Pediatric Gastroenterology, Hepatology & Nutrition

The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition (대한소아소화기영양학회)
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Dosage-Related Prebiotic Effects of Inulin in Formula-Fed Infants

  • Oswari, Hanifah (Department of Child Health, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia) ;
  • Widodo, Ariani Dewi (Research Task Force, Indonesian Pediatric Society (IDAI)) ;
  • Handayani, Frieda (Research Task Force, Indonesian Pediatric Society (IDAI)) ;
  • Juffrie, Mohammad (Research Task Force, Indonesian Pediatric Society (IDAI)) ;
  • Sundjaya, Tonny (Danone Nutricia Early Life Nutrition R&D) ;
  • Bindels, Jacques (Nutricia Research, Danone Nutricia Early Life Nutrition) ;
  • Hegar, Badriul (Department of Child Health, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia)
  • Received : 2018.05.30
  • Accepted : 2018.09.12
  • Published : 2019.01.15
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Abstract

Purpose: The aim of this study was to identify the minimally meaningful dosage of inulin leading to a prebiotic effect in Indonesian infants. Methods: In a randomized controlled double-blinded, parallel, 3-arm intervention study, 164 healthy formula-fed infants aged 3 to 5 months first obtained formula-A (without inulin) during a 4-week adaptation period. Subsequently, 142 subjects were subjected to a 4-week feeding period by administering either formula-A (no inulin), formula-B (0.2 g/100 mL inulin) or formula-C (0.4 g/100 mL inulin). The primary outcome parameter was %-bifidobacteria in faecal samples determined using quantitative polymerase chain reaction analyses. Secondary outcome parameters were faecal %-lactobacilli, pH and stool frequency, and consistency. Growth and tolerance/adverse effects were recorded as safety parameters. Results: Typical %-bifidobacteria and %-lactobacilli at the end of the adaptation period in the study population were 14% and 2%, respectively. For faecal pH, significant differences between formula groups A vs. C and A vs. B were found at the end of the intervention period. Testing for differences in faecal %-bifidobacteria and %-lactobacilli between groups was hampered by non-normal data set distributions; no statistically significant differences were obtained. Comparisons within groups revealed that only in formula group C, all the three relevant parameters exhibited a significant effect with an increase in faecal %-bifidobacteria and %-lactobacilli and a decrease in pH. Conclusion: A consistent prebiotic effect along with a decrease in pH and increase in %-bifidobacteria and %-lactobacilli was found only in the group administered 0.4 g inulin/100 mL.

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References

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