• International Journal of Computer Science & Network Security
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• v.21 no.2
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• pp.229-237
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• 2021

Our modern 'information-hungry' age demands delivery of information at unprecedented fast rates. Timely delivery of noteworthy information about recent events can help people from different segments of life in number of ways. As world has become global village, the flow of news in terms of volume and speed demands involvement of machines to help humans to handle the enormous data. News are presented to public in forms of video, audio, image and text. News text available on internet is a source of knowledge for billions of internet users. Urdu language is spoken and understood by millions of people from Indian subcontinent. Availability of online Urdu news enable this branch of humanity to improve their understandings of the world and make their decisions. This paper uses available online Urdu news data to train machines to automatically categorize provided news. Various machine learning algorithms were used on news headline for training purpose and the results demonstrate that Bernoulli Naïve Bayes (Bernoulli NB) and Multinomial Naïve Bayes (Multinomial NB) algorithm outperformed other algorithms in terms of all performance parameters. The maximum level of accuracy achieved for the dataset was 94.278% by multinomial NB classifier followed by Bernoulli NB classifier with accuracy of 94.274% when Urdu stop words were removed from dataset. The results suggest that short text of headlines of news can be used as an input for text categorization process.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.20 no.7
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• pp.2267-2276
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• 1996

Twin-fluid atomization has been widely used in combustors and process industries because of its high performance and simple structure. Flow visualization and pressure measurements were conducted to investigate the effects of gas flow in twin-fluid atomization. Schlieren photographs showed that changes in atomizing gas pressure, altered the wave patterns, and the lengths of both recitrculating toroid (impinging stangnation point) nad supersonic flow region in the jet. A longer supersonic wave pattern like net-shape wqas observed as atomizing gas pressure increased. The disintegration phenomenon of liquid delivery tube. The variation of spray angles with gas pressures were obtained by visualization using laser sheet beam. Suction pressuresat the nozzle orifice exit and recirculating region are shown to be used to estimate the stable atomization condition of a twin-fluid atomizer.

• Journal of Veterinary Clinics
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• v.21 no.3
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• pp.270-275
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• 2004

Anesthetic machines may be equipped with either a precision or nonprecision vaporizer. A precision vaporizer is designed to deliver an exact concentration of anesthetic agent. Goldman vaporizer is a low-flow, closed-circle circuit with a low resistance vaporizer, in circuit. Vaporizers used within circle system(VIC) are not usually temperature compensated and this is generally thought to be a disadvantage. As the volatile agent is vaporized, heat is extracted from the liquid and temperature decreases. This cooling of the liquid leads to a decrease in concentration of the anaesthetic agent delivered by the vaporizer. The purpose of this study is to examine the mechanical consistency of the delivery of isoflurane from Goldman vaporizer and precision vaporizer at various gas flow rates and temperatures. And we first studied isoflurane concentration according to room temperature changes delivered by a Goldman vaporizer and precision vaporizer using different gas flow. The room temperature of $15^{\circ}C,$ $20^{\circ}C,$ $28^{\circ}C$ and fresh gas flow rates of 0.5, 1.0, 1.5, 2.0, 3.0 l/min were used. The inspired agent concentration was measured using a Datex-Ohmeda multigas analyzer. As rose in room temperature, the isoflurane concentration of precision vaporizer approximated the dial setting. On the other hand, at a dial setting concentration of 5.0 percent the delivered isoflurane concentration of precision vaporizer was more than the dial setting in high temperature. The isoflurane concentration of precision vaporizer remained constant despite the increase in temperature. The isoflurane concentration of Goldman vaporizer was increased with rise in room temperature and decreased with rise in gas flow.

• The Korean Journal of Pain
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• v.26 no.4
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• pp.336-346
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• 2013

Intrathecal drug delivery is an effective and safe option for the treatment of chronic pathology refractory to conventional pain therapies. Typical intrathecal administered drugs are opioids, baclofen, local anesthetics and adjuvant medications. Although knowledge about mechanisms of action of intrathecal drugs are every day more clear many doubt remain respect the correct location of intrathecal catheter in order to achieve the best therapeutic result. We analyze the factors that can affect drug distribution within the cerebrospinal fluid. Three categories of variables were identified: drug features, cerebrospinal fluid (CSF) dynamics and patients features. First category includes physicochemical properties and pharmacological features of intrathecal administered drugs with special attention to drug lipophilicity. In the second category, the variables in CSF flow, are considered that can modify the drug distribution within the CSF with special attention to the new theories of liquoral circulation. Last category try to explain inter-individual difference in baclofen response with difference that are specific for each patients such as the anatomical area to treat, patient posture or reaction to inflammatory stimulus. We conclude that a comprehensive evaluation of the patients, including imaging techniques to study the anatomy and physiology of intrathecal environment and CSF dynamics, could become essential in the future to the purpose of optimize the clinical outcome of intrathecal therapy.

