• Journal of Electrical Engineering and Technology
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• 제11권4호
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• pp.810-819
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• 2016

Uncoordinated charging of large-scale electric vehicles (EVs) will have a negative impact on the secure and economic operation of the power system, especially at the distribution level. Given that the charging load of EVs can be controlled to some extent, research on the optimal charging control of EVs has been extensively carried out. In this paper, two possible smart charging scenarios in China are studied: centralized optimal charging operated by an aggregator and decentralized optimal charging managed by individual users. Under the assumption that the aggregators and individual users only concern the economic benefits, new load peaks will arise under time of use (TOU) pricing which is extensively employed in China. To solve this problem, a simple incentive mechanism is proposed for centralized optimal charging while a rolling-update pricing scheme is devised for decentralized optimal charging. The original optimal charging models are modified to account for the developed schemes. Simulated tests corroborate the efficacy of optimal scheduling for charging EVs in various scenarios.

• BMB Reports
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• 제55권2호
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• pp.65-71
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• 2022

Regenerative medicine is a research field that develops methods to restore damaged cell or tissue function by regeneration, repair or replacement. Stem cells are the raw material of the body that is ultimately used from the point of view of regenerative medicine, and stem cell therapy uses cells themselves or their derivatives to promote responses to diseases and dysfunctions, the ultimate goal of regenerative medicine. Stem cell-derived extracellular vesicles (EVs) are recognized as an attractive source because they can enrich exogenous microRNAs (miRNAs) by targeting pathological recipient cells for disease therapy and can overcome the obstacles faced by current cell therapy agents. However, there are some limitations that need to be addressed before using miRNA-enriched EVs derived from stem cells for multiplexed therapeutic targeting in many diseases. Here, we review various roles on miRNA-based stem cell EVs that can induce effective and stable functional improvement of stem cell-derived EVs. In addition, we introduce and review the implications of several miRNA-enriched EV therapies improved by multiplexed targeting in diseases involving the circulatory system and nervous system. This systemic review may offer potential roles for stem cell-derived therapeutics with multiplexed targeting.

• Parasites, Hosts and Diseases
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• 제60권5호
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• pp.309-315
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• 2022

Inflammatory bowel disease (IBD) is a chronic and recurrent illness of the gastrointestinal tract. Treatment of IBD traditionally involves the use of aminosalicylic acid and steroids, while these drugs has been associated with untoward effects and refractoriness. The absence of effective treatment regimen against IBD has led to the exploration of new targets. Parasites are promising as an alternative therapy for IBD. Recent studies have highlighted the use of parasite-derived substances, such as excretory secretory products, extracellular vesicles (EVs), and exosomes, for the treatment of IBD. In this report, we examined whether EVs secreted by Giardia lamblia could prevent colitis in a mouse model. G. lamblia EVs (GlEVs) were prepared from in vitro cultures of Giardia trophozoites. Clinical signs, microscopic colon tissue inflammation, and cytokine expression levels were detected to assess the effect of GlEV treatment on dextran sulfate sodium (DSS)-induced experimental murine colitis. The administration of GlEVs prior to DSS challenge reduced the expression levels of pro-inflammatory cytokines, including tumor necrosis factor alpha, interleukin 1 beta, and interferon gamma. Our results indicate that GlEV can exert preventive effects and possess therapeutic properties against DSS-induced colitis.

• Biomolecules & Therapeutics
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• 제31권3호
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• pp.253-263
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• 2023

The biogenesis and biological roles of extracellular vesicles (EVs) in the progression of liver diseases have attracted considerable attention in recent years. EVs are membrane-bound nanosized vesicles found in different types of body fluids and contain various bioactive materials, including proteins, lipids, nucleic acids, and mitochondrial DNA. Based on their origin and biogenesis, EVs can be classified as apoptotic bodies, microvesicles, and exosomes. Among these, exosomes are the smallest EVs (30-150 nm in diameter), which play a significant role in cell-to-cell communication and epigenetic regulation. Moreover, exosomal content analysis can reveal the functional state of the parental cell. Therefore, exosomes can be applied to various purposes, including disease diagnosis and treatment, drug delivery, cell-free vaccines, and regenerative medicine. However, exosome-related research faces two major limitations: isolation of exosomes with high yield and purity and distinction of exosomes from other EVs (especially microvesicles). No standardized exosome isolation method has been established to date; however, various exosome isolation strategies have been proposed to investigate their biological roles. Exosome-mediated intercellular communications are known to be involved in alcoholic liver disease and nonalcoholic fatty liver disease development. Damaged hepatocytes or nonparenchymal cells release large numbers of exosomes that promote the progression of inflammation and fibrogenesis through interactions with neighboring cells. Exosomes are expected to provide insight on the progression of liver disease. Here, we review the biogenesis of exosomes, exosome isolation techniques, and biological roles of exosomes in alcoholic liver disease and nonalcoholic fatty liver disease.

