Kim, Yong-Jin;Lee, Chi-Eun;Lee, Kook-Joo;Choi, Young-Ho;Hong, Jung-Suk
Journal of Yeungnam Medical Science
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v.18
no.1
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pp.85-93
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2001
Background: The number of glomerulus has been considered one of the etiologic factors especially for focal segmental glomerulosclerosis. However, glomeruli are too many to calculate them correctly. Although the fractionator method has became convinced, in which they used selected sections, not whole kidney sections, with same intervals, it is also very hard to get good results. Because it is still very time-consuming and laborous work which leads to make big observers' biases. Methods and Materials: We designed the index for glomerular number to estimate the tendency of increase or decrease of the number of it in different kidneys and which was evaluated by other conventional methods including fractionator method. Index was based upon the theory by Nyengaard; "the number of glomerulus correlates with the weight of kidney, which is positively correlated with body weight". Calculating formula is the number of glomeruli/surface areas of cortices, which contain calculated glomeruli multiplies by kidney weight/body weight. Results: We applied this index to kidneys of FGS/Kist mouse and those of RFM/Nga mouse. The former is spontaneous glomerulosclerosis model with heavy protein uria and renal failure and the latter is the mother side of FGS/Kist mouse but has no glomerular disease or protein uria. The number of glomerulus of FGS/Kist mouse was decreased by 30% to those of RFM/Nga mouse. Conclusion: This index was useful and reliable for estimating the relative glomerular number between two groups.
This study aims to explore the duty system of the lifelong learning counseling, and to analyze the needs of counseling practice which are conceived by lifelong education practitioners. Based on the related prior studies, the duty system of lifelong learning counseling was investigated and classified. Also, differences of how to recognize the importance of counseling job and how to practice counseling are assessed by Borich method. After data were collected by practitioners from lifelong education field, the dependent t-test and the Borich needs assessment formula were used for analysis of the collected data. The results are as follows: the 4 subdivided duties of lifelong learning counseling are formation of relationship, learner's analysis, learning promotion, and follow-up management. The 11 tasks are learner's interview, providing learning information, analysis of learner's characteristics and needs, learning level diagnosis, diagnosis of learning inhibiting factors, promotion of learning motivation, advice of learning course and learning method, support of study circle activity, career planning counseling, follow-up counseling, and counseling evaluation. According to the needs assessment, learner's analysis is conceived as the most important duty among the 4 sub-duties, and learner's analysis is regarded as second important duty by the counseling practitioners. Among the 11 tasks, providing learning information is the most important tasks among counseling practitioners, and analysis of learner's characteristics and needs is followed as second task. The duty system of the lifelong learning counseling and needs assessment data can be used as the basic data for lifelong education practitioners to conduct the duty of lifelong learning counseling efficiently and to support the lifelong learning plan according to learner's characteristics.
Journal of the Korea Academia-Industrial cooperation Society
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v.21
no.12
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pp.772-781
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2020
A direct shear member resists external forces through the shear transfer of reinforcing bars placed at the concrete interface. The current concrete structural design code uses empirical formulas based on the shear friction analogy, which is applied to the horizontal shear of concrete composite beams. However, in the case of a member with a large amount of reinforcing bars, the shear strength obtained through the empirical formula is lower than the measured value. In this paper, the limit state of newly constructed composite beams on an existing concrete girder is defined using stress field theory, and material constitutive laws are applied to gain horizontal shear strength while considering the tension-stiffening and softening effects of concrete struts. A simplified method of calculating the shear strength is proposed, which was validated by comparing it with the related design code provisions. As a result, it was confirmed that the method generally shows a similar tendency to the experimental results when the shear reinforcing bar yields, unlike the regulations of the design code, where differences in the predicted value of shear strength occur according to the shear reinforcement ratio.
