• 월간산업보건
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• 통권143호
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• pp.13-20
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• 2000

• Toxicological Research
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• 제17권
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• pp.201-203
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• 2001

The Japan Pharmaceutical Manufacturers Association. with the cooperation of the Japan Association of Contract Laboratories for Safety Evaluation. launched a collaborative study with 38 companies aimed at elucidating the correlation between histopathological/hematological findings and immune function. Seven substances were individually administered to Crj : CD (SD)IGS rats for 14 or 28 days. Their immunotoxicity was assessed by histopathology. hematology. plaque-forming cell assay. enzyme-linked immunosorbent assay of serum antibody to sheep red blood cells. and flow cytometry. Appropriate procedures for immunotoxicology evaluation of pharmaceuticals were considered.

• 한국항해항만학회지
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• 제27권6호
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• pp.619-624
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• 2003

Evaluating the risk of collision quantitatively plays a key role in developing the expert system of navigation and collision avoidance. This study analysed thoroughly how to determine the threshold function related to the avoidance time as described in the new evaluation of collision risk using sech function, and developed the appropriate equation as applicable.

• Ocean Systems Engineering
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• 제7권4호
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• pp.399-412
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• 2017

The Gauss-Legendre integral method is applied to numerically evaluate the Green function and its derivatives in finite water depth. In this method, the singular point of the function in the traditional integral equation can be avoided. Moreover, based on the improved Gauss-Laguerre integral method proposed in the previous research, a new methodology is developed through the Gauss-Legendre integral. Using this new methodology, the Green function with the field and source points near the water surface can be obtained, which is less mentioned in the previous research. The accuracy and efficiency of this new method is investigated. The numerical results using a Gauss-Legendre integral method show good agreements with other numerical results of direct calculations and series form in the far field. Furthermore, the cases with the field and source points near the water surface are also considered. Considering the computational efficiency, the method using the Gauss-Legendre integral proposed in this paper could obtain the accurate numerical results of the Green function and its derivatives in finite water depth and can be adopted in the near field.

• Korean Journal of Radiology
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• 제25권1호
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• pp.24-32
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• 2024

Despite improvements in operative techniques and perioperative care, post-hepatectomy liver failure (PHLF) remains the most serious cause of morbidity and mortality after surgery, and several risk factors have been identified to predict PHLF. Although volumetric assessment using imaging contributes to surgical simulation by estimating the function of future liver remnants in predicting PHLF, liver function is assumed to be homogeneous throughout the liver. The combination of volumetric and functional analyses may be more useful for an accurate evaluation of liver function and prediction of PHLF than only volumetric analysis. Gadoxetic acid is a hepatocyte-specific magnetic resonance (MR) contrast agent that is taken up by hepatocytes via the OATP1 transporter after intravenous administration. Gadoxetic acid-enhanced MR imaging (MRI) offers information regarding both global and regional functions, leading to a more precise evaluation even in cases with heterogeneous liver function. Various indices, including signal intensity-based methods and MR relaxometry, have been proposed for the estimation of liver function and prediction of PHLF using gadoxetic acid-enhanced MRI. Recent developments in MR techniques, including high-resolution hepatobiliary phase images using deep learning image reconstruction and whole-liver T1 map acquisition, have enabled a more detailed and accurate estimation of liver function in gadoxetic acid-enhanced MRI.

• Structural Engineering and Mechanics
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• 제63권6호
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• pp.789-797
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• 2017

Recently, some integrated structural identification/damage detection and reliability evaluation of structures with uncertainties have been proposed. However, these techniques are applicable for off-line synthesis of structural identification and reliability evaluation. In this paper, based on the recursive formulation of the extended Kalman filter, an on-line integration of structural identification/damage detection and reliability evaluation of stochastic building structures is investigated. Structural limit state is expanded by the Taylor series in terms of uncertain variables to obtain the probability density function (PDF). Both structural component reliability with only one limit state function and system reliability with multi-limit state functions are studied. Then, it is extended to adopt the recent extended Kalman filter with unknown input (EKF-UI) proposed by the authors for on-line integration of structural identification/damage detection and structural reliability evaluation of stochastic building structures subject to unknown excitations. Numerical examples are used to demonstrate the proposed method. The evaluated results of structural component reliability and structural system reliability are compared with those by the Monte Carlo simulation to validate the performances of the proposed method.

