• Journal of Pharmaceutical Investigation
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• v.36 no.4
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• pp.231-237
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• 2006

Hypoxia in solid tumors is known to contribute to intrinsic chemoresistance. Histocultures are in vitro 3 dimensional cultures of tumor tissues and maintain the characteristic microenvironment of human solid tumors in vivo including hypoxia and multicellular structure. In this study, we evaluated the pharmacodynamics of tirapazamine(TPZ), a hypoxia-selective cytotoxin, in human non small cell lung cancer(NSCLC) cells grown as monolayers and histocultures. Antiproliferative activity of TPZ was determined after various conditions of drug exposure, and cell cycle arrest and apoptosis were also measured using flow cytometry. In monolayers, hypoxia selectivity measured by hypoxic/normoxic cytotoxicity ratio was increased with longer exposure. Lower cytotoxicity of TPZ was observed in histocultures compared to monolayers, however, a similar level of cytotoxicity was obtained with longer exposure of 96 hr. TPZ induced $G_2/M$ arrest and apoptosis in both culture conditions, which were greatly enhanced under hypoxic condition. Our data clearly showed the different pharmacodynamics of TPZ in monolayers and histocultures. Antiproliferative activity of TPZ against human solid tumors can be improved with longer drug exposure by exploiting drug delivery systems or by combining angiogenesis inhibitors to maintain drug concentration in tumor tissues.

• Journal of the Korean Society for Library and Information Science
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• v.54 no.3
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• pp.285-314
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• 2020

The healthcare environment is becoming increasingly dependent on health information technology (HIT), with healthcare providers, patients, and other people engaged in the field producing and sharing information to improve healthcare delivery. This focus has raised the issue of Health Information Infrastructure (HII) to the forefront of policy, design, and law. While several studies have examined each element of HII, little attention has been paid to the overall infrastructure as a collection of technologies, institutions, standards, and practices. In order to fill the gap, this study focuses on medication reconciliation as an example of the wider phenomenon of HII. In particular, the study examines a medication reconciliation process (MRP) as an example to understand the key challenges facing the development of HII, how the challenges are interrelated, and how they can be met as a whole. Following a mixed methodology, involving workflow study, focus group discussions, and in-depth interviews, the study examines "data friction" along technical, institutional, regulatory, and legal dimensions. This study constitutes one of the first efforts to comprehensively investigate health information infrastructure and how technology and other dimensions in infrastructure are interrelated. The study therefore contributes to a better understanding of HII and the practical challenges that hinder the seamless flow of information in the healthcare environment.

• YAKHAK HOEJI
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• v.45 no.1
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• pp.108-115
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• 2001

We have recently reported the development of a high efficiency expression vector, pCK, which can drive a high level of gene expression in mouse skeletal muscle. In this study, we tested the therapeutic potential of pCK expressing human VEGF165, pCK-VEGF in the rabbit ischemic hind limb model. To determine the optimal dose of plasmid DNA, various concentrations of pCK-CAT were injected into the muscle of a rabbit hind limb and the levels of CAT activity were determined. It was found that the expression level of the exogenously added gene became stable between 250 and 1,000 $\mu$g. Based on this result, we tested whether intramuscular transfer of 500$\mu$g of pCK-VEGF could actually modulate collateral vessel development in a rabbit ischemic hind limb model. It was found that relative to the control group injected with the pCK lacking the VEGF sequence, single intramuscular doses (500$\mu$g) of pCK-VEGF produced statistically significant augmentation of collateral vessels as determined by the angiographic vessel count, maximal blood flow by Doppler flowmeter and the number of capillaries by histology. These results suggest that a single 500$\mu$g-delivery of pCK-VEGF is potent enough to induce sufficient angiogenic activity and achieve therapeutic benefit on this rabbit model.

• Korean Journal of Computational Design and Engineering
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• v.19 no.3
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• pp.214-223
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• 2014

This paper presents a bottleneck detection framework using simulation approach in a wafer FAB (Fabrication). In a semiconductor manufacturing industry, wafer FAB facility contains various equipment and dozens kinds of wafer products. The wafer FAB has many characteristics, such as re-entrant processing flow, batch tools. The performance of a complex manufacturing system (i.e. semiconductor wafer FAB) is mainly decided by a bottleneck. This paper defines the problem of a bottleneck process and propose a simulation based framework for bottleneck detection. The bottleneck is not the viewpoint of a machine, but the viewpoint of a step with the highest WIP in its upstream buffer and severe fluctuation. In this paper, focus on the classification of bottleneck steps and then verify the steps are not in a starvation state in last, regardless of dispatching rules. By the proposed framework of this paper, the performance of a wafer FAB is improved in on-time delivery and the mean of minimum of cycle time.

• Journal of Pharmaceutical Investigation
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• v.36 no.5
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• pp.293-297
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• 2006

Curcumin is a phytochemical compound with anticancer activity. Although curcumin has substantial pharmacological effect against various cancers, the low solubility of curcumin has hindered its development. For an organic solvent-free injectable formulation, we encapsulated curcumin in various liposomes. Due to its lipophilic property, curcumin was placed in the membrane region of liposomes. Curcumin was stably encapsulated in all formulations tested in this study. The cellular uptake of curcumin delivered in liposomal formulations or free form was measured in K562 human leukemia cell lines using a flow cytometry and MTT viability assay, respectively. Although all the liposomes could solubilize curcumin, the cellular levels and the anticancer effects of liposomal curcumin varied with the composition of liposomes. Moreover, liposomal curcumin down-regulated the expression of Notch-1, the molecule involved in the carcinogenesis, to the similar extent to free curcumin dissolved in dimethyl sulfoxide. These results warrant the development of liposomal curcumin as an injectable formulation for leukemia treatment.

