• The Journal of Korean Society for School & Community Health Education
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• v.19 no.3
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• pp.65-77
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• 2018

Background & Objectives: This study aims to investigate the health status of family caregivers with dementia patients and identify the factors related to their anxiety and depression. Methods: Data from 2015 Community Health Survey(n=2,426) was used. A chi-square test was performed to investigate the health status of family caregivers, and a multiple logistic regression analysis was used to identify the factors associated with anxiety and depression. Results: Odds ratio(OR) of anxiety and depression was 1.29 times higher in female, 2.49 times higher in over 70 years versus under 39 years. ORs were lower 34.0%, 26.0%, 26.0% in the working group, the physical activity group, the alcohol drinking group respectively. ORs of anxiety and depression were 4.54 times, 1.57 times higher in the stress group, the chronic disease group respectively. And ORs were 61.0%, 28.0% lower respectively when social networks and social activities was present. Conclusions: The rate of experiencing anxiety and depression was high in family caregivers with dementia patients. It is necessary to provide diverse programs to reduce the burden of family support, anxiety and depression of family caregivers.

• The Journal of the Korea Contents Association
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• v.20 no.6
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• pp.521-530
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• 2020

The purpose of this study was to develop and evaluate the nutrition education program for preschoolers focusing on family-linked cooking activities. After a pilot study and consultations of experts, a program(composed of twelve lessons) that was emphasized the right season food and cooking activities based on the social cognitive theory was developed. The lessons once-a-month and survey(pre and pro) were conducted to 29 preschoolers. The distribution of children was 72.5 months(mean age). The post-survey after the program was found to have significantly higher effects on nutrition knowledge and diet habits than the comparative group. Through this, the nutrition education program for preschoolers based on family-linked cooking activities developed in this study is effective in improving preschoolers' nutrition knowledge and diet habits, and provides grounds and implications for applying family-linked cooking activities to nutrition education.

• Journal of the Korean housing association
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• v.27 no.6
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• pp.65-75
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• 2016

Activities in the dwelling are inseparable from housing design. Spatial features often result from patterns of activities that take place within the dwelling. Activities are further elaborated to affect house plans, furniture, arrangement, and equipment. However, discrepancies still exist between housing design and behavior, where housing design often fails to accommodate activities and behavioral dimensions within the family and the dwelling. This paper addresses the relationship between dwelling activities and housing design by means of a qualitative study that aims to understand the needs of the Indonesian dwelling through activity analysis. To do so, the research adopts a methodology that involves collecting data from measurements of the house, house plan analysis, and photographs, in addition to in-depth semi-structured interviews with families. Taking Bandung as a case study, 9 houses and families were selected as respondents that share similar family life-cycles, number of family members, and building size. The findings from the study suggest that spacious and open plans are preferred by the family, while maintaining family privacy. Guest areas are used to host formal guests and to restrict visitor access in the house. Service areas such as kitchens and laundry areas are the core areas for household activities for cooking, laundry, and drying. To meet social activities such as community gathering, open plan design is necessary to allow flexibility of furniture reconfiguration to accommodate extra guests.

• Microbiology and Biotechnology Letters
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• v.30 no.4
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• pp.298-304
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• 2002

A family shuffling associating PCR-based and in vitro recombination and expression in Escherichia coli cdd mutant was carried out. Two cdd genes encoding cytidine deaminases (CDase) from thermophilic Bacillus caldolyticus and B. stearothermophilus were shuffled. Around 150 viable mutant colonies screened on AB minimal medium without uracil by E. coli cdd complementation were selected for cytidine deaminase assay and 4 candidates (SH1067, SH1077, SH1086, and SH1118) were chosen for the detailed study. The nucleotide sequence analyses of 4 selected mutants revealed that they have several point mutations and recombinations. Surprisingly, the SH 1067 showed 770 fold more specific CDase activity at $80^{\circ}C$ than that of T101 from parental B. stearothermophilus.

• Genomics & Informatics
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• v.21 no.2
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• pp.23.1-23.9
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• 2023

The mammalian sirtuin family, consisting of SIRT1-SIRT7, plays a vital role in various biological processes, including cancer, diabetes, neurodegeneration, cardiovascular disease, cellular metabolism, and cellular homeostasis maintenance. Due to their involvement in these biological processes, modulating sirtuin activity seems promising to impact immuneand aging-related diseases, as well as cancer pathways. However, more understanding is required regarding the safety and efficacy of sirtuin-targeted therapies due to the complex regulatory mechanisms that govern their activity, particularly in the context of multiple targets. In this study, the interaction landscape of the sirtuin family was analyzed using a systems biology approach. A sirtuin protein-protein interaction network was built using the Cytoscape platform and analyzed using the NetworkAnalyzer and stringApp plugins. The result revealed the sirtuin family's association with numerous proteins that play diverse roles, suggesting a complex interplay between sirtuins and other proteins. Based on network topological and functional analysis, SIRT1 was identified as the most prominent among sirtuin family members, demonstrating that 25 of its protein partners are involved in cancer, 22 in innate immune response, and 29 in aging, with some being linked to a combination of two or more pathways. This study lays the foundation for the development of novel therapies that can target sirtuins with precision and efficacy. By illustrating the various interactions among the proteins in the sirtuin family, we have revealed the multifaceted roles of SIRT1 and provided a framework for their possible roles to be precisely understood, manipulated, and translated into therapeutics in the future.

