• Genomics & Informatics
• /
• 제21권1호
• /
• pp.3.1-3.10
• /
• 2023

Characterization as well as prediction of the secondary and tertiary structure of hypothetical proteins from their amino acid sequences uploaded in databases by in silico approach are the critical issues in computational biology. Severe acute respiratory syndrome-associated coronavirus (SARS-CoV), which is responsible for pneumonia alike diseases, possesses a wide range of proteins of which many are still uncharacterized. The current study was conducted to reveal the physicochemical characteristics and structures of an uncharacterized protein Q6S8D9_SARS of SARS-CoV. Following the common flowchart of characterizing a hypothetical protein, several sophisticated computerized tools e.g., ExPASy Protparam, CD Search, SOPMA, PSIPRED, HHpred, etc. were employed to discover the functions and structures of Q6S8D9_SARS. After delineating the secondary and tertiary structures of the protein, some quality evaluating tools e.g., PROCHECK, ProSA-web etc. were performed to assess the structures and later the active site was identified also by CASTp v.3.0. The protein contains more negatively charged residues than positively charged residues and a high aliphatic index value which make the protein more stable. The 2D and 3D structures modeled by several bioinformatics tools ensured that the proteins had domain in it which indicated it was functional protein having the ability to trouble host antiviral inflammatory cytokine and interferon production pathways. Moreover, active site was found in the protein where ligand could bind. The study was aimed to unveil the features and structures of an uncharacterized protein of SARS-CoV which can be a therapeutic target for development of vaccines against the virus. Further research are needed to accomplish the task.

• 대한한방내과학회지
• /
• 제19권2호
• /
• pp.37-49
• /
• 1998

To make a objective diagnosis of the syndrome of cold-limbs, We investigated the 20 patients with cold limbs and GI trouble and 20 normal people as a control group. And we compared the thermal difference between Chon-jung(CV17) and Chung-wan(CV12 中脘), Chon-jung(CV17) and Ki-hae(氣海 CV6) and we compared the thermal differences of No-gung(PE8 勞宮) and Yong-chon(湧泉 KI1), too. The results were as follows. 1. All 20 patients had GI trouble and cold limbs. They had the symptom-Indigestion(16 cases-80%) with heart burn, tympanites, abdominal distention, hiccup, belching. Beside that symptom they also had constipation(6 cases-30%), diarrhea(3 cases-15%), headache & dizziness(6 cases-30%). And some had the menstrual syndrome, chronic fatigue, palpitation, insomnia, edema, arthralgia. 2. The thermal difference of the palms between the patients group and the control group were $25.70^{\circ}C,\;25.82^{\circ}C$, but they were not significant. 3. The thermal difference of the soles between the patients group and the control group were $23.58^{\circ}C,\;24.42^{\circ}C$ and the significancy was P=0.020 so it was significant(P<0.05). 4. The thermal difference of the palms and Chon-jung(CV17) between the patients group and the control group were $1.08^{\circ}C,\;0.76^{\circ}C$, but they were not significant. 5. The thermal difference of the sales and Chon-jung(CV17) between the patients group and the control group were $3.01^{\circ}C,\;1.90^{\circ}C$ and the significancy was P=0.003 so it was significant(P<0.05). 6. The thermal difference of Chon-jung(CV17) and Chung-wan(CV12 中脘) between the patients group and the control group was $0.30^{\circ}C,\;0.62^{\circ}C$ and the significancy was P=0.793 so it was significant(P<0.05). 7. The thermal difference of Chon-jung(CV17) and Ki-hae(CV6 氣海) between the patients group and the control group was $0.53^{\circ}C,\;0.68^{\circ}C$, but they were not significant. From the above, I could find the significance of D.I.T.I to diagnose the cold-feet not the cold-hands and the thermal difference between the trunk and limbs was more significant on cold-feet than on cold-hand, either.

