• Journal of the Korean Geosynthetics Society
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• v.12 no.4
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• pp.123-131
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• 2013

The patents trends registered in korea, the USA, Japan and Europe were analyzed to forecast the direction of R&D for the technology of sediment disaster. As a result of portfolio analysis, the number of patents in Korea have continued to rise, but have been placed behind the other countries. The level of technology of each country was investigated. In the survey technology and sensing technology, the Korean and USA situations were classified as a period of growth, and the Japanese situation was classified as a period of decline. In the control technology and protection technology, Korean situation was classified as a period of growth, and the Japanese situation was classified as a period of decline. As a result of analysis for a direction of R&D using blank technologies, standardization of analysis technologies for mechanism, fusion techniques between ICT and conventional techniques, development of eco-friendly materials and evaluation of structure should be developed by R&D in Korea.

• Journal of the Microelectronics and Packaging Society
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• v.18 no.3
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• pp.33-37
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• 2011

In this study, the degradation mechanism of mounted chip resistors with Ag-epoxy isotropic conductive adhesives (ICAs) under the humidity exposure ($85^{\circ}C$/85%RH) was examined by electrical resistance change and microstructural study. The effect of the chloride content in Ag-epoxy ICA on joint stability was also examined. The increasing range of the electrical resistance in the typical ICA joint was greater than that in the low Cl content ICA joint. In the case of the typical ICA joint, Sn oxides such as SnO, $SnO_2$, and Sn-Cl-O were formed inhomogeneously on the surface of the Sn plating during the $85^{\circ}C$/85%RH test. In contrast, no Sn-Cl-O was found in the low Cl content ICA joint during the $85^{\circ}C$/85%RH. It is suggested that Cl in Ag-epoxy ICA accelerate the electrical degradation of Sn plated chip components joined with Ag-epoxy ICA.

• 한국HCI학회:학술대회논문집
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• 2008.02a
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• pp.534-539
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• 2008

This paper is about intelligent hexapod robot for the support walking of the aged person. The robot using various sensors and small camera has various abilities of forward backward walking, turing left or right, control the speed of walking, avoiding the obstacles and detecting risky situation of fire or gas. To let the aged feel soft and safe walking, we used special servo motor and developed hexapod walking mechanism and effective algorithm.

• Journal of Microbiology
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• v.44 no.1
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• pp.35-41
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• 2006

The unique gene encoding thioredoxin reductase (TrxR) was previously cloned and characterized from the fission yeast Schizosaccharomyces pombe, and its expression was induced by oxidative stress. To elucidate tbe regulatory mechanism of the S. pombe TrxR gene, three fusion plasmids were generated using polymerase chain reaction: pYUTR20, pYUTR30, and pYUTR40. Plasmid pYUTR20 has an upstream region of 891 base pairs, pYUTR30 has 499 in this region, and pYUTR40 has an 186 bp upstream region. Negatively acting sequence is located between $-1,526\;\~\;-891bp$ upstream of the gene. The upstream sequence, responsible for the induction of TrxR by menadione (MD), is situated on the $-499\;\~\;-186bp$ region, which is also required for TrxR induction by mercuric chloride. The same region also appeared to be required for Pap1-mediated transcriptional regulation of the TrxR gene, which contains the two plausible Papl binding sites, TTACGAAT and TTACGCGA. Consistently, basal and inducible expression of the TrxR gene was markedly lower in the Pap1-negative TP108-3C cells than in wild-type yeast cells. In summary, up-regulation of the S. pombe TrxR gene is mediated by Pap1 via the transcriptional motif(s) located on the $-499\;\~\;-186bp$ region.

