• 한국미생물·생명공학회지
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• 제31권2호
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• pp.140-144
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• 2003

신호펩디드 가수분해는 모든 생물에 필수적인 단백질로 N-말단에 신호서열을 가진 단백질들의 신호서열을 잘라내는 효소로 serine과 lysine을 활성부위로 하는 특이한 dyad serine 효소류로 알려져있다. 최근에 신호펩디드 가수분해효소의 특성으로 새로운 항생제 이용 가능성 때문에 그 활성 메카니즘의 연구가 중요시되고 있다. 본 연구는 E. coli 신호펩디드 효소가 serine/lysine/aspartic acid로 하는 전형적인 triad serine 효소류의 메카니즘을 갖는다는 가정하에 Type Ⅰ 신호펩디드류의 하나인 E. coli에서 aspartic acid 99을 alanine으로 치환하여 효소의 enzymatic activity를 조사하였다. 그 결과 D99잔기는 E. coli Type Ⅰ 신호펩디드 효소의 활성메카니즘에 직접적으로 관여한다기보다는 그 효소를 구조적으로 안정화하는데 중요한 역할을 할 가능성이 있는 것으로 암시되어진다.

• 부모자녀건강학회지
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• 제3권2호
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• pp.49-66
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• 2000

Pregnancy is a task of creation in which a women mobilizes her self and the resources available to her in the generation of a new person. Through the pregnancy, a mother has formed the new human relationship with a fetus. Maternal-fetal relationship is considered one of mechanism making the relationship of mother and child. It is important to well-being of mother and fetus, too. The earliest interaction between a mother and her child is during prenatal period. Maternal-fetal dyad is unique and perceived interactions with the fetus make the pregnancy real for the mother. Maternal behavior is "instinctive" and is formed in early childhood by copy of the mother. But, Rubin argues that this behavior is an open intellectual system rather than a prepackaged bundle of traits. There is openness to new learning and a high value placed on knowing which occurs with silent organization in thought. Thus, nurses and other health professionals provide prenatal care that optimally is part of the environment in which the maternal-fetal dyad develops. Thus it is appropriate for nurses to increases their understanding of the dyad and to explore ways to enhance its development. This study focusses on the interaction ability and response of fetus, and the maternal-fetal interaction. The research of fetal responses that involve physiological changes and motor movement have been shown to coccur to both external sensory stimuli and to maternal emotional states. The fetus does also have sensory capacity to be aware of some maternal behaviors, and the motor ability to respond in a way the mother can notice. Thus, very rudimentary interactions appear to be possible. Maternal awareness of fetal activity was supported by several studies. More interesting to the present study are description of maternal-fetal interaction and the finding that there appear to be levels of sensitivity to the fetus involved in maternal-fetal interactions. First, recognition comes that the fetus is separate from the maternal self. Next, the fetus engages in. Lastly, the parent may describe active interaction with the fetus, believing that mother and fetus are communicating on a meaningful level. Several interventions, developed to promote more active interaction between mother and fetus, have been reviewed. In general, the parents were taught to stimulate the fetus and to notice the fetus' responses. This type of intervention might increase the mother's sensitivity to her unborn baby, and she may have a head start toward learning how to res pond sensitivity to the newborn infant. Research In the area of maternal-fetal interaction is scarce. Sensitive behavior is construed as an appropriate and timely response to a signal of need from another person, but no such signal of need can be claimed regarding the fetus. The highest level of maternal-fetal interaction, therefore, might be based more on maternal representations of the imagined fetus than on factual evidence of fetal participation.

• 복식문화학회:학술대회논문집
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• 복식문화학회 2003년도 정기총회 및 춘계학술발표대회
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• pp.53-54
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• 2003

본 연구의 목적은 Thibaut과 Kelley(1959)의 상호의존이론(a theory of interdependence)을 중심으로 가족 구성원 중 가장 밀접한 어머니와 딸을 dyads로 하여 의복의 선호와 소유 사이의 관계를 아동과 청소년 연령집단을 대상으로 알아보는 것이다. 피험자는 대전지역에 거주하는 초등학생(75명)과 고등학생(64명), 그리고 그들의 어머니(139명)로 편의 표집 방법에 의해 선정되었으며, 자료수집은 설문지법에 의하여 이루어졌다. 의복의 측정 도구는 의복범주(2)×디자인의 복잡성(2)×여향성ㆍ남향성(2)의 요인설계로 하여 24종류의 의복 자극물로 구성되었으며, 자극물에 대한 타당성은 전문가 집단과의 토론 및 예비조사를 통해 검증하였다. (중략)

• 분석과학
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• 제7권1호
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• pp.91-102
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• 1994

일련의 polypropylene 계통의 공중합체 및 삼중합체 중에서 단량체의 조성에 관한 조성비를 $^{13}C-NMR$ 스펙트럼을 이용하여 정량하였다. 고온에서 얻어진 고분자의 $^{13}C-NMR$ 스펙트럼은 아주 높은 분해능을 보이며, 이는 모든 시그날을 명확하게 지정하는 것을 가능하게 하였으며, 또한 단량체의 조성비를 계산할 수 있도록 하였다. 따라서 단량체의 조성비를 계산하는 방법을 새롭게 제시하였으며, 고분자에서 dyad, triad, tetrad 및 pentad의 조성비도 계산할 수 있다는 것을 보여 주었다. 이러한 단량체 조성에 관한 NMR 분석 결과는 표준 물질을 이용하여 정량한 IR data와 잘 일치한다는 것을 보여 준다.

