• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6131-6136
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• 2014

Objective: Epidemiology studies have reported conflicting results between glutathione S-transferase Mu-1 (GSTM1), glutathione S-transferase theta-1 (GSTT1) and glutathione S-transferase pi-1 (GSTP1) and ovarian cancer (OC) susceptibility. In this study, an updated meta-analysis was applied to determine whether the deletion of GSTM1, GSTT1 and GSTP1 has an influence on OC susceptibility. Methods: A published literature search was performed through PubMed, Embase, Cochrane Library, and Science Citation Index Expanded database for articles published in English. Pooled odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated using random or fixed effects models. Heterogeneity between studies was assessed using the Cochrane Q test and $I^2$ statistics. Sub-group analysis was conducted to explore the sources of heterogeneity. Sensitivity analysis was employed to evaluate the respective influence of each study on the overall estimate. Results: In total, 10 published studies were included in the final analysis. The combined analysis revealed that there was no significant association between GSTM1 null genotype and OC risk (OR=1.01, 95%CI: 0.91-1.12). Additionally, there was no significant association between GSTT1 genetic polymorphisms and OC risk (OR=0.98, 95% CI: 0.85-1.13). Similalry, no significant associations were found concerning the GSTP1 rs1695 locus and OC risk. Meanwhile, subgroup analysis did not show a significant increase in eligible studies with low heterogeneity. However, sensitivity analysis, publication bias and cumulative analysis demonstrated the reliability and stability of the current meta-analysis. Conclusions: These findings suggest that GSTs genetic polymorphisms may not contribute to OC susceptibility. Large epidemiological studies with the combination of GSTM1 null, GSTT1 null and GSTP1 Ile105Val polymorphisms and more specific histological subtypes of OC are needed to prove our findings.

• Clinical Endoscopy
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• 제55권2호
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• pp.167-182
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• 2022

Sedation can resolve anxiety and fear in patients undergoing endoscopy. The use of sedatives has increased in Korea. Appropriate sedation is a state in which the patient feels subjectively comfortable while maintaining the airway reflex for stable spontaneous breathing. The patient should maintain a state of consciousness to the extent that he or she can cooperate with the needs of the medical staff. Despite its benefits, endoscopic sedation has been associated with cardiopulmonary complications. Cardiopulmonary complications are usually temporary. Most patients recover without sequelae. However, they may progress to serious complications, such as cardiovascular collapse. Therefore, it is essential to screen high-risk patients before sedation and reduce complications by meticulous monitoring. Additionally, physicians should be familiar with the management of emergencies. The first Korean clinical practice guideline for endoscopic sedation was developed based on previous worldwide guidelines for endoscopic sedation using an adaptation process. The guideline consists of nine recommendations based on a critical review of currently available data and expert consensus when the guideline was drafted. These guidelines should provide clinicians, nurses, medical school students, and policy makers with information on how to perform endoscopic sedation with minimal risk.

• 정신신체의학
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• 제25권1호
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• pp.19-26
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• 2017

연구목적 본 연구는 그 동안 국내에서 진행된 폐쇄 기술 스포츠 종목의 인지불안과 경기 수행력의 관계를 종합적으로 분석하는데 목적을 두었다. 방법 본 연구에서 분석된 선정 연구는 1980년부터 2015년까지 국내에서 발표된 학술지 논문과 학위논문으로 설정하였다. 자료 수집을 위해 학술연구정보서비스(RISS), 한국학술정보(KISS), 국회도서관(NAL) 등을 이용하였으며, 검색을 위한 주요 사용 단어는 '골프', '양궁', '사격', '불안', '수행력' 그리고 '경기력' 이었다. 결과 최종 선정된 연구는 총 10편이었다. 폐쇄 스포츠 종목 선수들의 인지불안은 수행력의 부정적 영향을 미치는 것으로 나타났다(ESr=-.198). 성별에 따른 메타분석 결과, 남자선수(r=-.31)가 여자선수(r=-.05)에 비해 더 많은 인지불안을 가지고 있는 것으로 나타났다. 결론 본 연구는 폐쇄스포츠 종목 선수들의 인지불안과 수행력의 관계가 있다는 것을 시사하고 있다. 스포츠 선수의 심리적 측면과 관련된 향후 연구에서는 불안과 수행력의 관계에 대한 심층적인 결과를 제시해야 할 필요성이 있다.