• IMMUNE NETWORK
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• 제23권1호
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• pp.3.1-3.14
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• 2023

Microvilli are outer membrane organelles that contain cross-linked filamentous actin. Unlike well-characterized epithelial microvilli, T-cell microvilli are dynamic similar to those of filopodia, which grow and shrink intermittently via the alternate actin-assembly and -disassembly. T-cell microvilli are specialized for sensing Ags on the surface of Ag-presenting cells (APCs). Thus, these finger-shaped microprotrusions contain many signaling-related proteins and can serve as a signaling platforms that induce intracellular signals. However, they are not limited to sensing external information but can provide sites for parts of the cell-body to tear away from the cell. Cells are known to produce many types of extracellular vesicles (EVs), such as exosomes, microvesicles, and membrane particles. T cells also produce EVs, but little is known about under what conditions T cells generate EVs and which types of EVs are released. We discovered that T cells produce few exosomes but release large amounsts of microvilli-derived particles during physical interaction with APCs. Although much is unanswered as to why T cells use the same organelles to sense Ags or to produce EVs, these events can significantly affect T cell fate, including clonal expansion and death. Since TCRs are localized at microvilli tips, this membrane event also raises a new question regarding long-standing paradigm in T cell biology; i.e., surface TCR downmodulation following T cell activation. Since T-cell microvilli particles carry T-cell message to their cognate partner, these particles are termed T-cell immunological synaptosomes (TISs). We discuss the potential physiological role of TISs and their application to immunotherapies.

• 전자통신동향분석
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• 제25권6호
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• pp.29-37
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• 2010

본 논문에서는 무선망과 신호처리 기술의 발달과 1GHz급 이상의 고성능 모바일 장치의 등장에 따라 현재의 모바일 음성 서비스 품질과 확연히 차별화된 서비스를 제공하기 위해 3GPP에서 논의중인 EVS 코덱의 기술적 특성 및 최간 표준화 동향에 대해 기술한다. 3GPP에서는 지난 3월, 2년간의 논의를 거쳐 4G 모바일과 같은 EPS 시스템에서 차별화된 새로운 증감음성 품질의 서비스 제공이 필수적이라는 판단 하에 EVS 코덱 표준의 개발을 시작하였다. 현재 EVS 코덱 표준화를 위해 세부적인 가능과 성능 목표에 대해 협의를 진행중이며 표준의 완료 계획시점인 2012년 상반기경, 4G/LTE에서는 광대역 수준의 음성서비스에 비해 신호대역폭이 2배가 확장된 슈퍼와이드밴드급의 증감음성 서비스가 제공될 것으로 전망한다.

• Journal of Electrical Engineering and Technology
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• 제12권1호
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• pp.1-10
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• 2017

With the current global need for eco-friendly energies, the large scale use of Electric Vehicles (EVs) is predicted. However, the need to frequently charge EVs to an electrical power system involves risks such as rapid increase of demand power. Therefore, in this paper, we propose a practical smart EV charging scheme considering a Time-of-Use (ToU) price to prevent the rapid increase of demand power and provide load leveling function. For a more practical analysis, we conduct simulations based on the actual distribution system and driving patterns in the Republic of Korea. Results show that the proposed method provides a proper load leveling function while preventing a rapid increase of demand power of the system.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2015년도 제46회 하계학술대회
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• pp.1639-1640
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• 2015

These days most of countries concern about eco-friendly energy. With this trend, the interests for Electric Vehicles(EVs) have been increased not only for its eco-friendly characteristics but also for the possibility that it can be used as Distributed Generation(DG). However, in terms of using EVs as DG, it requires specific standards. If there is no regulation and many of EVs start to discharge, it could cause severe unstability in power system. As there is no proper standards or regulations of Vehicle-to-Grid(V2G) system, we suggest the development direction of standardization of V2G system in the Republic of Korea by examining other countries' V2G standards.

• 조명전기설비학회논문지
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• 제29권10호
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• pp.60-64
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• 2015

Many people think that Electric Vehicles(EVs) is the best method to resolve the problems of running out of fossil fuels. But EVs take long time for charging. So, EVs with battery swapping systems(EVBS) are developed to resolve this problem. Nonetheless, EVBS is not spreaded widely because the method of durability test in couplers is not defined. In this study, the evaluation method of durability test in couplers is defined by some standards and the measurement uncertainty is used to increase the reliability of EV couplers.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2012년도 전력전자학술대회 논문집
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• pp.596-597
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• 2012

본 논문은 EVs/PHEVs에 사용되는 Bidirectional-LDC 일체형 OBC의 회로구조 및 동작특성 분석결과를 보고한다. 설계된 OBC는 한 개의 트랜스포머와 히트싱크를 LDC 회로와 공유하며, OBC의 출력 측 브릿지 방식의 정류회로는 LDC 동작 시 양방향 운용이 가능하다. 논문에서는 배터리 충전 조건에 따른 적합한 동작모드 제어 알고리즘을 분석하고 검증을 위한 프로토타입의 시험결과를 보고한다.