• Journal of Microbiology
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• v.42 no.3
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• pp.233-238
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• 2004

Transcriptional regulation of the Schizosaccharomyces pombe y-glutamylcysteine synthetase (GCS) gene was examined using the two GCS-lacZ fusion plasmids pUGCS101 and pUGCS102, which harbor 607 bp and 447 bp upstream regions, respectively. The negatively-acting sequence was located in the -607 - -447 bp upstream region of the GCS gene. The upstream sequence responsible for induction by menadione(MD) and L-buthionine-(S, R)-sulfoximine (BSO) resides in the -607 - -447 bp region, whereas the sequence which codes for nitric oxide induction is located within the -447 bp region, measured from the translational initiation point. Carbon source-dependent regulation of the GCS gene appeared to be dependent on the nucleotide sequence within -447 bp region. The transcription factor Papl is involved in the induction of the GCS gene by MD and BSO, but not by nitric oxide. Induction of the GCS gene occurring due to low glucose concentration does not depend on the presence of Pap1. These data imply that induction by MD and BSO may be mediated by the Pap1 binding site, probably located in the -607 - -447 region, and also that the nitric oxide-mediated regulation of the S. pombe GCS gene may share a similar mechanism with its carbon-dependent induction.

• Economic and Environmental Geology
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• v.28 no.3
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• pp.287-303
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• 1995

Tungsten ore deposits in China show clearly their relationship between granitoids and orebodies. All kinds of different tungsten ore deposits, having the largest ore reserves in the world, occur in China. Major tungsten deposits in 1950'years were locally confined in three provinces such as Jiangxi, Hunan and Guangdong. However, the major tungsten ore deposits are replaced by new tungsten deposits such as Sandahozhuang, Xingluokeng, Shizhuan and Daminghsan deposit which may be larger than the previous major deposits. Tungsten ore deposits of China exhibit obviously the granitoid was the ore-bringer to form tungsten ore deposits. The wolframite-bearing quarz veins in China indicate that tungsten mineralization took place by crystallization of wolframite preferentially unless $Ca^{{+}{+}}$ was introduced from outside into the magma-origin-fluid, since it is understood that the scheelite in the Sangdong ore deposit was preferentially precipitated, because of chemical affinity, from the tungsten fluid in which Fe and Ca ions were as sufficient as to form magnetite, wolframite and scheelite. Tungsten deposits in the world are divided into two systems; W-Mo-Sn system and W-Mo system. Most of tungsten deposits in China dated to about 196-116 Ma belong to the W-Mo-Sn system, while late Cretaceous tungsten deposits such as the Sangdong deposit in Korea belongs to the W-Mo system. The genetic order of tin-tungsten-molybdenum mineralization observed in the Moping tungsten mine in China and the Sangdong in Korea may be attributed to volatile pressures in the same magma chamber. It is assumed from ages of tungsten mineralizations that ore elements such as tin, tungsten and molybdenum might be generated periodically by nuclear fission and fusion in a part of the mantle and the element generated was introduced into the magma chamber. The periodical generation of elements had determined association, depletion and enrichment of tin and molybdenum in tungsten mineralization and it results in little association of cassiterite in tungsten deposit of late Cretaceous ages. Different mechanism of emplacement of the ore-bearing magma has brought various genetic types of tungsten deposits as shown in China and the world.

• Journal of Microbiology and Biotechnology
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• v.26 no.5
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• pp.918-927
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• 2016

Cryptococcus neoformans is a life-threatening pathogenic yeast that causes devastating meningoencephalitis. The mechanism of cryptococcal brain invasion is largely unknown, and recent studies suggest that its extracellular microvesicles may be involved in the invasion process. The 14-3-3 protein is abundant in the extracellular microvesicles of C. neoformans, and the 14-3-3-GFP fusion has been used as the microvesicle's marker. However, the physiological role of 14-3-3 has not been explored. In this report, we have found that C. neoformans contains a single 14-3-3 gene that apparently is an essential gene. To explore the functions of 14-3-3, we substituted the promoter region of the 14-3-3 with the copper-controllable promoter CTR4. The CTR4 regulatory strain showed an enlarged cell size, drastic changes in morphology, and a decrease in the thickness of the capsule under copper-enriched conditions. Furthermore, the mutant cells produced a lower amount of total proteins in their extracellular microvesicles and reduced adhesion to human brain microvascular endothelial cells in vitro. Proteomic analyses of the protein components under 14-3-3-overexpressed and -suppressed conditions revealed that the 14-3-3 function(s) might be associated with the microvesicle biogenesis. Our results support that 14-3-3 has diverse pertinent roles in both physiology and pathogenesis in C. neoformans. Its gene functions are closely relevant to the pathogenesis of this fungus.

