• The Korean Journal of Applied Statistics
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• v.23 no.4
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• pp.693-703
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• 2010

Diseases of human or economical traits of cattles are occured by interaction of genes. We introduce expanded multifactor dimensionality reduction(E-MDR), dummy multifactor dimensionality reduction(D-MDR) and SNPHarvester which are developed to find interaction of genes. We will select interaction of outstanding gene combinations and select final best genotype groups.

• Korean Journal of Child Studies
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• v.37 no.6
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• pp.145-155
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• 2016

Objective: The purpose of this study was to investigate trajectories of child peer interaction and to compare the causal effects of their predictors, including child individual variables (i.e., gender, language ability, and cognitive ability) and teacher variables (i.e., teacher efficacy and teacher-child interaction). Methods: The participants of this study were 263 children and their teachers from the forth to sixth waves of longitudinal data from the Korean Children and Youth Panel Survey by the Korea Institute of Child Care and Education. The data was analyzed using Pearson's correlation and latent growth modeling. Results and Conclusion: The findings of this study are as follows: First, there was a linear decrease in child negative peer interaction over the course of 3 years, and significant individual differences were found in the trajectories (intercept and slope). Second, the predictors had significant casual effects on the trajectories of child negative peer interaction. The trajectories of child negative peer interaction involving girls, higher cognitive ability, and greater teacher-child interaction showed lower degree of intercept and a quicker decrease. Finally, the implications of findings are discussed.

• Journal of Microbiology and Biotechnology
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• v.23 no.1
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• pp.7-14
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• 2013

In the Bacillus amyloliquefaciens ${\alpha}$-amylase (BAA), the loop (residues 176-185; region I) that is the part of the calcium-binding site (CaI, II) has two more amino acid residues than the ${\alpha}$-amylase from Bacillus licheniformis (BLA). Arg176 in this region makes an ionic interaction with Glu126 from region II (residues 118-130), but this interaction is lost in BLA owing to substitution of R176Q and E126V. The goal of the present work was to quantitatively estimate the effect of ionic interaction on the overall stability of the enzyme. To clarify the functional and structural significance of the corresponding salt bridge, Glu126 was deleted (${\Delta}$E126) and converted to Val (E126V), Asp (E126D), and Lys (E126K) by site-directed mutagenesis. Kinetic constants, thermodynamic parameters, and structural changes were examined for the wild-type and mutated forms using UV-visible, atomic absoption, and fluorescence emission spectroscopy. Wild-type exhibited higher $k_{cat}$ and $K_m$ but lower catalytic efficiency than the mutant enzymes. A decreased thermostability and an increased flexibility were also found in all of the mutant enzymes when compared with the wild-type. Additionally, the calcium content of the wild-type was more than ${\Delta}E126$. Thus, it may be suggested that ionic interaction could decrease the mobility of the discussed region, prevent the diffusion of cations, and improve the thermostability of the whole enzyme. Based on these observations, the contribution of loop destabilization may be compensated by the formation of a salt bridge that has been used as an evolutionary mechanism or structural adaptation by the mesophilic enzyme.

• Clinical Nutrition Research
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• v.12 no.1
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• pp.7-20
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• 2023

Creating a complex balance between dietary composition, circadian rhythm, and the hemostasis control of energy is important for managing diseases. Therefore, we aimed to determine the interaction between cryptochrome circadian clocks 1 polymorphism and energy-adjusted dietary inflammatory index (E-DII) on high-sensitivity C-reactive protein in women with central obesity. This cross-sectional study recruited 220 Iranian women aged 18-45 with central obesity. The 147-item semi-quantitative food frequency questionnaire was used to assess the dietary intakes, and the E-DII score was calculated. Anthropometric and biochemical measurements were determined. By polymerase chain response-restricted length polymorphism method, cryptochrome circadian clocks 1 polymorphism was assigned. Participants were categorized into three groups based on the E-DII score, then categorized according to cryptochrome circadian clocks 1 genotypes. The mean and standard deviation of age, BMI, and high-sensitivity C-reactive protein (hs-CRP) were 35.61 ± 9.57 years, 30.97 ± 4.16 kg/m², and 4.82 ± 5.16 mg/dL, respectively. The interaction of the CG genotype and E-DII score had a significant association with higher hs-CRP level compared to GG genotype as the reference group (β, 1.19; 95% CI, 0.11-2.27; p value, 0.03). There was a marginally significant association between the interaction of the CC genotype and the E-DII score with higher hs-CRP level compared to the GG genotype as the reference group (β, 0.85; 95% CI, -0.15 to 1.86; p value, 0.05). There is probably positive interaction between CG, CC genotypes of cryptochrome circadian clocks 1, and E-DII score on the high-sensitivity C-reactive protein level in women with central obesity.

