• Atmosphere
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• v.34 no.2
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• pp.153-176
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• 2024

At 0843 UTC 30 May 2021, a commercial aircraft encountered severe turbulence at z = 11.5 km associated with the rapid development of Mesoscale Convective System (MCS) in the Gyeonggi Bay of Korea. To investigate the generation mechanisms of Near-Cloud Turbulence (NCT) near the MCS, Weather Research and Forecasting model was used to reproduce key features at multiple-scales with four nested domains (the finest ∆x = 0.2 km) and 112 hybrid vertical layers. Simulated subgrid-scale turbulent kinetic energy (SGS TKE) was located in three different regions of the MCS. First, the simulated NCT with non-zero SGS TKE at z = 11.5 km at 0835 UTC was collocated with the reported NCT. Cloud-induced flow deformation and entrainment process on the downstream of the overshooting top triggered convective instability and subsequent SGS TKE. Second, at z = 16.5 km at 0820 UTC, the localized SGS TKE was found 4 km above the overshooting cloud top. It was attributed to breaking down of vertically propagating convectively-induced gravity wave at background critical level. Lastly, SGS TKE was simulated at z = 11.5 km at 0930 UTC during the dissipating stage of MCS. Upper-level anticyclonic outflow of MCS intensified the environmental westerlies, developing strong vertical wind shear on the northeastern quadrant of the dissipating MCS. Three different generation mechanisms suggest the avoidance guidance for the possible NCT events near the entire period of the MCS in the heavy air traffic area around Incheon International Airport in Korea.

• Environmental Engineering Research
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• v.24 no.4
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• pp.680-689
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• 2019

Temperature effects on the generation of brake wear particles from railway vehicles were generated, with a particular focus on the generation of ultrafine particles. A real scale brake dynamometer test was repeated five times under low and high initial temperatures of brake discs, respectively, to obtain generalized results. Size distributions and temporal patterns of wear particles were analyzed through visualization using clustered heatmaps. Our results indicate that high initial temperature conditions promote the generation of ultrafine particles. While particle concentration peaked within the range of fine sized particles under both low and high initial temperature, an additional peak occurred within the range of ultrafine sized particles only under high initial temperature. The timing of peak occurrence also differed between low and high initial temperature conditions. Under low initial temperature fine sized particles were generated intensively at the latter end of braking, whereas under high initial temperature both fine and ultrafine particles were generated more dispersedly along the braking period. The clustered correlation heatmap divided particle sizes into two groups, within which generation timing and concentration of particles were similar. The cut-off point between the two groups was approximately 100 nm, confirming that the governing mechanisms for the generation of fine particles and ultrafine particles are different.

• Journal of Ocean Engineering and Technology
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• v.31 no.6
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• pp.405-412
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• 2017

Because of the rapid development of computer technology in recent years, wave models can utilize parallel calculations for the high-resolution prediction of open sea and coastal areas with high accuracy. Parallel calculations also allow national agencies in the relevant sectors to produce marine forecasting data through massive parallel calculations. Meanwhile, the eastern coast of the Korean Peninsula has been increasingly damaged by swell-like high waves, and many researchers and scientists are continuing their efforts to anticipate and reduce the damage. In general, the short-term transformation of swell-like high waves can be reproduced relatively well in the third generation wave models, but the transformation of relatively long period waves needs to be simulated with higher accuracy in terms of the nonlinear wave interactions to gain a better understanding of the low-frequency wave generation and development mechanisms. In this study, we developed a calculation module to improve the calculation of the nonlinear energy transfer in the 3rd generation wave model and integrated it into the wave model to effectively consider the nonlinear wave interaction. First, the nonlinear energy transfer calculation module and third generation model were combined. Then, the combined model was used to reproduce the wave transformation due to the nonlinear interaction, and the performance of the developed operation module was verified.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.4
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• pp.888-894
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• 2009

