• Journal of the Institute of Electronics Engineers of Korea SC
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• v.40 no.4
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• pp.275-281
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• 2003

A new neural oscillator has been designed and fabricated in an 0.5 ${\mu}{\textrm}{m}$ double poly CMOS technology. The proposed neural oscillator consists of a nonlinear variable resistor with negative resistance as well as simple transconductors and capacitors. The variable negative resistor which is used as a input stage of the oscillator consists of a positive feedback transconductors and a bump circuit with Gaussian-like I-V curve. The proposed neural oscillator has designed in integrated circuit with SPICE simulations. Simulations of a network of 4 oscillators which are connected with excitatory and inhibitory synapses demonstrate cooperative computation. Measurements of the fabricated oscillator chip with a $\pm$ 2.5 V power supply is shown and compared with the simulated results.

• Biomolecules & Therapeutics
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• v.30 no.6
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• pp.585-592
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• 2022

Treatment of triple-negative breast cancer (TNBC) has been limited due to the lack of molecular targets. In this study, we evaluated the cytotoxicity of hydroxyzine, a histamine H1 receptor antagonist in human triple-negative breast cancer BT-20 and HCC-70 cells. Hydroxyzine inhibited the growth of cells in dose- and time-dependent manners. The annexin V/propidium iodide double staining assay showed that hydroxyzine induced apoptosis. The hydroxyzine-induced apoptosis was accompanied down-regulation of cyclins and CDKs, as well as the generation of reactive oxygen species (ROS) without cell cycle arrest. The effect of hydroxyzine on the induction of ROS and apoptosis on TNBC cells was prevented by pre-treatment with ROS scavengers, N-acetyl cysteine or Mito-TEMPO, a mitochondria-targeted antioxidant, indicating that an increase in the generation of ROS mediated the apoptosis induced by hydroxyzine. Western blot analysis showed that hydroxyzine-induced apoptosis was through down-regulation of the phosphorylation of JAK2 and STAT3 by hydroxyzine treatment. In addition, hydroxyzine induced the phosphorylation of JNK and p38 MAPK. Our results indicate that hydroxyzine induced apoptosis via mitochondrial superoxide generation and the suppression of JAK2/STAT3 signaling.

• Journal of Family Resource Management and Policy Review
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• v.17 no.1
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• pp.81-102
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• 2013

The purpose of this study was to investigate the work-family reconciliation level of married women in double-income households. Specifically, the study aimed to test the positive spillover effects, asymmetry, and differential functions of work-family reconciliation. The study thus analyzed 1,114 married women in double-income households in the third-year data of the Korean Longitudinal Survey of Women and Families (KLoWF) done by Korean Women's Development Institute (KWDI), with the exception of those who were separated, divorced, or widowed from their husbands. The data were put to descriptive statistics, frequency analysis, and exploratory factor analysis using SPSS 20.0 for Windows. AMOS 20.0 was used to test the hypothesis on positive spillover effects, asymmetry, and differential functions. The analysis results confirm that work-family conflict, family-work conflict, work-family facilitation, and family-work facilitation are different concepts, thus supporting the hypothesis on positive spillover effects. Secondly, the negative effects of family on work were greater than those of work on family, whereas the positive effects of family on work were greater than those of work on family, which finding partially supported the hypothesis on asymmetry among the components of work-family reconciliation. Finally, the married women in double-income households with preschool children experienced more work-family conflict and family-work conflict than those with no preschool children, which result supported the hypothesis on differential functions between the two groups of women. The findings were combined to provide implications for the utilization of family resources, policies for work-family reconciliation, and plans for institutional supports to promote the work-family reconciliation of married women in double-income households.

• Investigative Magnetic Resonance Imaging
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• v.20 no.2
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• pp.95-104
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• 2016

Purpose: To evaluate the knee joint after double-bundle anterior cruciate ligament (ACL) reconstruction with three-dimensional (3D) isotropic magnetic resonance (MR) image, and to directly compare the ACL graft findings on 3D MR with the clinical results. Materials and Methods: From January 2009 to December 2014, we retrospectively reviewed MRIs of 39 patients who had reconstructed ACL with double bundle technique. The subjects were examined using 3D isotropic proton-density sequence and routine two-dimensional (2D) sequence on 3.0T scanner. The MR images were qualitatively evaluated for the intraarticular curvature, graft tear, bony impingement, intraosseous tunnel cyst, and synovitis of anteromedial and posterolateral bundles (AMB, PLB). In addition anterior tibial translation, PCL angle, PCL ratio were quantitatively measured. KT arthrometric values were reviewed for anterior tibial translation as positive or negative. The second look arthroscopy results including tear and laxity were reviewed. Results: Significant correlations were found between an AMB tear on 3D-isotropic proton density MR images and arthroscopic proven AMB tear or laxity (P < 0.05). Also, a significant correlation was observed between increased PCL ratio on 3D isotropic MRI and the arthroscopic findings such as tear, laxities of grafts (P < 0.05). KT arthrometric results were found to be significantly correlated with AMB tears (P < 0.05) and tibial tunnel cysts (P < 0.05). Conclusion: An AMB tear on 3D-isotropic MRI was correlated with arthroscopic results qualitatively and quantitatively. 3D isotropic MRI findings can aid the evaluation of ACL grafts after double bundle reconstruction.

