• Journal of Trauma and Injury
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• 제31권2호
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• pp.58-65
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• 2018

Purpose: Many doctors have difficulty in deciding the treatment duration in trauma patients to write in the casualty medical certificate. We tried to find a solution for this problem by using abbreviated injury scale (AIS). Methods: A total of 39 patients treated in our regional trauma center who requested an author to write treatment duration on casualty medical certificate from January 2014 to April 2017 were included. And the treatment duration was decided based on the PARK Formula (AIS). PARK Formula $(AIS)=(AIS{\times}2){\sim}([AIS{\times}2]+2)$ Results: Among 39 patients included and 36 (92.3%) had treatment duration on casualty medical certificate within the range of treatment duration calculated by PARK Formula (AIS). Compared to the PARK Formula (AIS), the mean value was 0.13 week (0.90 day) smaller. Comparing the treatment duration between Korean Medical Association (KMA) guideline and PARK Formula (AIS), only 22 patients (56.4%) showed agreement. The mean value was 1.02 week (7.18 days) smaller in KMA guideline. Conclusions: For the decision of the treatment duration in trauma patients, utilizing worldwide used AIS scoring system is very efficient. Using PARK Formula (AIS), doctors can document the treatment duration in the casualty medical certificate with ease. KMA should provide more practical 'treatment duration of each diagnosis in writing casualty medial certificate' for the doctors. We recommend PARK Formula (AIS) as a good alternative for KMA guide.

• 한국식품과학회지
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• 제32권5호
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• pp.1173-1178
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• 2000

본 연구에서는 크림이 첨가된 난백젖산균발효식품에서 Lactobacillus acidophilus(KCTC 2182)생균수의 경시적인 변화, 크림 첨가 난백젖산균발효식품으로 만든 아이스크림의 관능적인 특성과 경도를 조사하여 다음과 같은 결과를 얻었다. (1) 크림의 첨가비율이 높을수록 젖산균 생육곡선의 stationary phase가 연장되고, 발효시간별 생균수도 높은 경향을 나타냈다. (2) Formula 4(크림 첨가비율 40%)와 Formula 5(크림 첨가비율 50%)로 만든 아이스크림의 관능적 특성이 다른 시료보다 우수하였으며, Formula 4의 15시간 발효시료가 아이스크림 제조원료로서 적합하였다. (3) 경도의 측정 결과를 보면 크림의 첨가비율이 증가할수록 경도가 감소하여 Formula 5의 경도가 가장 낮았다.

• 대한한의학원전학회지
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• 제21권1호
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• pp.123-141
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• 2008

Objective Classification of herbal formulas through the analysis of compositional herb's is a suitable method in the aspects of the effective applications of herbal formulas. However, these classification methods have some problems in dealing with lots of herbal formulas because the estimations of herbal formula's effects are dependent upon one's memory. In this study, we aimed to establish the effective methodology to elicit the classified herbal formula's chart by introducing the DB systems without interfering with non-standard terms. Method : We entered the herbs informations of the composition of herbal formulas into database, made an alias tables of corresponding herbs, and achieved standardization of herb's informations. Using these databases, we made the classified herbal formula's chart according to the presence and the treatment informations of herbs. Results By analyzing the herbal formula into the set of compositional herbal elements, we could systemically express the parents and children herbal formula at once according to search terms. We provided the advanced searching tools entering the name of herbal formula and compositional herb together. Through these searching methods, it is facilitated to grasp the classified herbal formula's chart according to the addition and reduction of compositional herbs in Dong-uibogam(東醫寶鑑) and Bangjehak(方劑學)

• 대한본초학회지
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• 제31권6호
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• pp.29-35
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• 2016

