wound healing, migration of epidermis, formation of granulation tissue and number of capillary within the granulation tissue were measured in diabetic mice by local application and NZW rabbits by local application and prescription of medicine in vivo, and proliferation of human epidermal keratinocytes and human dermal fibroblasts and composition of extracellular matrix were measured in vitro. The results were summerized as follows. 1. $2\%,\;10\%$ GTS remarkably increased migration of epidermis in diabetic mice by local application. 2. $2\%,\;10\%$ GTS remarkably increased formation of granulation tissue, number of neovascularization within the granulation tissue in diabetic mice by local application. 3. 5\%,\;10\%$ GTS remarkably increased migration of epidermis in NZW rabbits by local application. 4. $5\%,\;10\%$ GTS remarkably increased fonnation of granulation tissue, number of neovascularization within the granulation tissue in NZW rabbits by local application. 5. $5\%,\;10\%$ GTS increased migration of epidennis in NZW rabbits by prescription of medicine. 6. $5\%,\;10\%$ GTS increased formation of granulation tissue, number of neovascularization within the granulation tissue in NZW rabbits by prescription of medicine. 7. GTS didn't show effect on the proliferation of human epidermal keratinocytes. 8. GTS increased the proliferation of cultured human dermal fibroblasts. 9. GTS increased the expression of procoliagen ${\alpha}1(I) mRNA in cultured human dermal fibroblasts. 10. GTS increased the expression of fibronectin mRNA in cultured human dennal fibroblasts according to dosage of GTS using northern blot hybridization but didn't increase, using RT-PCR. From the above results, it is conclude that GTS might use on wound healing.

• 한국물환경학회지
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• 제20권5호
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• pp.534-538
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• 2004

Granulation characteristics have been studied with an aerobic sequencing batch reactor(SBR). Organic loading of 2.46kg COD/$m^3$/day followed by 4.14kg COD/$m^3$/day had been applied to the lab-scale SBR with a very short settling time during the operating cycle. The granulation proceeded to the diameter range of 3 to 5 mm with MLSS concentration of 12,000mg/L at 45th days of operation while COD removal efficiency remained almost consistent after the granule formation. It has been noticed that aerobic granulation under the higher loading with a very short settling time seemed to be due to the microbial selection of better flocculating species.

• 대한심미치과학회지
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• 제30권1호
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• pp.33-39
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• 2021

상악 전치부 치아가 치조골 소실로 인해 상실되었을 때 심미적인 수복을 위해 소실된 치조골을 골재생 술식을 통해 회복 시키는 것은 매우 중요합니다. 발치와 동시에 치조골의 소실이 진행되기 때문에 발치 직후 치조제 보존술을 시행하는 것은 심미적인 수복을 위해 중요한 의미가 있습니다. 하지만 이 과정에서 primary closure를 하지 못하는 것이 골재생에 부정적인 영향을 줄 수 있습니다. 이를 극복하기 위해 발치와 내의 granulation tissue를 이용해 primary closure를 시도할 수 있습니다. 이렇게 할 경우 open wound에 비해 골재생에 유리한 환경을 제공함으로써 치조제가 잘 보존됨을 넘어 잘 증강되는 것을 증례를 통해 확인할 수 있었습니다.

• Journal of Periodontal and Implant Science
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• 제52권4호
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• pp.298-311
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• 2022

Purpose: The aim of this study was to evaluate the clinical outcomes of periodontal granulation tissue preservation (PGTP) in access flap periodontal surgery. Methods: Twenty patients (stage III-IV periodontitis) with 42 deep periodontal pockets that did not resolve after non-surgical treatment were consecutively recruited. Access flap periodontal surgery was modified using PGTP. The clinical periodontal parameters were evaluated at 9 months. The differences in the amount of granulation tissue width (GTw) preserved were evaluated and the influence of smoking was analyzed. Results: GTw >1 mm was observed in 97.6% of interproximal defects, and the granulation tissue extended above the bone peak in 71.4% of defects. At 9 months, probing pocket depth reduction (4.33±1.43 mm) and clinical attachment gain (CAG; 4.10±1.75 mm) were statistically significant (P<0.001). The residual probing depth was 3.2±0.89 mm. When GTw extended above the interproximal bone peak (i.e., the interproximal supra-alveolar granulation tissue thickness [iSUPRA-GT] was greater than 0 mm), a significant CAG was recorded in the supra-alveolar component (1.67±1.32 mm, P<0.001). Interproximal gingival recession (iGR) was significant (P<0.05) only in smokers, with a reduction in the interdental papillary tissue height of 0.93±0.76 mm. In non-smokers, there was no increase in the iGR when the iSUPRA-GT was >0 mm. The clinical results in smokers were significantly worse. Conclusions: PGTP was used to modify access flap periodontal surgery by preserving affected tissues with the potential for recovery. The results show that preserving periodontal granulation tissue is an effective and conservative procedure in the surgical treatment of periodontal disease.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 2005년도 추계학술대회 학술발표 논문집 제15권 제2호
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• pp.483-487
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• 2005

We introduce a new architecture of hetero-hybridized feed-forward neural networks composed of fuzzy set-based polynomial neural networks (FSPNN) and polynomial neural networks (PM) that are based on a genetically optimized multi-layer perceptron and develop their comprehensive design methodology involving mechanisms of genetic optimization and Information Granulation. The construction of Information Granulation based HFSPNN (IG-HFSPNN) exploits fundamental technologies of Computational Intelligence(Cl), namely fuzzy sets, neural networks, and genetic algorithms(GAs) and Information Granulation. The architecture of the resulting genetically optimized Information Granulation based HFSPNN (namely IG-gHFSPNN) results from a synergistic usage of the hybrid system generated by combining new fuzzy set based polynomial neurons (FPNs)-based Fuzzy Neural Networks(PM) with polynomial neurons (PNs)-based Polynomial Neural Networks(PM). The design of the conventional genetically optimized HFPNN exploits the extended Group Method of Data Handling(GMDH) with some essential parameters of the network being tuned by using Genetie Algorithms throughout the overall development process. However, the new proposed IG-HFSPNN adopts a new method called as Information Granulation to deal with Information Granules which are included in the real system, and a new type of fuzzy polynomial neuron called as fuzzy set based polynomial neuron. The performance of the IG-gHFPNN is quantified through experimentation.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2005년도 ICCAS
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• pp.1505-1509
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• 2005

This paper introduces a new architecture of genetically optimized self-organizing fuzzy polynomial neural networks by means of information granulation. The conventional SOFPNNs developed so far are based on mechanisms of self-organization and evolutionary optimization. The augmented genetically optimized SOFPNN using Information Granulation (namely IG_gSOFPNN) results in a structurally and parametrically optimized model and comes with a higher level of flexibility in comparison to the one we encounter in the conventional FPNN. With the aid of the information granulation, we determine the initial location (apexes) of membership functions and initial values of polynomial function being used in the premised and consequence part of the fuzzy rules respectively. The GA-based design procedure being applied at each layer of genetically optimized self-organizing fuzzy polynomial neural networks leads to the selection of preferred nodes with specific local characteristics (such as the number of input variables, the order of the polynomial, a collection of the specific subset of input variables, and the number of membership function) available within the network. To evaluate the performance of the IG_gSOFPNN, the model is experimented with using gas furnace process data. A comparative analysis shows that the proposed IG_gSOFPNN is model with higher accuracy as well as more superb predictive capability than intelligent models presented previously.