• 정보관리연구
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• 제42권4호
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• pp.95-113
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• 2011

IT의 융합과 함께 시작된 새로운 천년을 맞이하면서 도서관 전문직은 새로운 변화에 적응하기 위해 지속적으로 기술개발과 평생학습을 위한 노력을 해야 하는 상황에 직면하고 있다. 이 논문은 인도의 도서관계에서 이러한 상황에서 실무와 교육을 위한 전문지식과 기술을 지속적으로 새로이 하기 위해 마련하고 있는 최신의 프로그램과 활동들을 분석하였다. 특히 이 논문에서는 인도가 가지고 있는 조직적인 인프라와 문헌정보학의 교육과 연구, 실무에 응용할 수 있는 새로운 분야들에 대해 집중적으로 살펴보았다. 이러한 프로그램과 이를 통해 얻은 잠재적인 능력들은 인도는 물론 서아시아를 포함한 인근국가의 프로그램개발과 인프라구축, 나아가서는 인력개발을 위한 협력에도 도움이 될 것이다.

• 정보관리연구
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• 제39권2호
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• pp.45-74
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• 2008

본 연구는 기록 정보 커뮤니케이션 증거적 기능을 보유한 연구노트의 중요성과 연구기록 물적 성격을 규명하여 연구윤리와 연구문화를 개선시키기 위한 올바른 연구노트 관리 제도화 방향을 알아보기 위해 시작되었다. 이를 위해 문헌분석과 설문분석으로 국내외 연구기관의 연구노트 제도, 서면 연구노트와 기록물관리, 전자 연구노트의 도입과 디지털 기록물로 나누어 국내 연구노트의 현황을 점검하였다. 연구노트가 법적 분쟁에 말려들 가능성, 증거적 요건 구비와 점검자의 서명, 자율적인 연구노트제도 운영의 한계, 30년간 보존의 어려움, 전자 연구노트 도입과 활용도 제고 등에 대해서는 연구노트 제도화를 위해 추가 검토가 필요하다. 연구결과 연구기관의 지식관리와 증거적 가치를 위한 연구노트 제도화, 관리부서의 예산확보는 물론 홍보 및 교육과 함께 공동 협력 대응, 특허나 기술이전과 관련시켜 연구노트에 대한 연구원들의 인식 전환, 지속적인 연구노트 작성 교육을 대학교에서부터 실시, 전자 연구노트를 연구실업무전산화시스템이나 연구과제관리시스템과 연계해 도입해야만 바람직한 연구노트 관리와 제도화가 가능하다.

• Clinical and Experimental Pediatrics
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• 제63권2호
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• pp.34-43
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• 2020

Phenylketonuria is a disease caused by congenital defects in phenylalanine metabolism that leads to irreversible nerve cell damage. However, its detection in the early days of life can reduce its severity. Thus, many countries have started disease screening programs for neonates. The present study aimed to determine the worldwide prevalence of classic phenylketonuria using the data of neonatal screening studies.The PubMed, Web of Sciences, Sciences Direct, ProQuest, and Scopus databases were searched for related articles. Article quality was evaluated using the Joanna Briggs Institute Critical Appraisal Evaluation Checklist. A random effect was used to calculate the pooled prevalence, and a phenylketonuria prevalence per 100,000 neonates was reported. A total of 53 studies with 119,152,905 participants conducted in 1964-2017 were included in this systematic review. The highest prevalence (38.13) was reported in Turkey, while the lowest (0.3) in Thailand. A total of 46 studies were entered into the meta-analysis for pooled prevalence estimation. The overall worldwide prevalence of the disease is 6.002 per 100,000 neonates (95% confidence interval, 5.07-6.93). The meta-regression test showed high heterogeneity in the worldwide disease prevalence (I²=99%). Heterogeneity in the worldwide prevalence of phenylketonuria is high, possibly due to differences in factors affecting the disease, such as consanguineous marriages and genetic reserves in different countries, study performance, diagnostic tests, cutoff points, and sample size.