• Korean Journal of Medicinal Crop Science
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• v.10 no.4
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• pp.288-293
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• 2002

Allergen-removed-extract was produced from Rush verniciflua by two phase methods. Phase one was high temperature treatment of Rush verniciflua tree to get allergen-removed-extract. Phase two was extraction of solution from phase one product using water or organic solvents. The solutions from above method show high antioxidant activity, anticancer activity, and improvement in lung function, but did not contain urushiol family compounds.

• Advances in Traditional Medicine
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• v.7 no.1
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• pp.100-102
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• 2007

The crude ethanol extract of leaves of Avicennia officinalis Linn. (Family: Avicenniaceae) was screened for its antinociceptive activity. The extract produced significant writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 250 and 500 mg/kg body weight (P < 0.001) comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight. The result tends to suggest the antinociceptive activity of the extract.

• Journal of the Korean Applied Science and Technology
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• v.37 no.1
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• pp.7-16
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• 2020

The Fabaceae family are being used as traditional medicine. The aim of this study was to compare the antioxidant effects as well as the cell protecting effects of extracts of 5 species (Astragalus membranaceus, Caesalpinia sappan L., Glycyrrhiza uralensis F., Pueraria lobate O., Pterocarpus santalinus L.) in Fabaceae family. The extracts from 5 species were tested by radical scavenging activity test, total phenolic contents and the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay on human liver carcinoma (HepG2) cell line. Anti-oxidant effects of the extracts (5 mg/mL) from C. sappan was 93.49% by radical scavenging activity test. In addition, A. membranaceus extracts showed a weak radical scavenging activity. Anti-oxidant effects of the extracts (5 mg/mL) from A. membranaceus was 7.83% by radical scavenging activity test. Total phenolic contents of the extracts from C. sappan and A. membranaceus were 310.93 mg GAE/g extract, 15.33 mg GAE/g extract, respectively. Cell protecting effects against H₂O₂ treatment were observed at 100 ㎍/mL concentration of C. sappan and P. santalinus extracts. These results suggest that C. sappan and P. santalinus might be best anti-oxidant in Fabaceae family.

• Korean Journal of Culture and Social Issue
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• v.12 no.1
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• pp.1-14
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• 2006

The purpose of this study was to investigate the influences of impulsivity, family' gambling and the distance from the gambling facilities, on adolescents' gambling activity, gambling belief and gambling motivation in the future. A total of 567 high school students in Jeongseon and Taeback(the Kangwon-Land Casino area or near the Kangwon-Land Casino), in Gwhachoen City(near the Seoul Race Park), and in Whachoen(far from the gambling facilities area) were participated in this study, and completed the questionnaires for measuring adolescents' gambling activity, gambling belief and gambling motivation in the future, impulsivity and family gambling behaviors. Results showed there were positive relationships impulsivity, family' gambling, adolescents' gambling activity, gambling belief and gambling motivation in the future. There were significant relationships among dwelling areas, gambling behaviors, and beliefs. Especially, adolescents in Jeongseon have more likely gambling behaviors, and the gambling beliefs were more dysfunction than ones in Gwhachoen and Whachoen. And adolescents in Whachoen had the lowest gambling motivation. Also, the correlation between the impulsivity and gambling-related behaviors was significant. The implication of this study was as fellow. When planing the politic intervention for preventing the problem gambling in the future it was necessary to consider the distance from the gambling facilities as environmental component and impulsivity as personal component.

• Journal of the Korean housing association
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• v.13 no.3
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• pp.33-43
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• 2002

The purpose of this paper is to develop a space program of the new community center in multi-family housing. The community center defined in this study is a communal facility which integrate cultural and welfare facilities and activity programs into a complex. Through the analysis of the community programs and spaces for multi-family housing community, a new community center program is proposed. And basic area guidelines are proposed through the making of the space modelling of the important area of the center. According to the guidelines, more spaces compared to the present standards and conditions are needed for a new community center. However, the adjustment of area regulation is essential, considering the fast changing trend of resident's social needs. A new regulation system that controls the total area of function spaces of a community center, rather than controlling each function and area, is required. This kind of system makes it possible to decide programs freely within the limit of total floor area regulation by neighborhood's characteristics and residents'preference.