• Journal of Oral Medicine and Pain
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• 제43권1호
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• pp.16-20
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• 2018

Graft-versus-host disease (GVHD) is frequent complications of hematopoietic stem cell transplantation. In the chronic GVHD (cGVHD), the oral cavity is the most commonly affected region. The clinical manifestations include erythema, ulceration, lichenoid-hyperkeratotic change in oral mucosa, dry mouth, and limitation of mouth opening. The initial treatment strategy of oral cGVHD patients is topical corticosteroid therapy in various formulation. However, corticosteroid resistance appears in some patients. We report a case of a 25-year-old male patient with oral cGVHD, who has resistance to topical corticosteroid medication, treated with 0.03% tacrolimus ointment and low-dose doxycycline. The patient showed subjective and objective improvement without side effect.

• 한국조리학회지
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• 제24권3호
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• pp.35-46
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• 2018

This study investigated the quality characteristics of makpyeon made of dry milled rice powder according to soaking time. Makpyeon samples made of dry milled rice powder were analyzied with various soacking time, the moisture content, pH, Hunter's color value texture characteristics, attribute difference test and acceptance test. The moisture content of makpyeon did not indicate difference among samples. pH resulted in MS90 showed the lowest moisture content. The L-value (lightness) and a-value (greenness) result in that MS0 showed the highest and decreased according to soaking time. The b-value (yellowness) increased according to soaking time, MS90 showed the highest. TPA resulted in that MS90 indicated the highest hardness, chewiness, gumminess and the lowest adhesiveness. Hardness of makpyeon samples was higher than sulgitteok samples, adhesiveness was lower than those of sulgitteok in each soaking time. Based on attribute difference test, the score of brightness, moistness, glossy, particle size were decreased and firmness were increased according to soaking times. Flavor, taste and mouth feel attribute was stronger in makpyeon samples with the longer soaking time. Acceptance results showed that MS0 and MS30 (soaking for 30 min) were preferred the most. Also limitations and future research directions of this study were discussed.

• 치위생과학회지
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• 제16권4호
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• pp.310-316
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• 2016

스트레스, 구강건강, 구강건강관련 삶의 질 연관성 분석을 위해 2016년 6월 2주 동안 D지역 대학생 452명을 대상으로 조사한 결과 다음과 같은 결론을 얻었다. 스트레스는 여학생이 남학생보다 높게 조사되었고(p<0.05), 스트레스 상위군이 하위군보다 구강건조증, 구취, TMJ 통증 인식이 높게 조사되었으며(p<0.05), 스트레스 상위군이 하위군보다 OIDP에 부정적 영향을 경험하는 것으로 조사되었다(p<0.05). 스트레스와 구강건강, OIDP 상관관계 분석결과 스트레스는 구강건조증, 구취, TMJ 통증과 통계적으로 유의한 양의 상관관계가 있었고, OIDP는 구강건조증, 구취, TMJ 통증, 스트레스와 통계적으로 유의한 양의 상관관계가 있었다. 이와 같이 스트레스는 구강건강, 구강건강관련 삶의 질에 부정적 영향을 미치는 것으로 조사되었다. 그러므로 대학생들의 스트레스 대처능력과 자가구강관리능력을 향상시켜 심신이 건강한 사회인으로 성장할 수 있도록 교육이 이루어져야 할 것이다.

• 치위생과학회지
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• 제14권1호
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• pp.51-58
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• 2014

본 연구의 목적은 근로자의 구강건조증상과 다양한 구강자각증상에 대하여 알아보고 근로자의 구강건강관련 삶의 질에 미치는 요인들에 대해 조사 분석하여 근로자의 구강건강증진을 도모하는 프로그램개발을 위한 기초자료를 제공하고자 2012년 8월 1일부터 9월 20일까지 전라북도 소재의 5개의 산업장 근로자를 대상으로 분석한 결과 다음과 같은 결론을 얻었다. 1. 구강건조증상은 사무직 근로자가 2.59점으로 영업직 근로자 1.71점보다 유의하게 구강건조증상 정도가 높았다 (p<0.001). 2. OHIP-14는 비정규직이 2.05점, 정규직이 1.82점으로 나타났다(p<0.00 1). 3. 구강건조증상은 OHIP-14와 양의 상관관계를 보였다 (r=0.456). OHIP-14는 연령과는 양의 상관관계를 보였으며 (r=0.209), 최종학력과 음의 상관관계를 보였다(r=-0.136). 4. 구강건조증상이 심할수록(${\beta}=0.383$, p<0.001), 연령이 높을수록(${\beta}=0.221$, p<0.001), 치과질환을 갖고 있다고 느꼈을 때(${\beta}=0.146$, p<0.01) OHIP-14에 유의하게 영향을 미치는 요인으로 나타났다. 결론적으로 위와 같이 근로자들의 구강건강관련 삶의 질에 영향을 미치는 요인을 참고하여 산업장 근로자의 구강건강증진을 도모하는 프로그램을 개발하고 국가보건정책 부분에서 산업구강보건 개선을 위해 적극 고려해야 할 것으로 생각된다.

