• Journal of Nutrition and Health
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• 제55권1호
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• pp.1-9
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• 2022

In the past few decades, great progress has been made on understanding the interaction between nutrition and health status. But despite this wealth of knowledge, health problems related to nutrition continue to increase. This leads us to postulate that the continuing trend may result from a lack of consideration for intra-individual biological variation on dietary responses. Precision nutrition utilizes personal information such as age, gender, lifestyle, diet intake, environmental exposure, genetic variants, microbiome, and epigenetics to provide better dietary advices and interventions. Recent technological advances in the artificial intelligence, big data analytics, cloud computing, and machine learning, have made it possible to process data on a scale and in ways that were previously impossible. A big data platform is built by collecting numerous parameters such as meal features, medical metadata, lifestyle variation, genome diversity and microbiome composition. Sophisticated techniques based on machine learning algorithm can be used to integrate and interpret multiple factors and provide dietary guidance at a personalized or stratified level. The development of a suitable machine learning algorithm would make it possible to suggest a personalized diet or functional food based on analysis of intra-individual metabolic variation. This novel precision nutrition might become one of the most exciting and promising approaches of improving health conditions, especially in the context of non-communicable disease prevention.

• Journal of the Korean Society of Clothing and Textiles
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• 제47권1호
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• pp.1-16
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• 2023

The smart fashion industry is showing steady growth worldwide, which will create new value throughout the fashion industry and become an essential element for efficient lifestyles. This study attempted to examine the development trend of smart fashion products from a design perspective and present the direction of design as a fashion item incorporating smart technology from a functional perspective. For this purpose, the category of portable smart fashion and the characteristics of the research object were considered through current status survey and previous research review. Among smart fashion, accessories and clothing/fabric products that have been released thus far that apply portable fashion design principles are selected and its characteristics are analyzed. In addition, function keywords were extracted based on the product description provided by the manufacturer and the function-oriented types were classified to identify each type's design characteristics. Therefore, the area receiving the signal and the sensor size should be considered, as should the fashion accessory type that combines various materials and colors. The clothing/textile type requires a design that mainly focuses on functions related to bio-signal interactions.

• East Asian Journal of Business Economics (EAJBE)
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• 제11권2호
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• pp.39-57
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• 2023

Purpose - This paper is to examine the work of a third party in the process of import and export management. In other words, the purpose of this paper is investigate the status and functional role of a third party in relation to each terms of the trade contract. Research design, data, methodology - This study consists of 5 chapters through literature survey. It will examine the involvement of the third party through each terms. Chapter 1 introduction, Chapter 2 deals with trade contracts, Chapter 3 investigates the shipping terms, payment terms, and insurance terms, and Chapter 4 reviews with commercial arbitration. And in Chapter 5, it looks at the conclusion and implications. Results - The relevant party in the import and export management process may be a third party through outsourcing, not the principal. At this time, in fulfilling each condition of trade, it can be seen that the implementation of tasks through the participation of a third party with high expertise can more smoothly and productively implement the overall import and export management. Therefore, it can be seen that the implementation of the trade business in which the third party participated can be interpreted in terms of derivative effects and at the same time can be a way to improve the principal's competitiveness procedurally. Conclusions -Through this study, in the import and export management, the performance of the work through the agent makes the entire process more smooth and efficient. Outsourcing of roles using the expertise of a third party, a subcontractor rather than a principal, is desirable and important.

• Journal of Korea Trade
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• 제27권5호
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• pp.91-112
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• 2023