• 대한물리의학회지
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• 제10권1호
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• pp.99-105
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• 2015

PURPOSE: The purpose of this study was to investigate the differenceof GMFM evaluationcapacity according to the preparation and review times on the college students. METHODS: 58 subjects among physical therapymajor studentswere recruited. The group was constructed the fourgroupsbypreparation and review times. The firstgroup was less than 1hour, the second group wasmore than 1 hour ~ less than 2 hours, the third group was more than 2 hours ~ less than 3 hours, the fourth group was more than 3 hours that was preparation and reviewtimes. The students were performed GMFM evaluation capacity after they learned the normal motor development for 5 weeks and evaluation method. They continued the preparation and review learning about the lesson during 5 weeks. RESULTS: The group of more than 3 hours was the highest and next order was the group of more than 1 hour ~ less than 2 hours, group of less than 1hour on GMFM evaluation capacity. CONCLUSION: Preparation and review times improved the GMFM evaluation capacity of students. Therefore, Emphasizing the preparation and review of learning is proper way to increase the evaluation capacity. In addition, the professor should create the appropriate teaching strategies using preparation and review times to upgrade a learner's ability.

• 전기학회논문지
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• 제62권7호
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• pp.994-1002
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• 2013

This study suggests a generalized availability and safety evaluation model to evaluate the influences to the system's fault tolerant capabilities depending on automatic fault detection function such as the automatic periodic testings. The conventional evaluation model of automatic fault detection function deals only with the self diagnostics, and supposes that the fault detection coverage of self diagnostics is always constant. But all of the fault detection methods could be degraded. For example, the periodic surveillance test has the potential human errors or test equipment errors, the self diagnostics has the potential degradation of built-in logics, and the automatic periodic testing has the potential degradation of automatic test facilities. The suggested evaluation models have incorporated the loss or erroneous behaviors of the automatic fault detection methods. The availability and the safety of each module of the safety grade platform have been evaluated as they were applied the automatic periodic test methodology and the fault tolerant evaluation models. The availability and safety of the safety grade platform were improved when applied the automatic periodic testing. Especially the fault tolerant capability of the processor module with a weak self-diagnostics and the process parameter input modules were dramatically improved compared to the conventional cases. In addition, as a result of the safety evaluation of the digital reactor protection system, the system safety of the digital parts was improved about 4 times compared to the conventional cases.

• 한국산업정보학회논문지
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• 제22권6호
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• pp.95-105
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• 2017

본 연구는 중소기업들의 경쟁력을 증대하기 위하여 평가진단 체크시트 모델을 개발하는 것이다. 평가진단 체크시트 개발 절차는 사전조사(주력기업 조사, 업종특징 분석. 핵심기능 선정 등), 연구개발(핵심기능 체크시트 개발, 핵심기능 향상도구 개발)순으로 진행하였다. 평가모델은 5개 부문(비전과 전략체계, 품질보증과 제품안전, 현장관리 수준, 통계적 공정관리, 개선활동)으로 대별한 후, 각 부문별로 1)인식, 2)체계, 3)운영, 4)검토 및 보완의 4가지 내용으로 구분하여 구성하였다. 본 평가모델은 특히 지방자치단체 내에 산재해 있는 중소기업 중에서 주력 중소기업을 선정하여 집중 육성하는데 많은 기여를 하게 될 것으로 기대되며, 이를 통해 해당 중소기업의 경쟁력이 향상될 것으로 판단된다.

• 충청수학회지
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• 제22권3호
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• pp.467-480
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• 2009

In 1859, Bernhard Riemann, in his epoch-making memoir, extended the Euler zeta function $\zeta$(s) (s > 1; $s{\in}\mathbb{R}$) to the Riemann zeta function $\zeta$(s) ($\Re$(s) > 1; $s{\in}\mathbb{C}$) to investigate the pattern of the primes. Sine the time of Euler and then Riemann, the Riemann zeta function $\zeta$(s) has involved and appeared in a variety of mathematical research subjects as well as the function itself has been being broadly and deeply researched. Among those things, we choose to make a further investigation of the following subjects: Evaluation of $\zeta$(2k) ($k {\in}\mathbb{N}$); Approximate functional equations for $\zeta$(s); Series involving the Riemann zeta function.