Objectives : Blood stasis (BS) is related to be caused by blood circulation and stagnation which are cancer, atherosclerosis and hyperlipidemia in traditional medicine. We extracted 3 kinds of BS formula; Seogakjihwang-tang (SGT), Tonggyuhawlhyul-tang (THT), Hyulbuchukeo-tang (HCT). This study was conducted to investigate whether the 3 kinds of herbal formula extracts have inhibitory efficacy association with anti-adipogenesis. Methods : To investigate the anti-adipogenesis, we used the mouse fibroblast cell line, 3T3-L1 which differentiated into adipocytes in response to insulin, IBMX and dexamethasone (MDI). Cytotoxicity of herbal formula extracts were examined by CCK-8 kit. Intracellular lipid droplets were detected by Oil-Red-O staining. Triglyceride (TG) and leptin were measure using elisa kit. Results : The yield of water extracts was 14.62% (SGT), 21.27% (THT), 20.02% (HCT). Lipid accumulation was reduced significantly by 3 kinds of herbal formula compared to control. Especially, THT and HCT decreased lipid droplet, respectively at all concentration. The TG and leptin were also inhibited by 3 kinds of herbal formula. The IC50 of TG were $280.51{\mu}g/m{\ell}$ (SGT), $52.62{\mu}g/m{\ell}$ (THT), $313.99{\mu}g/m{\ell}$ (HCT). The IC50 of leptin were $348.76{\mu}g/m{\ell}$ (SGT), $164.02{\mu}g/m{\ell}$ (THT), $257.00{\mu}g/m{\ell}$ (HCT). THT was better than other herbal formula on anti-adipogenesis. Conclusion : kinds of herbal formula inhibited adipogenesis in MDI-induced 3T3-L1 adipocytes, as indicated by the significant reduction in TG and leptin concentration without cytotoxicity. Therefore, 3 kinds of herbal formula for BS might act as a therapeutic agent for preventing lipid diseases, such as obesity and atherosclerosis.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제22권1호
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• pp.63-71
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• 2019

Purpose: The aim of this study was to identify the minimally meaningful dosage of inulin leading to a prebiotic effect in Indonesian infants. Methods: In a randomized controlled double-blinded, parallel, 3-arm intervention study, 164 healthy formula-fed infants aged 3 to 5 months first obtained formula-A (without inulin) during a 4-week adaptation period. Subsequently, 142 subjects were subjected to a 4-week feeding period by administering either formula-A (no inulin), formula-B (0.2 g/100 mL inulin) or formula-C (0.4 g/100 mL inulin). The primary outcome parameter was %-bifidobacteria in faecal samples determined using quantitative polymerase chain reaction analyses. Secondary outcome parameters were faecal %-lactobacilli, pH and stool frequency, and consistency. Growth and tolerance/adverse effects were recorded as safety parameters. Results: Typical %-bifidobacteria and %-lactobacilli at the end of the adaptation period in the study population were 14% and 2%, respectively. For faecal pH, significant differences between formula groups A vs. C and A vs. B were found at the end of the intervention period. Testing for differences in faecal %-bifidobacteria and %-lactobacilli between groups was hampered by non-normal data set distributions; no statistically significant differences were obtained. Comparisons within groups revealed that only in formula group C, all the three relevant parameters exhibited a significant effect with an increase in faecal %-bifidobacteria and %-lactobacilli and a decrease in pH. Conclusion: A consistent prebiotic effect along with a decrease in pH and increase in %-bifidobacteria and %-lactobacilli was found only in the group administered 0.4 g inulin/100 mL.

• 한국지반환경공학회 논문집
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• 제12권11호
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• pp.23-30
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• 2011

본 연구에서는 터널의 상부에 작용하는 토압을 평가하는데 있어서 기존의 Terzaghi 공식이 가지는 문제점을 해결하기 위해 흙의 팽창성(Dilatancy)을 고려하여 Terzaghi 공식을 수정하였다. Terzaghi 공식과 수정식에 대한 수학적 해석결과, 터널의 토압은 수정식이 Terzaghi 공식에 비해 작게 나타났으며 토피고가 커질수록 그 차이는 증가하였다. 터널모형실험 결과와 비교해 본 결과, Terzaghi 공식에 의해 계산된 상부토압은 굴착 전 토압의 약 70%이며, 수정식에 의하면 약 60% 정도로 나타났고, 터널모형실험에 의해 측정된 토압은 약 40% 정도 임을 볼 수 있었다. 또한 유한요소해석을 이용하여 Terzaghi 공식과 수정식에 의해 산정된 터널 상부토압과 전단변형률을 비교해본 결과 수학적 해석결과와 동일하게 수정식이 Terzaghi 공식보다 작게 나타났다.

