• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.6049-6053
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• 2013

Background: Following research demonstrating an increased risk for meningiomas in the Jewish population of Shiraz (Iran) we conducted a cohort analysis of meningiomas among Jews originating in Iran and residing in Israel. Materials and Methods: We use the population-based registry data of the Israeli National Cancer Registry (INCR) for the main analysis. All benign meningioma cases diagnosed in Israel from January 2000 to the end of 2009 were included. Patients that were born in Iran, Iraq, Turkey, Bulgaria and Greece were used for the analysis, whereby we calculated adjusted incidence rates per 100,000 people and computed standardized incidence ratios (SIRs) comparing the Iranian-born to each of the three other groups. Results: Iranian-born Jews had statistically significant higher meningioma rates rates compared to other Jews originating in Balkan states: 1.46 fold compared to Turkish Jews and 1.86 fold compared to the Bulgaria-Greece group. There was a small increase in risk for the Iranian born group compared to those who were born in Iraq (1.06, not significant). Conclusions: Higher rates of meningiomas were seen in Jews originating in Iran that are living in Israel as compared to rates in neighboring countries of origin. These differences can be in part attributed to early life environmental exposures in Iran but probably in larger amount are due to genetic and hereditary factors in a closed community like the Iranian Jews. Some support for this conclusion was also found in other published research.

• 한국축산식품학회:학술대회논문집
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• 한국축산식품학회 2006년도 정기총회 및 제37차 춘계 국제학술발표대회
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• pp.179-183
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• 2006

Denaturing high-performance liquid chromatography(DHPLC) is used in a wide variety of genetic applications and is an efficient method for detection of mutations involving one or a few nucleotides. We developed a high-throughput DHPLC method for identifying polymorphisms in the MC1R gene that are characteristic of Hanwoo cattle. We compared 10 tissue samples from Hanwoo cattle, 10 samples from Holstein cattle and 10 samples from Hanwoox Holstein crossbred cattle to determine whether DHPLC analysis can be used to distinguish between these genotypes. Samples obtained from Hanwoo cattle had a unique profile of peaks that could be used as a molecular fingerprint for this breed. We also analyzed two hundred samples in a trial in which we were blinded to the genotype of the samples and correctly identified the breed-of-origin of 594 out of 600 sequence variations(99%).

• The Plant Pathology Journal
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• 제29권3호
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• pp.260-273
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• 2013

The incidence and distribution of Tobacco mosaic virus (TMV) and related tobamoviruses was determined using an enzyme-linked immunosorbent assay on 1,926 symptomatic horticultural crops and 107 asymptomatic weed samples collected from 78 highly infected fields in the major horticultural crop-producing areas in 17 provinces throughout Iran. The results were confirmed by host range studies and reverse transcription-polymerase chain reaction. The overall incidence of infection by these viruses in symptomatic plants was 11.3%. The coat protein (CP) gene sequences of a number of isolates were determined and disclosed to be a high identity (up to 100%) among the Iranian isolates. Phylogenetic analysis of all known TMV CP genes showed three clades on the basis of nucleotide sequences with all Iranian isolates distinctly clustered in clade II. Analysis using the complete CP amino acid sequence showed one clade with two subgroups, IA and IB, with Iranian isolates in both subgroups. The nucleotide diversity within each subgroup was very low, but higher between the two clades. No correlation was found between genetic distance and geographical origin or host species of isolation. Statistical analyses suggested a negative selection and demonstrated the occurrence of gene flow from the isolates in other clades to the Iranian population.

• 동의생리병리학회지
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• 제19권5호
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• pp.1154-1161
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• 2005

Yin Yang theory is the first and the last one to interpret diseases apply to treatment in oriental medicine. So it is regarded as the way of heaven and earth, the discipline of all things, the origin of change, the beginning of giving birth and death, the source of spirit. These regulatory passages are needed to compare with western medical physiology and analyzed whether it has scientific bases or not. The Yin Yang theory of traditional oriental medicine are summerized from the descriptions of Scripture of Documents, Ying Wei theory of Huangdi Neijing. Meanwhile up-to-date neurobiological and molecular genetic theories on circadian physiology are reviewed in western medicine. Sunshine is transferred through RGC to SCN, herein the central circadian rhythm is made by zeitgeber and interaction of melatonin secreted from pineal body and orexin from mp pan of hypothalamus. So HPA axis is activated and controlled under the circadian rhythm and affects peripheral tissues and cells of whole body through glucocorticoid hormones. First of all, the circadian rhythm makes the basic patterns of human life in biological and sociological meaning. It is almost same context with the record of the Scripture of Documents. Also the Ying Qi and Wei Qi is basically same with the sleep-awake mechanism, that is melatonin/orexin signal or per/clk/bmal/cry genes with circadian activation and activity of each organ's physiological function. Conclusively it can be said that Yin Yang is a priori principle of living things and the beginning of giving birth and death for activation of them biologically, as is described in Huangdi Neijing.

