• Molecules and Cells
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• v.42 no.11
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• pp.804-809
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• 2019

Oncogenic gain-of-function mutations are clinical biomarkers for most targeted therapies, as well as represent direct targets for drug treatment. Although loss-of-function mutations involving the tumor suppressor gene, STK11 (LKB1) are important in lung cancer progression, STK11 is not the direct target for anticancer agents. We attempted to identify cancer transcriptome signatures associated with STK11 loss-of-function mutations. Several new sensitive and specific gene expression markers (ENO3, TTC39C, LGALS3, and MAML2) were identified using two orthogonal measures, i.e., fold change and odds ratio analyses of transcriptome data from cell lines and tissue samples. Among the markers identified, the ENO3 gene over-expression was found to be the direct consequence of STK11 loss-of-function. Furthermore, the knockdown of ENO3 expression exhibited selective anticancer effect in STK11 mutant cells compared with STK11 wild type (or recovered) cells. These findings suggest that ENO3-based targeted therapy might be promising for patients with lung cancer harboring STK11 mutations.

• International Journal of Automotive Technology
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• v.2 no.3
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• pp.85-91
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• 2001

Characteristics of methane direct-injection spark-ignition stratified combustion in lean hydrogen mixture were analyzed both in a single cylinder engine and in a constant volume combustion chamber. Combustion pressure and Instantaneous combustion chamber wall temperature during the combustion process were measured with a thin-film thermocouple and used in analyses of combustion and cooling loss. Results in this research show that the premixed hydrogen increases cooling loss to combustion chamber wall while achieving combustion promotion, and the combustion system is effective especially in lean mixture conditions. Analysis of flame propagation was also done with Schlieren photography in the constant volume combustion chamber.

• The Journal of Fisheries Business Administration
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• v.44 no.1
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• pp.15-24
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• 2013

Recently the Korean court accepts two typies of fisheries damages caused by oil pollution.. One is the direct loss of fisheries production originated from pollution of oil spillover. The other is the indirect loss of fisheries production originated from governmental measure of restricting fishing activities because of safety of marine product of oil spillover areas. The paper tries to suggest the appropriated measure of oil pollution damages of hanging and floating netcage aquaculture fisheries using the court judgement for responsibility restriction on Herbei Spirit Case. The paper tries to compare the damge estimation method of floating netcage aquaculture fisheries with that of natural aquaculture fisheries using conventional theory of the population biology of living resources characterized with age distribution.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.27 no.10
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• pp.15-20
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• 2013

In this paper, wireless power transfer system using the magnetic resonance was designed and applied to LED lighting for implementation of wireless lighting. This lighting was made by the converted DC driving type and the direct AC driving type. In the former, transferred AC power was rectified into DC and regulated to the specified voltage value, which leads to produce the loss at the rectifying and regulating circuit. In the latter, wireless-transferred AC power was directly applied to LED, which get rid of the loss derived from the additional circuit. For the efficiency-comparison between the former and the latter, the power at each stage was measured when the same optical output radiated from LED lighting part. The result revealed that the direct AC driving type had 18% higher efficiency than the DC driving type and confirmed that LED lighting using magnetic resonance wireless power transfer system can be efficient by direct AC power supply. And the direct AC driving type had the simple circuit structure and the simple LED lighting formation, so this can leads to various application.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.21 no.10
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• pp.1194-1199
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• 2010

In this paper, for a relay-based cellular network, a interference avoidance beamforming technique is proposed to enhance direct link capacity while minimizing loss in the capacity of concurrent relaying link. A direct link is transmitted by beamforming at the transmitter, and the relaying link with the least interference to the direct link is scheduled to transmit data by a collision avoidance scheduling algorithm. Simulation results show that the proposed IA beamforming provides a considerable direct link capacity enhancement while minimizing relaying link capacity loss by effectively mitigating inference between concurrent direct and relaying links only with limited feedback.