Purpose - This study empirically investigates how the effects of localized knowledge spillovers on technology adoption are conditional on the organizational capabilities of potential adopters. Design/methodology - The empirical model utilized in this study examines how the presence of prior adopters of advanced manufacturing technologies affects a plant's technology adoption decision differently based on its organizational capabilities, measured by plant size and plant status (single-plant firm vs. multi-plant firm). Moreover, this study investigates how the scope of knowledge spillovers from prior adopters, both in terms of geographical and functional proximities, differ for plants with different organizational capabilities. Findings - The main findings of this study are as follows: 1. Although plants with lower organizational capabilities are less likely to adopt advanced technologies, such plants receive greater marginal benefits from knowledge spillovers from prior adopters in their region. 2. Plants with greater organizational capabilities can benefit from knowledge spillovers from a wider set of prior adopters. In other words, while plants with lower organizational capabilities tend to benefit from knowledge spillovers from "similar" and "local" adopters, plants with greater organizational capabilities can also benefit from knowledge spillovers from "not-too-similar" or are geographically distant prior adopters. Originality/value - While existing studies mainly focus on the effects of the various kinds of regional agglomeration, few studies investigate localized knowledge spillovers in technology adoption. Moreover, no prior studies have explored how the effects of knowledge spillovers on technology adoption depend on a plant's organizational capabilities and how the scope of knowledge spillovers differs for plants with different organizational capabilities. This study is the first to empirically investigate this topic.

• IMMUNE NETWORK
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• 제22권1호
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• pp.4.1-4.22
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• 2022

In the era of immunotherapeutic control of cancers, many advances in biotechnology, especially in Ab engineering, have provided multiple new candidates as therapeutic immuno-oncology modalities. Bispecific Abs (BsAbs) that recognize 2 different antigens in one molecule are promising drug candidates and have inspired an upsurge in research in both academia and the pharmaceutical industry. Among several BsAbs, T cell engaging BsAb (TCEB), a new class of therapeutic agents designed to simultaneously bind to T cells and tumor cells via tumor cell specific antigens in immunotherapy, is the most promising BsAb. Herein, we are providing an overview of the current status of the development of TCEBs. The diverse formats and characteristics of TCEBs, in addition to the functional mechanisms of BsAbs are discussed. Several aspects of a new TCEB-Blinatumomab-are reviewed, including the current clinical data, challenges of patient treatment, drawbacks regarding toxicities, and resistance of TCEB therapy. Development of the next generation of TCEBs is also discussed in addition to the comparison of TCEB with current chimeric antigen receptor-T therapy.

• The Korean Journal of Pain
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• 제37권1호
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• pp.34-40
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• 2024

Background: This study aimed to evaluate the efficacy of pulsed radiofrequency applied using transcutaneous electrodes in carpal tunnel syndrome (CTS). Methods: After randomization, the patients received two cycles of noninvasive pulsed radiofrequency (NiPRF), once weekly, or splinting (the control group) for three months. Clinical evaluations were recorded at baseline and weeks 4 and 8. The Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) was used to determine the functional status and symptom severity. Results: Sixty-two patients were followed up for three months. There was no difference between the groups in the BCTQ scores before and after treatment. The NiPRF group found a significant difference between the BCTQ measurements at all time intervals (paired sample t-test; P < 0.001). In the splint group, there was a significant difference only between the basal-1st month and basal-3rd month (paired samples t-test; P < 0.001). The main effect of the time variable was statistically significant (ANOVA; P < 0.001), but the group variable was not. There was no correlation between the BCTQ results measured at any time and the electroneuromyelogragphy findings in either group. Conclusions: NiPRF effectively improves symptoms and functionality in patients with CTS for up to 3 months. Thus, NiPRF can be considered an easy, safe, and useful alternative treatment modality for CTS.

• Journal of Life Science
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• 제25권8호
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• pp.917-924
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• 2015

This study aimed to evaluate the protective effect of Orostachys malacophyllus (OM) and fermented O. malacophyllus (FOM) in Sprague-Dawley rats who had been intoxicated with 1% (w/w) orotic acid (OA) for 10 days. The activities of several hepatic enzymes, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and cholinesterase, were increased when OA was given, but these parameters were significantly decreased by FOM treatment. In addition, OA treatment resulted in an increased lipid peroxidative index (thiobarbituric acid-reactive substances, TBARS). A worsened antioxidant status (reduced glutathione) in the liver and serum was also observed. FOM treatment improved the antioxidant status of OA-induced fatty-liver rats, which was evaluated by decreased levels of the lipid peroxidative index and improved antioxidant status in the liver and serum. The contents of liver non-heme iron were increased with OA treatment and significantly decreased with FOM treatment, which suggested that the lipid peroxidation contents were inversely correlated with liver non-heme iron content. Based on these results, FOM is considered a material with significant potential for development into a functional health food that can improve fatty-liver conditions.