• 성인간호학회지
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• 제22권3호
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• pp.260-270
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• 2010

Purpose: The main question is systematic review of the published in Korea and foreign countries on warming therapy for surgical patients. Methods: The researchers searched at Medline, CINAHL, KERIS, Adult Nursing Association, Korean Society of Nursing Science, Korean Academy of fundamentals of Nursing, and National Assembly Library web site for the published on warming therapy for surgical patients from 1980 to 2008. Words for search were operation/surgery, warming, operation/surgery and warming. Studies were included randomized controlled trial, and there were no restrictions regarding operative phase and outcome measures. Results: 36 published researches that met the criteria were mostly published in foreign countries between 2000 and 2008 and focused on surgery with general anesthesia. Sample size ranged from 21 to 60 subjects, age range between 21 and 60 years of age. Thirty different warming therapies were reported, fifty-two different dependent variables. Outcome indicators included active external warming, intra-operative, and body temperature. 'Positive effects' and 'no effects' equaled. The most frequently reported 'positive effects' were body temperature, shivering, and acid-base balance. No effects were more likely to be heart rate, blood pressure, and hemodynamics. Conclusion: Many types of warming therapy, are reported in the literature with little information about the efficacy of each, many different dependant variables were studied. There were no consistent reports as to length of time used for warming procedures. Overall, the effects of warming therapy are inconsistent. And additional research must be down before any particular method of warming can be used with confidence as to its effectiveness. Attention must be made as to the research design, better measurement of the dependent variables. This review may serve as a base.

• 생명과학회지
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• 제33권8호
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• pp.663-679
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• 2023

본 리뷰 논문은 2010년부터 2022년까지의 인공지능을 활용한 신약개발 관련 연구동향을 분석하여 정리하였다. 이러한 분석을 통해 2,421개 연구의 초록을 코퍼스로 구성하고, 전처리를 거쳐 빈도가 높고 연결 중심성이 높은 단어를 추출하였다. 분석 결과 2010-201년과 2020-2022년 단어빈도 추이는 비슷한 것으로 구분되어 나타났다. 연구 방법으로는 2010년부터 2020년까지 머신 러닝을 활용한 연구가 많이 진행되었고, 2021년부터는 딥러닝을 활용한 연구가 증가하고 있다. 이러한 연구를 통해 이루어지고 있는 인공지능 활용연구 동향에 대해 분야별로 살펴보고 관련 연구의 장점, 문제점, 도전과제 등을 살펴보았다. 파악되어진 연구 동향은 2021년 이후로 약물의 재배치를 인공지능 활용 연구, 항암제 개발을 위한 컴퓨터 활용 연구, 임상시험에 인공지능 적용 연구 등과 같이 인공지능 적용 분야가 확대되고 있다는 점이다. 이러한 과정을 통해 향후 이루어질 것으로 예상되는 인공지능 활용 신약개발 연구의 전망에 대해 간략히 제시하였다. 위의 인공지능 기술 발전과 함께 바이오와 의료데이터의 신뢰성과 안전성이 확보되어진다면 인공지능 활용 신약개발의 방향이 개인 맞춤형 의료와 정밀의료 분야로 진행되어질 것으로 판단하기에 이에 대한 지속적인 노력이 필요하리라 본다.

• 원예과학기술지
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• 제28권6호
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• pp.1025-1038
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• 2010