• The KSFM Journal of Fluid Machinery
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• v.16 no.1
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• pp.17-23
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• 2013

Recently so much attention has been focused on renewable energy and, since its sources to exploit are already almost saturated in the country, the practical alternative to this situation could be a micro-turbine which uses the low head and low flow. From a point of view of local micro-turbine design capacity and manufacturing technology, the problems such as the accumulation of technical skills, the expansion of related industries, the national policy expansion and the turbine efficiency to improve are still vulnerable and it's true that there are also negative views about the economic feasibility, the technicity and the operation management of the micro-turbine. However, if the improvement can be done in technology of low-head double regulation micro-turbine to generate more outputs and the operation management can be reliably realized, the micro-turbine will be re-evaluated as an appliable source of renewable energy, even the output is small, and by a paradigm shift, it could realize a power generation as an economic and rational system.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.34 no.10
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• pp.7-15
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• 2006

The effects of strake incidence-angle on the vortex characteristics and the wing-surface pressure distribution for a double-delta wing with strake were investigated experimentally. The strake incidence-angle of negative sign(strake is pitched down from the main-wing upper-surface) increased the suction pressure of the wing-upper surface, which was the same effect of increase of angle of attack. This change of the suction pressure was caused by the closer movement of the vortex cores to the wing upper surface rather than the increase of the vortex strength.

• Toxicological Research
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• v.17 no.4
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• pp.255-265
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• 2001

Epidemiologic studies have demonstrated an association between short-term exposure to particulate air pollutants and increased mortality. However the biological mechanism underlying these associations have not been fully established and also the chemical and physical characteristics of the pollutant particles are not well understood. The metal constituents of air pollutant particles and their bioavailability are considered to Play an important role as possible mediators of Particle-induced airway injury and inflammation. Sprague-Dawley rat alveolar macrophage cells (NR8383) were exposed to airborne and acid-leached particulate matter (PM). Titanium oxide and nickel subsulfide were used as negative and positive controls. Particle-induced reactive oxygen species formation in cells was detected using the fluorescent probe 2',7'-dichlorofluorescin diacetate. Expression of TNF-$\alpha$ and IL-6 were measured by enzyme-linked immunosorbent assay, and PM-induced DNA double-strand breaks were determined with $\lambda$DNA/Hind III marker. Metals associated with air pollutant particles mediated intracellular oxidant production in alveolar macrophages, and the cytotoxicity and proinflammatory cytokine production induced by PM were associated with oxidative stress. The oxidants produced by air pollutant particles also are likely to induce DNA double-strand breaks. Our findings in alveolar macrophage cells exposed to PM and acid-leached PM support the hypothesis that metal components in urban air pollutants and their bioavailabilities might play an Important role in the induction of the adverse health effects.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.13 no.4
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• pp.318-325
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• 2000

Dynamic behaviors of saturated-fatty acids $C_{16}$, $C_{18}$, $C_{20}$ and 8A5H with azobenzene were measured by displacement current method when the molecules are stimulated by pressure light and heat. When a barrier was compressed I-A, $\pi$-A isotherms of $C_{16}$, $C_{18}$, and $C_{20}$ were similar to each other but the displacement current of $C_{20}$ which has a long alkyl chain was relatively low. 8A5H showed the form of double liquid films and had a reversible reaction when a barrier was compressed and then expanded. When the molecules of 8A5H were stimulated by 365[nm] light the positive currents which were generated by the structural changes from trans to cis were measured. But the negative currents of the structural changes from cis to trans by 450[nm] light were too weak to detect. When the temperature of the water subphase was increased the surface pressures of the monolayers were increased early because of the thermal activations of the molecules and the double liquid films of 8A5H were disappeared above 40[$^{\circ}C$]EX>].

• Journal of Ocean Engineering and Technology
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• v.33 no.3
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• pp.280-288
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• 2019

A submerged breakwater is one of the coastal structures used to reduce wave energy and coastal erosion. However, a submerged breakwater has a negative aspect in that a strong rip current occurring around an open inlet due to a difference in mean water levels at the front and rear sides of the structure leads to scouring. Such scouring has a bad effect on its stability. In order to eliminate this kind of demerit, this study investigated an artificial reef of the overflow type with openings. We also developed a program where the flows around the artificial reef of the overflow type could be analyzed numerically. An unstructured grid system was used to cover the various geometries, and the level set method was applied to treat the movement of the free surface. To verify these numerical schemes, hydraulic physical tests were performed on the submerged breakwater and double breaking type artificial reef. Then, the wave height and velocity distribution around the reef were examined using the experimental results. Comparisons between the results of hydraulic and numerical tests showed reasonable agreement.

• Advances in nano research
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• v.10 no.4
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• pp.373-383
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• 2021

In this work, silver nitrate complexes of sulfanilamide-5-methyl-2-thiophene carboxaldehyde (SMTCA) ligand intercalated Zn/Al-layered double hydroxide [Ag-SMTCA-LDH] were synthesized for the potential application as an antimicrobial system. The SMTCA ligand was synthesized by reacting sulfanilamide and 5-methyl-2-thiophene carboxaldehyde in methanol and further complexation with silver nitrate metal ions [Ag-SMTCA]. The structural analyses of synthesized compounds confirmed an intercalation of Ag-SMTCA into Zn/Al-NO₃-LDH by flake/restacking method. SMTCA, Ag-SMTCA and Ag-SMTCA-LDH were characterized by ¹H nuclear magnetic resonance (¹H NMR) spectroscopy, Fourier-transform infrared (FTIR), ultraviolet-visible (UV-Vis) spectrophotometer, scanning electron microscopy (SEM) and transmission electron microscopy (TEM), X-ray diffraction (XRD), and thermogravimetric analysis (TGA). It was found that Ag-SMTCA-LDH exhibited good antimicrobial activity against both gram-positive (Bacillus subtilis, [B. subtilis], Staphylococcus aures, [S. aureus]) and gram-negative (Escherichia coli, [E. coli], Pseudomonas aeruginosa [P. aeroginosa]) bacteria as well as excellent antioxidant activity.