• Title/Summary/Keyword: Effects of Absorption

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Effects of Domperidone, Scopolamine Butylbromide and Cimetidine on Absorption and Bioavailability of Ciprofloxacin in Rats (랫트에 있어서 시프로플록사신의 흡수와 생체이용율에 미치는 돔페리돈, 스코폴라민부틸브로마이드 및 시메티딘의 영향)

  • Yim, Hye-Suk;Park, Gee-Bae;Lee, Do-Ike;Lee, Kwang-Pyo
    • Journal of Pharmaceutical Investigation
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    • v.22 no.2
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    • pp.125-131
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    • 1992
  • The effects of domperidone, scopolamine butylbromide and cimetidine on the absorption and bioavailability of ciprofloxacin were studied in female rats. Ciprofloxacin was given in a single oral dose of 30 mg/kg to control group. Ciprofloxacin was concurrently administered with domperidone $(T_1\;group)$, scopolamine butylbromide $(T_2\;group)$, and cimetidine $(T_3\;group)$ to rats, respectively. Significantly changed pharmacokinetic parameters observed in $T_2$group when compared with control group were first-order absorption rate constant, $Ka(4.43{\pm}0.85$\;versus\;2.86{\pm}0.41\;hr^{-1},\;p<0.05)$, time needed to reach peak concentration, $T_{max}\;(32.27{\pm}2.46\;versus\;51.75{\pm}5.51\;min,\;p<0.05)$, area under the plasma concentration-time curve, AUC $(332{\pm}19\;versus\;477{\pm}27\;{\mu}g{\cdot}min/ml,\;p<0.05)$ and absolute bioavailability, Fabs $(60.6{\pm}3.6\;versus\;87.0{\pm}5.0%,\;p<0.05)$. On the other hand, domperidone and cimetidine did not significantly affect the absorption of ciprofloxacin. It is suggested that when scopolamine butylbromide is selected for clinical use, there is need for awareness of the reduction in absorption rate and the enhancement in absorption extent of ciprofloxacin.

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Effects of Acid and Pre-Reductant in the Analysis of Arsenic by Hydride Generation-Atomic Absorption Spectrometry (HG-AAS법에 의한 비소 분석에서 산 및 Pre-Reductant가 분석에 미치는 영향)

  • Lim, Heon-Sung;Lee, Sueg-Geun
    • Analytical Science and Technology
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    • v.13 no.2
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    • pp.151-157
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    • 2000
  • Effects of acids and pre-reductants in the analysis of arsenic have been studied by hydride generation-atomic absorption spectrometry. The analytical results were strongly dependent on the acid concentrations. All the pre-reductants was very effective to observe the arsenic signal at strong acid concentrations (3 M-5 M). However, at the low acid condition (${\leq}0.1M$), L-cysteine only showed a reasonable effect on the absorption signal. When the sample was treated with the nitric acid, absorption signal was unstable and was also decreased. Although interference effects were observed from metal ions such as $Cr^{6+}$ and $Br^{5+}$ at low acid condition, the generation of hydride could be increased by the strong acid condition.

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Analysis of Heat and Mass Transfer on Helical Absorber (헬리컬 흡수기의 흡수 열물질전달 해석)

  • Gwon, O-Gyeong;Im, Jong-Geuk;Yun, Jeong-In;Kim, Seon-Chang;Yun, Jae-Ho
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.24 no.11
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    • pp.1428-1436
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    • 2000
  • The absorption of vapor involves simultaneous heat and mass transfer in the vapor/liquid system. In this paper, a numerical study for vapor absorption process into LIBr-H$_2$O solution film flowing over helical absorber has been carried out. Axisymmetric cylindrical coordinate system was adopted to model the helical tube and the transport equations were solved by the finite volume method. The effects of operating conditions, such as the cooling water temperature. the system pressure, the film Reynolds number and the solution inlet concentration have been investigated in view of the absorption mass flux and the total absorption mass flux and the total absorption rate. The results for the temperature and concentration profiles, as well as the local absorption mass flux at the helical absorber are presented. It is shown that solution inlet concentration affected other than operation conditions for a mass flux.

Effect of Ginseng Saponin Fraction on Absorption of Cholesterol and Serum Lipid Components (인삼 사포닌 분획이 Cholesterol의 흡수 및 혈청지질 성분에 미치는 영향)

  • 정인실;조영동
    • Journal of Ginseng Research
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    • v.9 no.2
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    • pp.232-239
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    • 1985
  • The effects of total saponin, triol and diol saponin, and prosapogenin of ginseng on the absorption of cholesterol and the component of serum lipids was observed as a function of time using isotopic method. The following results were obtained. 1) Labelled cholesterol absorption was observed to be enhanced after adminstrations of total saponin, triol saponin, and. prosapogenin of ginseng to rat (Sprague Dawley). 2) Decreases in the amount of serum lipid were observed after administration of total saponin and prosapogenin of ginseng.

