• 유통과학연구
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• 제8권1호
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• pp.35-42
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• 2010

본 연구는 종합슈퍼마켓에서 소비자 구매경향별 구매시점광고(POP)에 대한 반응과 POP를 접한 후 최종 구매단계에서의 중요 의사결정 요인과의 관계를 규명하기 위한 연구이다. 본 연구결과를 살펴보면 첫째, 종합슈퍼의 POP광고반응 중 소비자들은 엔드켑(End Cap)에 대한 반응점수가 높은 것으로 나타났으며, 둘째는 성별 충동적 구매경향에 대한 차이는 전반적으로 남성이 여성보다 높았다. 또한, 구매경향 간, 변수들 간의 상관관계를 살펴본 결과 충동적 구매와 비계획적 구매경향(r=.325), 충동적 구매경향과 즉각적 구매경향(r=.249)에서 상관관계가 있는 것으로 나타났다.(p<0.01) 본 연구 결과 소비자의 소비패턴도 점점 합리성 추구하며 계획적 쇼핑과 더불어 소비에 있어 POP 광고가 자신의 합리성 또는 계획성을 촉진시키는 요인이 되었을 때 POP 광고가 비로소 소비로 연결될 수 있다는 연구결과를 도출하였다.

• 약학회지
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• 제41권4호
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• pp.399-406
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• 1997

The effects of different $K^+$ channel blockers were investigated on the non-adrenergic non-cholinergic (NANC) relaxations in the circular muscle of the rabbit proximal stomach. Non-selective blockers of $K^+$ channels, 4-aminopyridine (4-AP, 3~30${\mu}M$) and tetraethylammonium (TEA, 100~1000${\mu}M$) significantly enhanced the NANC relaxations in a concentration-dependent manner. The enhancement was more prominent for the NANC relaxations induced by the electric field stimulation (EFS) with lower frequencies. Blockers of large conductance $Ca^{2+}$-activated $K^+$ channels, charybdotoxin and iberiotoxin, a blocker of small conduntance $Ca^{2+}$-activated $K^+$ channels, apamin and a blocker of ATP-sensitive $K^+$ channels, glibenclamide had no effect on the NANC relaxations, respectively. Exogeneous administration of nitric oxide (NO, 1~30${\mu}M$) caused concentration-dependent relaxations which showed a similarity to those obtained with EFS. None of the $K^+$ channel blockers had an effect on the concentration-dependent relaxation in response to NO. These results suggest that prejunctional $K^+$ channels regulate the release of NO from the NANC nerve in the rabbit proximal stomach as the inhibition of prejunctional $K^+$ channels increases the NANC relaxation induced by the EFS.

• Molecules and Cells
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• 제44권10호
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• pp.723-735
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• 2021

Spemann organizer is a center of dorsal mesoderm and itself retains the mesoderm character, but it has a stimulatory role for neighboring ectoderm cells in becoming neuroectoderm in gastrula embryos. Goosecoid (Gsc) overexpression in ventral region promotes secondary axis formation including neural tissues, but the role of gsc in neural specification could be indirect. We examined the neural inhibitory and stimulatory roles of gsc in the same cell and neighboring cells contexts. In the animal cap explant system, Gsc overexpression inhibited expression of neural specific genes including foxd4l1.1, zic3, ncam, and neurod. Genome-wide chromatin immunoprecipitation sequencing (ChIP-seq) and promoter analysis of early neural genes of foxd4l1.1 and zic3 were performed to show that the neural inhibitory mode of gsc was direct. Site-directed mutagenesis and serially deleted construct studies of foxd4l1.1 promoter revealed that Gsc directly binds within the foxd4l1.1 promoter to repress its expression. Conjugation assay of animal cap explants was also performed to demonstrate an indirect neural stimulatory role for gsc. The genes for secretory molecules, Chordin and Noggin, were up-regulated in gsc injected cells with the neural fate only achieved in gsc uninjected neighboring cells. These experiments suggested that gsc regulates neuroectoderm formation negatively when expressed in the same cell and positively in neighboring cells via soluble factors. One is a direct suppressive circuit of neural genes in gsc expressing mesoderm cells and the other is an indirect stimulatory circuit for neurogenesis in neighboring ectoderm cells via secreted BMP antagonizers.

