• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.691-694
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• 2013

Purpose: By carrying out a meta-analysis of randomized controlled trials that compared sorafenib or combined chemotherapy with placebo or combined chemotherapy, the effectiveness of sorafenib in hepatocellular carcinoma was evaluated in the present study, which also provided clinical practice guidelines of evidence-based-medicine. Methods: We reviewed PubMed citations concerning sorafenib treating hepatocellular carcinoma in randomized controlled trials from Jan 2000 to July 2012. All the literature was extracted by Cochrane systematic reviews and underwent meta-analysis with RewMan 5.0 software. Results: Finally, four papers documenting randomized controlled studies were included. Compared with controls, sorafenib was shown to significantly increase overall survival (OS), time to progression (TTP), and disease control rates (DCR), but not the time to symptom progression (TTSP) in hepatocellular carcinoma patients. The incidence of grade-III/IV adverse reactions, including hand-foot-skin reactions, diarrhea, hypertension and skin rash or desquamation, in sorafenib treatment group was higher than that in controls. However, there was no significant difference in the incidence of hypodynamia between the two groups. Conclusions: Sorafenib exerts significant curative effects in hepatocellular carcinoma.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6681-6686
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• 2013

Background: Fatal adverse events (FAEs) have been reported with sorafenib, a vascular endothelial growth factor receptor kinase inhibitor (VEGFR TKI). We here performed an up-to-date and detailed meta-analysis to determine the overall risk of FAEs associated with sorafenib. Methods: Databases, including PubMed, Embase and Web of Science, and abstracts presented at the American Society of Clinical Oncology annual meetings were searched to identify relevant studies. Eligible studies included randomized controlled trials evaluating sorafenib effects in patients with all malignancies. Summary incidence rates, relative risks (RRs), and 95% confidence intervals (CIs) were calculated for FAEs. In addition, subgroup analyses were performed according to tumor type and therapy regimen. Results: 13 trials recruiting 5,546 patients were included in our analysis. The overall incidence of FAEs with sorafenib was 1.99% (95%CI, 0.98-4.02%). Patients treated with sorafenib had a significantly increased risk of FAEs compared with patients treated with control medication, with an RR of 1.77 (95%CI 1.25-2.52, P=0.001). Risk varied with tumour type, but appeared independent of therapy regimen. A significantly increased risk of FAEs was observed in patients with lung cancer (RR 2.26; 95% CI 1.03-4.99; P= 0.043) and renal cancer (RR 1.84; 95% CI 1.15-2.94; P= 0.011). The most common causes of FAEs were hemorrhage (8.6%) and thrombus or embolism (4.9%). Conclusions: It is important for health care practitioners to be aware of the risks of FAEs associated with sorafenib, especially in patients with renal and lung cancer.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.7
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• pp.3191-3194
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• 2014

Adenocarcinoma of lung has high incidence and a poor prognosis, woith chemotherapy as the main therapeutic tool, most commonly with cisplatin. However, chemotherapy resistance develops in the majority of patients during clinic treatment. Mechanisms of resistance are complex and still unclear. Although annexin play important roles in various tumor resistance mechanisms, their actions in cisplatin-resistant lung adenocarcinoma remain unclear. Preliminary studies by our group found that in cisplatin-resistant lung cancer A549 cells and lung adenocarcinoma tissues, both mRNA and protein expression of annexins A1, A2 and A3 is increased. Using a library of annexin A1, A2 and A3 targeting combined molecules already established by ourselves we found that specific targeting decreased cisplatin-resistance. Taken together, the underlined effects of annexins A1, A2 and A3 on drug resistance and suggest molecular mechanisms in cisplatin-resistant A549 cells both in vivo and in vitro. Furthermore, the study points to improved research on occurrence and development of lung adenocarcinoma, with provision of effective targets and programmes for lung adenocarcinoma therapy in the clinic.

• Journal of the Korean Operations Research and Management Science Society
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• v.39 no.2
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• pp.111-130
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• 2014

For the key factors determining victory of combat, many works have been focusing on qualitative analyses in the past. As military training paradigm changes along with technology developments, demands for scientific analysis to prepare future military strength increase regarding military training results, and big data analysis has opened such possibility. We analyze the data from KCTC (Korea Combat Training Center) training to investigate the factors affected victory in offensive operations. In this context, we develop a way to measure the victory and the factors related to it from existing studies and military doctrines. We first identify Independent variables that affect offensive operations through variable selection and propose a mathematical model to explain combat victory by performing multiple regression analysis. We also verify our results with battalion-level live training data as well as previous studies on victory factors in the military doctrines.

