• Journal of Marine Bioscience and Biotechnology
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• v.6 no.2
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• pp.102-109
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• 2014

Cetaceans (whales, dolphins, and porpoises) are aquatic mammals that experienced drastic changes during the transition from terrestrial to aquatic environment. Morphological changes include streamlined body, alterations in the face, transformation of the forelimbs into flippers, disappearance of the hindlimbs and the acquisition of flukes on the tail. For a prolonged diving, cetaceans acquired hypoxia-resistance by developing various anatomical and physiological changes. However, molecular mechanisms underlying these adaptations are still limited. CREB-binding protein (CREBBP) is a transcriptional co-activator critical for embryonic development, growth control, metabolic homeostasis and responses to hypoxia. Natural selection analysis of five cetacean CREBBPs compared with those from 15 terrestrial relatives revealed strong purifying selection, supporting the importance of its role in mammals. However, prediction for amino acid changes that elicit functional difference of CREBBP identified three cetacean specific changes localized within a region required for interaction with SRCAP and in proximal regions to KIX domain of CREBBP. Mutations in CREBBP or SRCAP are known to cause craniofacial and skeletal defects in human, and KIX domain of CREBBP serves as a docking site for transcription factors including c-Myb, an essential regulator of haematopoiesis. In these respects, our study provides interesting insights into the functional adaptation of cetacean CREBBP for aquatic lifestyle.

• Communications for Statistical Applications and Methods
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• v.28 no.3
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• pp.233-250
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• 2021

This paper studies if the accuracies of mortality models (LC model vs. 4-parametric model) are aggravated if a mortality structure changes due to the impact of COVID-19. LC model (LCM) uses dimension reduction for fitting to the log mortality matrix so that the performance of the dimension reduction method may not be good when the matrix structure changes. On the other hand, 4-parametric factor model (4-PFM) is designed to use factors for fitting to log mortality data by age groups so that it would be less affected by the change of the mortality structure. In fact, the forecast accuracies of LCM are better than those of 4-PFM when life-tables are used whereas those of 4-PFM are better when the mortality structure changes. Thus this result shows that 4-PFM is more reliable in performance to the structural changes of the mortality. To support the accuracy changes of LCM the functional aspect is explained by computing eigenvalues produced by singular vector decomposition

• Korean Journal of Psychosomatic Medicine
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• v.7 no.1
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• pp.103-115
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• 1999

Objectives : A large of studies have found an association between premenstrual syndrome and affective disorder, in particular, depression. Some studies have reported that women with depressive disorders may experience menstrual cycle-associated changes in the severity of their symptoms. This study was designed to compare the characteristics of premenstrual changes between control group and affective patient group, and to assess possible risk factors for premenstrual changes in patients. Methods : Eighty normal controls and eighty outpatients given maintenance therapy with fixed dose for at least more than four weeks were asked to complete questionnaires on menstrual history, obstetric-gynecological history, and functional impairment. In addition, to compare the characteristics of premenstrual changes, 16 items based on DSM-IV criteria A for premenstrual dysphoric disorder were rated on the following scale : 0(no change), 1(mild), 2(moderate), 3(severe). Moderate or severe change in each item was considered as premenstrual change and the subjects who reported more than one premenstrual change were defined as premenstrual change group. Results : The results were as follows : 1) The percentage of premenstrual change group was 32.6% in patient group and 50% in control group. 2) Frequently reported premenstrual changes were as follows in control group : breast tenderness; anger ; affective liability ; lethargy, easy fatigability, or marked lack of energy ; abdominal pain or discomfort. In patients, the mood or behavioral changes were frequently reported. The changes were as follows : lethargy, easy fatigability, or marked lack of energy ; change in appetite; affective liability ; sense of difficulty in concentrating : hypersomnia or insomnia. 3) In the premenstrual change group, the patients with only mood or behavioral changes were significantly more than those with only physical changes or both changes. 4) The severity of functional impairment was significantly correlated with the frequency of mood or behavioral changes in patients. 5) There were no significant differences in menstrual characteristics between patients with premenstrual changes and patients without them except the severity of dysmenorrhea. And the severity of dysmenorrhea was correlated with the frequency of premenstrual change. Conclusion : The proportion of patients with affective disorder, who reported moderate-to-severe premenstrual changes, experiencing mood or behavioral changes larger than those experiencing physical changes during premenstrual period. It is possible that some patients with affective disorder, who reported premenstrual mood or behavioral changes, suffer from coexisting premenstrual syndrome with affective disorder or premenstrual exacerbation of affective disorder. Since the more premenstrual changes, the severer functional impairment, the patients reporting mood or behavioral disturbance in premenstrual period should be carefully evaluated, and appropriate therapeutic stategies might be considered.

• Bulletin of the Korean Chemical Society
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• v.35 no.11
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• pp.3326-3330
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• 2014

A quinoline-thiooxorhodamine conjugate fluorescent sensor (1) has been synthesized. Sensor 1 exhibits high selectivity and sensitivity to $Hg^{2+}$ in $H_2O$/DMSO (95/5, v/v, HEPES 20 mM, pH = 7.4) solution with fluorescence detection. Other tested metal ions do not induce any significant fluorescence intensity changes. Sensor 1 interacts with $Hg^{2+}$ through a 1:1 binding stoichiometry with a good anti-inference ability. In addition, fluorescent imaging of $Hg^{2+}$ in Hela cells is also successfully demonstrated.