The Journal of the Institute of Internet, Broadcasting and Communication
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v.23
no.4
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pp.41-46
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2023
Human urine is a process of excreting waste products in the blood, and it is easy to collect and contains various substances. Urinalysis is used to check for diseases, health conditions, and urinary tract infections. There are three methods of urinalysis: physical property test, chemical test, and microscopic test, and chemical test results can be easily confirmed using urine test strips. A variety of items can be tested on the urine test strip, through which various diseases can be identified. Recently, with the spread of smart phones, research on reading urine test strips using smart phones is being conducted. There is a method of detecting and reading the color change of a urine test strip using a smartphone. This method uses the RGB values and the color difference formula to discriminate. However, there is a problem in that accuracy is lowered due to various environmental factors. This paper applies a deep learning model to solve this problem. In particular, color discrimination of a urine test strip is improved in a smartphone using a lightweight CNN (Convolutional Neural Networks) model. CNN is a useful model for image recognition and pattern finding, and a lightweight version is also available. Through this, it is possible to operate a deep learning model on a smartphone and extract accurate urine test results. Urine test strips were taken in various environments to prepare deep learning model training images, and a urine test service application was designed using MobileNet V3.
The standard construction manual of the SDA(Separated Doughnut Auger) piling method was proposed so that the resisting capacity of the augered piles could work effectively. 405 dynamic pile load tests and 30 static pile load tests were performed for 265 test piles, which were installed by the SDA piling method in 33 sites in Korea. The results of the pile load tests showed that the end bearing capacity of the SDA augered piles depended on the property of various soil stratums and did not agree with ones estimated by the existing formula based on several standard design codes. On the basis of the pile load test results, four formulas were presented according to bearing stratums to estimate quantitatively the unit end bearing capacity of the SDA augered piles. The formulas for the unit end bearing capacity of piles on soils or weathered rocks were related to N-value given by SPT(Standard Penetration Test), while the unit end bearing capacity on bedrock was suggested to be more than 1500 $tf/m^2$. The presented formulas were compared with the existing formulas, which were presented by several standard design codes to design the augered piles. In order to use correctly the presented formulas, the quality of Standard Penetration Test should be controlled precisely. Also it is desirable to choose a pilot construction site, where both dynamic and static pile load tests are performed.
As a part of Load and Resistance Factor Design(LRFD) code development in Korea, in this paper an intensive reliability analysis was performed to evaluate reliability levels of the two static bearing capacity methods for driven steel pipe piles adopted in Korean Standards for Structure Foundations by the representative reliability methods of First Order Reliability Method(FORM) and Monte Carlo Simulation(MCS). The resistance bias factors for the two static design methods were evaluated by comparing the representative measured bearing capacities with the design values. In determination of the representative bearing capacities of driven steel pipe piles, the 58 data sets of static load tests and soil property tests were collected and analyzed. The static bearing capacity formula and the Meyerhof method using N values were applied to the calculation of the expected design bearing capacity of the piles. The two representative reliability methods(FORM, MCS) based computer programs were developed to facilitate the reliability analysis in this study. Mean Value First Order Second Moment(MVFOSM) approach that provides a simple closed-form solution and two advanced methods of FORM and MCS were used to conduct the intensive reliability analysis using the resistance bias factor statistics obtained, and the results were then compared. In addition, a parametric study was conducted to identify the sensibility and the influence of the random variables on the reliability analysis under consideration.
This paper proposes a design formulae that evaluates the design strength of T-joints made of cold-formed square hollow steel sections with longitudinal branch plate. The T-joints had a configuration that a branch member used to longitudinal plate to the main chord in the plane. This study focused on the branch plate T-joints governed by the main chord flange failure mode among the experimental results. Based on the test results of the longitudinal branch plate T-joint in the square hollow sections, the ultimate strength on the T-joints was defined as 1.5 times the load at 1% B the strength of joints that governed the serviceability in control for $16.7{\leq}2\gamma(B/T){\leq}31.3$ and $0.20{\leq}{\beta}(b1/B){\leq}0.75$. Existing yield line models for normal T-joints were investigated to be the main chord flange failure for the branch plate T-joint, and this proposal design formula was based on the theory of the yield line model. Finally, the value of the finite element method compared with the value of the test and theory for the T-joints verified the validity of the design formulae.