• 동의생리병리학회지
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• 제32권6호
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• pp.355-360
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• 2018

The purpose of this study is to find out the direction of development of the expert diagnosis system by questioning student satisfaction after practicing Oriental Diagnosis System (ODS). A questionnaire survey was conducted for 73 students who attended Pusan National University Graduate School of Korean Medicine and conducted clinical practice from the second semester of 17 years to the first semester of 18 years. The questionnaire survey consisted of 6 questions about the satisfaction of current expert system and 5 questions about supplementation and addition. As a result of the questionnaire analysis, the question about the necessity of the expert diagnosis system and the benefit of clinical practice using the expert diagnosis system indicated high positive response rate. On the other hand, there is a difference in the results of the dialysis before and after using the expert diagnosis system. So, It seems that the reliability of the results of the expert diagnosis system is still low. The results of the questionnaire indicate that the need for expert diagnosis system is beneficial, but it is necessary to supplement the current system in order to improve clinical utility in the future.

• Biomolecules & Therapeutics
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• 제27권3호
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• pp.265-275
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• 2019

Technological advances of mankind, through the development of electrical and communication technologies, have resulted in the exposure to artificial electromagnetic fields (EMF). Technological growth is expected to continue; as such, the amount of EMF exposure will continue to increase steadily. In particular, the use-time of smart phones, that have become a necessity for modern people, is steadily increasing. Social concerns and interest in the impact on the cranial nervous system are increased when considering the area where the mobile phone is used. However, before discussing possible effects of radiofrequency-electromagnetic field (RF-EMF) on the human body, several factors must be investigated about the influence of EMFs at the level of research using in vitro or animal models. Scientific studies on the mechanism of biological effects are also required. It has been found that RF-EMF can induce changes in central nervous system nerve cells, including neuronal cell apoptosis, changes in the function of the nerve myelin and ion channels; furthermore, RF-EMF act as a stress source in living creatures. The possible biological effects of RF-EMF exposure have not yet been proven, and there are insufficient data on biological hazards to provide a clear answer to possible health risks. Therefore, it is necessary to study the biological response to RF-EMF in consideration of the comprehensive exposure with regard to the use of various devices by individuals. In this review, we summarize the possible biological effects of RF-EMF exposure.

• Journal of Gastric Cancer
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• 제19권1호
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• pp.49-61
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• 2019

Purpose: The perigastric vagus nerve may play an important role in preserving function after gastrectomy, and intraoperative neurophysiologic tests might represent a feasible method of evaluating the vagus nerve. The purpose of this study is to assess the feasibility of neurophysiologic evaluations of the function and viability of perigastric vagus nerve branches during gastrectomy. Materials and Methods: Thirteen patients (1 open total gastrectomy, 1 laparoscopic total gastrectomy, and 11 laparoscopic distal gastrectomy) were prospectively enrolled. The hepatic and celiac branches of the vagus nerve were exposed, and grabbing type stimulation electrodes were applied as follows: 10-30 mA intensity, 4 trains, $1,000{\mu}s/train$, and $5{\times}$frequency. Visible myocontractile movement and electrical signals were monitored via needle probes before and after gastrectomy. Gastrointestinal symptoms were evaluated preoperatively and postoperatively at 3 weeks and 3 months, respectively. Results: Responses were observed after stimulating the celiac branch in 10, 9, 10, and 6 patients in the antrum, pylorus, duodenum, and proximal jejunum, respectively. Ten patients responded to hepatic branch stimulation at the duodenum. After vagus-preserving distal gastrectomy, 2 patients lost responses to the celiac branch at the duodenum and jejunum (1 each), and 1 patient lost response to the hepatic branch at the duodenum. Significant procedure-related complications and meaningful postoperative diarrhea were not observed. Conclusions: Intraoperative neurophysiologic testing seems to be a feasible methodology for monitoring the perigastric vagus nerves. Innervation of the duodenum via the celiac branch and postoperative preservation of the function of the vagus nerves were confirmed in most patients.