• 한국전산구조공학회논문집
• /
• 제20권1호
• /
• pp.65-73
• /
• 2007

구조 역섭동 문제에서, 신뢰할 만한 결과를 얻기 위해서는 정의되지 않은 모든 자유도가 미지변수로 간주되기 때문에 많은 전산자원이 필요하다. 본 연구에서는 축소시스템 기법과의 연동을 통해 정의되지 않은 자유도를 축소시스템에서 정의된 자유도 정보로 대체함으로써 해의 정확성과 계산의 효율성을 확보하는 기법을 제안한다. 일반적으로 구조 시스템을 축소할 경우, 시스템 축소변환 행렬에 오차가 포함되게 된다. 이 오차로 인해 축소기법을 적용하여 역섭동 문제의 정확한 해를 구하는 것은 쉽지 않은 문제이다. 이러한 문제를 해결하기 위해서 자유도 변환행렬을 매 단계마다 개선하는 반복적 축소 시스템 기법을 적용한다. 자유도 기반 축소시스템의 신뢰성은 주자유도 선정 위치와 변환행렬의 반복 계산 횟수에 의해 결정되며, 변환행렬의 반복 계산을 줄이기 위해서는 시스템 구축 초기에 주자유도가 잘 선정되어야 한다. 따라서, 본 연구에서는 축소모델의 정확도를 향상시키고 변환 행렬의 반복 계산을 최소화하기 위해 2단계 축소기법을 적용하여 주자유도 위치를 선정한다. 최종적으로 수치예제를 통해서 반복적 역섭동법의 효용성을 확인한다.

• Tuberculosis and Respiratory Diseases
• /
• 제67권4호
• /
• pp.325-330
• /
• 2009

Background: Pulmonary tuberculosis (TB) is still common disease among the elderly patients in Korea where the overall incidence of TB is decreasing. Adverse drug reactions (ADR) associated with anti-TB drugs occurs frequently. Especially the aged tends to have more frequent ADRs than younger ones. These ADRs can cause significant morbidity, compromise therapeutic effects of drugs and even induce drug resistance. Therefore we evaluated the effect of ADRs on the first-line anti-TB drugs in elderly patients with active pulmonary TB. Methods: We retrospectively reviewed the charts and radiological findings of the patients with 65 and older who were bacteriologically confirmed as active TB and treated with standard anti-TB drugs for at least 6 months. Major ADR was defined with temporary or continuous stop of any first-line drugs intake. Results: An ADR was noted in 54% of all patients. The incidence of major ADR was 32% in all elderly patients. Dermatologic ADR (9%) was the most common among the major ADRs. GI trouble (8%), arthralgia (6%), visual change (6%), hepatotoxicity (4%), and fever (1%) were also noted. The drugs responsible for major ADR were ethambutol (62%), pyrazinamide (35%), rifampin (18%) and isoniazid (9%). Major ADRs were associated with higher ESR level at the initiation of anti-TB drugs. Conclusion: First-line anti-TB drugs in elderly patients frequently caused the major ADRs. Therefore the elderly patients receiving anti-TB drugs should be closely monitored and better tolerable therapy should be considered as part of a TB research agenda.

• 한국지리정보학회지
• /
• 제13권1호
• /
• pp.101-113
• /
• 2010

최근에 발생하는 강우양상은 강우일수는 감소하고, 강우강도는 증가해 홍수발생 빈도 역시 증가하는 추세이다. 이를 반영하기 위한 기존의 방법은 수공구조물의 설계홍수량을 산정할 때 가능최대강우량을 도입하거나, 설계빈도를 높이는 등의 확정론적 방법에 의존한다. 그러나 이렇게 설계기준을 상향 조정한 경우, 설계빈도의 강우가 발생하지 않으면 수공구조물의 경제성 측면에서 문제가 될 소지가 있다. 또한 수공구조물의 규모가 클수록 인근 주민과의 마찰이 커지고, 환경 문제의 발생 역시 고려하지 않을 수 없다. 이에 따라 설계빈도의 무조건적인 상향조정에 의존하기보다 추계학적 방법을 도입한 수문량의 확충 및 매개변수의 불확실성을 수공구조물 설계 시에 고려하기 위한 연구가 활발히 진행되고 있다. 본 연구에서는 강우발생의 불확실성을 반영하여 제내지에서의 침수범위를 GIS상에서 검토하였다. 이를 위해 log-ratio 방법, Johnson 시스템, 직교변환을 활용한 다변량 Monte Carlo 기법으로 추계학적 시간에 따른 강우변동을 생성하였다. 생성된 강우변동 결과를 토대로 수문분석, 홍수위 분석 등을 실시하고 FLUMEN 모형을 적용하여 해당유역에 대한 홍수범람시 침수범위를 산정하였다. 본 연구결과는 실제 강우의 불확실성을 반영하고 있어 시 공간적 강우특성이 반영된 유역별 주민대피지도, 홍수위험지도 등을 제작하는데 활용될 수 있을 것으로 판단된다.