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Optical Transmittance Change of Pd Thin Film by Hydrogen Absorption and Desorption (수소 흡수-방출에 의한 Pd 박막의 광투과도 특성변화)

  • Cho, Young sin
    • Transactions of the Korean hydrogen and new energy society
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    • v.12 no.4
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    • pp.287-292
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    • 2001
  • The optical transmittance change of Pd thin film due to hydrogen absorption and desorption was examined at room temperature. Hydrogen absorption and desorption cycling effects on optical transmittance were measured 6 times in the pressure range between 0 and 640 torr. Optical transmittance of Pd film was increasing with increasing hydrogen pressure. Ratio of optical transmittance to the change of pressure at $\beta$ phase is bigger than that of low hydrogen pressure range.

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SPARING EFFECTS OF COBALT OR NICKEL ON ZINC NUTRITION AND THE DIFFERENCE IN ZINC ABSORPTION BETWEEN ANCONA AND NEW HAMPSHIRE X LEGHORN CROSS CHICKS

  • Chung, A.S.;Sunde, M.L.;Grummer, R.H.;Hoekstra, W.G.
    • Asian-Australasian Journal of Animal Sciences
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    • v.1 no.2
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    • pp.73-79
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    • 1988
  • Experiments were conducted to determine whether supplemental cobalt (Co) or nickel (Ni) would prevent the signs of zinc (Zn) deficiency in chicks fed a high calcium (1.5%) corn-soybean diet and to examine the difference in $^{65}Zn$ absorption rates between inbred Ancona and crossbred New Hampshire X Single Comb White Leghorn chicks. In the initial experiment, the supplementation of 27 ppm Ni, 27 ppm Co or 54 ppm Co to a basal diet increased weight gain and reduced feather defects; 54 ppm Ni tended to increase weight gain but did not reduce feather defects. In further experiments, chicks fed the diet supplemented with 54 ppm Co usually showed increased weight gain and reduced feather defects; however, chicks fed a diet supplemented with 54 ppm Ni less frequently showed these effects. In another test, Ancona chicks fed a diet supplemented with 30 ppm Zn (except during a $^{65}Zn$ absorption study period) showed lower weight gain, more feather defects and less $^{65}Zn$ absorption than did New Hampshire X Leghorn cross chicks. Similar results were achieved with two strains of chicks fed the basal and 54 ppm Ni, 54 ppm Co or 60 ppm Zn supplemented diets. The sparing effects of Co on Zn which were commonly observed and the lesser effect of Ni or Zn were shown to be, at least in part, the result of increased availability of dietary Zn. That Ancona chicks required more Zn than New Hampshire cross chicks for the development of feathers and for growth is partly the result of decreased Zn absorption from the type of diets fed.

EFFECTS OF COBALT AND NICKEL ON ZINC AVAILABILITY IN CHICKS AND PIGS FED PRACTICAL-TYPE DIETS HIGH IN CALCIUM

  • Chung, A.S.;Lee, S.T.;Grummer, R.H.;Hoekstra, W.G.
    • Asian-Australasian Journal of Animal Sciences
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    • v.1 no.2
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    • pp.81-88
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    • 1988
  • Experiments were conducted with chicks and pigs to determine whether the sparing effects of cobalt (Co) or nickel (Ni) on zinc (Zn) nutrition were due to an improved Zn availability. They included a Zn balance study with New Hampshire X Leghorn cross chicks, a $^{65}Zn$ absorption study with Ancona chicks and a $^{65}Zn$ balance study with pigs. The basal diet was a corn-soybean type diet high in calcium. In the Zn balance study with New Hampshire X Leghorn cross chicks, Zn retention percentages for basal, + 54 ppm Ni or + 54 ppm Co were 39.4, 40.4 and 48.3, respectively. In the $^{65}Zn$ absorption study with chicks, adding these levels of Ni or Co to the basal diet increased $^{65}Zn$ absorption from 12.8% to 14.0% and 15.1%, respectively. Supplemental Ni and Co increased the proportion of body $^{65}Zn$ found in liver and bone. With the pig experiment, $^{65}Zn$ retention percentages for basal, +54 ppm Co and + 60 ppm Zn groups were 20.0, 26.7 and 12.2, respectively; while Zn retention values (mg) in the body were 29.5, 45.1 and 60.5, respectively. In addition, supplemental Co increased $^{65}Zn$ concentration in the blood, liver, kidney and duodenum. These studies showed that supplementation of the basal diet with Co resulted in increased absorption of dietary Zn in chicks and pigs. The effect of Ni in chicks was less than that of Co. The ability of supplemental Co and to a lesser extent of Ni to improve weight gain as well as reduce other Zn-deficient signs in both species fed a practical corn-soybean type diet high in in calcium can be explained, at least in part by an associated increase in Zn absorption. The possible mechanism involved in these effects are discussed.