• Journal of the Korean Data and Information Science Society
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• 제27권6호
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• pp.1585-1592
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• 2016

한국프로야구에서 팀의 승률을 예측하는 것은 야구팬들에게중요한 관심사이다. 팀들의 승률을 1982년부터 2015년까지의 모든 한국프로야구 기록을 이용하여 야구의 피타고라스 모형과 선형회귀모형을 사용하여 추정하고 평균제곱오차의 제곱근 (root mean squared error; RMSE)을 이용하여 상대적 효율성을 비교하였다. 결론적으로 승률이 높거나 낮은 경우에는 피타고라스 모형, 승률이 50% 근방에서는 선형회귀모형이 각각 효율성이 뛰어났다. 또한 전체데이터를 사용하는 경우에는 피타고라스모형이 상대적 효율성이 좋았으며, 효율성이 비슷하면 선형회귀모형이 사용과 이해도의 측면에서 좀 더 바람직하다고 할 수 있다.

• 한국초등과학교육학회지:초등과학교육
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• 제33권2호
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• pp.242-257
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• 2014

Researchers have employed a diversity of definitions and measurement methods for creativity. As a result, creativity research is underrepresented in the literature and the findings of different studies often prove difficult to draw into a coherent body of understanding. With regard to assessment, there are some important problems both in creativity research and practice, such as originality bias and Big-C creativity bias in teachers' perceptions about creativity and creative thinking, and additive rather than multiplicative scoring systems of creativity assessment. Drawing upon most widely accepted conceptions of the creativity construct, I defined 'student's scientific creativity' as the ability to make a product both original and useful to the student in terms of little-c creativity, and 'scientist's scientific creativity' as the ability to come up with a product both original and useful to the science community in terms of Big-C creativity. In this study, an 'Assessment Formula for Scientific Creativity' was developed, which is consisted of the multiplication of originality and usefulness scores rather than the sum of the two scores, and then, with scores calculated from the assessment formula, the scientific explanations generated by children were categorized into four types: routine, useful, original, and creative types. The assessment formula was revealed to be both valid and reliable. The implications of the assessment formula for scientific creativity are examined. The new assessment formula may contribute to the comprehensive understanding of scientific creativity to guide future research and the appropriate interpretation of previous studies.

• 동의생리병리학회지
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• 제30권6호
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• pp.385-396
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• 2016

It is a fact that the existing pharmacological research method is difficult to explain the effect and mechanism of action of herbal formula of Korean medicine. We are now very pleased with the development of modern science and the development of a methodology for studying herbal formula characterized by network targets and multi-component therapeutics over the human body. In this review, systems pharmacology or network pharmacology is demonstrated how these are applied to explain the effectiveness of herbal medicine. The post-genomic era provides a unique opportunity for the two fields to understand and benefit from each other. In particular, recent research trends, research methodology, useful databases and results of research on herbal formula are introduced. China already has a policy of scientific development of traditional chinese medicine (TCM) and the development of Chinese medicine industry with a focus on herbal formula research at national level, and in Korea, it is urgent to support and nurture the methodology appropriate to the characteristics of the herbal formula in order to study the safety and efficacy of Korean medicine.

• Journal of Mycology and Infection
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• 제24권1호
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• pp.1-8
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• 2019

Background: Scalp seborrheic dermatitis is a common disease characterized by flaking and itching of the scalp. Conventional treatment options, such as the use of topical corticosteroids and antifungal agents, may cause adverse effects and reduce user satisfaction rates; thus, it is important to explore other treatment options for scalp seborrheic dermatitis. Objective: We aimed to evaluate the efficacy and safety of a new-formula shampoo containing natural ingredients, including the extract of Rosa centifolia petals, epigallocatechin gallate, zinc pyrithione, and climbazole. Methods: A total of 50 patients with scalp seborrheic dermatitis were enrolled and divided into two groups: the new-formula shampoo-treated group and the 1.5% ciclopirox olamine shampoo-treated group. Clinical severity scores, sebum secretion, and inflammatory cytokines were assessed. In addition, patient satisfaction and adverse events were assessed using a questionnaire. Results: The new-formula shampoo was comparable with ciclopirox in reducing the clinical severity scores and sebum secretion. Patients' improvement scores and user satisfaction rates were higher in the new-formula shampoo group than in the 1.5% ciclopirox olamine shampoo-treated group. The inflammatory cytokine levels considerably changed in both groups during the course of the study. Conclusion: Thus, the new-formula shampoo can be considered a treatment option for patients with scalp seborrheic dermatitis.