• Journal of the Korean Society of Environmental Restoration Technology
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• v.7 no.6
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• pp.61-74
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• 2004

Hydraulic engineers and scientists working on river restoration recognize the need for a deeper understanding of natural streams as a complex and dynamic system, which involves not only abiotic elements(flow, sediments) but also biotic components. From this point of view, the role played by riverine vegetation dynamics and flow conditions becomes essential. Hydro-mechanic interaction between flow and flexible plants covering a river bed is studied in this paper and some previous works are discussed. Measurements of turbulence and flow resistance in vegetated open channel were performed using rigid and flexible tube. Measuring detailed turbulent velocity profiles within and above submerged and flexible stems allowed to distinguish different turbulent regimes. Some interesting relationships were obtained between the velocity field and the deflected height of the plants, such as a reduced drag coefficient in the flexible stems. Turbulent intensities and Reynolds stresses were measured showing two different regions : above and inside the vegetation domain. In flexible vegetated open channel, the maximum values of turbulent intensities and Reynolds stresses appear above the top of canopy. Method to predict a flow resistance in flexible vegetated open channel is developed by modifying an analytical model proposed by Klopstra et al. (1997). Calculated velocity profiles and roughness values correspond well with flume experiments. These confirm the applicability of the presented model for open channel with flexible vegetation. The new method will be verified in the real vegetated conditions in the near future. After these verifications, the new method should be applied for nature rehabilitation projects such as river restorations.

• Analytical Science and Technology
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• v.28 no.3
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• pp.187-195
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• 2015

The heat of sublimation (HOS) is an essential parameter used to resolve environmental problems in the transfer of organic contaminants to the atmosphere and to assess the risk of toxic chemicals. The experimental measurement of the heat of sublimation is time-consuming, expensive, and complicated. In this study, quantitative structural property relationships (QSPR) were used to develop a simple and predictive model for measuring the heat of sublimation of organic compounds. The population-based forward selection method was applied to select an informative subset of descriptors of learning algorithms, such as by using multiple linear regression (MLR) and the support vector machine (SVM) method. Each individual model and consensus model was evaluated by internal validation using the bootstrap method and y-randomization. The predictions of the performance of the external test set were improved by considering their applicability to the domain. Based on the results of the MLR model, we showed that the heat of sublimation was related to dispersion, H-bond, electrostatic forces, and the dipole-dipole interaction between inter-molecules.

• Journal of Korean Academy of Nursing
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• v.44 no.3
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• pp.294-304
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• 2014

Purpose: The influence of dietary composition on blood pressure is an important subject in healthcare. Interactions between antihypertensive drugs and diet (IBADD) is the most important factor in the management of hypertension. It is therefore essential to support healthcare providers' decision making role in active and continuous interaction control in hypertension management. The aim of this study was to implement an ontology-based clinical decision support system (CDSS) for IBADD management (IBADDM). We considered the concepts of antihypertensive drugs and foods, and focused on the interchangeability between the database and the CDSS when providing tailored information. Methods: An ontology-based CDSS for IBADDM was implemented in eight phases: (1) determining the domain and scope of ontology, (2) reviewing existing ontology, (3) extracting and defining the concepts, (4) assigning relationships between concepts, (5) creating a conceptual map with CmapTools, (6) selecting upper ontology, (7) formally representing the ontology with Protege (ver.4.3), (8) implementing an ontology-based CDSS as a JAVA prototype application. Results: We extracted 5,926 concepts, 15 properties, and formally represented them using Protege. An ontology-based CDSS for IBADDM was implemented and the evaluation score was 4.60 out of 5. Conclusion: We endeavored to map functions of a CDSS and implement an ontology-based CDSS for IBADDM.