• 동의생리병리학회지
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• 제29권5호
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• pp.370-377
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• 2015

There is a growing interest in halitosis and diverse Korean medical studies are being conducted about it. But there are few study about teatment effect of halitosis after Korean medical care, treatment duration, and factor affecting recovery rate. Thus, the purpose of this study is to research clinical characteristic of halitosis patients, factor affecting halitosis, recovery rate of halitosis, treatment duration, factor affecting recovery rate by analyzing halitosis patients retrospectively. People who were over 19 and visited Korean medical clinic in Seoul to want to be treated halitosis in 2014 were analyzed retrospectively. We analyzed general and living characteristics of halitosis patients, halitosis-related symptoms and diseases, level of halitosis and halitosis-related symptoms both before and after treatment, treatment duration of halitosis patients, prescription of halitosis patients, recovery rate of level of halitosis and halitosis-related symptoms by general characteristic and duration of symptoms. Female, thirties, and Nonsmoker had the highest proportion in general characteristic. The average duration of halitosis is 41.6months and treatment duration is 2.55months. The average of sensory evaluation score is 3.40±2.53, subjective evaluation score is 5.02±1.53, lump sensation on throat is 3.52±2.50, postnasal drip is 1.11±1.88, dry mouth is 4.13±2.17, quality of life is 6.07±1.13. Gamichiuitang is used the most among prescriptions. Sensory evaluation, subjective evaluation, lump sensation on throat, postnasal drip, dry mouth, and quality of life had better score compared with pre-treatment. Duration of symptoms is in weak inverse proportion to sensory evaluation, subjective evaluation, dry mouth, quality of life. This study is meaningful in the way to find recovery rate of halitosis after korean medical care, treatment duration, and factor affecting recovery rate not progressed until now. But this study also has limits such as not analyzing objective data using halitosis measuring instrument and lack of methodical scale about quality of life. Therefore, succeeding study such as clinical trials is needed to verify reliability of Korean medical treatment.

• 한국방사선학회논문지
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• 제9권6호
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• pp.357-362
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• 2015

테크네슘을 이용한 침샘검사의 시간-방사능 곡선에서 다양한 기능매개변수지표를 획득하여 환자 군과 건강한 정상군과의 비교를 통해 유용성을 알아보고자 하였다. 2014년 12월부터 2015년 2월까지 구강 건조증으로 침샘검사를 시행한 환자군 30명과 건강한 정상군 10명을 대상으로 하였다. 99mTc-과산화테크네슘 370 MBq을 정맥으로 주사 후 20분에 비타민C 파우더를 입안에 투여하여 10분 동안 촬영하였다. 분석방법은 귀밑샘과 턱밑샘의 관심영역을 정하여 시간-방사능 곡선을 그린 후 곡선의 각 위치에서 다양한 기능매개변수 지표를 획득하고, 구강 건조증 환자군와 정상군을 비교하였다. 비교 및 측정에 적용된 방법으로는 섭취율(uptake ratio, UR), 최대 방사능 시간(time at maximum counts, Tmax), 최소 방사능 시간(time at minimum counts, Tmin), 최대 축적율(maximum accumulation, MA), 축적 속도(accumulation velocity), 최대 배출율(maximum secretion, MS), 최대 자극 배출율(maximum stimulation secretion, MSS), 배출속도(secretion velocity, SV)를 사용하였다. 환자군과 정상군간의 기능매개변수지표 비교에서 환자군의 최소 방사능 시간(Tmin)을 제외한 모든 지표에서 건강한 정상군이 환자군에 비하여 유의한 차이를 보였고, 시간에 따른 변화량에서도 정상군이 환자군에 비하여 유의한 차이를 보였다. 결론적으로 침샘검사에서 다양한 기능매개변수지표를 이용한 정량분석은 구강 건조증 환자의 침샘 기능을 객관적이고 표준화된 정보로 평가하는데 유용할 것으로 사료된다.

• 성인간호학회지
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• 제26권4호
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• pp.393-402
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• 2014

Purpose: The aim of this study was to describe the risk of dysphagia among older adults in senior centers and to find the relationships between the risk of dysphagia and dysphagia-specific quality of life. Methods: The participants were 260 community-dwelling older adults, aged 65 years in two senior centers. Data were collected by self-report questionnaires or face to face interviews. The instruments were the modified dysphagia risk assessment scale for elderly and dysphagia-specific quality of life questionnaire. The data were analyzed using t-test, $x^2$-test, logistic regression, and pearson's correlation. Results: 162 older adults (62.3%) were classified as having the risk of dysphagia. Severe dry mouth (OR=15.677, CI=2.986~82.297), neurologic disease (OR=10.125, CI=1.092~93.899), gastritis (OR=5.731, CI=1.482~22.173), denture discomfort (OR=2.969, CI=1.016~8.677), teeth discomfort (OR=2.61, CI=1.311~5.196) were the significant factors predicting the risk of dysphagia. There is a significant correlation between the risk of dysphagia and dysphagia-specific quality of life. Conclusion: Dysphagia could be a major health problem among community dwelling older adults. It can affect the dysphagia-specific quality of life. Older adults having severe dry mouth, neurologic disease, or gastritis should receive dysphagia risk assessment and proper management on a regular basis. An effective nursing intervention needs to be developed for the older adults with risk factors of dysphagia.

