• Journal of applied mathematics & informatics
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• v.26 no.1_2
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• pp.355-364
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• 2008

Under pathological stress stimuli, dynamics of a biological system can be changed by alteration of several components such as functional proteins, ultimately leading to disease state. These dynamics in disease state can be modeled using differential equations in which kinetic or system parameters can be obtained from experimental data. One of the most effective ways to restore a particular disease state of biology system (i.e., cell, organ and organism) into the normal state makes optimization of the altered components usually represented by system parameters in the differential equations. There has been no such approach as far as we know. Here we show this approach with a cardiac hypertrophy model in which we obtain the existence of the optimal parameters and construct an optimal system which can be used to find the optimal parameters.

• Transactions of the Korean Society of Automotive Engineers
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• v.5 no.5
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• pp.20-26
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• 1997

A System for reducing vehicle body roll by active control is developed. The stabilizer bar with hydraulic rotary actuator produces anti-roll moment which suppresses roll tendency. This reduction of roll improves the driving safety as well as the ride comfort. Vehicle test data shows considerable reduction of roll angle during steady-state turning. Also improvement of ride comfort is achieved by making the actuator freely rotatable, i.e. by connecting all chambers of actuator in normal driving conditions. A control algorithm using steering wheel angle and vehicle speed signal as input valve is applied. It is compared with signal of the G-sensor.

• Journal of Veterinary Clinics
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• v.17 no.1
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• pp.212-218
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• 2000

Osteoporosis is a bone disease associated with reduced bone mineral density resulting in debilitating bone fractures. The present study was carried out to determine the influence of ovariectomy(OVX) on serum level of sex steroid and bone metabolism, as well as bone mechanical property, in OVX subjects in comparison with controls. Body weight and food intake was significantly increased in OVX subjects than in controls. The serum level of estradiol(E2) was significantly lower in OVX subjects than in controls. The serum level of calcium and alkalin phosphatae were significantly increased in OVX subjects than in controls. The bone strength, based on the three point bending test, was not significantly different. Seven weeks after ovariectomy, the cavities in the bone reached 223% of the normal. In conclusion, seven weeks after ovariectomy osteoporo sis was evidently appeared.

• Journal of Veterinary Clinics
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• v.17 no.1
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• pp.289-292
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• 2000

A Holstein cattle with third pregnancy was found to have clinical emergency findings of anxiety, dyspnea and recumbency at just before parturition. So Cesarean section and observation of internal organs were taken. Macroscopic examination showed enlargement of th lymph nodes and spleen, and ascites. A large tumor mass with solid and white to gray-white and focal hemorrhage, 55$\times$120cm in dimension and weighing 25.5kg was found in pelivc cavity. For conventional light microscopy, tissue samples were fixed in 10% neutral formalin solution, and then paraffin embedding, sectining and H-E staining were performed. In microscopic findings, tumor tissue, lymph node and spleeen were composed of mainly lymphoid tumor cells and the number of white blood cells in peripheral blood were increased 10-fold more than in normal. We concluded this tumor was bovine lymphoma.

• Journal of Microbiology
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• v.38 no.3
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• pp.117-121
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• 2000

Recent advances in studies of bacterial gene expression and light microscopy show that cell-to cell communication and communication and community behavior are the rule rather than the exception. One type of cell-cell communication, quorum sensing in Gram-negative bacteria involves acyl-homoserine lactone signals. This type of quorum sension represents a dedicated communication system that enables a given species to sense when it has reached a critical population density. and to respond by activating expression of specific genes. The LuxR and LuxI proteins of Vibrio fisheri are the founding members of the acyl-homoserine lactone quorum sensing signal receptor and signal generator families of proteins. Acyl-homeserine lactone signaling in Pseudomonas aeruginosa is one model for the relationship between quorum sensing community behavior, and virulence. In the P. aeruginosa model. quorum sensing is required for normal biofilm maturation and virulence. There are multiple quorum-sensing circuits that control the expression of dozens of specific genes in P. aeruginosa.

• Proceedings of the Korean Geotechical Society Conference
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• 2010.09a
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• pp.428-444
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• 2010

After underground excavation being introduced in dometic, many technologies have been storing up. One of them, measurement, has been recognized as an important item under excavation construction. But, unlike a large-scale construction, it was not been treated importantly at the general small-scale structures with poor ordering and original design was unchanged under construction was normal if the problem didn't occur on monitoring. In this paper, the site which safe and economical management as well as shortening construction period was made effectively using measurement result was introduced. Also, the site which was completed safely with analyzing measurement and reinforcement when unusual symptom happened was introduced. Using measurement result effectively will be able to obtain the safety and prevent unnecessary economical loss.

• Journal of Pharmaceutical Investigation
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• v.40 no.spc
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• pp.45-61
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• 2010

Polymeric based nanomedicines have been developed for diagnosing, treating, and preventing diseases in human body. The nanosized drug delivery systems having various structures such as micelles, nanogels, drug-conjugates, and polyplex were investigated for a great goal in pharmaceutics: increasing therapeutic efficacy for diseases and decreasing drug toxicity for normal tissues. The functional polymers used for constituting these drug delivery systems should have several favorable properties such as stimuli-responsibility and biodegrdability for controlled drug release, and solublization capacity for programmed drug encapsulation. This review discusses recent developments and trends of functional polymers (e.g., pH-sensitive polymers, biodegradable polymers, and cationic polymers) used for nanosized drug carriers.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2004.10a
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• pp.1228-1231
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• 2004

We analyzed the impulse on 24 sensors location under the foot using the Parotec system for the investigation of the relationship between the shoe type and the foot pathologies. Total 7 kinds of shoes, i.e. sport shoe, high heel shoes (5cm heel, 8cm heel, 13cm heel), platform shoe, inline skate, and heelys were evaluated for 20 normal subjects. Compared with the impulse distribution of the sport shoe, greater impulses were shown at the 1$^{st}$ phalange and the 1$^{st}$ metatarsal-phalangeal head in high-heel shoes, lateral tarsal bone and medial metatarsal bone in platform shoe, medial tarsal bone in inline-skate, and medial tarsal bone and 1st phalange in heelys shoe. The result of this study is expected to provide useful information about the relationship between the shoe type and the foot pathologies.ies.

• The Korean Journal of Ceramics
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• v.4 no.2
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• pp.68-71
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• 1998

The effect of Mn and Nb additions on the electrical properties of BaTiO$_3$ has been studied by means of equilibrium electrical conductivity as a function of temperature, oxygen partial pressure(Po$_2$) and composition. If the manganese ion is added to the normal Ti site, i.e. BaTi$_{1-x}Mn_xO_{\delta-6}$, the equilibrium conductivity shows strong evidence of acceptor-doped behavior. The conductivity minimum, corresponding to the transition from oxygen excess, p-type behavior to oxygen deficient, n-type behavior with decreasing Po$_2$, is displaced to lower Po$_2$ and is broadened and flattened. The partial replacement of Mn ion with Nb decreases the acceptor-doped effect and the total replacement exhibits a typical donor-doped behavior. It was confirmed that unlike undoped or other acceptor-doped behavior. It was confirmed that unlike undoped or other acceptor-doped samples, for the p-type region, the electrical conductivity follows the 1/6th power dependence of oxygen partial pressure.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2001.12a
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• pp.357-360
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• 2001

In this paper, we study the existence and uniqueness of fuzzy solution for the nonlinear fuzzy differential equations with nonlocal initial condition in E$\sub$N/$\^$2/ by using the concept of fuzzy number of dimension 2 whose values are normal convex upper semicontinuous and compactly supported surface in R$_2$.