• 자원환경지질
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• 제25권1호
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• pp.41-50
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• 1992

Mineral assemblages, mineral chemistries and stable isotope compositions of altered rocks of the Ogmae, Seongsan, Haenam and Gusi mines near the Haenam volcanic field in the southwestern part of the Korea peninsula were studied. Characteristic hydrothermal alteration zones in these deposits occurring in the Cretaceous volcanics and volcanogenic sediments, acidic tuff, and rhyolite, were outlined. Genetic environment with particular reference to the spatial and temporal relationships for these deposits were considered. The alteration zones defined by a mineral assemblage in the Ogmae and Seongsan deposits can be classified as alunite, pyrophyllite, kaolinite or dickite, quartz, illite or illite/smectite. Alunite was not developed in the Gusi and Haenam deposits. Boundaries between the adjacent zones are always gradational except for vein-type alunite. Alteration zones are superimposed upon each other in some localities. These deposits formed $71.8{\pm}2.8{\sim}76.6{\pm}2.9$ Ma ago, which is the almost same age of later volcanic rocks $79.4{\pm}1.7{\sim}82.8{\pm}1.2$ Ma, the Haenam Group, corresponding to Campanian. It indicates that hydrothermal alteration of these deposits appeared to be related to felsic volcanism in the area. Consideration of the stability between kaolinite, alunite, pyrite and pyrophyllite, and the geothermometry based on the mineral chemistry of illite and chlorite suggests that the maximum formation temperature for alunite and pyrophyllite can be estimated at about $250^{\circ}C$ and $240{\sim}290^{\circ}C$, respectively. It also suggests that these deposits were formed by acidic sulfate solution with high aqueous silica and potassium activity in a shallow depth environment. Compositional variation of alunite also suggests that the physico-chemical conditions fluctulated considerably during alteration processes, indicating shallow depth environment. The Haenam deposit was formed at a relatively greater depth than the others. The sulfur isotope composition of alunite and pyrite indicates that sulfur probably had a magmatic source, and the oxygen isotope composition for kaolinite indicates that the magmatic hydrothermal solution was diluted by circulating meteoric water.

• 대한영양사협회학술지
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• 제22권4호
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• pp.251-260
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• 2016

This study was conducted to determine recognition of Chikhanwoo, promote its market competitiveness, and vitalize its uses in Korea. This research was carried out on 465 people, including 264 of the general public and 191 livestock farmers. For awareness of Chikhanwoo, 53.6% of the general public and 86.9% of livestock farmers recognized Chikhanwoo (P<0.001) through TV, Internet, news, magazines, and others. For consumption behaviors of Chikhanwoo meat, 4.3% of the general public and 1.9% of livestock farmers have purchased Chikhanwoo meat in the past. Most of them hinted at their intention to repurchase and highly intimated their wish to purchase on whether Chikhanwoo tastes better, is more nutritious and is safer than Hanwoo. In addition, they thought country of origin and price were the most important factors for purchasing (P<0.001). For recognition of the Hanwoo grading system, they preferred $1^{{+}{+}}$ and $1^+$, significantly (P<0.001). For need for quality certification, most respondents thought that the government should introduce a quality certification system for Chikhanwoo. For importance factor of prevalence of Chikhanwoo meat, marketability value had the highest degree of importance, followed by taste, quality, tradition and cooking methods (P<0.001). Results of this study show that domestic consumption of Chikhanwoo can be boosted by supplying Chikhanwoo meat with a differentiated taste and a safety assurance to the general public. There is also need to enhance genetic resources and improve brand value of Chikhanwoo. Continuous research and efforts should be made for the development of the livestock market.

• 한국인터넷방송통신학회논문지
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• 제11권1호
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• pp.1-5
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• 2011

최근에 개발되는 대부분의 800MHz 이상 소출력 무선기기는 회로 본체에 안테나를 별도로 돌출 분리시키지 않고 일체형으로 설계하고 있다. 이와 같은 일체형 무선기기의 성능평가는 고전적 개념의 송신기 출력, 안테나 성능을 분리하여 측정하던 방식의 변화를 요구하고 있어, 본 연구는 이와 같은 시대적 환경에 적합한 새로운 측정방식을 제안하고 관련 기기를 개발하였다. 즉, 소형 무선기기를 원점으로 360도 전방향으로 전계를 측정하여 TRP를 측정하고, 반대로 수신레벨 역시 360도 전방향에서 측정하여 TIS를 측정하여 무선기기의 정량적 평가를 할 수 있도록하였다. 뿐만 아니라 송신기의 급전점 전력을 측정할 수 있는 경우 PCB상에 부착된 안테나의 이득, 회로 주변 유전재료, 도전재료가 방사 또는 수신레벨에 미치는 영향을 정량적으로 측정할 수 있도록 하여 효과적인 주파수 관리에 기여하고 일체형 무선기기의 최적설계와 성능관리에 효율성을 제고시킬 수 있었다.