• Journal of Oral Medicine and Pain
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• 제42권3호
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• pp.62-71
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• 2017

Purpose: The purpose of this study was to examine the rate of salivation before and after olfactory stimulation using BPO (black pepper oil) and then, to collect basic data for screening the possibility of introducing olfactory stimulus to prevent and improve dry mouth. Methods: The subjects in this study were 60 college students in Jeon-Nam province. The subjects were randomly divided into 3 groups; the BPO group (n=20), the lavender oil (LVO) group (n=20), and the distilled water (DW) group (n=20). The amount of whole saliva before and after olfactory stimulation was measured 14 times for a 4-week period. Results: In the BPO and LVO groups, the amount of whole saliva increased after the olfactory stimulation and it was most prominent in the BPO group (p<0.05). The difference of whole salivation was higher in the BPO group (p<0.05) and there was no significant difference in the salivary flow rate in the DW group. After 14 times of measurement for 4 weeks, the BPO and LVO groups showed an increase in salivary rate at an early stage compared without stimulation (p<0.05), but there was no significant difference between the 2 groups in the middle. Since the twelfth measurement, whole saliva secretion increased and maintained the elevated level (p<0.05). Conclusions: The olfactory stimulation using BPO may contribute to stimulating salivation. Further studies are needed for subjects with dry mouth symptoms. In the future, qualitative and quantitative studies should be conducted for people who complains about oral dryness.

• 생물정신의학
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• 제5권1호
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• pp.114-121
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• 1998

Bethanechol, a cholinergic agonist, has been recommended for the management of peripheral anticholinergic side effects during the treatment of antipsychotic medications. But there have been few studies which have evaluated the drug interactions of antipsychotics and bethanechol, even the treatment effects of bethanechol on anticholinergic side effects. So the authors have evaluated whether psychopathology and plasma haloperidol and reduced haloperidol concentrations are significantly changed or not when bethanechol was administrated with maintained doses of haloperidol and other coadministrated drugs(such a benztropine). Also we have evaluated the abating effects of bethanechol on anticholinergic side effects during the treatment with haloperidol. Fifteen schizophrenics with higher than 5 of total score of anticholinergic side effects of 'Rating scale for side effect' were assigned to two groups, and bethanechol 30mg/day and 60mg/day were applied on each group for 4 weeks. The daily haloperidol dosages were fixed before 2 weeks of study. We assessed anticholinergic side effects by 'Rating scale for side effect' and psychopathology by BPRS, and plasma haloperidol and reduced haloperidol concentrations by HPLC at baseline, 2nd week and 4th week. The results were as followed, 1) there was no significant change of plasma haloperidol and reduced haloperidol concentration, 2) at baseline, the dosage of haloperidol showed significant correlation with the total score of anticholinergic side effect, but not at 2nd week and 4th week, 3) in 60mg/day group, dry mouth and the total score of anticholinergic side effects were significantly improved, but not in 30mg/day group, 4) there was no significant change of BPRS except withdrawal at 2nd week. These results suggest that coadministration of bethanechol influenced neither on psychopathology nor on plasma haloperidol and reduced haloperidol concentrations and that improved dry mouth and total score of anticholinergic side effects at 60mg/day.

• 사상체질의학회지
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• 제23권1호
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• pp.33-43
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• 2011

1. Objectives: This study is aimed to develop the algorithm, which can help clinicians diagnose Soeumin's symptomology, based on the indexes such as dry mouth, water drinking, sweat, urine, appetite, digestion, and stool, etc. 2. Methods: This research analyzes the items of "Donguisusebowon(東醫壽世保元)" to reveal the inevitable and sequential indexes of Soeumin's symptomology diagnosis, in order of exterior-interior pattern differentiation, favorable-unfavorable pattern differentiation, and mild-severe-dangerous-urgent pattern differentiation. 3. Results and Conclusions: 1) 1st step: Soeumin's exterior pattern and interior pattern are differentiated in terms of heat and cold, respectively. Stool and digestion are used to confirm the difference. 2) 2nd step: The existence of sweat is used to find out that an exterior pattern is with or without favor, while the indexes of stool, dry mouth, and generalized pain are used to identify an interior pattern with or without favor. 3) 3rd step: The favorably exterior-heat pattern can be either mild or severe by the indexes of cold-heat, stool, tidal fever, and manic raving, panting and straight looking, while the unfavorably exterior-heat pattern can be either dangerous or urgent by the ones of cold-heat, stool, and urine. And, the favorably interior-cold pattern can be either mild or severe by the indexes of stuffiness and fullness, jaundice, and edema, while the unfavorably interior-cold pattern can be either mild or severe by the ones of vexation level.