It has been reported that silibinin, a natural polyphenolic flavonoid, induces cell death in various cancer cell types. However, the underlying mechanisms by which silibinin induces apoptosis in human glioma cells are poorly understood. The present study was therefore undertaken to examine the effect of silibinin on glioma cell apoptosis and to determine its underlying mechanism in human glioma cells. Apoptosis was estimated by FACS analysis. Reactive oxygen species (ROS) generation and mitochondrial membrane potential (${\Psi}m$) were measured using fluorescence dyes DCFH-DA and $DiOC_6$(3), respectively. Cytochrome c release from mitochondria and caspase-3 activation were estimated by Western blot analysis using specific antibodies. Exposure of cells to 30 mM silibinin induced apoptosis starting at 6 h, with increasing effects after 12-48h in a time-dependent manner. Silibinin caused ROS generation and disruption of ym, which were associated with the silibinin-induced apoptosis. The silibinin-induced ROS generation and disruption in ym were prevented by inhibitors of mitochondrial electron transport chain. The hydrogen peroxide scavenger catalase blocked ROS generation and apoptosis induced by silibinin. Silibinin induced cytochrome c release into cytosolic fraction and its effect was prevented by catalase and cyclosporine A. Silibinin treatment caused caspase-3 activation, which was inhibited by DVED-CHO and cyclosporine A. Pretreatment of caspase inhibitors also protected against the silibinin-induced apoptosis. These findings indicate that ROS generation plays a critical role in the initiation of the silibinin-induced apoptotic cascade by mediation of the mitochondrial apoptotic pathway including the disruption of ${\Psi}m$, cytochrome c release, and caspase-3 activation.

• Biomolecules & Therapeutics
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• v.20 no.6
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• pp.526-531
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• 2012

During our on-going studies to identify bioactive compounds in medicinal herbs, we found that saucerneol F (SF), a naturally occurring sesquilignan isolated from Saururus chinensis (S. chinensis), showed in vitro anti-inflammatory activity. In this study, we examined the effects of SF on the generation of 5-lipoxygenase (5-LO) dependent leukotriene $C_4$ ($LTC_4$), cyclooxygenase-2 (COX-2) dependent prostaglandin $D_2$ ($PGD_2$), and on phospholipase $C{\gamma}1$ ($PLC{\gamma}1$)-mediated degranulation in SCF-induced mouse bone marrow-derived mast cells (BMMCs). SF inhibited eicosanoid ($PGD_2$ and $LTC_4$) generation and degranulation dose-dependently. To identify the molecular mechanisms underlying the inhibition of eicosanoid generation and degranulation by SF, we examined the effects of SF on the phosphorylation of $PLC{\gamma}1$, intracellular $Ca^{2+}$ influx, the translocation of cytosolic phospholipase $A_2$ ($cPLA_2$) and 5-LO, and on the phosphorylation of MAP kinases (MAPKs). SF was found to reduce intracellular $Ca^{2+}$ influx by inhibiting $PLC{\gamma}1$ phosphorylation and suppressing the nuclear translocations of $cPLA_2$ and 5-LO via the phosphorylations of MAPKs, including extracellular signal-regulated protein kinase-1/2 (ERK1/2), c-Jun N-terminal kinase (JNK), and p38. Taken together, these results suggest that SF may be useful for regulating mast cell-mediated inflammatory responses by inhibiting degranulation and eicosanoid generation.

• Nuclear Engineering and Technology
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• v.28 no.1
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• pp.79-92
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• 1996

In a repository containing low-level waste, gas generation will occur principally by the coupled processes of metal corrosion and microbial degradation of cellulosic waste. This paper describes a mathematical model designed to address gas generation by these mechanisms and assesses the potential effects of gas generation on the performance of a radioactive waste repository. The metal corrosion model incorporates a three-stage process encompassing aerobic and anaerobic corrosion regimes ; the microbial degradation model simulates the activities of eight different microbial populations, which are maintained as functions both of pH and of the concentrations of particular chemical species. A prediction is made for gas concentrations and generation rates over an assessment period of ten thousand years in a radioactive waste repository. The results suggest that H$_2$will be the principal gas generated within the radioactive waste cavern.

