• Asian-Australasian Journal of Animal Sciences
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• v.23 no.1
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• pp.1-6
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• 2010

The objectives of this study were to i) investigate genetic performance for linear type traits of individual Holstein dairy cows, especially focusing on comparative traits, and to estimate genetic variances for these traits using actual data, and ii) compare genetic performance and improvement of progeny by birth country of the cows. Linear type traits defined with five comparative traits on this study were general stature composite (GSC), dairy capacity composite (DCC), body size composite (BSC), foot and leg composite (FLC), and udder composite (UDC). These traits were scored from 1 to 6 with 1 = poor, 2 = fair, 3 = good, 4 = good plus, 5 = very good and 6 = excellent. Final scores (FS) were also included in this study. Data used was collected from the years 2000 to 2004 by the Korea Animal Improvement Association (KAIA). Only data of more than five tested cows by herd appraisal date and by sires having more than ten daughters were included to increase the reliability of the data analyses. A total of 30,204 records of the selected traits, which was collected from 26,701 individuals having pedigree information were used. Herd appraisal date, year of age, lactation stage (grouped by month), and time lagged for milking (in hours) were assumed as fixed effects on the model. Animal additive genetic effects considering pedigree relationship and residual errors were assumed with random effects. Year of age at appraisal date was classified from one to nine years of age, assigning the value of nine years of age for animals that were greater than or equal to nine years of age. From our results, the estimate for heritability was 0.463, 0.346, 0.473, 0.290, and 0.430 on GSC, DCC, BSC, FLC and UDC, respectively. The estimate for FS heritability was 0.539. The greatest breeding values for GSC were estimated for Canada, with the breeding values for American lines increasing for 10 years starting in 1989 but tending to decrease after that until 2004. For DCC, the breeding values for American and Canadian lines showed similar patterns until 1999, after which the breeding values for the American lines declined sharply. For BSC, data from Korea, Canada and the USA followed similar trends overall except when the breeding values of the American lines decreased starting in 1999. Overall, the methods used to evaluate genetic performance in this study were acceptable and allowed for the discovery of differences by country of genetic origin, likely due in part to the American use of selection indexes based primarily on milk yield traits until methods for evaluating other traits began to emerge.

• Journal of the Korean earth science society
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• v.21 no.5
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• pp.635-646
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• 2000

Geological achievements of the 20th century revolutionized our views about geological understanding and concept. A good example is the concept of continental drift suggested early in the 20th century and later explained in terms of seafloor spreading and plate tectonics. Our understanding of the compositions of materials forming earth has also improved during the20th century. Radio and stable isotopes together with biostratigraphy and sequence stratigraphy allow us to interpret the evolution of sedimentary basins in terms of plate movement and sedimentation processes. The Deep Sea Drilling Project initiated in 1960s and continued as the Ocean Drilling Project in 1980s is one of the most successful international research observations, and new developments in computational techniques have provided a wholly new view about the interior of the earth. Most of the geological features and phenomena observed in deep sea and around continental margins are now explained in terms of global tectonic processes such as superplumes flowing up from the interior of our planet and interacting with such as Rodinia Pannotia and Nena back in the Precambrian time. The space explorations which began in the late 1950s opened up a new path to astrogeology, astrobiology, and astropaleontology. The impact theory rooted in the discovery of iridium and associated phenomena in 1980s revived Cuvier's catastrophism as a possible explanation for the extinctions of biotas found in the geological record of this planet. Due to the geological achievements made in the 20th century, we now have a better understanding of geologic times and processes that were too long to be grasped by human records.

• The KIPS Transactions:PartD
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• v.10D no.3
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• pp.447-458
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• 2003

The basic assumption of conventional data mining methodology is that the data set of a knowledge discovery process should be fixed and available before the process can proceed. Consequently, this assumption is valid only when the static knowledge embedded in a specific data set is the target of data mining. In addition, a conventional data mining method requires considerable computing time to produce the result of mining from a large data set. Due to these reasons, it is almost impossible to apply the mining method to a realtime analysis task in a data stream where a new transaction is continuously generated and the up-to-dated result of data mining including the newly generated transaction is needed as quickly as possible. In this paper, a new mining concept, open data mining in a data stream, is proposed for this purpose. In open data mining, whenever each transaction is newly generated, the updated mining result of whole transactions including the newly generated transactions is obtained instantly. In order to implement this mechanism efficiently, it is necessary to incorporate the delayed-insertion of newly identified information in recent transactions as well as the pruning of insignificant information in the mining result of past transactions. The proposed algorithm is analyzed through a series of experiments in order to identify the various characteristics of the proposed algorithm.