• Archives of design research
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• 제18권4호
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• pp.247-256
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• 2005

This study investigated the status of kitchen of units in elderly housing facilities and the housing needs of residents. Compared with a lot of comprehensive and alternative studies on elderly housing facilities until now, specialized studies of behavior of elderly housing life and detailed dimensional study have hardly made. Therefore we intend to examine the status of kitchen planning on representative elderly housing facilities in Korea. As the methods of this study, we executed a field study into 4 representative elderly housing facilities in Korea. We visited each 2 units out of the outstanding 4facilities and surveyed the total 8 kitchens. Then we analyzed the space planning and kitchen furniture design of them and the state of kitchen commodities, and measured the kitchen equipment. In addition, we executed interview about satisfaction, preference, use from the residents. As a result, we could find out that depending on whether residents were sewed with meal offered from the facilities or not, the pattern of usage and commodities were quite different. It is necessary to supply the simplest spaces just for preparing some refreshment and tea are suitable. And for the self-cooking residents, much larger cabinets and utility rooms are additionally needed. Safety and functional aspect were quite well designed. Washing machines are usually built-in the kitchen cabinets, and residents are satisfied with this arrangement. We hope that the supplementary study about old people habit and behavior will be a good data of kitchen planning for Korean-type elderly housing units of facilities.

• Archives of design research
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• 제16권4호
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• pp.313-322
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• 2003

The residential and welfare facilities for the elderly are continuously increasing due to change of value on family under situation of aging population increase. And it is predicted that accommodation capacity of facilities for the elderly and its rate those facility takes compared to whole social welfare facilities will be accelerated considering past increase speed. On the other hand, about 60％ of elderly people have low physical and mental level almost dose to handicapped people therefore special environmental concerns helping their independent living are necessary. The purpose of this study is to analyze whether facilities for the elderly are adequate to accommodate their request condition by understanding color among environmental factors is one of most important factor for smooth understanding, communication and psychological remedy effect for thou. For this purpose, importance and effect of color and visual characteristic and reaction to color in elderly environment are researched through documents and visited 10 facilities in Seoul and Kyunggi region to research interior color status. And measuring of color on 5 main spaces of the facilities such as lobby/lounge, corridor, dining room, bedroom, stairway/ramp are done under analysis of its functional and aesthetic level based on Moon ＆ Spencer's color theory.

• Clinics in Shoulder and Elbow
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• 제23권1호
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• pp.11-19
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• 2020

Background: The purpose of this study was to evaluate and compare deltoid origin status following large rotator cuff repair carried out using either an open or an arthroscopic method with a propensity score matching technique. Methods: A retrospective review of 112 patients treated for full-thickness, large rotator cuff tear via either a classic open repair (open group) or an arthroscopic repair (arthroscopic group) was conducted. All patients included in the study had undergone postoperative magnetic resonance imaging (MRI) and clinical follow-up for at least 12 and 18 months after surgery, respectively. Propensity score matching was used to select controls matched for age, sex, body mass index, and affected site. There were 56 patients in each group, with a mean age of 63.3 years (range, 50-77 years). The postoperative functional and radiologic outcomes for both groups were compared. Radiologic evaluation for postoperative rotator cuff integrity and deltoid origin status was performed with 3-Tesla MRI. Results: The deltoid origin thickness was significantly greater in the arthroscopic group when measured at the anterior acromion (P=0.006), anterior third (P=0.005), and middle third of the lateral border of the acromion level (P=0.005). The deltoid origin thickness at the posterior third of the lateral acromion was not significantly different between the arthroscopic and open groups. The arthroscopic group had significantly higher intact deltoid integrity with less scarring (P=0.04). There were no full-thickness deltoid tears in either the open or arthroscopic group. Conclusions: Open rotator cuff repair resulted in a thinner deltoid origin, especially from the anterior acromion to the middle third of the lateral border of the acromion, at the 1-year postoperative MRI evaluation. Meticulous reattachment of the deltoid origin is as essential as rotator cuff repair when an open approach is selected.