• Journal of Biomedical Engineering Research
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• v.18 no.3
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• pp.243-251
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• 1997

In this paper, we have reported two interesting flow effects arising in the TRFGE sequence using water flow phantom. First, we have shown that the TRFGE sequence is indeed not affected by "in-flow" effect from the unsaturated spins flowing into the imaging slice. Second, the enhancement of "in-plane flow" signal in the readout gradient direction was observed when the TRFGE sequence was used without flow compensation. These two results have many interesting applications in MR imaging other than fMRI. Results obtained were also compared with the results obtained by the conventional gradient echo(CGE) imaging. Experiments were performed at 4.7T MRI/S animal system (Biospec, BRUKER, Switzerland). A cylindrical phantom was made using acryl and a vinyl tube was inserted at the center(Fig. 1). The whole cylinder was filled with water doped with $MnCl_2$ and the center tube was filled with saline which flows in parallel to the main magnetic field along the tube. Tailored RF pulse was designed to have quadratic ($z^2$) phase distribution in slice direction(z). Imaging parameters were TR/TE = 55~85/10msec, flip angle = $30^{\circ}$, slice thickness = 2mm, matrix size = 256${\times}$256, and FOV= 10cm. In-flow effect : Axial images were obtained with and without flow using the CGE and TRFGE sequences, respectively. The flow direction was perpendicular to the image slice. In-plane flow : Sagittal images were obtained with and without flow using the TRGE sequence. The readout gradient was applied in parallel to the flow direction. We have observed that the "in-flow" effect did not affect the TRFGE image, while "in-plane flow" running along the readout gradient direction enhanced the signal in the TRFGE sequence when flow compensation gradient scheme was not used.

• Biotechnology and Bioprocess Engineering:BBE
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• v.7 no.1
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• pp.52-55
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• 2002

Flow cytometric techniques were used to investigate cell size, protein content and cell cycle behavior of recombinant Saccharomyces cerevisiae strains producing human lysozyme (HLZ). Two different signal sequences, the native yeast $MF\alpha1$ signal sequence and the rat $\alpha-amylase$ signal sequence, were used for secretion of HLZ. The strain containing the rat $\alpha-amylase$ signal sequence showed a higher level of internal lysozyme and lower specific growth rates. Flow cytometric analysis of the total protein content and cell size showed the strain harboring the native yeast signal sequence had a higher total protein content than the strain containing the rat $\alpha-amylase$ signal sequence. Cell cycle analysis indicated that the two lysozyme producing recombinant strains had an increased number of cells in the $G_2+M$ phase of the yeast cell cycle compared with the host strain SEY2102.

• Journal of Korea Society of Industrial Information Systems
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• v.17 no.3
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• pp.43-49
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• 2012

Information obtained from DFD(Data Flow Diagram) are very important in system maintenance, because most legacy systems are analyzed using DFD in structured analysis. In our thesis, we design and implement an extractor for design sequence of database tables using DFD. Our extractor gets DFDs as input data, transform them into a directed graph, and extract design sequence of DB tables. We show practicality of our extractor by applying it to a s/w system in operation.

• Journal of the military operations research society of Korea
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• v.10 no.2
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• pp.75-83
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• 1984

Consider an m machine flow shop with blocking. The processing time of job j,j=1,..., n on each one of the m machines is equal to the same random variable $X_j$ and is distributed according to $F_i$. We assume that the processing times are stochastically ordered, i.e., $F_{1_{-st}}{<}F_{2_{st}}{<}cdots_{-st}{<}F_n$. We show that the sequence 1,3,5,...,n-1,n,n-2,...,6,4,2 when n is even and sequence 1,3,5,...,n-2,n,n-1 ... 6,4,2 when n is odd minimizes the expected makespan and that the sequence 1,...,n minimizes the expected flow time.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.34 no.4
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• pp.82-88
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• 2011

A typical job sequencing problem is studied in this research to improve productivities in manufacturing companies. The problem consists of two-stage parts and assembly processes. Two parts are provided independently each other and then two sequential assembly processes are followed. A new heuristic is developed to solve the new type of sequencing problem. Initial solution is developed in the first stage and then the initial solution is improved in the second stage. In the first stage, a longer part manufacturing time for each job is selected between two, and then a sequence is determined by descending order of the times. This initial sequence is compared with Johnson's sequence obtained from 2-machine assembly times. Any mismatches are tried to switch as one possible alternative and completion time is calculated to determine whether to accept the new sequence or not to replace the current sequence. Searching process stops if no more improvement can be made.