• 보험의학회지
• /
• 제24권
• /
• pp.97-117
• /
• 2005

Internally Korean insurance market is that whole life products' growth are becoming slowdown that's why new insurance products have appeared on the market in consideration of consumer's needs recently. Externally domestic insurance market competitions has drifted from insurance industry to whole financial industry since bankasurance started. Life insurance companies should open up a new market to survive from severe competitions. Worksite marketing can be an alternative. An insurer make arrangements with an employer about an insurance terms which an insurer offers in Worksite marketing. Then eligible individuals enroll in the plans at their own discretion and pay 100 percent of the premium for coverage through payroll deductions. An employer doesn't need to pay extra money for additional benefit but can raise employee's loyalty and satisfaction of company through worksite marketing. An employee can be covered at discounted premium rate and less strict underwriting guidelines to an insurer compared to individual insurance. In developed countries specially U.S insurance market, Worksite marketing is getting very popular and growing rapidly due to the advantages. Worksite marketing has both individual insurance characters and group insurance characters. Individual insurance characters are that employees enroll in the plans at their own discretion and pay 100 percent of the premium for coverage. Group insurance characters are that actively at work and participation etc. An insurer have to reflect these two characters on Worksite marketing when an insurance company work out a plan for developing products and underwriting guidelines. When an insurer devise worksite products, one should consider participation level which means percentage of eligible employees participating. Participation is related to anti-selection. As we know underwriting is essential for every kind of insurance, especially underwriting plays major role in worksite marketing. We can see that in the below. Firstly, it has a function in calculation of premium rate. When calculate premium rate for worksite products underwriters have to estimate expected participation level and risk factors. So underwriters and acturies keep in close contact with each other. Secondly, underwriting methods are important. When an insurer underwrite worksite products, there are three kinds of underwriting methods. These are Simplified issue underwriting, Full underwriting and Guaranteed issue underwriting. Simplified issue underwriting typically requires no medical examination, but usually requires supplying satisfactory answers to one or several health and/or lifestyle questions. Full underwriting requires a complete medical history questionnaire that may further require an exam. Guaranteed issue underwriting means that coverage is issued without the employee having to provide evidence of insurability. When insurer set the GI limit are usually based on the type of industry, number of eligible employees, the average amount of coverage and participation level. In addition to insurer should have a clear definition of eligible employee on the insurance provision and application form. It will minimize possibility of trouble claims and anti-selection. An insurer also establish preexisting condition exclusion and special guidelines for late entrants. When an insurer introduce Worksite marketing to Korean insurance market, an insurer has to examine market research to analyze potential market and strategy of sales most of all. Also an insurer should review real situation of the U.S, England and Japanese market etc. There are a lot of new technologies about worksite marketing process that an insurer should learn. When an insurer consider many things which we explained it can be a real alternative.

• 한국전산구조공학회논문집
• /
• 제27권5호
• /
• pp.421-427
• /
• 2014

현실세계의 구조물은 대부분 동하중의 영향을 받고 있지만, 구조해석이나 구조 최적화를 수행할 때는 정하중이 작용하는 것으로 가정한다. 실제 하중인 동하중을 고려하게 되면 다양한 하중들을 고려해야 하기 때문에 전산자원과 시간비용 측면에서 많은 제약이 따르기 때문이다. 그러나, 단순한 정하중 조건만을 고려하면 구조안전성 측면에서 바람직하지 못하기 때문에 가중치를 적용하거나 동하중을 대체하는 등가정하중을 적용하여 관련 문제를 보완하려는 연구가 진행되어 왔다. 본 연구에서는 등가정하중을 적용하여 동하중을 받고 있는 구조물에 대한 구조최적화 기법을 제안한다. 본 연구에서 적용하는 등가정하중은 기존 연구에서 제안한 바 있는 주자유도를 기반으로 하여 등가정하중 부과 위치를 결정하고 최적화 과정을 통해 산출한다. 이 과정에서 지나치게 큰 하중이 구해지지 않도록 가중치를 고려한 구속조건을 추가하여 기존 연구의 등가정하중의 최적화 과정을 보완하였다. 수치예제에서는 동하중이 작용하는 트러스 구조물과 평판 구조물에서 최적화된 등가정하중을 적용하여 사이즈 최적화를 수행함으로써 제안된 최적화 기법의 신뢰성을 검증한다.

