Archives of Pharmacal Research
- Volume 16 Issue 4
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- Pages.259-264
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- 1993
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Effects of Radioprotectors on DNA Repair Capacity of Tumor Cells
- Kim, Choon-Mi (College of Pharmacy, Ewha Womans University) ;
- Kim, Mi-Kyung (College of Pharmacy, Ewha Womans University)
- Published : 1993.12.01
Abstract
Three cell lines, CHO, L929 and B16 which are non-tumorigenic and cancer cells, respectively, were first tested for their survival in the presence of radioprotective ginseng protein fraction(GPF0. The influence of three radioprotectors-CPF, cysteamine, and 1-Methyl-2-bis[(2-methylthio)vinyl] quinolinium iodide (MVQI) on DNA repair capacity of UV damaged cells survival test, the GPF showed higher cytotoxicity in L929 and B16 than in CHO cells. However, the degree of cell killing was also investigated by measuring
Keywords
- Radioprotectors;
- Cell survival;
- UV damage;
- DNA repair capacity;
- PUVA treatment;
- $^3H$-thymidine incorporation