• Proceedings of the KIEE Conference
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• 1998.07b
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• pp.515-518
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• 1998

This paper proposes a new hybrid algorithm for auto-tuning fuzzy controllers improving the performance. The presented algorithm estimates automatically the optimal values of membership functions, fuzzy rules, and scaling factors for fuzzy controllers, using a genetic-MGM algorithm. The object of the proposed algorithm is to promote search efficiency by a genetic and modified gradient optimization techniques. The proposed genetic and MGM algorithm is based on both the standard genetic algorithm and a gradient method. If a maximum point don't be changed around an optimal value at the end of performance during given generation, the genetic-MGM algorithm searches for an optimal value using the initial value which has maximum point by converting the genetic algorithms into the MGM(Modified Gradient Method) algorithms that reduced the number of variables. Using this algorithm is not only that the computing time is faster than genetic algorithm as reducing the number of variables, but also that can overcome the disadvantage of genetic algorithms. Simulation results verify the validity of the presented method.

• Anatomy and Cell Biology
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• v.56 no.1
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• pp.94-108
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• 2023

Cancer cell heterogeneity is a serious problem in the control of tumor progression because it can cause chemoresistance and metastasis. Heterogeneity can be generated by various mechanisms, including genetic evolution of cancer cells, cancer stem cells (CSCs), and niche heterogeneity. Because the genetic heterogeneity of CSCs has been poorly characterized, the genetic mutation status of CSCs was examined using Exome-Seq and RNA-Seq data of liver cancer. Here we show that different surface markers for liver cancer stem cells (LCSCs) showed a unique propensity for genetic mutations. Cluster of differentiation 133 (CD133)-positive cells showed frequent mutations in the IRF2, BAP1, and ERBB3 genes. However, leucine-rich repeat-containing G protein-coupled receptor 5-positive cells showed frequent mutations in the CTNNB1, RELN, and ROBO1 genes. In addition, some genetic mutations were frequently observed irrespective of the surface markers for LCSCs. BAP1 mutations was frequently observed in CD133-, CD24-, CD13-, CD90-, epithelial cell adhesion molecule-, or keratin 19-positive LCSCs. ASXL2, ERBB3, IRF2, TLX3, CPS1, and NFATC2 mutations were observed in more than three types of LCSCs, suggesting that common mechanisms for the development of these LCSCs. The present study provides genetic heterogeneity depending on the surface markers for LCSCs. The genetic heterogeneity of LCSCs should be considered in the development of LCSC-targeting therapeutics.

• International Journal of Automotive Technology
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• v.4 no.4
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• pp.181-191
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• 2003

Since the nonlinearity and uncertainties which inherently exist in vehicle system need to be considered in active suspension control law design, this paper proposes a new control strategy for active vehicle suspension systems by using a combined control scheme, i.e., respectively using a genetic algorithm (GA) based self-tuning PID controller and a fuzzy logic controller in two loops. In the control scheme, the PID controller is used to minimize vehicle body vertical acceleration, the fuzzy logic controller is to minimize pitch acceleration and meanwhile to attenuate vehicle body vertical acceleration further by tuning weighting factors. In order to improve the adaptability to the changes of plant parameters, based on the defined objectives, a genetic algorithm is introduced to tune the parameters of PID controller, the scaling factors, the gain values and the membership functions of fuzzy logic controller on-line. Taking a four degree-of-freedom nonlinear vehicle model as example, the proposed control scheme is applied and the simulations are carried out in different road disturbance input conditions. Simulation results show that the present control scheme is very effective in reducing peak values of vehicle body accelerations, especially within the most sensitive frequency range of human response, and in attenuating the excessive dynamic tire load to enhance road holding performance. The stability and adaptability are also showed even when the system is subject to severe road conditions, such as a pothole, an obstacle or a step input. Compared with conventional passive suspensions and the active vehicle suspension systems by using, e.g., linear fuzzy logic control, the combined PID and fuzzy control without parameters self-tuning, the new proposed control system with GA-based self-learning ability can improve vehicle ride comfort performance significantly and offer better system robustness.