• Journal of Pharmaceutical Investigation
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• v.35 no.4
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• pp.233-241
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• 2005

Ursolic acid (UA), a bioactive triterpene acid, has been known to increase collagen content in human skin in addition to other actions such as anti-inflammatory, skin-tumor prevention and anti-invasion. However, it is poorly soluble in water. Therefore, we firstly prepared microemulsion system with benzyl alcohol, ethanol and Cremophor EL, RH 40 and Brij 35 as surfactant in order to increase solubility of UA and then prepared microemulsion was dispersed in o/w cream base for the topical delivery of UA in an effort to improve anti-wrinkle effect. The pseudo-ternary phase diagrams were developed and various microemulsion formulations were prepared using benzyl alcohol as an oil, Cremophor EL, RH 40 and Brij 35 as a surfactant. The droplet size of microemulsions was characterized by dynamic light scattering. The accumulation of VA in the skin from topical cream was evaluated in vitro using hairless mouse skins. The mean droplet size was $26.8{\pm}6.6$ nm for microemulsions II with Cremophor EL. All UA creams showed pseudoplastic flow and hysterisis loop in their rheogram, depending on the type of materials added in topical creams. The in vitro accumulation data demonstrated the UA topical cream prepared with the combination of Poloxamer 407 and Xanthan gum as a copolymer showed higher accumulation percentage than those prepared with either Poloxamer 407 or Xanthan gum. These results suggest that UA topical cream using microemulsion systems may be promising for the topical delivery of UA.

• Journal of Korean Society on Water Environment
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• v.32 no.6
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• pp.589-599
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• 2016

Implemented since 2004, TPLC (Total Pollution Load Control) is the most powerful water-quality protection program. Recently, uncertainty of prediction using steady state model increased due to changing water environments, and necessity of a dynamic state model, especially the watershed model, gained importance. For application of watershed model on TPLC, it needs to be feasible to adjust the relationship (mass-balance) between discharged loads estimated by technical guidance, and arrived loads based on observed data at the watershed outlet. However, at HSPF, simulation is performed as a semi-distributed model (lumped model) in a sub-basin. Therefore, if the estimated discharged loads from individual pollution source is directly entered as the point source data into the RCHRES module (without delivery ratio), the pollutant load is not reduced properly until it reaches the outlet of the sub-basin. The hypothetic RCHRES generated using the HSPF BMP Reach Toolkit was applied to solve this problem (although this is not the original application of Reach Toolkit). It was observed that the impact of discharged load according to spatial distribution of pollution sources in a sub-basin, could be expressed by multi-segmentation of the hypothetical RCHRES. Thus, the discharged pollutant load could be adjusted easily by modification of the infiltration rate or characteristics of flow control devices.

• Journal of Advanced Marine Engineering and Technology
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• v.40 no.9
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• pp.756-761
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• 2016

The objective of this study is to design and manufacture a fuel pump with the plunger diameter of 4 mm and stroke of 7 mm that can be mounted in a small single-cylinder four-stroke agricultural diesel engine, and to investigate the performance characteristics of the pump. The combustion pressure in a cylinder was reproduced by forming the back pressure of 1, 6, 11, 16 and 21 bar with a nitrogen gas in the home-manufactured modeling cylinder. In the experiment, the discharge pressure was measured at the spot of 1 cm away from the discharge port of a developed fuel pump. The delivery pressure and delivery flow rate were measured at the spot of 30 cm away from the discharge port of the pump, and the pump efficiency was calculated. The pump motor speed was changed from 600 to 800, 1000, 1200 and 1400 rpm. It is found that the delivery feed rate of fuel pump is increased as the rotational speed is raised, and is decreased as the back pressure, compression pressure in the cylinder, is increased. Also, the pump efficiency is reduced as the rotational speed and back pressure are increased.