• The Journal of the Korea Contents Association
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• v.22 no.7
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• pp.202-215
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• 2022

The purpose of this study is to identify gamification techniques and characteristics of digital marketing based on the main information communication, learning, and play of the current consumer group, and to present effective gamification digital marketing plans for the MZ generation. The summary of the research process is as follows. First, the characteristics and definitions of MZ generation and gamification were described and the concept was clarified. Second, domestic and foreign gamification cases were compared and analyzed. Studies show that we should be wary of gamification digital marketing, which fails to reflect the characteristics of the fun-seeking MZ generation by failing to organically connect the mechanisms and structures of gamification, focusing only on visible elements, such as Point, Badge, and Leaderboard. In addition, customers who lose the fun of obtaining rewards and leave because they feel that the rewards (points, badges, leaderboards) they provide are worthless should be prevented.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.37 no.5B
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• pp.385-394
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• 2012

The tactical mobile communication network, which comprises a part of the next-generation Tactical Information and Communication Network (TICN), provides means of communication and control for Tactical Multi-Functional Terminals (TMFT) belonging to a Mobile Subscriber Access Point (MSAP). The next-generation of MSAP is capable of constructing a backbone network via LCTR and HCTR directional antennas. At the same time, WMN modules are used to create and manage a wireless mesh backbone. When directional antennas are used in mobile environments, seamless services cannot be efficiently supported as the movement of the node prevents the angle of the antenna to constantly match. Therefore, data communication through the wireless mesh networks is required to provide direct communication between mobile MSAPs. Accordingly, mutual authentication and data encryption mechanisms are required to provide reliable data transmission in this environment. To provide efficient mutual authentication between MSAP devices, the process of verifying a certificate of the other MSAP device through its own authentication server is required. This paper proposes mutual authentication mechanisms where the MSAP requiring authentication and the MSAP that permits it initiates low-cost and efficient authentication in a distributed way. More specifically, we propose a method of applying EAP-ELS (Extensible Authentication Protocol-Transport Layer Security) in the next-generation TICN.

• Convergence Security Journal
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• v.19 no.1
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• pp.97-101
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• 2019

If the operating system's core file contains an Intel PT, the debugger can not only check the program state at the time of the crash, but can also reconfigure the control flow that caused the crash. We can also extend the execution trace scope to the entire system to debug kernel panics and other system hangs. The second-generation PT, the WinIPT library, includes an Intel PT driver with additional code to run process and core-specific traces through the IOCTL and registry mechanisms provided by Windows 10 (RS5). In other words, the PT trace information, which was limited access only by the first generation PT, can be executed by process and core by the IOCTL and registry mechanism provided by the operating system in the second generation PT. In this paper, we compare and describe methods for collecting, storing, decoding and detecting malicious codes of data packets in a window environment using 1/2 generation PT.

• Food Science and Biotechnology
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• v.17 no.5
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• pp.1079-1085
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• 2008

The chemopreventive activity of sulforaphane (SFN) occurs through its inhibition of carcinogen-activating enzymes and its induction of detoxification enzymes. However, the exact mechanisms by which SFN exerts its anti-carcinogenic effects are not fully understood. Therefore, the mechanisms underlying the cytoprotective effects of SFN were examined in MCF-7 breast cancer cells. Exposure of cells to SFN (10 ${\mu}M$) induced a transcriptional change in the AKR1C3 gene, which is one of aldo-keto reductases (AKRs) family that is associated with detoxification and antioxidant response. Further analysis revealed that SFN elicited a dose- and time-dependent increase in the expression of both the NRF2 and AKR1C3 proteins. Moreover, this up-regulation of AKR1C3 was inhibited by pretreatment with antioxidant, N-acetyl-L-cysteine (NAC), which suggests that the up-regulation of AKR1C3 expression induced by SFN involves reactive oxygen species (ROS) signaling. Furthermore, pretreatment of cells with LY294002, a pharmacologic inhibitor of phosphatidylinositol 3-kinase (PI3K), suppressed the SFN-augmented Nrf2 activation and AKR1C3 expression; however, inhibition of PKC or MEK1/2 signaling with $G\ddot{o}6976$ or PD98059, respectively, did not alter SFN-induced AKR1C3 expression. Collectively, these data suggest that SFN can modulate the expression of the AKR1C3 in MCF-7 cells by activation of PI3K via the generation of ROS.