• Journal of Internet Computing and Services
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• v.13 no.2
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• pp.119-126
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• 2012

The purpose of this study is to test the motivations for e-Learning service usage of smart device users. To do this, empirical data were collected by conducting a field survey with 382 smart-device based e-learners, and structural equation model was used for the purpose of analyzing the data acquired by the survey. A structural equation model was designed and constructed by such factors like usefulness, enjoyment, word-of-mouse(WOM) effect, and social interaction on e-Learning usage intention. In addition, social interaction has an influence on WOM effect. The results of the analysis are summarized as follows; first, usefulness, enjoyment, and WOM have direct effects on e-Learning usage intention. Second, social interaction not only has direct influence on e-Learning usage intention but also has indirect influence carried by WOM effect. The findings have significant implications which the study inquires into the factors for e-Learning usage motivations of smart-device based e-learners.

• Archives of design research
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• v.17 no.1
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• pp.109-118
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• 2004

With the remarkable progression of network and the sophistication of contents, we now see various ways of communication methods in World Wide Web. In such trend, 3D web deserves our attention, which is applied for various areas such as education, game, chatting, e-commerce. Among those, by using 3D contents, e-commerce, especially the customized e-commerce, can give users more rich information about products. However, most of current 3D e-commerce sites are adopting a mere tool-based methods without considering contents and interaction required for the customized e-commerce. So, this paper proposes the direction of developing 3D interaction program for the customized e-commerce, based on a study on the required information elements about products and the interaction of controlling those factors. The evaluation to compare with the existing program is follows by the development of practical program, to give more persuasive reasons on the advantages of 3D e-commerce program.

• Journal of the HCI Society of Korea
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• v.12 no.3
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• pp.5-11
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• 2017

Korean traditional dance has cultural value and is human's cultural heritage. But they are in danger which is caused by lack of bearers and public interest. E-Learning of traditional dance using network technology and digital media can be a solution to extinction problem. The aim of this study is to propose the E-Learning courses and systems for learning traditional dance. E-Learning systems were evaluated in accordance with the HCI (Human Computer Interaction) user evaluation. This study contribute to overcoming distance constraints by offering synchronous E-Learning education system of traditional dance as intangible cultural heritage through new media experience.

• International Journal of Computer Science & Network Security
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• v.21 no.5
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• pp.98-112
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• 2021

This study aimed at measuring students' interaction in distance education through the electronic platform among intermediate school students, by identifying the level of students' interaction in distance education and differences between them, as well as its impact on their motivation to learn. To achieve the aim of the study, two scales were designed for this purpose and were applied to a sample consisting of (268) individuals. The results showed that the level of students' interaction through the e-learning platform was at a high level. The results also showed that there was no statistically significant difference between the mean scores of males and females in the scale of students' interaction through the e-learning platform. There was no statistically significant difference between them in their motivation for distance learning via the online platform. There were also no statistically significant differences related to the grade variable in the level of interaction through the electronic platform and in the motivation to learn, while there was a positive statistically significant effect of interaction through the electronic platform on students' motivation to learn.

• Communications for Statistical Applications and Methods
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• v.17 no.5
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• pp.667-678
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• 2010

It is important to detect the gene-gene interaction in GWAS(Genome-Wide Association Study). There are many studies about detecting gene-gene interaction. The one is Multifactor dimensionality reduction method. But MDR method is not applied continuous data and expanded multifactor dimensionality reduction(E-MDR) method is suggested. The goal of this study is to evaluate the power of E-MDR for identifying gene-gene interaction by simulation. Also we applied the method on the identify interaction e ects of single nucleotid polymorphisms(SNPs) responsible for economic traits in a Korean cattle population (real data).

• Bulletin of the Korean Chemical Society
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• v.29 no.2
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• pp.305-308
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• 2008

We performed coupled-cluster calculations to determine the intermolecular interaction energy between two TiAu4 clusters. Our ab initio calculations predict that the binding energy is 2.89 eV, which is somewhat larger than the known binding energy of 2.0 eV for TiH4-TiH4. The intermolecular binding energy is relatively high, despite TiAu4 having all the attributes of a magic cluster. The favorable orbital interaction between occupied Au(6s) and unoccupied Ti(3d) orbitals leads to the strong dimeric interaction for TiAu4-TiAu4.