To share an understanding of trajectory measurement in surveys using borehole, this tutorial summarizes the relevant mathematical principles of the borehole deviation survey based on coordinate transform. For uncased or open holes, calculations of the azimuth-deviation-tool face rotation using three-component accelerometer and magnetometer measurements are summarized. For the steel-cased holes, calculations are based on the time-derivative formula of the coordinate transform matrix; yaw-pitch-roll angles through time are mathematically determined by integrating the threecomponent angular velocity measurements from the gyroscope while also removing the Earth's rotation effect. Sensor and data fusion to increase the accuracy of borehole deviation survey is explained with an example of the method. These principles of borehole deviation surveys can be adapted for attitude estimation in air-borne surveys or for positioning in tunnels where global positioning system (GPS) signals cannot be accessed. Information on the optimization filter that must be incorporated in sensor fusion is introduced to help future research.
Pan evaporation has been used as an indirect method for the estimation of reservoir evaporation. Therefore, in this study, pan evaporation estimation equations using only temperature data were suggested in the case that available meteorological data is limited. A formula for estimating the pan evaporation were suggested by comparing estimated pan evaporation with measured pan evaporation in 12 study areas in Korea. The suggested pan evaporation equations were verified in 44 study areas by comparing not only with temperature-based equations but also with equations using other meteorological data (temperature, wind speed, relative humidity, and sunshine duration). The study results indicate that the suggested equations in this study provide much better pan evaporation estimates, compared with other temperature-based equations. Overall, the suggested equations provide appropriate pan evaporation estimates in most of 56 study areas. Therefore, the suggested equations using only temperature data in this study are considered appropriate for the estimation of pan evaporation in Korea especially in the case that available meteorological data is limited. In the future, using the air temperature and pan evaporation data measured at the reservoir, further research is needed to examine the applicability of suggested equations for the estimation of reservoir evaporation.
Objectives : This paper serves to explore current trends of systems biology in Traditional Chinese Medicine (TCM) and examine how it may influence the Traditional Korean medicine. Methods : Literature review method was collectively used to classify Introduction to systems biology, diagnosis and syndrome classification of systems biology in TCM perspective, physiotherapy including acupuncture, herbs and formula functions, TCM systems biology, and directions of academic development. Results : The term 'Systems biology' is coined as a combination of systems science and biology. It is a field of study that tries to understand living organism by establishing a theory based on an ideal model that analyzes and predicts the desired output with understanding of interrelationships and dynamics between variables. Systems biology has an integrated and multi-dimensional nature that observes the interaction among the elements constructing the network. The current state of systems biology in TCM is categorized into 4 parts: diagnosis and syndrome, physical therapy, herbs and formulas and academic development of TCM systems biology and its technology. Diagnosis and syndrome field is focusing on developing TCM into personalized medicine by clarifying Kidney yin deficiency patterns and metabolic differences among five patterns of diabetes and analyzing plasma metabolism and biomarkers of coronary heart disease patients. In the field of physical therapy such as acupuncture and moxibustion, researchers discovered the effect of stimulating acupoint ST40 on gene expression and the effects of acupuncture on treating functional dyspepsia and acute ischemic stroke. Herbs and formulas were analyzed with TCM network pharmacology. The therapeutic mechanisms of Si Wu Tang and its series formulas are explained by identifying potential active substances, targets and mechanism of action, including metabolic pathways of amino acid and fatty acid. For the academic development of TCM systems biology and its technology, it is necessary to integrate massive database, integrate pharmacokinetics and pharmacodynamics, as well as systems biology. It is also essential to establish a platform to maximize herbal treatment through accumulation of research data and diseases-specific, or drug-specific network combined with clinical experiences, and identify functions and roles of molecules in herbs and conduct animal-based studies within TCM frame. So far, few literature reviews exist for systems biology in traditional Korean medicine and they merely re-examine known efficacies of simple substances, herbs and formulas. For the future, it is necessary to identify specific mechanisms of working agents and targets to maximize the effects of traditional medicine modalities. Conclusions : Systems biology is widely accepted and studied in TCM and already advanced into a field known as 'TCM systems biology', which calls for the study of incorporating TCM and systems biology. It is time for traditional Korean medicine to acknowledge the importance of systems biology and present scientific basis of traditional medicine and establish the principles of diagnosis, prevention and treatment of diseases. By doing so, traditional Korean medicine would be innovated and further developed into a personalized medicine.
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