• Management & Information Systems Review
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• v.3
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• pp.257-285
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• 1999

Korea Postal Service(KPS) nowadays lies in competitive environment with alternative business such as door-to-door delivery service. Customers began to complain about postal service quality and ask the government to reform a public firm through management innovation. But, Korea Postal Service has not met the break-even point between it's revenue and expenditure because the service is under the government system and cannot independently make major decisions on products, pricing, services, personnel management, financial policies and etc. The objective of this study is to provide marketing planners and practitioners with some guidelines when they establish marketing strategies and to help marketers on theories and practical instructions about postal service marketing when they interact with customers. I. A field survey on both customer satisfaction and internal staff satisfaction was conducted to get some ideas for the marketing strategy planning. II. Practical guidelines and instructions were made for marketers to communicate with customers in various areas such as pricing, product, service demand, marketing channel, promotion, and etc. III. Some suggestions on marketing policies for planners and mangers in the marketing strategy were described including personnel resource as well as physical resource. IV. Special issues on small packet market and direct mail market were discussed and some alternative solutions were proposed. V. Database marketing strategy was emphasized to get new business opportunities such as direct mail, and to provide differential services to customers as much as their contribution into the profitability for KPS. VI. Cyber Post Office should be constructed on Internet to provide new services which are combined with physical material flow and information technologies.

• The Research Journal of the Costume Culture
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• v.27 no.6
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• pp.582-598
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• 2019

Intermedia is a term that refers to the convergence of different media. It has not only enabled the delivery of brand message but also developed interactive communication in a contemporary fashion show context. This study investigates the presentation methods of contemporary fashion shows affected by intermedia. We examined the research and theory related to intermedia and fashion shows by accessing articles since the 2000s concerning 252 shows by 30 designers that tended to demonstrate the use of intermedia. Our analysis highlighted four particular characteristics: "medium scalability" (the unity of art and fashion and the unity of life and fashion); "synesthetic flow" (the audience's emotional immersion, represented by the actual performance and performances of the models); "participatory accessibility" (performance participation through action and instrumental support); and "immaterial symbolization" (an intuitive symbol that emphasizes both the direct outward appearance and the metaphorical symbolism so that the object is expressed in a figurative sense). From these results, we identified considerable synergy between the characteristics of intermedia and contemporary fashion shows. Therefore, it might be useful to conduct an experimental study on this area of research.

• Advances in aircraft and spacecraft science
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• v.1 no.4
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• pp.409-425
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• 2014

Converging flows of a gas and a liquid at a microchannel cross junction, under proper conditions, can result in the formation of periodic, dispersed microslugs. This microslug formation phenomenon has been proposed as the basis for a fuel injection system in a novel, 'discrete' monopropellant microthruster designed for use in next-generation miniaturized satellites. Previous experimental studies demonstrated the ability to generate fuel slugs with characteristics commensurate with the intended application during steady-state operation. In this work, numerical and experimental techniques are used to study the effect of valve actuation on slug characteristics, and the results are used to compare with equivalent steady-state slugs. Computational simulations of a valve with a 1 ms valve-actuation cycle show that as the ratio of the response time of the valve to the fully open time is increased, transient effects can increase slug length by up to 17%. The simulations also demonstrate that the effect of the valve is largely independent of surface tension coefficient, which is the thermophysical parameter most responsible for slug formation characteristics. Flow visualization experiments performed using a miniature valve with a 20 ms response time showed less than a 1% change in the length of slugs formed during the actuation cycle. The results of this study indicate that impulse bit and thrust calculations can discount transient effects for slower valves, but as valve technology improves transient effects may become more significant.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.22 no.52
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• pp.155-170
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• 1999

I think that there are few domestic enterprises that recognize standardization of logistics equipments is necessary, which causes a lot of waste in costs and also reduces their business competitiveness. The purpose of this paper is to make the companies be aware of this situation, to exactly analyze where the Korean logistics equipments status are, and further to provide practical directions of methods and activities for effective standardization. Through analysis in the study, there were some findings, as listed below. First, the standardization level of each company varies depending on its own corporate characteristics. Second, if a company adopted standardization process in logistics equipments, it would accelerate process of work efficiency or productivity. Third, when logistics equipment are standardized, it would boost efficiency in storage utilization. Fourth, the delivery services through this standardized logistics would be implemented at a higher speed than before due to the accelerated flow of materials. According to the above findings, it is confirmed that logistics standardization would greatly affect on business performance positively. For the domestic manufactures to facilitate logistics system more easily, as an easiest way, it is required to build logistics standardization teams and surveys. Then afterwards, to achieve it earlier than expected, the company-wide education and training for workers have to be followed to let them be aware of necessity and inevitability about standardized logistics.

• Journal of the Korea Safety Management & Science
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• v.4 no.2
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• pp.71-81
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• 2002

Today's environment of enterprise is changing. They have to face customer' demands with the right product, the right service and supply them at the right time. And also cut down logistics and inventory cost and bring up the profit as much as they can. This means the change of putting enterprise first in importance to putting customer first importance. therefore to correspond to customer's demand, shorting lead time is becoming a essential condition. The answer to this changes of environment is supply chain management. In the Supply chain, The ATP function doesn't only give customers to conformation of delivery. It can be used by the core function with ATP rule that can reconcile supplies and demands on the supply chain. Therefore We can be acquire the conformation about on the due date of supplier by using the ATP function of management about real and concurrent access on the supply chain, also decide the affect about product availability due to forecasting or customer's orders through the ATP. In this paper, It consolidates the necessity on a CTP and analyzes data which is concerned of ATP. Under the these environments, defines the ATP rule that can improve the customer value and data flow related the LTV(Life Time Value) and builds on a algorithm.