• BMB Reports
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• v.50 no.12
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• pp.640-646
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• 2017

Regulatory B cells, also well-known as IL-10-producing B cells, play a role in the suppression of inflammatory responses. However, the epigenetic modulation of regulatory B cells is largely unknown. Recent studies showed that the bromodomain and extra-terminal domain (BET) protein inhibitor JQ1 controls the expression of various genes involving cell proliferation and cell cycle. However, the role of BET proteins on development of regulatory B cells is not reported. In this study, JQ1 potently suppressed IL-10 expression and secretion in murine splenic and peritoneal B cells. While bromodomain-containing protein 4 (BRD4) was associated with $NF-{\kappa}B$ on IL-10 promoter region by LPS stimulation, JQ1 interfered the interaction of BRD4 with $NF-{\kappa}B$ on IL-10 promoter. In summary, BRD4 is essential for toll like receptor 4 (TLR4)-mediated IL-10 expression, suggesting JQ1 could be a potential candidate in regulating IL-10-producing regulatory B cells in cancer.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.11 no.1
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• pp.48-60
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• 2007

Palpation of the pulse has been used in Korean traditional medicine since ancient times to assess physical health. Pulse wave contour may be obtained by measuring arterial pressure or blood volume change of skin. The latter is called as Photoplethysmography(PPG) or digital volume pulse(DVP). The PPG signal is measured by a device comprising an infrared light sourece and a photodetector. Although less widely used, this technique deserves further consideration because of its simplicity and ease of use. The contour of the PPG is formed as a result of a complex interaction between the left ventricle and the systemic circulation. It usually exhibits an early systolic peak and an early diastolic peak. the first peak is formed mainly by pressure trasmitted along a direct path from the left ventricle to the finger. The second peak is formed in part by pressure transmitted along the aorta and large arteries to sites of impedance mismatch in the lower body. The contour of the PPG is sensitive to changes in arterial tone and is influenced by ageing and large artery stiffness. Measurements taken directly from the PPG or from its second derivative can be used to assess these properties. In some mathematical approaches, the extraction of periodic components using frequency analysis was tried to analysis of the PPG. But we don't understand yet what kind of factor in the cardiovascular system or human body is related with the respective specific Fourier components of PPG. This review describes the background to measurement principles, representative contour, contour analysis and frequency domain analysis of PPG, and current and future.

• Proceedings of the Korean Society of Plant Pathology Conference
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• 2003.10a
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• pp.117.3-118
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• 2003

We tested for the presence of double-stranded RNA (dsRNA) mycovirus in 827 Fusarium graminearum isolated from diseased barley and maize. dsRNA mycoviruses with various sizes were isolated. Of them, it was previously reported that dsRNA from DK2l isolate had pronounced morphological changes, including reduction in mycelial growth, increased to red pigmentation, reduced virulence and sporulation. (Chu et al., Appl. Environ. Microbiol. 2002). For better understanding of this hypovirulence associated with DK2l dsRNA virus, we determined the complete nucleotide sequence of dsRNA genome and named Fusarium hypovirus DK2l strain (Fhv-DK2l ). Genomic RNA of Fhv-DK2l was determined to be 6625 nucleotides in length excluding the poly (A) tail and contained three putative open reading frame. RNA-dependent RNA polymerase (RdRp) and helicase domain were expected in ORF A, 54 to 4709 nucleotide position. ORE B, 4752 to 5216 nucleotide position, and ORF C, 5475 to 6578 nucleotide position, were predicted to encode 16.7kDa and 41.3kDa protein respectively each. We could not detect any conserved domains from these two proteins. Phylogenetic analysis showed Fhv-DK2l was related to Cryphonectria hypovirus 3. Ten additional isolates were found that were infected with dsRNA mycoviruses. These mycoviruses contain 2 to 4 different segments of dsRNAs with the size range of approximately 1.7 to 10-kbp in length. The presence of dsRNAs isolates did not affect colony morphology and were transmissible through conidia and ascospore with incidence of 30-100％. These results indicate that there is genomic diversity of dsRNA mycoviruses that infect F. graminearum isolates and that impact of virus infection on host's morphology and virulence is determined by the interaction between dsRNAs and the fungal host, not by the mere presence of the dsRNAs