• Journal of Korean Association for Spatial Structures
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• v.16 no.3
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• pp.79-88
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• 2016

An outrigger damper system has been proposed to reduce dynamic responses of tall buildings. In previous studies, an outrigger damper system was optimally designed to decrease a wind-induced or earthquake-induced dynamic response. When an outrigger damper system is optimally designed for wind excitation, its control performance for seismic excitation deteriorates. Therefore, a smart outrigger damper system is proposed in this study to make a control system that can simultaneously reduce both wind and seismic responses. A smart outrigger system is made up of MR (Magnetorheological) dampers. A fuzzy logic control algorithm (FLC) was used to generate command voltages sent for smart outrigger damper system and the FLC was optimized by genetic algorithm. This study shows that the smart outrigger system can provide good control performance for reduction of both wind and earthquake responses compared to the general outrigger system.

• Proceedings of the Korean Society For Composite Materials Conference
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• 2001.05a
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• pp.9-12
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• 2001

An active control of the vibration transmitted by longitudinal load in flight control system is investigated numerically. The flight control system is modeled as a finite, thin shell cylinder with constant thickness. A vibration source is generated by exterior monopole source. Distributed piezoelectric actuator is used to control of the vibration. Thin shell theory is used to formulate the numerical models. The amplitude of vibration at discrete location and power transmission are minimized by analytical optimization method. Genetic algorithm is used as numerical optimization method to search optimal actuator position and size which amplitude of vibration is minimized.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.25 no.12
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• pp.1950-1959
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• 2001

An active control of the vibration transmitted by longitudinal load in flight control system is investigated numerically. The flight control system is modeled as a finite, thin shell cylinder with constant thickness. A vibration source is generated by exterior monopole source. Distributed piezoelectric actuator is used to control of the vibration. Thin shell theory is used to formulate the numerical models. The amplitude of vibration at discrete location and power transmission are minimized by analytical optimization method. Genetic algorithm is used as numerical optimization method to search optimal actuator position and size which amplitude of vibration is minimized.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2001.04a
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• pp.598-601
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• 2001

As many sensors and actuators are used in many automated system, various industrial networks are adopted for digital control system. In order to take advantages of the networking, however, the network implementation should be carefully designed to satisfy real-time requirements considering network delays. This paper presents the implementation scheme of a networked control system via Profibus-DP network. More specifically, the effect of the network delay on the control performance was evaluated on a Profibus-DP testbed, and a GA based PID tuning algorithm is proposed to demonstrate the fesibility of the networked control system.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.10 no.4
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• pp.40-47
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• 2001

In this pater, the QLQG/LTR control method is applied for the position control of the nonlinear timing belt driving sys-tem. Parameters fo the plant are identified by genetic algorithm and nonlinear elements, such as Coulomb friction and dead-zone, and quasi-linearized by RIDE method. Comparing with the LQG/LTR contro. the QLQG/LTR has similar structures of the LQG/LTR, but this method can consider nonlinear effects in designing the controller. Thus, the QLQG/LTR control system is robust to hard nonlinearities such as Coulomb friction, dead-zone, etc. Forma given hard non-linear system through experiments, it is shown that the tracking performance of the QLQG/LTR control system can be very improved that the LQF/LTR control system.

• Journal of Institute of Control, Robotics and Systems
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• v.4 no.4
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• pp.433-440
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• 1998

The purpose of this study is to provide an integrated process control system for plasma etching. The control system is designed to employ neural network for the modeling of plasma etching process and to utilize genetic algorithm to search for the appropriate selection of control input variables, and to provide a control chart to maintain the process output within a desired range in the real plasma etching process. The target equipment is the one operating in DRAM production lines. The result shows that the integrated system developed is practical value in the improved performance of plasma etching process.

• Journal of Korean Association for Spatial Structures
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• v.15 no.4
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• pp.81-89
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• 2015

Damped outrigger systems have been proposed as a novel energy dissipation system to protect tall buildings from severe earthquakes and strong wind loads. In this study, semi-active damping devices such as magnetorheological (MR) dampers instead of passive dampers are installed vertically between the outrigger and perimeter columns to achieve large and adaptable energy dissipation. Control performance of semi-active outrigger damper system mainly depends on the control algorithm. Fuzzy logic control algorithm was used to generate command voltage sent to MR damper. Genetic algorithm was used to optimize the fuzzy logic controller. An artificial earthquake load was generated for numerical simulation. A simplified numerical model of damped outrigger system was developed. Based on numerical analyses, it has been shown that the semi-active damped outrigger system can effectively reduce both displacement and acceleration responses of the tall building in comparison with a passive outrigger damper system.