• Archives of Plastic Surgery
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• v.38 no.4
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• pp.369-375
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• 2011

Purpose: Many hemostatic agents and dressings have been tested with variable degree of success. Chitosan has a positive charge, it attracts red blood cells, which have a negative charge. Our goal is to test the efficacy of new developed chitosan-based hemostatic materials in providing durable hemostasis in a high-flow arterial wound model. Methods: We compared each group with SD rats motality tests and in vitro blood compatibility test by blood clotting index (BCI). We devided the SD rats into 6 groups (N =15) by type of hemostatic agents. A: 100% nonwoven chitosan (degree of the deacetylation: 90%). B: 50% N-acetylation on nonwoven of chitosan gel (degree of the deacetylation: 50%). C: 60% N-acetylation on nonwoven of chitosan ge (degree of the deacetylation: 40%)l. D: Cutanplast$^{(R)}$. E: HemCon$^{(R)}$ F: Gauze. In vivo test, a proximal arterial injury was created in unilateral femoral arteries of 90 anesthetized SD rats. Each materials was made same size and thickness then applied to the injury site for 3 minutes. In vitro test, we compared each group with BCI in human blood. Results: In vivo test, group A showed lower motality rate of 46% than any other groups, Group B and C showed lower motality rate of 60% than group D and E's motality rate of 66%. In vitro test, BCI of group A ($30.6{\pm}1.2$) and B ($29.3{\pm}1.0$) were showed nearly about group D ($29.1{\pm}1.8$) and E ($27.4{\pm}1.6$). Group C ($37.1{\pm}2.0$) showed higher BCI than group A and B, it means group C decreased blood clotting. Conclusion: In conclusion, this study suggests a newly developed chitosan-based hemostatic materials induced durable hemostasis and increased blood clotting, and are considered as effective biologic hemostatic agents.

• Parasites, Hosts and Diseases
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• v.58 no.4
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• pp.393-402
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• 2020

Toxoplasma gondii is an intracellular parasite that causes severe disease when the infection occurs during pregnancy. Adenosine is a purine nucleoside involved in numerous physiological processes; however, the role of adenosine receptors in T. gondii-induced trophoblast cell function has not been investigated until now. The goal of the present study was to evaluate the intracellular signaling pathways regulated by adenosine receptors using a HTR-8/SVneo trophoblast cell model of T. gondii infection. HTR8/SVneo human extravillous trophoblast cells were infected with or without T. gondii and then evaluated for cell morphology, intracellular proliferation of the parasite, adenosine receptor expression, TNF-α production and mitogen-activated protein (MAP) kinase signaling pathways triggered by adenosine A₃ receptor (A₃AR). HTR8/SVneo cells infected with T. gondii exhibited an altered cytoskeletal changes, an increased infection rate and reduced viability in an infection time-dependent manner. T. gondii significantly promoted increased TNF-α production, A₃AR protein levels and p38, ERK1/2 and JNK phosphorylation compared to those observed in uninfected control cells. Moreover, the inhibition of A₃AR by A₃AR siRNA transfection apparently suppressed the T. gondii infection-mediated upregulation of TNF-α, A₃AR production and MAPK activation. In addition, T. gondii-promoted TNF-α secretion was dramatically attenuated by pretreatment with PD098059 or SP600125. These results indicate that A₃AR-mediated activation of ERK1/2 and JNK positively regulates TNF-α secretion in T. gondii-infected HTR8/SVneo cells.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.6
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• pp.728-735
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• 2017

With the proliferation of digital devices, the devices have generated considerable additive white Gaussian noise while acquiring digital images. The most well-known denoising methods focused on eliminating the noise, so detailed components that include image information were removed proportionally while eliminating the image noise. The proposed algorithm provides a method that preserves the details and effectively removes the noise. In this proposed method, the goal is to separate meaningful detail information in image noise environment using the edge strength and edge connectivity. Consequently, even as the noise level increases, it shows denoising results better than the other benchmark methods because proposed method extracts the connected detail component information. In addition, the proposed method effectively eliminated the noise for various noise levels; compared to the benchmark algorithms, the proposed algorithm shows a highly structural similarity index(SSIM) value and peak signal-to-noise ratio(PSNR) value, respectively. As shown the result of high SSIMs, it was confirmed that the SSIMs of the denoising results includes a human visual system(HVS).