• Journal of Korea Multimedia Society
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• v.20 no.10
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• pp.1678-1688
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• 2017

Infiltration is one of detrimental problems occurring in nursing or medical settings. Early detection of infiltration is essential to minimize the risk of injury from infiltration. To perform a preliminary study on the point of care and automated infiltration detection system, bioelectrical impedance was investigated using bioelectrical impedance analyzer. We would like to report experimental results that allow impedance parameters to effectively distinguish infiltration. Electrodes were attached to both sides of the transparent dressing on the fusion site where IV solution was being infused. Then, impedance parameters before and after infiltration were measured as a function of time and frequency. The experimental results are as follows. After infiltration was intentionally induced by puncturing the vein wall with a needle, the resistance gradually decreased with time. That is, when an alternating current having a frequency of 20 kHz was applied to the electrodes, the resistance gradually decreased with time, reflecting the accumulation of IV solution in the extracellular fluid since the current could not pass through the cell membrane. Impedance parameters and equivalent circuit model for human cell were used to examine the mechanism of current flow before and after infiltration, which could be used for early detection of infiltration.

• Journal of the Korean earth science society
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• v.34 no.7
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• pp.662-668
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• 2013

We examine the effects of El Ni$\tilde{n}$o on tropospheric ozone through the simulation of a Climate-Chemistry model for a 40-year period (1971-2010). The Empirical Orthogonal Function (EOF) analysis reveals that the tropospheric ozone concentration in the central-eastern Pacific decreases when the El Ni$\tilde{n}$o occurs, which is consistent with the observation. However, the increase of ozone over Indian Ocean-Indonesia regions is weak in the simulation compared to the observations. We analyze details of the 2006 El Ni$\tilde{n}$o event to understand the mechanism that caused the change of ozone due to El Ni$\tilde{n}$o. It is found that enhanced convection as well as higher water vapor followed by shortened lifetime has led to lower the tropospheric ozone. Downward motion induced by the changes of atmospheric circulation due to sea surface temperature forcing, together with the decrease of water vapor, has brought ozone produced in the upper troposphere over the Indian Ocean.

• BMB Reports
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• v.40 no.3
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• pp.341-348
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• 2007

Herpesvirus saimiri (HVS), a member of the $\delta$-herpesvirus family, encodes an oncoprotein called Saimiri Transforming Protein (STP) which is required for lymphoma induction in non-human primates. Previous study has shown that STP-C, an oncoprotein of HVS, activates NF-$\kappa$B signaling pathway. However, the detailed mechanism of STP-Cmediated NF-$\kappa$B activation has not been reported yet. We first report that STP-C interacts with TRAF6 protein in vivo and in vitro and further investigation shows that $Glu_{12}$ residue of STP-C is critical for binding to TRAF6. Introduction of ubiquitin together with STP-C augments NF-$\kappa$B activity compared to that of STP-C expression alone. STP-C expression further induces ubiquitination of endogenous TRAF6. In addition, either a deubiquitination enzyme, CYLD or a dominant negative E2-conjugation enzyme reduced NF-$\kappa$B activity in spite of the presence of STP-C, supporting that the interaction between STP-C and TRAF6 induces ubiquitination of TRAF6. NF-$\kappa$B activation by STP-C through the ubiquitinated TRAF6 causes the increased production of IL-8, an inflammatory chemokine and the enhanced expression of costimulatory molecule ICAM, which might ultimately contribute cellular transformation by the exposure of HVS-infected cells with inflammatory microenvironment and chronic activation.