• Journal of KIISE:Information Networking
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• v.31 no.1
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• pp.81-90
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• 2004

A Mobile Ad Hoc Network (MANET) is a collection of wireless mobile nodes dynamically self-organizing in arbitrary and temporary network topologies without the use of any existing network infrastructure. The AODV (Ad Hoc On-Demand Distance Vector) Protocol is one of the typical reactive routing protocols, in that mobile nodes initiate routing activities only in the presence of data packets in need of a route. In this paper, we focus upon the local repair mechanism of AODV. When a link is broken, the upstream node of the broken link repairs the route to the destination by initiating a local route discovery process. The process involves the flooding of AODV control messages in every node within a radius of the length from the initiating node to the destination. In this paper, we propose an efficient local repair scheme for AODV called AFLRS (AODV-based Fast Local Repair Scheme). AFLRS utilizes the existing routing information in the intermediate nodes which have been on the active route to the destination before a link break occurs. AFLRS can reduce the flooding range of AODV control messages and the route recovery time because it can repair route through the intermediate nodes. For the performance evaluation of the proposed AFLRS, we have simulated the local repair mechanisms by using NS2 and AODV-UU. The performance results show that AFLRS can achieve faster route recovery than the local repair mechanism of AODV.

• Korean Journal of Psychosomatic Medicine
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• v.25 no.1
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• pp.3-11
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• 2017

Objectives : The aim of this study was to draw attention toward so called 'behavioral variant frontotemporal dementia(bvFTD) phenocopy syndrome', which is difficult to discriminate with the primary psychiatric disorders, showing poor response to conventional therapeutic drugs, leading to higher risk to misdiagnoses and legal problems. Furthermore, the author insisted that our interest and study on them must be continued. Methods : English articles published during 2000 thru 2016 had been searched by internet with the combination of words such as 'frontotemporal', 'phenocopy' and 'behavioral', and reviewed. Besides, two clinical vignettes were described. Results : Precise diagnosis is important because patients' behavioral symptoms can influence on their families and community. However, disease-modifying treatment for bvFTD are not developed until now, and recent therapeutic drugs are only good for specific symptoms, while deterioration progresses in spite of proper psychiatric management. The possible bvFTD patients are not progressed into probable bvFTD clinically, showing no decline of cogntive and social function, no decrease of activity function, longer survival time, and normal neuroimaging for several years. Conclusions : Rather than expected, there are much more patients having clinical symptoms, course and diagnostic findings including neuroimaging, which are atypical to classical frontotemporal dementia and primary psychiatric disorders. If our knowledge and discriminating ability is improved, discovery rate of that cases will be increased. However, the identity of these atypical features are not clarified until now, it must be further actively investigated.

• Archives of design research
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• v.11 no.3
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• pp.149-162
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• 1998

This study is what tried to examine the importance of material in industrial design. Then, if planning is to start of product design, the use of material is the last step to complete design. Design material has existed from the time before mankind were born, and the new material which is useful for human beings is developing rapidly. It is no exaggeration to say that our environment is the aggregation of material which was surrounded with us. Then, material has the timely, spatial and cultural feature as well as physical feature. Besides, all sorts of functions of communicating information are being contained in accordance with the character of material. The outside surface of material has the function to develop the sense organ of human beings. This study examines 4 kinds of cultural features in design materials and shown by findings is as follows : Rrst is the technical progressivity to lead new Design form. Second is the symbolic nature to perform the communication function. Third is the sensible attribute to develop surface effect of Design material. Fourth is the future-oriented nature to convince the future such as new material and technology etc. Thus, so as to perform the competitive product design, it is important to grasp the harmony between material and design, structure and processing, and the substantial meaning that the material has and apply them properly, above all. Because the discovery of material will be the measure to forecast future design.

• Journal of Internet Computing and Services
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• v.13 no.3
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• pp.115-126
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• 2012

Mashups have become very popular over the last few years, and their use also varies for IT convergency services. In spite of their popularity, there are several challenging issues when combining Open APIs into mashups, First, since portal sites may have a large number of APIs available for mashups, manually searching and finding compatible APIs can be a tedious and time-consuming task. Second, none of the existing portal sites provides a way to leverage semantic techniques that have been developed to assist users in locating and integrating APIs like those seen in traditional SOAP-based web services. Third, although suitable APIs have been discovered, the integration of these APIs is required for in-depth programming knowledge. To solve these issues, we first show that existing techniques and algorithms used for finding and matching SOAP-based web services can be reused, with only minor changes. Next, we show how the characteristics of APIs can be syntactically defined and semantically described, and how to use the syntactic and semantic descriptions to aid the easy discovery and composition of Open APIs. Finally, we propose a goal-directed interactive approach for the dynamic composition of APIs, where the final mashup is gradually generated by a forward chaining of APIs. At each step, a new API is added to the composition.