• Journal of Nutrition and Health
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• v.51 no.1
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• pp.73-86
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• 2018

Purpose: The aim of this study was to design optimized food intake patterns that meet the nutritional recommendations with minimal changes from the current food intake patterns among Korean adults using linear programming. Methods: Data of a one day 24-hour dietary recall from the 2010 ~ 2014 Korea National Health and Nutrition Survey were used to quantify the food items that Korean adults usually consumed. These food items were categorized into seven groups and 24 subgroups. The mean intakes and intake distributions of the food groups and the food subgroups were calculated for eight age (19 ~ 29, 30 ~ 49, 50 ~ 64, and over 65 years old) and gender (male and female) groups. A linear programming model was constructed to minimize the difference between the optimized and mean intakes of the food subgroups while meeting the Dietary Reference Intakes for Koreans (KDRIs) for energy and 13 nutrients, and not exceeding the typical quantities of each food subgroup consumed by the respective age and gender groups. Results: The optimized food intake patterns, which were a set of quantities of 24 food subgroups, were obtained mathematically for eight age and gender groups. Overall, major modifications of current diet were required to increase the intake of vegetables and milk/dairy products and decrease the Kimchi intake. The optimized intake of seasonings, including salt, was calculated to be 0 g for all the age and gender groups. Conclusion: The optimized food intake patterns designed using linear programming in this study lack feasibility because they suggest a seasoning consumption of 0 g. Modification of intake goal for sodium is needed to obtain optimized food intake patterns with improved feasibility.

• Journal of Science and Technology Studies
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• v.16 no.2
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• pp.65-98
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• 2016

Living Lab is being introduced and applied as an innovation model driven by social entities (residents, users, etc.) and as an innovation place based on local and field. This study analyzed three living lab cases of Bukchon IoT living lab, Seong-Daegol energy transition living lab, and Daejeon Geonneoyu project, which were designated as 'Living Lab' to solve local problems. We analyzed the local problem, the problem solving goal, the role of each participant and the subject, the living lab promotion system, the significance in each case. In addition, the types and characteristics of living labs were elucidated and future development plans were discussed. The result is as follow. First, each case has a tendency to link science technology and ICT with local problem solving though there is a difference between the technologies used. Second, local residents played a leading role in the whole living lab process from problem identification to technical experimentation, diffusion and application. Third, the role of the intermediaries commonly played an important role in the operation of the living lab. Last but not least, each case has different types of living lab. Bukchon IoT living lab being operated as a project by the government / municipality to create a living lab activity-base or to support actors' activities. On the other hand, the Seong-Daegol energy transition living lab and Daejeon Geonneoyu project were conducted by the civil society itself to define problems and explore technologies in order to solve local problems.

• International Area Studies Review
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• v.22 no.3
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• pp.29-66
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• 2018

The purpose of the study was to point out the limitation of the conceptual discussions in which researches on gender responsive budgeting have remained so far and to empirically analyze the effect of institutionalization of gender responsive budgeting on the gender equality by using macro data. The units of the analysis were 73 countries which implements gender responsive budgeting among the 229 countries registered in the World Bank. Panel data were established on the materials of 7-year period from 2006 to 2012, which were analyzed by Fixed Effect Model. Gender Equality (Gender Gap Index) which is the ultimate goal of gender budgeting was established as the dependent variable while Institutionalization of Gender Responsive Budgeting (formal and qualitative classification) was established as the independent variable. In addition, social and economic factors, political factors and geographical factors which were judged to affect dependent variables were established as control variables. As a result of analysis, the institutionalization of gender responsive budgeting has positive effect on gender equality. Thus, the study confirmed that gender responsive budgeting has positive effect on gender equality in countries with legal, procedural and formal foundations rather than in countries with simple rhetoric in catchwords and documents. Moreover, the higher the level of institutionalization of gender responsive budgeting is, the more positive effect it has on the gender equality. Therefore, the study found out that efforts need to be accompanied to enhance the level of institutionalization in order to increase the effectiveness of institutionalization of gender responsive budgeting.

• International Journal of Computer Science & Network Security
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• v.21 no.4
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• pp.167-177
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• 2021