• Journal of Power System Engineering
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• v.20 no.2
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• pp.32-42
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• 2016

Under part load condition of spark-ignition engine, pumping loss had great effect on engine efficiency. To reduce pumping loss, the study designed spark-ignited engines to make direct spray of gasoline to combustion chamber. In spark-ignited direct-injection engines, ignition probability is important for successful combustion and flame propagation characteristics are also different from pre-mixed combustion. This study designed a visualization testing device to study ignition probability of spark-ignited direct-injection LPG fuel and combustion flame characteristics. This visualization device consists of combustion chamber, fuel supply system, air supply system, electronic control system and data acquisition system. Ambient pressure, ambient temperature and ambient air flow velocity are important parameters on ignition probability of LPG-air mixture and flame propagation characteristics, and the study also found that sprayed LPG fuel can be directly ignited by spark-plug under proper ambient conditions. To all successful cases of ignition, the study recorded flame propagation image in digital method through ICCD camera and its flame propagation characteristics were analyzed.

• Journal of Korean Society on Water Environment
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• v.25 no.5
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• pp.785-791
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• 2009

Using artificial rainfall simulator, the soil loss, which is deemed as the most cause of muddy water problem among Non-point source (NPS) pollutant, was studied by the analysis of direct runoff, groundwater discharge, and soil water storage properties concerned with rainfall intensity, slope of area, and land cover. The direct runoff showed increasing tendency in both straw covered and bared soil as slope increases from 5% to 20%. The direct runoff volume from straw covered surface were much lower than bared surface. The infiltration capacity of straw covered surface increased, because the surface sealing by fine material of soil surface didn't occur due to the straw covering. Under the same rainfall intensity and slope condition, 2.4~8.2 times of sediment yield were occurred from bared surface more than straw covered surface. The volume of infiltration increased due to straw cover and the direct runoff flow decreased with decrease of tractive force in surface. To understand the relationship of the rate of direct runoff, groundwater discharge, and soil water storage by the rainfall intensity, slope, and land cover, the statistical test was performed. It shows good relationship between most of factors, except between the rate of groundwater storage and rainfall intensity.

• Korean Journal of Weed Science
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• v.18 no.1
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• pp.12-19
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• 1998

The pattern of rice cultivation in Korea is changing from hand transplanting and machine transplanting into direct-seeding for low input and cost-down practices. However, there are still some obstacles to establish the direct-seeding cultural practices because of poor seedling stand, lodging, and weed infestation. In particular, there were much more and wide weed occurrence in direct-seeding rice as compared with the transplanted rice. Weed occurrence in terms of dry weight of weeds was highest in dry direct-seeded rice followed by sowing an puddled soil, sowing on submerged soil in order as compared with transplanting with infant rice seedling. Echinochloa crux-galli was a common dominant weed with 35~44% distribution in any direct-seeding methods. The dominant weed species were E. crux-galli, Cyperus difformis, C. serotinus, and Ludwigia prostrata in dry-seeded rice. The dominant weed species in water-seeded rice were E. crus-galli, Eleocharis kuroguwai, Scirpus juncoides, and Monochoria vaginalis. Yield loss of rice due to weeds at weedy condition was 96% in dry direct-seeded rice. In water-seeded rice, yield loss was 61%, whereas yield loss was 40% in machine transplanting with infant rice seedling.

• Journal of Korean Academy of Nursing
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• v.29 no.1
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• pp.161-173
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• 1999