• Tribology and Lubricants
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• 제35권1호
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• pp.52-58
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• 2019

In the case of high-voltage connectors applied to automobiles, waterproofing has become an important issue for the safety of automobiles. In this study, structural analysis is performed on silicone rubber-type waterproof seals used in the voltage connector. For the structural analysis, the tensile properties of the actual rubber seal are evaluated using a miniaturized tensile testing machine. The Mooney-Rivlin material constants of the rubber seal are determined as follows; $D_1=0$, $C_{01}=0.241$, $C_{10}=0.0142$. The analysis shows that the contact pressure at the top of the seal where the seal and male connector are in contact is approximately three times higher than that at the bottom of the seal where the seal and female connector are in contact. It is confirmed that the waterproofing performance of the rubber seal depends on the contact pressure of the seal bottom where the seal and female connector are in contact. The contact pressure for waterproofing is found to be 4.7 bar. The strain concentration of the curved part is attributed to excessive initial tension. Therefore, a redesign is recommended for uniform stress or strain distribution in the curved section of the seal in response to the stress relaxation problem due to permanent deformation.

• BMB Reports
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• 제52권6호
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• pp.403-408
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• 2019

Dorsoventral patterning of body axis in vertebrate embryo is tightly controlled by a complex regulatory network of transcription factors. Ventx1.1 is known as a transcriptional repressor to inhibit dorsal mesoderm formation and neural differentiation in Xenopus. In an attempt to identify, using chromatin immunoprecipitation (ChIP)-Seq, genome-wide binding pattern of Ventx1.1 in Xenopus gastrulae, we observed that Ventx1.1 associates with its own 5'-flanking sequence. In this study, we present evidence that Ventx1.1 binds a cis-acting Ventx1.1 response element (VRE) in its own promoter, leading to repression of its own transcription. Site-directed mutagenesis of the VRE in the Ventx1.1 promoter significantly abrogated this inhibitory autoregulation of Ventx1.1 transcription. Notably, Ventx1.1 and Xcad2, an activator of Ventx1.1 transcription, competitively co-occupied the VRE in the Ventx1.1 promoter. In support of this, mutation of the VRE down-regulated basal and Xcad2-induced levels of Ventx1.1 promoter activity. In addition, overexpression of Ventx1.1 prevented Xcad2 from binding to the Ventx1.1 promoter, and vice versa. Taken together, these results suggest that Ventx1.1 negatively regulates its own transcription in competition with Xcad2, thereby fine-tuning its own expression levels during dorsoventral patterning of Xenopus early embryo.

• 한국정보통신학회논문지
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• 제24권3호
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• pp.441-447
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• 2020

전 세계적으로 매년 약 5천만 톤의 전기 및 전자 폐기물이 발생하고 있는 상황에서 사물인터넷 디바이스가 2025년 약 750억 개에 달할 것으로 예상하고 있다. 그러나 사물인터넷 디바이스의 폐기 처리에 필요한 식별 기법에 대한 연구는 미미하다. 본 논문에서는 이러한 문제를 해결하기 위해 사물인터넷 디바이스의 재활용 가능률과 재생 가능률, 각 부품의 재활용률 및 재생률 등의 EoLT(End-of-Life Treatment) 정보를 포함한 식별자를 제안하며, 객체 식별자, 모바일 RFID 및 QR 코드로 구현한다. 구현된 객체 식별자와 모바일 RFID는 통신 네트워크를 통해 원격 서버와 연동하여 사용될 수 있고, 구현된 QR 코드는 스마트폰 앱을 통해 간단히 사용될 수 있다.

• 전기전자학회논문지
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• 제24권4호
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• pp.1074-1080
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• 2020

본 논문은 공정, 전압 및 온도에 둔감하며, 출력전압 상태에 따라 3가지 동작모드가 가능한 디지털 제어 벅 변환기를 제안한다. 기존 디지털 제어 방식의 벅 변환기는 A/D 변환기, 카운터 및 딜레이 라인 회로를 사용하여서 정확한 출력 전압을 제어하였다. 정확한 출력 전압 제어를 위해서는 카운터 및 딜레이 라인 비트 수를 증가시켜서 회로 복잡성 증가 문제점을 지니고 있다. 이러한 회로의 복잡성 문제를 해결하기 위해서 제안된 회로에서는 8비트 및 16 비트 양 방향 쉬프트 레지스터를 사용하고 최대 128비트 해상도까지 듀티비 제어가 가능한 벅 변환기를 제안한다. 제안하는 벅 변환기는 CMOS 180 나노 공정 1-poly 6-metal을 사용하여 설계 및 제작하였으며, 2.7V~3.6V의 입력 전압과 0.9~1.8V의 출력 전압을 생성하고, 리플전압은 30mV, 전력 효율은 최대 92.3%, 과도기 응답속도는 4us이다.