Analysis of the Sound field in a Reverberation Room(II) (잔향실의 음장해석 (II))

  • 임정빈;권영필
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 1997.04a
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    • pp.681-686
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    • 1997
  • Foamed aluminum is well known metallic porous sound absorption material which has excellent properties of light weight and high absorbing performance. For the purpose of finding out the sound field characteristics within a simple closed cubic enclosure with foamed aluminum, analytic and experimental studies are performed. For the first time, the standing wave apparatus is used to measure absorption coefficient and impedance of the foamed aluminum. Next, the sound effects of absorption material in acoustically loaded rectangular enclosure are identified according as the foamed aluminim is to be or not.

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The effect of temperatures on the absorption of creosote solution by wood (처리온도(處理溫度)가 크레오소오트 약액(藥液)의 목재내(木材內) 흡수(吸收)에 미치는 영향(影響))

  • Lee, Phil Woo
    • Journal of Korean Society of Forest Science
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    • v.5 no.1
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    • pp.16-21
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    • 1966
  • This experiment was accomplished to study the effect affecting to the absorption of creosote solutions by treating temperatures 20, 50 and $80^{\circ}C$ when the small test pieces were treated as short timed immersion process. The test speciemens used in this experiment were cut into 180 pieces of $2.5{\times}2.5{\times}5cm$ size from the air dried sapwood of Righda Pine (Pinus rigida M.). They were controlled to about 8 to 9% moisture contents and measured specific gravities. Four creosote solutions of $S_1$(straight creosote), $S_2$(creosote 70% : heavy oil 30%), $S_3$(creosote 50% : heavy oil 50%) and $S_4$(creosote 30% : heavy oil 70%), and three treating temperatures of $T_1$($20^{\circ}C$), $T_2$($50^{\circ}C$) and $T_3$($80^{\circ}C$) were applied by factorial split plot design in the each treatment of 3, 7, 15, 30 and 60 minutes immersion. According to the results this study may be concluded briefly as follows : 1. In this immersion process the absorption effects of creosote mixtures by the increase of temperatures are recognized considerably in the each treating times. However in the straight creosote of treated solutions the effective differences were not shown but most effective differences were shown in the $S_2$ solution. 2. Although the solutional absorptions were raised considerably by temperature increase in every treating times the absorption effects of creosote mixtures were not reached to that of straight creosote because the effects are considerably lowered if the treating solutions were mixed with heavy oil even a small quantities. 3. The relations between the creosote contents of treating solutions and the absorptions in wood are shown as Fig. 1, 2, 3, 4 and 5. In these figures the absorption curves made by higher temperature treatment $T_3$ are on the lower treatments $T_1$ and $T_2$ if the solutions were mixed with heavy oil. 4. This report is a part of the consolidated results announced at the annual meetings of Korean Forestry Association in 1964 and 1965.

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Influence of Organizational Factors on Business Performance in INNOBIZ SMEs: Focusing on the Mediating Effects of Absorption Capacity (기술혁신형 중소기업의 조직요인이 경영성과에 미치는 영향: 흡수역량의 매개효과를 중심으로)

  • Sung, KiWook;Om, KiYong
    • Journal of Korea Society of Industrial Information Systems
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    • v.27 no.3
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    • pp.59-88
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    • 2022
  • As the open innovation paradigm spreads, the ability to search for new external knowledge and combine it with the organization's existing knowledge has been cosidered to play an important role in improving business performance of a company. This study empirically analyzed the influence of such organizational variables as empowering leadership, organizational learning culture, and interdepartmental cooperation on business performance of innovative technology SMEs focusing on the mediating effects of absorption capacity. For this purpose, a survey was conducted on 15,227 INNOBIZ SMEs, and 326 usable questionnaires were collected and analyzed using the structural equation model. Statistical analyses showed that the direct influence of empowering leadership, organizational learning culture, and interdepartmental cooperation on business performance was not found, but indirect effects of three organizational variables on business performance proved significant using absorption capacity as a mediating variable. This result also indicates that empowering leadership, organizational learning culture, and interdepartmental cooperation are important antecedent variables of absorption capacity.