• Journal of muscle and joint health
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• v.20 no.1
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• pp.22-30
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• 2013

Purpose: The International Classification of Functioning, Disability and Health (ICF) model was proposed by the World Health Organization for enhancing interdisciplinary communication. The purpose of this study was to examine the functional status of acute stroke patients using ICF core sets-short form. Methods: A set of 15 ICF items on functional status was used by nurses for their daily nursing assessment on functional status in 44 acute stroke patients in a university hospital. Results: The highest level of function was "consciousness", while the lowest was "defecation". Compared with functional status on the first day, consciousness, ingestion, language (mental), and defecation functions were significantly improved on the 14th day. However, there was no significant changes in items on activity and participation or environmental functions. Conclusion: These findings suggest that the function-specific nursing interventions for acute stroke patients need to be developed. Future research needs to test the usefulness of ICF items as an measurement tool.

• Korean Journal of Adult Nursing
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• v.19 no.1
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• pp.132-143
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• 2007

Purpose: The purpose of this study was to identify effects of a self-management program on symptom and functional status, health perception, and quality of life(QOL) of patients with CHF. Methods: Patients with CHF as defined through clinical judgment using the Framingham criteria and EF<50% were enrolled in the study (experimental: 21, control: 20). The symptom focused self-management program consisted of coping behaviors for symptoms including dyspnea, chest discomfort/pain, dizziness, ankle edema, and basic self-management including medications, diets, activity, lifestyle changes. Experimental group received an educational booklet after survey, and periodic telephone follow-up by a trained nurse. Data were collected the 3rd day after admission and at 1 month, 3 months, and 6 months after discharge using questionnaires. Results: Significant differences were found in the presence of symptoms, health perception, and QOL between groups during follow-up. Although no significant difference was found in functional status, the experimental group reported better functional status than the control group. Conclusion: By facilitating self-management of CHF using tailored interventions including education programs and telephone monitoring, it is expected that patients will be able to monitor their symptoms routinely, adhere to therapeutic regimen, and have a better QOL.

• The Journal of Korean Physical Therapy
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• v.18 no.1
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• pp.11-31
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• 2006

Purpose: The purpose of this study is to investigate the effect of neuromuscular re-eduction program and traditional intervention program. Methods: It is focused on difference between changes of experimental before and after on 30 stroke patient's physical composition, body water and functional independence. Results: The obtained results are as follows ; 1. In the comparison of change in physical composition between the experimental group and control group, the between-subjects factors were not a significant difference. 2. In the comparison of change in body water between the experimental group and control group, the between-subjects factors were not a significant difference. 3. In the comparison of change in functional independence between the experimental group and control group, the between-subjects factors were a significant difference in 8 items and total FIM (p<0.01; p<0.05) but, were not a significant difference in 11 items. Conclusion: the neuromuscular re-eduction program was more effect then traditional intervention program in functional independence but, was not a significant difference in body composition and body water.

• Journal of Plant Biotechnology
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• v.43 no.1
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• pp.1-11
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• 2016

Single nucleotide polymorphism (SNP) is an abundant form of genetic variation within individuals of species. DNA polymorphism can arise throughout the whole genome at different frequencies in different species. SNP may cause phenotypic diversity among individuals, such as individuals with different color of plants or fruits, fruit size, ripening, flowering time adaptation, quality of crops, grain yields, or tolerance to various abiotic and biotic factors. SNP may result in changes in amino acids in the exon of a gene (asynonymous). SNP can also be silent (present in coding region but synonymous). It may simply occur in the noncoding regions without having any effect. SNP may influence the promoter activity for gene expression and finally produce functional protein through transcription. Therefore, the identification of functional SNP in genes and analysis of their effects on phenotype may lead to better understanding of their impact on gene function for varietal improvement. In this mini-review, we focused on evidences revealing the role of functional SNPs in genes and their phenotypic effects for the purpose of crop improvements.

• Journal of the Korean Society of Physical Medicine
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• v.1 no.1
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• pp.117-123
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• 2006

Objectives : The purpose of this study was conducted to find correct facilitation and clinical facilitation with proprioceptive neuromuscular facilitation (PNF). Methods : This is a literature study with books, articles, seminar note and books for PNF international course. Results : Treatment approach was changed from managements of reflex to facilitation. The facilitation will make passive or active motion. But it can not match with normal functional activities, lack of the active movement, and facilitation of musculoskeletal can interaction with environment. Conclusions : Facilitation of the Functional activities in the main therapy goal. Any necessary information, such as visual and acoustical information must be integrated. Spatial summation and temporal summation integrated also. Integrated information for the facilitation will be increased activity of alpha-motorneurons, activity of interneurons, and muscle fiber structural changes from slow twitch fibers to fast twitch fibers. Suggested facilitate goal-oriented of movements at a functional level and reduce stiffness at structural level.

• Journal of Fashion Business
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• v.13 no.2
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• pp.123-135
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• 2009

To cope with the threats posed by climate change actively, this study tries to examine multi-functional fashion design with the moral awareness of environment, which could be a direct cause of climate change. Literature and patents on multi-functional fashion design following climate change at home and abroad are examined to find the trend of multi-functional fashion designs. And fashion design that can protect human body to cope with climate change is analyzed. This study found that first, it is necessary to recognize the environment problems in the design process so that material is used to the minimum to minimize pollution and enable welfare and continuation of human society; second, environmentally friendly production and rational consumption such as manual production without waste of energy and material need to be favored to minimize the destruction of environment; third, to cope with environment and climate changes, design that allows an item to have diverse functions is needed so that it can have varied lengths, widths, and thicknesses, and it can be put on and taken off.