The purpose of this study was to develope and test the structural model for quality of life in women having hysterectomies. A hypothetical model was constructed on the basis of previous studies and a review of literature. The conceptual framework was built around eight constructs. Exogenous variables included in this model were marital intimacy, importance of uterus, professional support, positive coping behavior and pre-operative symptoms. Endogenous variables were spouse's support, sense of loss and quality of life. Empirical data for testing the hypothetical model was collected using a self-report questionnare from 203 women having hysterectomies at the outpatient clinics of four general hospitals and a mail survey in Pusan City. The Data was collected from December, 1997 to January, 1998. Reliability of the eight instruments was tested with Cronbach's alpha which ranged from 0.639-0.915. For the data analysis, SPSS 7.5 WIN Program and LISREL 8.12 WIN Program were used for descriptive statistics and covariance structural analysis. The results of covariance structure analysis were as follows : 1. Hypothetical model showed a good fit with the empirical data. ［$\chi$$^2$＝6.93(df＝5, P＝.23), GFI＝.99, AGFI＝.94, RMSR＝.019, NNFI＝.97, NFI＝.98, CN＝440, standardized residuals(-2.14-2.10)］ 2. For the parsimony of model, a modified model was constructed by deleting 3 paths and adding 1 path according to the criteria of statistical significance and meaning. 3. The modified model also showed a good fit with the data. ［$\chi$$^2$＝5.26(df＝7, P＝.63), GFI＝.99, AGFI＝.97, RMSR＝.014, NNFI＝1.02, NFI＝.99, CN＝710, standardized residuals(-1.46-1.70)］ Results of the testing of the hypothesis were as follows : 1. Marital intimacy(${\gamma}$11＝.78, t＝14.37) and professional support(${\gamma}$13＝.12, t＝2.12) had a significant direct effect on the spouse's support. 2. Pre-operative symptoms(${\gamma}$25＝.32, t＝3.12), importance of uterus(${\gamma}$22＝.20, t＝2.61) and spouse's support($\beta$2l＝-.19, t＝-2.43) had a significant direct effect on the sense of loss. 3. Sense of loss($\beta$32＝-.66, t＝-9.83) had a direct effect on the quality of life. Marital intimacy had a direct(${\gamma}$31＝.19, t＝3.33), indirect(${\gamma}$31＝.14, t＝2.52) and total effect(${\gamma}$31＝.25, t＝4.41) on the quality of life. Professional support had a direct effect(${\gamma}$33＝.11, t＝2.07) and total effect(${\gamma}$33＝.13, t＝2.31) on the quality of life. The direct effect of pre-operative symptoms(${\gamma}$35＝-.36, t＝4.02) and positive coping behavior(${\gamma}$34＝.15, t＝2.06) had the insignificant effect on the quality of life while, due to the idirect effect these variables had overall significant effect on the quality of life. The results of this study showed that the sense of loss had the most significant direct effect on the quality of life. Marital intimacy, pre -operative symptoms and spouse's support had a significant direct effect on this sense of loss. These four variables, the sense of loss, marital intimacy, pre-operative symptoms and spouse's support, were identified as relatively important variables. The results of this study suggested that there is needed to determine if nursing intervention would alleviate this sense of loss and promote a greater quality of life in women who have had hysterectomies.

• Proceedings of the Korea Water Resources Association Conference
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• 2009.05a
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• pp.986-990
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• 2009

Using artificial rainfall simulator, the soil loss, which is deemed as most cause of muddy water problem among Non-point source(NPS) pollutant, was studied by the analysis of direct runoff flow, groundwater runoff, and groundwater storage properties concerned with rainfall intensity, slope of area, and land cover. The direct runoff showed increasing tendency in both straw covered and bared boxes which are 5%, 10%, and 20% sloped respectively. Also the direct runoff volume from straw covered surface boxes were much lower than bared surface boxes. It's deemed as that the infiltration capacity of straw covered surface boxes were increased, because the surface sealing by fine material of soil surface didn't occurred due to the straw covering. Under the same rainfall intensity and slope condition, 2.4 ${\sim}$ 8.2 times of sediment yield were occurred from bared surface boxes more than straw covered surface boxes. The volume of infiltrated were increased due to straw cover, the direct runoff flow were decreased with decreasing of tractive force in surface. To understand of relationship the rate of direct runoff flow, groundwater runoff, and groundwater storage by the rainfall intensity, slope, and land cover, the statistical test was performed. It shows good relationship between most of factors, expect between the rate of groundwater storage and rainfall intensity.