• Journal of Microbiology and Biotechnology
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• v.19 no.3
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• pp.331-337
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• 2009

Interleukin-13 (IL-13) has been proposed as a therapeutic target for bronchial asthma as it plays crucial roles in the pathogenesis of the disease. We developed an in vitro test system measuring transcriptional downregulatory activities on IL-13 as a primary screening method to select drug candidates from natural products. The promoter region of IL-13 (-2,048 to +1) was cloned into the upstream of a luciferase gene in the plasmid pGL4.14 containing the hygromycin resistance gene as a selection marker, generating pGL4.14-IL-13. The EL-4 thymoma and RBL-2H3 mast cells transiently expressing this plasmid highly produced the luciferase activities by responding to PI (PMA and ionomycin) stimulation up to 8-fold and 13-fold compared with the control, respectively, whereas cyclosporin A, a well-known antiasthmatic agent, significantly downregulated the activities. The BF1 clone of RBL-2H3 cells constitutively expressing pGL4.14-IL-13 was established by selecting surviving cells under a constant lethal dose of hygromycin treatment. The feasibility of this system was evaluated by measuring the downregulatory activities of 354 natural products on the IL-13 promoter using the BF1 clone. An extract from Morus bombycis (named TBRC 156) significantly inhibited PI-induced luciferase activities and IL-13 mRNA expression, but not the protein expression. Fisetin (named TBRC 353) inhibited not only PI-induced luciferase activities and mRNA expression, but also the IL-13 protein secretion, whereas myricetin (named TBRC 354) could not suppress the IL-13 expression at all. Our data indicated that this in vitro test system is able to discriminate the effects on IL-13 expression, and furthermore, that it might be suitable as a simple and time-saving primary screening system to select antiasthmatic agents by measuring transcriptional activities of the IL-13 promoter.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.11
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• pp.94-103
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• 2017

As automatic hacking tools and techniques have been improved, the number of new vulnerabilities has increased. The CVE registered from 2010 to 2015 numbered about 80,000, and it is expected that more vulnerabilities will be reported. In most cases, patching a vulnerability depends on the developers' capability, and most patching techniques are based on manual analysis, which requires nine months, on average. The techniques are composed of finding the vulnerability, conducting the analysis based on the source code, and writing new code for the patch. Zero-day is critical because the time gap between the first discovery and taking action is too long, as mentioned. To solve the problem, techniques for automatically detecting and analyzing software (SW) vulnerabilities have been proposed recently. Cyber Grand Challenge (CGC) held in 2016 was the first competition to create automatic defensive systems capable of reasoning over flaws in binary and formulating patches without experts' direct analysis. Darktrace and Cylance are similar projects for managing SW automatically with artificial intelligence and machine learning. Though many foreign commercial institutions and academies run their projects for automatic binary analysis, the domestic level of technology is much lower. This paper is to study developing automatic detection of SW vulnerabilities and defenses against them. We analyzed and compared relative works and tools as additional elements, and optimal techniques for automatic analysis are suggested.

• Korean Journal of Psychosomatic Medicine
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• v.22 no.2
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• pp.55-62
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• 2014

The relationship of mind and body has stimulated extensive discussion for a long time. However, answers are ambigous and not forthcoming yet. Meanwhile, after the western medicine had embraced materialistic paradigm, conditions which cannot be substantiated by organic change were pushed out to periphery under the banner of "Medically Unexplained Symptoms". Medical experts endeavored to understand these mysterious illnesses based on the mind-body relationship and provided a frame of interpretation called Psychosomatic Medicine. This frame of interpretation had influenced not only the communication practice but also the health-seeking behavior and even the subjective experience of patients regarding their illnesses. The frame of interpretation had been drastically changed many times keeping pace with the socio-economic situation and the new scientific discoveries. Accordingly, body or mind was given differential importance by medical experts. For instance, when treatment modalities were lacking, mind was given excessive importance and patients were blamed for their unconscious motives, characterological weaknesses and for their lack of responsibility. In contrast, after the discovery of effective drug, mind was given no more attention and patients were no longer blamed for their contribution to suffering. In this paper, the historical change of the frame of interpretation for understanding migraine and headache was presented as an example. By this, it can be demonstrated how the frame of interpretation has modified the subjective experience of patients, and how the patients' responsibilities were viewed differently. This observation can help to realize the enormous influence of the frame of interpretation provided by medical experts.