당근($Daucus$ $carota$ L. var. $sativa$)은 세계적으로 널리 이용되는 작물 중 하나이다. 또한 Vitamin A의 전구체인 ${\beta}$-carotene의 함량이 높아 영양적으로도 주요한 작물이다. 하지만 종자 표피세포에서 생성되는 종자모는 종자발아시 흡수를 저해하며 발아를 억제하여 기계적인 제모작업을 거쳐 상품화되고 있다. 이러한 과정에서 발생하는 여러가지 단점을 보완하기 위해 무모종자 당근 품종의 육종이 필요하다. 따라서 본 연구는 단모종자 표현형 CT-ATR615 OP 666-13 개체와 control 유모종자 표현형 CR-ATR615 OP-CK1-9개체의 종자 cDNA library를 작성하여 EST sequence비교를 통해 표현형의 차이에 따라 종자모 형성에 관련하여 발현양상을 비교 분석하였다. BlastX 결과를 바탕으로 개체간 동일한 결과를 제외한 EST sequence를 각각 FunCat 기능별 category로 분류하였다. Metabolism category에서 단모종자 표현형 개체가 오히려 유모종자 표현형 개체보다 높은 발현량을 보이는 것을 확인하였으며, 단모 및 장모종자 개체간의 protein folding and stabilization, subcellular localization category에서 나타난 뚜렷한 발현량 차이는 종자모 형성에 많은 영향을 미치는 것으로 예측되었다. 또한 분석된 EST sequece를 바탕으로 개체별로 각각 50개 및 59개의 SSR site를 확인하였으며, 각각 2개씩의 SNP site를 확인하였다. 이들 SSR 및 SNP site의 primer 작성하여 마커로 개발하였으며, 이를 종자모 형성에 관련된 분자마커 개발에 이용하는 것은 물론 당근의 계통 분류 및 여러가지 형질 관련 분자 마커 연구에 활용 가능할 것으로 기대된다.

• 대한물리치료과학회지
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• 제18권4호
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• pp.31-46
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• 2011

The purpose of this survey was to give data and information about type and needs of Home Physical Therapy, Visiting Physical Therapy and School Physical Therapy for physical and nurse. The subjects were 154(99 physical therapists and 55 nurses) who were working at geriatric rehabilitation hospitals and children hospitals. The period of questionary collection was from the 15 of August to the 15th of September 2011. And data was analysis from 99 articles such as journals related to physical therapy, and searched with keyword 'home and visiting physical therapy' by web site and Korea National Assembly Library from 1991 to 2011. The data was analysis with percentage, mean, standard deviation and ANOVA by SPSS PC 12.0. The results were as follows; 1. The definition of 'Home Physical Therapy' has been community based on physical therapy service for the patient who had diagnosis by medical doctor, has been based on medical law. The definition of 'Visiting Physical Therapy' has been community based on physical therapy service at home for the patient who had diagnosis by medical doctor, for the national basic living security, and senior citizen over 65 years who lives alone, has been based on law for community health and law of long term health insurance. The definition of 'School Physical Therapy' has been school based on physical therapy service at school after class for the disabled children who are studying at school, has been based on special education law article 28. 2. As for the knowledge of the Home and Visiting and School Physical Therapy, both groups PT and nurse were 'I do not know'125(81.3%) of the difference the concept of 3 definitions, so it means to need education and information about the different concept of three physical therapy. As for the needs of home and visiting physical therapy, both groups of PT and Nurse were 'needs' 151(98.1%). Physical therapist showed of 'Needs' on visiting physical therapy 35(35.4%), home physical therapy 32(32.3%), and schole physical therapy 32(32.3%). Nurse showed of 'Needs' on home physical therapy 23(41.8%). visiting physical therapy 19(34.5%), school physical therapy 13(23.6%). Therefore it is necessary to have home and visiting physical therapy as for the elderly and disabled person. 3. As for the qualification of Home and Visiting physical therapist, both PT and nurse groups showed as follows; take post graduation education program for home and visiting therapy after became PT : home physical therapist 108(70.1%), visiting physical therapist 106(68.8%). So it means education center or university can be developed post graduation program for home and visiting physical therapist. 4. As for the 'Needs' of school physical therapy, both groups of PT and nurse showed as follows; 'Needs' 142(92.2%), 'Needs superviser education program' 148(96.1%), in PT group showed 'I will participate of education program' 92(92.9%). 5. As for the present states of research papers or report of home, visiting, and school physical therapy was as follows; the 103 papers for 8 fields about' the needs of home and visiting physical therapy' from 1991 to 2011, the 13 papers for 2 fields about school physical therapy from 2001 to 2011, so total papers were 114 articles.