• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2006년도 PARALLEL CFD 2006
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• pp.209-210
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• 2006

• 동의생리병리학회지
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• 제16권1호
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• pp.99-103
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• 2002

Geopungdodam-tang(GDT) have been used in oriental medicine for many centuries as a therapeutic agent of apoplexy. The mechanism of GDT on the cerebral blood flow is not known. The purpose of this Study was to investigate effects of GDT on the pial arterial diameter and action mechanism of GDT-induced increased regional cerebral blood flow(rCBF). The changes of regional cerebral blood f1ow(rCBF) was determinated by Laser-Doppler Flowmetry(LDF), and the changes of pial arterial diametet were determinated by video microscopy methods and video analyzer. The results were as follows ; 1. Pial arterial diameter was significantly increased by GDT in a dose-dependent manner. 2. Pretreatment with L-NNA significantly inhibited GDT induced increased rCBF. 3. Pretreatment with methylene blue significantly inhibited GDT induced increased rCBF. 4. Pretreatment with indomethacin inhibited GDT induced increased rCBF. These results suggest that GDT causes a diverse response of cerebral hemodynamics(rCBF and pial arterial diameter). The cerebral hemodynamics is also mediated by nitric oxide synthase, cyclic GMP(guanylyl cydase) and prostaglandin(cyclooxygenase).

• 대한한의학회지
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• 제28권3호통권71호
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• pp.183-196
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• 2007

Objective : This study was conducted in order to find the effects of Gammaekdaejo-tang (Ganmaidazao-tang, GDT) by subjecting rats to immobilization stress, thereby inducing depression, anxiety and acquisition-retention defects. Method : Rats treated with normal saline, GDT 200mg/kg and GDT 400mg/kg were subjected to stress by immobilization. Afterwards, behavior changes were observed by elevated plus maze test, acquisition test and retention test in the Morris water maze. The results were obtained by immunohistochemically measuring stress hormone (corticosteroid) levels in the blood. Results and Conclusions : 1. The open arm test in the elevated plus maze showed that compared with the normal group, the time spent decreased in the control group and increased in the GDT 400mg/kg group. 2. The locomotor activity test in the elevated plus maze revealed that the control group showed significant activity decrease compared with the normal group but significant increase in the GDT 400mg/kg group. 3. The acquisition test in the Morris water maze showed that the acquisitive ability of the control group significantly deteriorated on the 3rd and 4th day compared with the normal group, but improved significantly in the GDT 200mg/kg and GDT 400mg/kg groups. 4. The retention test on the 7th day in the Morris water maze revealed that the retentive ability of the control group significantly deteriorated compared with the normal group, but the retentive ability of the GDT 400mg/kg group significantly improved. 5. The blood levels of corticosteroid in the control group increased significantly compared with the normal group but the levels of corticosterone in the blood of the GDT 400mg/kg group significantly decreased.

• 대한한방내과학회지
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• 제39권1호
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• pp.1-8
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• 2018

Objectives: This study seeks to investigate the effects of Gamidohongsamul-tang (GDT) on the Gene expression levels of eNOS, KLF2, ICAM-1 and VCAM-1 in HUVEC cells. Methods: HUVEC cells were treated at a concentration of 1, 10, 100 (${\mu}g/ml$) of Gamidohongsamul-tang (GDT). To measure the NOS, KLF2, ICAM-1 and VCAM-1 gene expression in HUVEC cells, the synthesized cDNA was subjected to polymerase chain reaction (PCR) and electrophoresis was performed to verify gene expression level. Results: 1. GDT significantly increased eNOS and KLF2 gene expression. 2. GDT significantly reduced ICAM-1 and VCAM-1 gene expression. Conclusions: These experiments suggest that Gamidohongsamul-tang (GDT) regulates gene expression related with anti-dyslipidemic effects in HUVEC cells. In order to clinically apply this to diseases related to dyslipidemia, such as cardiovascular disease, additional in vivo experiments are needed to verify the anti-dyslipidemic effects of GDT.

• 한방재활의학과학회지
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• 제19권2호
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• pp.89-102
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• 2009

Objectives : This study was carried out to understand the immunity responses and anti-oxidation effect of the Gamidaeganghwal-tang(GDT) on rheumatoid arthritis by using the THP-1 cells and the serum of CIA mice. Methods : For this purpose, GDT was orally administerd to mice with rheumatoid arthritis induced by collagen II. To investigate the immunity responses, value of cytokine and gene expression in the THP-1 cell, levels of cytokines in the serum of CIA(collagen type II induced arthritis) mice, number of immunocyte in PBMC of CIA mice were measured. Then, anti-oxidant activity, scavenging activity on DHHP(2,2-diphenyl-1-picrylhydrazyl) free radical and SOD(Superoxide dismutae)-like activity of GDT was observed. Results : 1. The levels of IL-$1{\beta}$, IL-6, IL-8, MCP-1 at 100, $50{\mu}g/m{\ell}$ of GDT were significantly reduced in the THP-1 cell. 2. The levels of TNF-${\alpha}$, COX-2 mRNA expression at 100, $50{\mu}g/m{\ell}$ of GDT and IL-$1{\beta}$, IL-6 at $100{\mu}g/m{\ell}$ of GDT were significantly reduced in the THP-1 cell line. 3. The levels of IL-6, TNF-${\alpha}$ and IL-$1{\beta}$ were significantly reduced in the serum of CIA mice. 4. The absolute number of CD3+, CD4+ and CD8+ cells were significantly induced, CD3+/CD69+, CD3+/CD49+, CD19+, B220+/CD23+ cells were significantly reduced in PBMC. 5. Scavenging activity on DPPH free radical and SOD-like activity were significantly induced in a concentration dependent manner. Conclusions : Taking all these observations, GDT considered to be effective in treating rheumatoid arthritis. Therefore we have to survey continuously in looking for the effective substance and mechanism in the future.