• Archives of Pharmacal Research
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• 제16권4호
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• pp.259-264
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• 1993

Three cell lines, CHO, L929 and B16 which are non-tumorigenic and cancer cells, respectively, were first tested for their survival in the presence of radioprotective ginseng protein fraction(GPF0. The influence of three radioprotectors-CPF, cysteamine, and 1-Methyl-2-bis[(2-methylthio)vinyl] quinolinium iodide (MVQI) on DNA repair capacity of UV damaged cells survival test, the GPF showed higher cytotoxicity in L929 and B16 than in CHO cells. However, the degree of cell killing was also investigated by measuring $^3H$-thymidine incorporation of PUVA treated cells. In cell survival test, the GPF showed higher cytotoxicity in L929 and B16 than in CHO cells. However, the degree of cell killing was not high enough to consider it as an antitumorigenic agent. Variable results were obtained in the effects on DNA repair capacity depending on the protectors and cell lines used. In pretreatment, the presence of GPF and MVOI brought about a sinificant increase in the capacity in both CHO and B16 cells. However, in L929, the enhancing effect was not shown. In all three cell lines, cysteamine showed lower repair capacity than control, suggesting the primary damage reduction in stronger enhancing effects in L929 and B16 cells, while it was weaker in CHO cells. Here also cystemine hsowed a very little or no increase in the capacity in all three cell lines. These results demonstrate that GPF has mild cytotoxicity in tumorignic cells and that GPF and MVQI enhance DNA repair capacity of UV damaged cells, whether they are tumorigenic or not. On the other hand, cysteamine shows only damage reduction effect. Celles of different genetic origin seem to give different responses to the modifier and different modifiers may possibly work by different mechanisms.

• 한국도로학회논문집
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• 제18권2호
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• pp.91-101
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• 2016

PURPOSES : The aim of this study was to compare the performance of the QUEENSOD method and the gravity model in estimating Origin-Destination (O/D) tables for a large-sized microscopic traffic simulation network. METHODS : In this study, an expressway network was simulated using the microscopic traffic simulation model, VISSIM. The gravity model and QUEENSOD method were used to estimate the O/D pairs between internal and between external zones. RESULTS: After obtaining estimations of the O/D table by using both the gravity model and the QUEENSOD method, the value of the root mean square error (RMSE) for O/D pairs between internal zones were compared. For the gravity model and the QUEENSOD method, the RMSE obtained were 386.0 and 241.2, respectively. The O/D tables estimated using both methods were then entered into the VISSIM networks and calibrated with measured travel time. The resulting estimated travel times were then compared. For the gravity model and the QUEENSOD method, the estimated travel times showed 1.16% and 0.45% deviation from the surveyed travel time, respectively. CONCLUSIONS : In building a large-sized microscopic traffic simulation network, an O/D matrix is essential in order to produce reliable analysis results. When link counts from diverse ITS facilities are available, the QUEENSOD method outperforms the gravity model.

• Journal of Microbiology
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• 제43권4호
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• pp.354-360
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• 2005

Heat-labile enterotoxin B subunit (LTB) of enterotoxigenic Escherichia coli (ETEC) is both a strong mucosal adjuvant and immunogen. It is a subunit vaccine candidate to be used against ETEC-induced diarrhea. It has already been expressed in several bacterial and plant systems. In order to construct yeast expressing vector for the LTB protein, the eltB gene encoding LTB was amplified from a human origin enterotoxigenic E. coli DNA by PCR. The expression plasmid pLTB83 was constructed by inserting the eltB gene into the pYES2 shuttle vector immediately downstream of the GAL1 promoter. The recombinant vector was transformed into S. cerevisiae and was then induced by galactose. The LTB protein was detected in the total soluble protein of the yeast by SDS-PAGE analysis. Quantitative ELISA showed that the maximum amount of LTB protein expressed in the yeast was approximately $1.9\%$ of the total soluble protein. Immunoblotting analysis showed the yeast-derived LTB protein was antigenically indistinguishable from bacterial LTB protein. Since the whole-recombinant yeast has been introduced as a new vaccine formulation the expression of LTB in S. cerevisiae can offer an inexpensive yet effective strategy to protect against ETEC, especially in developing countries where it is needed most.