• 생물정신의학
• /
• 제20권3호
• /
• pp.111-117
• /
• 2013

Objectives We investigated the effectiveness and safety when treated in schizophrenics with paliperidone palmitate, a long acting injectable antipsychotic. Methods This was a 24-week open-label study, performed at one center in Korea. The eligible patients with schizophrenia diagnosed by Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) criteria were enrolled. Patients received long-acting paliperidone palmitate injection (234 mg, baseline; 156 mg, week 1 ; then once 4 weeks flexible dosing). Effectiveness assessments were measured by the Positive and Negative Syndrome Scale (PANSS), The Clinical Global Impression Severity Scale (CGI-S), The Personal and Social Performance (PSP) at baseline, week 1, every 4 weeks untill 24 weeks or endpoint. Safety assessments were measured by The Extrapyramidal Symptom Rating Scale (ESRS), body weight (BW) and incidence of adverse events. Oral antipsychotics were stopped or tapered off within next 14 days. Results Of 20 patients recruited, 9 patients (45%) completed the study. Paliperidone palmitate produced a significant improvement in PANSS total score from baseline to endpoint. The response rate was 75% [mean change (${\pm}SD$) $-25.9{\pm}14.4$, all p < 0.001]. The CGI-S and PSP total scores significantly improved during 24 weeks (All p < 0.001). Eighty percent of patients reported adverse events and most common adverse events (${\geq}10%$) in paliperidone palmitate were anticholinergic adverse event, extrapyramidal symptoms, weight gain, akathisia, insomnia, headache, agitation, anxiety and GI trouble. ESRS score is not statistically significant, but tends to get better at the end of the study when compared to baseline. Conclusions Our study results demonstrated maintained effectiveness and safety of paliperidone palmitate treatment in schizophrenics. And provides both clinicians and patients with a new choice of treatment that can improve the outcome of long term therapy. Their potential effectiveness and safety should be better addressed by future randomized-controlled trials.

• 대한공간정보학회지
• /
• 제6권2호
• /
• pp.69-79
• /
• 1998

현대사회는 도로, 상 하수도, 가스, 전화 등 여러 가지 사회기반시설물의 효율적 관리가 필수적이다. 그 중에서도 하수도시설은 지역 주민의 생활환경보호와 공공수역의 수질 보전을 위하여 가능한 최적의 상태로 관리되어야 한다. 기존의 일부 지자체 및 기업체에서는 이러한 하수도시설물을 효율적으로 관리할 수 있도록 하수관리시스템을 개발하여 사용하고 있다. 이러한 시스템의 제약점은 관망의 관리기능만을 제공할 뿐 관망에 부하되는 하수량에 대한 분석기능은 제공치 않으며, 일부 제공된 분석기능은 모든 관거를 획일적인 조건에서 분석하는 관계로 실제업무의 적용에는 현실적으로 타당치 않은 실정이다. 따라서 이번 연구에서는 이러한 하수시설물에 대한 관망분석을 도시계획도를 기본으로 용도지역별 특성에 따라 조건을 달리하여 분석할 수 있는 시스템을 개발하였다. 본 시스템은 각각의 하수관에 부하되는 하수량을 파악학 수 있음은 물론 우수량의 변화 및 인구밀도의 변화에 따라 부하되는 하수량의 변화에 대한 모의실험의 지원과 도시의 팽창 및 신도시의 건설에 따른 하수도 시설설계에 대한 의사결정을 지원할 수 있도록 하였다. 이러한 본 연구의 결과물은 통수능 부족관거의 검색을 통하여 민원발생시 적절한 의사결정지원이 가능하며, 관련 업무의 효율성증대 및 대민서비스 향상에 기석도가 크리라 판단된다.

• 대한치과보철학회지
• /
• 제54권1호
• /
• pp.41-48
• /
• 2016

치아 상실에 이어 심각한 치조골 소실을 보이는 무치악 환자들은 전통적인 방식의 총의치를 사용하는데 어려움이 많다. 이러한 문제를 보완할 수 있도록 임플란트를 이용한 피개의치가 사용되고 있다. SFI-bar$^{(R)}$는 진료실에서 직접 조정이 가능한 기성품으로 복잡한 기공과정을 필요로 하는 기존의 바 시스템보다 간결하여 시간과 비용을 절감할 수 있다. 첫 번째 증례는 55세 남자 환자로 기존 하악 임플란트-지지 피개의치가 파절되었다는 주소로 내원하였고 내구성이 있으며 통증이 없는 의치를 원하였다. 파절된 Locator$^{(R)}$ 어태치먼트를 제거 후 바를 이용한 피개의치로 치료하였다. 두 번째 증례는 파킨슨병을 앓고 있는 77세 여자 환자로 하악 치조골이 심각하게 흡수되어 의치가 자주 탈락한다는 주소로 내원하였고 통증이 없고 유지력이 있는 의치를 원하였다. 하악 전치부에 두개의 임플란트를 식립한 후 임플란트에 연결된 어댑터에 바를 연결하였다. 그 후 바에 맞는 여성부를 새로운 의치에 장착하여 치료하였다. 2년의 추적 관찰 결과 상기 환자 모두 심미적, 기능적으로 만족할만한 결과를 보였으므로 증례를 보고하고자 한다.