• 조명전기설비학회논문지
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• 제26권7호
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• pp.92-98
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• 2012

It is made compulsory to install SPD for the purpose of protecting electric and electronic devices when an abnormal voltage such as lightning occurs to power line using power frequency of 60Hz. Recently, the high speed communication technology utilizing power line is receiving attention again as a communication technology for smart grid. The SPD influences the performances of power line communication when using SPD and power line communication system together. In order to improve the performance of power line communication, a proposed scheme for series connection of gas discharge tube to ZnO varistor was presented. This paper measured the impacts of series connection of GDT to SPD using ZnO varistor on the limit voltage of Class III SPD. This paper also presented the DC operating voltage of GDT which satisfies the limit voltage of power line communication system and SPD simultaneously.

• 공업화학
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• 제21권2호
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• pp.205-210
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• 2010

본 연구에서는 기체방전관의 과전압 보호 성능과 수명에 미치는 절연파괴 특성을 알아보기 위하여 황동전극을 이용하여 기체방전관을 제조하였다. 황동전극을 이용한 기체방전관의 절연파괴 특성은 인가전압의 기울기와 방전관 내부의 질소기체 압력을 통하여 알아보았다. 방전관 인가전압의 기울기가 증가할수록 절연파괴 전압과 방전 시 소비되는 에너지량이 크게 상승되었고, 절연파괴 시간은 감소되었다. 방전관 내부 질소기체의 압력이 감소할수록 절연파괴 전압과 절연파괴 소요시간, 방전 소비에너지량이 크게 감소되었다. 결과적으로, 방전관의 과전압 보호 성능 및 수명을 증진시키기 위해서는 절연파괴 전압과 절연파괴 소요시간, 방전 시 소비되는 에너지량이 감소되어야 함을 알 수 있었다. 한편, 방전관 내부 질소기체 압력이 방전관의 자체 수명 및 과전압 보호 성능에 영향을 미침을 알 수 있었다.

• 대한의생명과학회지
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• 제26권3호
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• pp.210-216
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• 2020

The purpose of this study was to evaluate GDH & Toxin (GDT) tests for the identification of the presence of Clostridioides difficile (C. difficile) as well as to detect whether any toxin was present in the feces of patients suspected of diarrhea associated with C. difficile. Data related to the results of toxin and culture (TC) tests and GDT tests conducted on patients with diarrhea and suspected CDI between January 2017 and august 2018, positive test rates, patient ages and sexes, whether the patients were hospitalized, and turnaround time (TAT) were analyzed retrospectively. Of the 7,554 total tests conducted for CDI diagnosis, 1,010 TC tests (14.9%) were positive, while 92 GDT tests (12.0%) were positive. Of these positive cases, 815 (80.7%) identified through TC test and 80 (87%) identified through GDT test were inpatients. also, among the patients with positive test results, 497 (49.2%) diagnosed through TC test and 45 (48.9%) diagnosed through GDT test were aged 61 years or older. The total time required to complete a TC test was 83.6 hours, while the time required for a GDT test was 11.2 hours, equating to an approximately three-day difference between the two tests. The detection of toxin-producing C. difficile is important in CDI diagnosis, but the commonly used Enzymeimmunoassay (EIA) toxin tests with low sensitivity result in delayed CDI diagnosis time. Therefore, primary screening tests for CDI diagnosis using the GDT method and secondary tests using additional methods are considered most effective.

• 한국조명전기설비학회:학술대회논문집
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• 한국조명전기설비학회 2006년도 춘계학술대회 논문집
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• pp.355-359
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• 2006

ZnO varistor and GDT(gas discharge tube) have proven to be good protective devices because of their flexibility and high reliability. ZnO varistors are characterized by their excellent nonlinear properties. GDTs are used for applications in communication or signaling circuits because they have very low capacitance. Therefore, It is very important to understand the V-I characteristic of ZnO varistor and GDT for designing SPD to protect apparatus or personnel from high transient voltage. This paper gives experimental V-I characteristic data of ZnO varistor and GDT for protecting electronic equipments from surge up to maximum discharge current.

• 한국음향학회지
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• 제41권1호
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• pp.58-63
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• 2022

본 연구는 저주파수 순음(264 Hz, 373 Hz, 528 Hz)을 이용하여 Within-/Cross-Channel Gap Detection Thresholds(WC/CC GDTs)를 통해서 피치인식 및 시간적 청각정보처리능력 특성을 알아보기 위해 실험연구를 실시하였다. 정상청력을 갖는 청년층 40명과 장년층 20명을 대상으로 WC/CC GDTs를 측정·비교분석하였다. WC GDTs 결과는 두 그룹 모두 평균적으로 2 ms ~ 4 ms를 갖으며, 통계적으로 유의미한 차이를 보이지 않았다. CC GDTs는 WC GDTs에 비해 두 그룹 모두 크게 증가하였으며, 특히 장년층의 결과가 청년층 결과에 비해 모두 8배 ~ 10배 증가하여 통계적으로 유의미한 차이를 보였다. CC GDTs는 선/후행음의 주파수의 차이가 커질수록 모두 증가하는 경향이 나타났으며, 청년층은 증가폭이 일정한 반면 장년층은 증가폭이 둔화되는 경향을 보였다. 또한, 이러한 자료는 기존 음악적 자극에 대한 GDT와는 다른 경향을 나타내었다. 연구 결과는 GDT가 피치인식 메커니즘에 영향을 미칠 수 있으며 청각 신경계의 비선형 반응에 대한 심리음향적 근거자료로 활용될 수 있을 것이다.