• 한국사회복지학회:학술대회논문집
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• 2004.04a
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• pp.365-382
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• 2004

The purpose of this study was to explore the concepts of health among people with mobility disabilities in order to develop a new holistic model of health and to identify implications for social work practice. A qualitative study based on face-to-face interviews with people with mobility disabilities was conducted. Nine consumers and nine social workers with mobility disabilities participated in the study. Social constructionism, heuristic paradigm, empowerment paradigm, and strength perspectives were used to form conceptual foundations to guide the study. Study participants' holistic descriptions of the concept of health encompassed five domains: biological/physical, mental/emotional, financial, relationships with others, and spiritual. Participants described health as harmony among these five domains. Harmony indicates that all five domains contribute to the concept of health, and that each domain is related to the others. Participants also viewed disability and health as an interconnected whole, not separate concept. The conceptual model developed in this study expands on the existing concepts of health by considering multiple factors at the personal and environmental levels, as well as interactions among the factors and between the levels. The personal level has five domains: biological/physical, mental/emotional, spiritual, financial, and relationships with others. The environmental level has also five domains: relationship with others, financial, social programs, social attitudes toward peoplewith disabilities, and physical environment. All factors under the personal and environmental levels also affect each other. The holistic concept of health for people with disabilities is not solely a part of the person, but rather is a function of the interaction between the person and their environment. The study demonstrated that people with disabilities have strength and resiliency, and health is an attainable goal for them, particularly when environmental and cultural barriers are addressed. The focus of social work practice should be the removal of those barriers encountered by their consumers with disabilities, as well as, the enhancement of internal factors that facilitate well-being.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.44 no.6
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• pp.42-48
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• 2007

In x-ray imaging system, two kinds of noises are involved. First, the charge generated from the radiation interaction with the detector during exposure. Second, the signal is then added by readout electronics noise. But, x-ray images are not modeled by Gaussian noise but as the realization of a Poisson process. In this paper, we apply a new approach to remove Poisson noise from medical X-ray image in the wavelet domain, the applied methods shows more excellent results in cone-beam CT.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.15 no.4
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• pp.232-241
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• 2003

The interaction of incident monochromiatic waves with N bottom-mounted porous circular cylinders is investigated in the frame of three-dimensional linear potential theory. The fluid domain is divided into N+l regions i.e. a single exterior region and N interior regions, and the diffraction potential in each fluid region is expressed by an eigenfunction expansion method (Williams and Li,2000). The analytic results show that the porous structure reduces both the wave forces and the run-up wave around the cylinder. To verify the developed model, the systematic model test with a line array of porous cylinders is conducted at the wave tank (30m$\times$7m$\times$1.5m). The analytic results are in good agreement with the experimental results within measured frequency range. It is concluded that the breakwater constructed with an array of porous circular cylinders shows the performance of an effective wave barrier together with the seawater-exchange effect and is considered to have vast potentials for the use of seawater-exchanging breakwater in the future.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.12 no.3
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• pp.116-129
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• 2000

The interaction of incident monochromatic waves with a tensioned, flexible, circular membrane submerged horizontally below free surface is investigated in the frame of three-dimensional linear hydro-elastic theory. The velocity potential is split into two parts i.e. the diffraction potential representing the scattering of incident waves by a rigid circular disk and the radiation potential describing motion induced waves by elastic responses of flexible membrane. The fluid domain is divided into three regions, and the diffraction and radiation potentials in each region are expressed by the Fourier Bessel series. The displacement of circular membrane is expanded with a set of natural functions, which satisfy the membrane equation of motion and boundary conditions. The unknown coefficients in each region are determined by applying the continuity of pressure and normal velocity at the matching boundaries. The results show that various types of wave focusing are possible by controlling the size, submergence depth, and tension of membrane.