The scientific paper studies the impact of tourism and traveling on the economic level of development of countries at the macro level and its relationship with other sectors of the economy. Tourism is one of the budget-forming factors of every economy. This work describes the main trends in the development of tourism. It is determined that about one third of tourism revenues are generated by the food sector, i.e., the culinary niche of tourism. Culinary tourism is a new direction of tourism, but it is developing quite dynamically in the EU. Culinary is an important part of rural tourism in the EU and culinary tourism is actively promoted at fairs and festivals. In recent years rural tourism has been developing both at the international level and in Ukraine, primarily due to its features, which include the implementation of the principles of sustainable community development, preservation of local traditions and cultural values, gastronomic events to promote them. The aim of the article is to study the theoretical aspects of the development of gastronomic tourism in the world, to analyze the actual condition of gastronomic tourism in the EU and Ukraine, identifying prospects and ways to develop regional gastronomic tourism. The methodological and informational basis of the work is analytical reports and researches related to the development of event tourism and statistics. Systematic and logistical approaches to the studied problems were used to achieve this goal. Various general scientific and special research methods were also used. Based on PESTLE analysis, key aspects of the external environment of gastronomic tourism in Ukraine are identified. We took into account the principles of sustainable development: political, economic, social, technological, legal and environmental. The main trends in the development of gastronomic tourism in the world are studied and it is found that the greatest development in the coming years will be the trend of combining gastronomic and event tourism on the basis of sustainable development. The main preconditions and possibilities of introduction of this holistic approach to the strategy of development of the tourist branch of Ukraine are determined. A model of sustainable value chain of gastronomic tourism in the region is formed and the main advantages of its implementation are identified: formation of a regional brand, preservation of culinary traditions, development of green farming, minimization of negative impact on the environment, sustainable development of communities.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.5
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• pp.188-198
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• 2021

The purpose of this study is to verify the mediating effect from acceptance of the latest 4th Industrial Revolution technologies on the relationships between interest in the latest technologies, resistance to the latest technologies, and anxiety in workers at welfare institutions for the disabled. In order to achieve this goal, data were collected from July to August 2018 from workers at disability welfare centers in P Metropolitan City, and we analyzed data from 187 persons. Multiple regression analysis was applied to test the causal relationships between variables; the step-by-step analysis model of Baron and Kenny (1986) was used to verify mediating effects, and the Sobel test was performed to verify their significance. The analyses verified that the degree of interest in the latest technologies affects the degree of resistance to, and anxiety over, the latest technologies through acceptance of the latest technologies. At the same time, we verified that the degree of interest had a complete mediation effect because it did not directly affect the acceptance. In addition, the Sobel test result showed that the mediating effect was statistically significant. In other words, it was found that the degree of interest in the latest 4th Industrial Revolution technologies from workers at welfare institutions for the disabled increases the possibility of adaptation to future society by lowering resistance and anxiety through acceptance of the latest technologies. Based on these results, a plan to reduce resistance to, and anxiety over, the latest technologies was sought, and related measures to increase interest in the latest technologies and their acceptance are suggested.

• The Journal of the Korea Contents Association
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• v.21 no.7
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• pp.222-237
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• 2021

The purpose of this study is to develop an ACT group counseling program for the purpose of alleviating and healing the job stress and burnout of nursing care workers and to verify the effectiveness of the ACT group counseling program. To this end, the goal and theoretical model, content, operation and evaluation of the program were composed and applied according to the procedure. The main research results are as follows. First, as a result of measuring the job stress of the study subjects, there was a positive change in the group participating in the program. Second, as a result of measuring the level of job burnout of the study subjects, there was a positive change in the group participating in the program. Third, as a result of measuring the level of role conflict of the study subjects, there was a positive change in the group participating in the program. Fourth, as a result of measuring the level of over-role of the study subjects, there was a positive change in the group participating in the program. Fifth, as a result of measuring the level of role ambiguity of the study subjects, there was a positive change in the group participating in the program. As a practical implication, by including the ACT theory and practice plan in various nursing care providers training courses, the ability to respond to job burnout and job stress is increased, and ultimately, by increasing the psychological flexibility of nursing care workers, the opportunity for essential change in attitude toward work and life describe what to provide.

• The Journal of the Korea Contents Association
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• v.19 no.8
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• pp.572-583
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• 2019

This study sought to find out what the most ideal and appropriate native English speakers-Korean English teacher cooperative class model and the defining factors for organizing effective cooperative classes in the English education environment of our country. To achieve this goal, a total of 165 sixth graders of five elementary schools in Seoul were subject to the study. For about a month from April 1 to April 30, 2019, the survey and statistical analysis were conducted, including multiple return analysis, correlation analysis, cross analysis, and t/F verification. In summary, the results of the study are as follows. First, it was found that among the recognition of cooperative classes between native English speakers and Korean English teachers, it affected the defining factors in the order of class-related skills, task orientation, teaching-learning strategies, and motivation. Second, based on learner characteristics, the difference in perception of cooperative classes between native English speakers and Korean English teachers was verified, and the perception of native-Korean English teachers' cooperative classes was different depending on gender and the type of English cooperative classes currently participating, but the recognition of native-Korean English-Korean English cooperative classes, which were statistically significant, was not confirmed. Third, according to learner characteristics, the difference in the definition factors of the learner was verified and the difference between the sexes occurred, but the learner-defined factors according to the current type of English cooperative class did not occur. Also, there was no difference in the definition factors of scholars according to the type of English cooperative classes desired.