• International Journal of Industrial Entomology and Biomaterials
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• v.24 no.1
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• pp.41-47
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• 2012

The Scarites aterrimus (Coleoptera: Carabidae) dwells exclusively on coastal sandy dunes. Previously, we investigated the nation-wide magnitude and nature of genetic diversity of the species using mitochondrial COI gene and found moderate to low magnitude of sequence diversity, the presence of closely related haplotypes, and relatively high gene flow estimate. Based on these observations we concluded that the species had no historical barriers that bolster genetic subdivision and possible population decline. In this study, we additionally sequenced mitochondrial COII gene from 23 individuals collected from 9 Korean localities to confirm previous findings. Sequencing of 688 bp COII gene provided 5 haplotypes ranging in sequence divergence from 0.145% to 0.291% (1 ~ 2 bp), further confirming low sequence divergence of the species. Gene flow estimates and genetic diversity estimates also support the previous findings that there had been no historical barriers that bolster genetic subdivision.

• Journal of Korean Society of Transportation
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• v.20 no.5
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• pp.67-79
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• 2002

In this paper, observed trajectories of a vehicle platoon are viewed as one realization of a finite sequence of random trajectories. In this point of view, we develop novel and mathematically rigorous concept of traffic flow variables such as local traffic density, instantaneous traffic flow, and velocity field and investigate their nature on a general probability space of a sequence of random trajectories which represent vehicle trajectories. We present a simple model of random trajectories as an illustrative example and, derive the values of traffic flow variables based on the new definitions in this model. In particular, we construct the model for the sequence of random vehicle trajectories with a system of stochastic differential equations. Each equation of the system nay represent microscopic random maneuvering behavior of each vehicle with properly designed drift coefficient functions and diffusion coefficient functions. The system of stochastic differential equations nay generate a well-defined probability space of a sequence of random vehicle trajectories. We derive the partial differential equation for the expected cumulative plot with appropriate initial conditions. By solving the equation with numerical methods, we obtain the values of expected cumulative plot, local traffic density, and instantaneous traffic flow. In addition, we derive the partial differential equation for the expected travel time to a certain location with appropriate initial and/or boundary conditions, which is solvable numerically. We apply this model to a case of single vehicle trajectory.

• Journal of the Korean Operations Research and Management Science Society
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• v.20 no.1
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• pp.115-130
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• 1995

This paper considers a single machine nonpreemptive scheduling problem with a given common due date. In the problem, the optimal job sequence is sought to minimize the sum of earliness/tardiness and flow time measures in the situation where all jobs are available at time zero, and weights per unit length of earliness/tardiness and flow time are V and W, respectively. Some dominant solution properties are characterized to deriva both an optimal starting time for an arbitrary sequence and sequence improvement rules. The optimal schedule is found to the case W .geq. V/. By the way, it is difficult to find the optimal schedule for the case W < V. Therefore, the derived properties are put on together to construct a heuristic solution algorithm for the case W < V, and its effectiveness is rated at the mean relative error of about 3% on randomly generated numerical problems.

• Journal of the Korean Operations Research and Management Science Society
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• v.17 no.3
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• pp.47-57
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• 1992

The purpose of this paper is to improve the operation performance of unit-load Automated Guided Vehicles (AGV's) used as a carrier and mobile workstation in a flow-shop type flexible manufacturing system. An algorithm is developed to determine the optimal job sequence which minimizes the vehicle idle time on the line and the production makespan by the use of the entering interval and travel time between workcenters. An entering times of AGV's and the minimum number of AGV's required are calculated by optimal job sequence. When the numbe rof AGV's is limited, enterling times of AGV's are adjusted to maximize the efficient use of vehicles. A numerical example is given to illustrate the application of the algorithm.

• Proceedings of the KOSOMBE Conference
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• v.1990 no.05
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• pp.25-27
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• 1990

By designing the gradient pulses to be velocity compensated during one pulse cycle in SSFP (steady state free precession) imaging, the flowing spins can be maintained in the steady state. In the new SSFP sequence the flow signal which might be lost in conventional SSFP imaging sequences can be restored owing to the signal contribution from the preceding pulse cycles. By using the proposed SSFP sequence substantial restoration of the flow signal has been observed for the CSF (cerebro spinal fluid) of the human head.