• 한국임상수의학회지
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• 제28권1호
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• pp.113-121
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• 2011

Foot-and-mouth disease (FMD) is a severe vesicular disease of cloven-hoofed animals including domesticated ruminants and pigs. Acute clinical signs may be mild in sheep and goats but are associated with lameness in pigs and mouth lesions with vesicles in cattle. The required condition for a successful pathogen appears to be the ability to counteract both the host innate and adaptive immune response. FMD virus (FMDV) inhibits the induction of antiviral molecules and interferes with the secretory pathway in the infected cell. The surface expression of Major Histocompatibility Complex (MHC) class I molecules is reduced in infected cells. Thus, the ability of the host to recognize and eliminate virus infected cells is decreased. Furthermore, FMDV infection results in a rapid, but transient lymphopenia, reducing the number of T and B cells, and affecting T cell function. The virus appears to premature apoptosis-mediated cell death because it has a very short replication cycle and is able to rapidly produce large amounts of virus. FMDV engages the host protective response at multiple steps to ensure its effective replication and pathogenesis. This review describes the recent pathological and immunological studies to overcome the powerful abilities of FMDV to counteract defense mechanism of host.

• 한국임상수의학회지
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• 제29권4호
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• pp.315-318
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• 2012

2010년초 국내 구제역 발생에서 사슴에서 구제역 A형 감염 사례를 확인하였다. 2002년 O형 구제역이 돼지에서 발생된 이후에 8년만인 2010년 1월에 처음 소에서 A형 구제역이 발생된 이후 6농가에서 발생하였고, 같은 해 3월 발생농가 주변 이동제한 해제를 위한 사슴 항체검사에서 2마리의 사슴에서 구제역 항체양성을 확인하였다. 추가적으로 동일농장에 사육중인 12두에 대한 추가 검사에서 구제역바이러스는 검출되지 않았으며, 비교적 높은 구제역A형에 대한 중화항체가 검출되었다. 그 이후 구제역 A형에 대한 추가 발생은 없었다.

• 한국콘텐츠학회논문지
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• 제17권5호
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• pp.565-573
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• 2017

재난 재해 발생 시, 정부의 위기 대응방식에 대한 사후 평가는 향후 유사한 위기 상황이 발생할 경우를 대비하고 국가의 장기적인 위기관리의 초석이 되는 필수적인 단계이다. 본 논문에서는 국내에서 발생한 구제역에 관하여 정부에서 어떠한 대응 전략을 펼쳤는지를 언론에 보도된 기사 내용을 통해 분석한 연구로써, 먼저 온라인 뉴스 기사로부터 구제역에 관한 키워드들을 추출하여 데이터 큐브를 구성한 후, OLAP 연산과 연관규칙 분석을 수행함으로써 시간 축에 따른 정부의 위기상황 대응행동 및 그에 따른 사회적 파급 효과들을 분석한다. 구제역이 가장 심각했던 2010년 11월부터 2011년 12월까지 국내에서 발생한 구제역에 관한 정부의 위기 상황 대응 방법을 사례분석을 통해 분석하였다.

• 한국축산식품학회지
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• 제38권6호
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• pp.1155-1159
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• 2018

Foot-and-mouth disease (FMD) is an infectious disease affecting pigs. The control of FMD in swine husbandry is very important because its outbreak results in a vast economic loss. FMD vaccination has effectively controlled FMD; however, it results in economic loss associated with the incidence of lesions in the pork meat at the injection site. The objective of this study was to investigate the effects of transdermal needle-free injection (NFI) of the FMD vaccine on the incidence of lesions at the injection site. Pigs (n=493) in the control group were vaccinated with the FMD vaccine using a commercial syringe needle, while 492 pigs in the transdermal NFI group received the FMD vaccine using a needle-free gas-powered jet injector. After the slaughter of the pigs, the incidence of lesions at the injection site of all pigs was checked by plant workers. The result of this study showed that the incidence of lesions in the pork ham from pigs vaccinated with NFI was 14.82% lower than that in control pigs (p<0.01). In addition, lesions generated in the NFI group were found just in the subcutaneous tissue. Therefore, the incidence of lesions at the injection site in pork from pigs vaccinated with the FMD vaccine can be effectively reduced by using transdermal NFI rather than a conventional syringe needle.

• 동물자원연구
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• 제28권2호
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• pp.78-96
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• 2017

구제역은 발생 시 전염이 쉽게 일어나며 심각한 경제적 피해를 일으키는 질병이다. 구제역의 방역정책은 발견 직후 빠른 살처분이 최선책이나, 전파 속도나 상황 등에 따라 타지역 백신 접종 등의 방법을 시행할 수도 있다. 이러한 방법을 적용하기 위해서는 구제역을 빠르고 정확하게 진단할 필요성이 있다. 개발된 진단법들은 구제역의 확진, 혈청형의 동정, 백신 접종 후 항체의 생성 확인 등에 사용된다. 많은 진단법들이 개발되었지만 아직은 빠른 시간 내에 검출이 가능하며 동시에 정확성도 가진 방법이 드물다. 그렇기에 기존의 방법들을 개선시킨 새로운 진단법이 필요하다. 현재는 대부분 혈청학적 진단법인 ELISA에 의존하거나 분자 유전학적 기술인 PCR을 사용한다. 가장 최근 기술은 그 둘을 합치는 방법으로, 어떻게 하면 더 신속하고 저비용이면서, 민감하고 정확한 방법이 될 수 있을지 연구가 진행되고 있다.