• 한국산학기술학회논문지
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• 제19권12호
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• pp.128-137
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• 2018

본 논문은 비싼 신호보내기 이론과 자기향상동기를 중심으로 주도적 성격과 지식 공유 행위 간 관계, 그리고 더 나아가 조직의 인정 간 관계를 검증하였다. 개인의 성격적 특질에 더하여, 상황적 요인으로 직무 특성을 고려하였는데, 본 논문에서는 직무 복잡성과 다양성이 주도적 성격과 지식 공유 행위, 조직 인정 간 정(+)의 관계를 조절할 것이라는 조절된 매개모형을 제안하였다. 한국 기업들을 대상으로 상사-부하 쌍(dyad) 설문을 실시하여 총 166쌍의 응답을 실증 분석한 결과, 예측한대로 주도적 성격을 가진 구성원일수록 지식 공유 행위를 보다 많이 보이는 것으로 나타났으며, 이러한 지식 공유 행위는 조직 내 상사가 평가한 조직 인정을 궁극적으로 높이는 것으로 나타났다. 뿐만 아니라, 직무 복잡성과 다양성이 높을 때가 낮을 때보다 지식 공유 행위에 의해 매개된 주도적 성격과 조직 인정 간 정(+)의 관계를 보다 강화하는 것으로 나타나 예측한대로 조절변수 관련 가설들도 지지되었다. 이러한 결과들은 조직 공유의 동기가 무엇이고, 이를 활성화시키는 경계조건들이 무엇인지를 밝힘으로써 지식경영 분야에 이론적 실무적 함의를 제공한다고 할 수 있다.

• 동의신경정신과학회지
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• 제31권4호
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• pp.269-278
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• 2020

Objectives: Yukmijihwang-won (Liuweidihuang-wan in Chinese) is a frequently used medicinal herbal formula. It is used as Yin tonic in Korea and China to recover patients from Yin deficiency. However, the scientific evidence on this drug has not revealed the beneficial effect or mechanism of its effects on the neurological disorder. We designed this study to examine the antidepressive and analgesic effects of Yukmijihwang-won (YJ-01) and the minor modification of YJ-01, YJ-06 on the reserpine-induced pain-depression dyad mice model. Methods: Reserpine (1 mg/kg) was administered subcutaneously once a day for three consecutive days to induce pain and depression-like behavior. The oral administration of YJ-01 and YJ-06 (100, 200, or 300 mg/kg) was performed once daily from three days after the reserpine injection. Results: Repeated administration of the YJs significantly reduced the immobility time in a forced swimming test and increased the moved distance and number of crossings in the open field test. In the von-Frey filament test, the oral administration of YJs remarkably suppressed the increase in paw withdrawal frequency. Conclusions: The results of this study suggest that YJ-01 and 06 may be good candidates to treat the pain-depression dyad.

• Journal of Photoscience
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• 제9권2호
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• pp.347-349
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• 2002

Synthetic zinc chlorins possessing a hydrophylic polyoxyethylene chain at the 17 -position were prepared. An amphiphilic zinc chlorin possessing a single chIorin moiety showed absorption maxima at 675 nm in an aqueous medium, indicating that the zinc chIorin did not form large aggregates but a dimeric structure. In contrast, amphiphilic zinc chlorin dyads in which two zinc chlorin moieties were connected with a hydrophilic polyoxyethylene linkage showed red-shifted absorption band around 720-740 nm in an aqueous medium. The result indicated that the amphiphilic zinc chlorin dyad self-aggregated to form chlorosome-like oligomer.

• 아동학회지
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• 제20권1호
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• pp.147-164
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• 1999

The purpose of this study was to investigate (1) intergenerational transmission from mother's internal working model of relationships formed in her childhood and infant's attachment patterns and (2) the associations among maternal working models, maternal sensitivity, and infant attachment patterns. The subjects were twenty 12- to 20-month-old infants and their mothers. The Adult Attachment Interview (1996) was used to assess mother's internal work model of relationships. Interviews were audio-recorded and transcribed verbatim. Each dyad was videotaped in the modified Ainsworth Strange Situation(1978) and filmed for 3 minutes in the Questionaire Situation of Smith and Pederson (1988). Mothers were classified as autonomous(F), dismissing(Ds), preoccupied(E), or unresolved/disorganized(Ud). Infants were classified as secure(B), insecure-avoidant(A), or insecure-resistant(C). Exact A/B/C/D and Ds/F/E/Ud agreement was observed in 55% of the dyads. Maternal sensitivity was related to infant attachment patterns but not to maternal working models.

• 아동학회지
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• 제24권3호
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• pp.15-26
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• 2003

This research investigated young children's social interaction and task performance in dyadic collaboration. The independent variables were gender and social skill level(high/low groups). Twenty-four pairs each 4-year-old boys and 4-year-old girls(total 96 subjects) worked at a block reconstruction. Two researchers judged degree of dyadic collaboration. Data were processed by 2 way ANOVA and Pearson's product correlation. While no main effect for gender was found, the effect for social skill level(high/low groups)was significant for social interaction. There was positive correlation between social interaction and task performance.

• 아동학회지
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• 제31권1호
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• pp.219-234
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• 2010

This study examined the influence of mothers' reading and scaffolding behaviors on children's emotional experiences and memory recall during picture book reading. Sixty children, aged 6 and their mothers participated in this study. Each child-mother dyad was observed in a lab setting which was designed to evaluate child-mother interactions during a picture book reading. The data were analyzed using correlation and multiple regression techniques. Our results indicated that mothers' task-oriented reading behavior affected the children's lack of positive emotions, whereas mothers' fun-oriented reading behavior was associated with the children's positive emotions. The task-oriented reading behavior also accounted for children's poor memory performance in relation to the book. These results were discussed in terms of the relationship between emotion and cognition through book reading experiences.