• Journal of The Korea Institute of Healthcare Architecture
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• v.17 no.3
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• pp.7-16
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• 2011

This study is a part of the architectural planning to meet the military healthcare development project according to the Korea national defense reform 2020. At this time, it is intended to identify the overall issues and to set the improvement directions of military hospital planning. Literature reviews, such as military healthcare development project, Korea national defense reform 2020, etc., and case studies for the advanced foreign military hospitals and several Korean private hospitals is analyzed. And also, field surveys, such as questionnaire collections for patients and workers, interviews with surgeons and department officials, and observation survey were conducted in order to be realistic improvement suggestions for military hospital planning issues.

• International Journal of Reliability and Applications
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• v.5 no.2
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• pp.75-80
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• 2004

Relationships between inventory policy and operational availability of military equipment maintained under a logistics support system are analyzed. A continuous review inventory model with a stochastic demand typically used in a military logistics support is considered and some numerical studies are provided.

• Bulletin of the Korean Chemical Society
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• v.31 no.6
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• pp.1609-1614
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• 2010

Acetylcholinesterase reactivators are crucial antidotes for the treatment of organophosphate intoxication. Standard in vitro test was chosen using a rat brain homogenate as the source of AChE. Screening of reactivation potency was performed with two concentration of reactivator (1000 ${\mu}M$ and 10 ${\mu}M$). Results were compared to established reactivators pralidoxime, methoxime, HI-6, trimedoxime and obidoxime. More than 30 novel reactivators performed equal or better reactivation ability of POX-inhibited AChE compared to currently used reactivators. The structure-activity relationship for reactivators of paraoxon-inhibited AChE was developed.

• International Journal of Internet, Broadcasting and Communication
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• v.14 no.3
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• pp.101-107
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• 2022

In Korea, the military has been conducting counseling forthe preemptive detection of psychologically unstable soldiers to prevent unexpected accidents and to help them adapt to military life. However, several soldiers feel anxious about face-to-face counseling with military officers and they have difficulty expressing themselves. Video See-Through HMD is a state-of-the-art mixed reality device that converts the user's real view into a digital view, which leads users to feel the actual situation as the virtual. To validate its usefulness as a new psychological counseling aid, we investigated 11 army soldiers who are under the counseling program in barracks. During the counseling conversation, participants were asked to wear or take off the Video See-Through HMD repeatedly. All conversations were recorded for behavioral observation. As a result, 80% of the soldiers showed a relatively stable state of mind when wearing the Video See-Through HMD, which leads them to be innocent and frank about their concerns. This method could improve the effectiveness of counseling to prevent unexpected accidents caused by unnoticeable psychological instabilities of the clients.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.4
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• pp.1145-1149
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• 2012

Aim: To clarify any association between the hOGG1 Ser326Cys polymorphism and susceptibility to gastric cancer. Methods: A meta-analysis based on 11 eligible case-control studies involving 5,107 subjects was carried out to summarize the data on the association between hOGG1 Ser326Cys polymorphism and gastric cancer risk. Results: No association was found between hOGG1 Ser326Cys polymorphism and gastric cancer risk (dominant model: OR = 0.95, 95% CI: 0.83-1.09, p = 0.486, ph (p values for heterogeneity) = 0.419; additive model: OR = 1.02, 95% CI: 0.81-1.30, p = 0.850, ph = 0.181; recessive model: OR = 1.09, 95% CI: 0.80-1.48, p = 0.586, ph = 0.053). Subgroup analysis based on ethnicity (Asian and Caucasian) and smoking status (ever smoker and never smoker) did did notpresent any significant association. Sensitivity analysis did not perturb the results. Conclusions: This study strongly suggested there might be no association between the hOGG1 Ser326Cys polymorphism and gastric cancer risk. However, larger scale studies are needed for confirmation.

• Journal of the Society of Disaster Information
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• v.19 no.3
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• pp.471-480
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• 2023

Purpose: This study intends to present a future research direction for military education by identifying and analyzing research trends in the field of education related to soldiers in academic research published in Korea. Method: In domestic academic papers published from 2000 to 2022, 269 final papers were selected from among the papers conducted on the subjects of 'soldiers' and 'education'. The final selected literature was analyzed by categorizing it into year, research subject, research method type, number of researchers, research topic, and research content. Result: First, since 2010, the number of studies has gradually increased, and 31 articles were published in 2021, with the largest number of studies. Second, the largest number of studies were conducted on the entire military, followed by the Army and Nursing Officers. Third, qualitative research methods were used a little more in research methods. Fourth, the number of researchers with two or more researchers was steadily increasing. Fifth, most of the research topics were development, design, and improvement. Sixth, in terms of detailed research contents, most of the studies were related to soldiers' spirit(mental force) education and military education and training. Conclusion: Through this study, it was confirmed that military education was studied in various subjects. The direction of future research should be in-depth research from various perspectives with a lot of interest in military education and safety.