• 대한정형외과 초음파학회지
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• 제3권1호
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• pp.32-37
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• 2010

정형외과 영역에서 초음파를 이용한 진단과 치료가 광범위하게 사용되고 있다. 특히 족부 및 족관절에서의 초음파를 이용한 진단 족부 및 족관절의 해부학적 특성상 매우 유리한 것으로 알려져 있다. 족부 및 족관절에 발생하는 다양한 질환의 원인과 치료를 시행하기 위해서는 족부 및 족관절의 해부학적, 생역학적 특징을 잘 이해하여야 한다. 족부 및 족관절은 총 28개의 뼈와 많은 수의 인대, 건으로 이루어져 있으며 이들간의 유기적인 결합을 통해 신체를 지탱하는 정적 기능과 걷는 동적 기능을 동시에 수행할 수 있는 복잡한 구조 물이다. 그리고 작은 공간에 여러 구조물이 밀집되어 있어서 질환이 있는 부위의 정확한 이학적 검사가 요구된다. 그러므로 해부학적, 생역학적 지식을 바탕으로 이학적 검사를 체계적으로 시행함으로써 초음파를 이용한 진단 및 치료에 정확성을 기할 수 있다.

• 대한족부족관절학회지
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• 제9권2호
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• pp.204-208
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• 2005

Kohler's disease is an uncommon idiopathic osteochondrosis of the tarsal navicular. The diagnosis is clinical and the natural history is benign. The treatment is symptomatic, including shoe supports when the symptoms are mild and initial cast immobilization for at least 8 weeks when the symptoms are more intensive. The final clinical outcome is always favorable. Although it has been fully described both clinically and radiologically, There have been a few long-term follow-up reports in worldwide. This case report presents a Kohler's disease of the tarsal navicular with long-term follow-up of 12 years.

• 대한족부족관절학회지
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• 제1권1호
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• pp.23-29
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• 1997

Freiberg's disease is a pathologic condition of the second or third metatarsal head, rarely the forth or fifth metatarsal head, and it becomes abnormally enlarge due to avascular necrosis of subchondral cancellous bone. From Nov. 1982 to Sep. 1994, we treated surgically 10 cases of the disease who complained the continuous symptoms inspite of proper conservative management. Metatarsal head excision was done in 8 cases and resurfacing of the cartilagenous portion of the metatarsal head in 2 cases. During the average follow up of 55 months, the pain was relieved in all patients who were underwent surgical intervention but the stiffness of the metatarsophalangeal joint was remained in most of cases. It seems to be a logical treatment of choice in younger and active patients that conservative management is the initial treatment but more ablative procedure is needed for the continued symptoms. We can propose the metatarsal head excision or resurfacing of the involved joint is effective treatment method with simple procedure and minimize morbid period than other procedures such as corrective osteotomy.

• 대한의용생체공학회:의공학회지
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• 제27권6호
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• pp.351-356
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• 2006

The purpose of this study is to investigate the gait characteristics in Parkinson's disease patients. Specifically, the total stance time and the ratio of each stance phase (heel strike, mid-stance, propulsion) are analyzed from the foot-pressure measurement system which requires low cost and small space compared to the conventional gait analysis system. The gait characteristics were analyzed in 23 Parkinson's disease patients (before and after L-dopa medication), 34 elderly (sixties) normal subjects and 21 young (twenties) normal subjects. Bradykinesia global score (self-developed score of slowness of body movement) of patients before medication was determined to see the relationship between the score and the gait characteristics. The total stance time was greater in the erde. of patients, elderly, youngs (p<0.05). The phase ratio of heel strike and propulsion was smaller and that of mid-stance was greater in the order of patients, elderly, youngs (p<0.05). However, there was no significant difference in the above gait characteristics of patients before and after medication. There was a tendency, though statistically non-significant, that the total stance time is longer and the propulsion phase ratio is shorter in patients with greater Bradikinesia global scale, and this tendency was relieved after medication.

• 한국동물위생학회지
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• 제33권2호
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• pp.97-103
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• 2010

Foot-and-mouth disease (FMD) commonly infects cloven-hoofed livestock animals such as cattle, pig, sheep, and goat and its clinical signs are well-known. Besides livestock, FMD can be transmitted among cloven-hoofed animals in the wild. FMD mostly affects livestock animals in farms, but, wild animals are likely to play a pivotal role in spreading the disease due to their way of free living. In the case of deer, the clinical signs of FMD vary widely from subclinical to severe infections. Thus, in some deer species, it may be hard to verify clinical signs of FMD. A deer may carry the virus up to 11 weeks after exposure, shedding the virus during the period. However, deer is not considered as a typical host for persistent infection like buffalo, cattle or sheep. In Korea, small-scale livestock farms which have less than 10 animals make up 63.6% of the entire livestock farms. Considering raising environment in deer farms, it is assumed that the risk of virus excretion and consequent transmission of FMD among deers is relatively lower than other cloven-hoofed animals. However, Sika deer and Elk which are typical deer species in Korea would manifest mild to subclinical symptoms upon FMD infection. Therefore, laboratory testing is necessary to confirm FMD in these animals because of difficulty in verifying clinical signs and the risk of virus shedding during inapparent infection.