• Tuberculosis and Respiratory Diseases
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• v.81 no.4
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• pp.319-329
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• 2018

Background: Bronchoalveolar lavage (BAL) is a necessary procedure for diagnosis of various lung diseases. High-flow nasal cannula (HFNC) oxygen delivery was recently introduced. This study aimed to investigate the safety and effectiveness of HFNC oxygen supply during BAL procedure in patients with acute respiratory failure (ARF). Methods: Patients who underwent BAL while using HFNC at a partial pressure of oxygen in arterial blood/fraction of inspired oxygen ($PaO_2/FiO_2$; PF) ratio of 300 or below among patients who had been admitted from March 2013 to May 2017 were retrospectively investigated. Results: Thirty-three BAL procedures were confirmed. Their baseline PF ratio was $166.1{\pm}46.7$. $FiO_2$ values before, during, and after BAL were $0.45{\pm}0.12$, $0.74{\pm}0.19$, and $0.57{\pm}0.14$, respectively. Flow (L/min) values before, during, and after BAL were $26.5{\pm}20.3$, $49.0{\pm}7.2$, and $40.8{\pm}14.2$, respectively. Both $FiO_2$ and flow during and after the procedure were significantly different from those before the procedure (both p<0.001). Oxygen saturation levels before, during, and after BAL measured by pulse oximeter were $94.8{\pm}2.9$, $94.6{\pm}3.5$, and $95.2{\pm}2.8%$, respectively. There were no significant differences in oxygen saturation among the three groups. Complications of BAL procedure included transient hypoxemia, hypotension, and fever. However, there was no endotracheal intubation within 24 hours. Baseline PF ratio in "without HFNC" group was significantly higher than that in "with HFNC" group. There were no differences in complications between the two groups. Conclusion: The use of HFNC during BAL procedure in ARF patients was effective and safe. However, there were no significant differences in oxygen saturation level and complications comparing "without HFNC" group in mild ARF. More studies are needed for moderate to severe ARF patients.

• Polymer(Korea)
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• v.31 no.3
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• pp.215-220
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• 2007

The control of the surface energy by electrohydrodynamic force provides electrospraying with various potential advantages such as simple particle size control, mono-dispersity, high recovery, and mild processing conditions. The advantages are quite helpful to improve the stability of protein drug and control its release. Herein, the nano-encapsulation of protein drugs using electrospraying was investigated. Albumin as a model protein was processed using uniaxial and co-axial electrospraying, and chitosan, polycaporlactone (PCL), and poly (ethylene glycol) (PEG) were used as encapsulation materials. The major processing parameters such as the conductivity of spraying liquids, flow rate, the distance of electrical potential gradient, etc were measured to obtain the maximum efficiency. In the chitosan systems, mean particles size decreases as flow rate and the distance between nozzle and the collecting part decreases. In the uniaxial technique of the PCL systems, mean particles size decreases as flow rate decreases. In the coaxial technique of the PCL systems, it was found that the particles size gets larger under the application of the higher ratio of inner-to-outer liquid flow rates. The primary particles formed out of an electrospraying nozzle showed narrow particle size distribution, but once they arrived to the collecting part, aggregation behavior was observed obviously. Efficient nano-encapsulation of albumin with PCL, PEG, and chitosan was conveniently achieved using electrospraying at above 12 kV.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.27 no.1
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• pp.64-71
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• 2016

Objectives: The objective of this study was to examine the effects of osmotic-controlled release oral delivery system methylphenidate on changes in regional cerebral blood flow (rCBF) in children with attention-deficit hyperactivity disorder (ADHD) using single photon emission computed tomography (SPECT). Methods: A total of 26 children with ADHD (21 boys, mean age: $9.2{\pm}2.05$ years old) were recruited. Each ADHD participant was examined for changes in rCBF using technetium-99m-hexamethylpropylene amine oxime brain SPECT before and after 8 weeks methylphenidate medication. Brain SPECT images of pediatric normal controls were selected retrospectively. SPECT images of ADHD children taken before medication were compared with those of pediatric normal controls and those taken after medication using statistical parametric mapping analysis on a voxel-wise basis. Results: Before methylphenidate medication, significantly decreased rCBF in the cerebellum and increased rCBF in the right precuneus, left anterior cingulate, right postcentral gyrus, right inferior parietal lobule and right precentral gyrus were observed in ADHD children compared to pediatric normal controls (p-value<.0005, uncorrected). After medication, we observed significant hypoperfusion in the left thalamus and left cerebellum compared to pediatric normal controls (p-value<.0005, uncorrected). In the comparison between before medication and after medication, there was significant hyperperfusion in the superior frontal gyrus and middle frontal gyrus and significant hypoperfusion in the right insula, right caudate, right middle frontal gyrus, left subcallosal gyrus, left claustrum, and left superior temporal gyrus after methylphenidate medication (p-value<.0005, uncorrected). Conclusion: This study supports dysfunctions of fronto-striatal structures and cerebellum in ADHD. We suggest that methylphenidate may have some effects on the frontal lobe, parietal lobe, and cerebellum in children with ADHD.