• BMB Reports
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• v.57 no.6
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• pp.281-286
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• 2024

Adult hippocampal neurogenesis plays a pivotal role in maintaining cognitive brain function. However, this process diminishes with age, particularly in patients with neurodegenerative disorders. While small, non-coding microRNAs (miRNAs) are crucial for hippocampal neural stem (HCN) cell maintenance, their involvement in neurodegenerative disorders remains unclear. This study aimed to elucidate the mechanisms through which miRNAs regulate HCN cell death and their potential involvement in neurodegenerative disorders. We performed a comprehensive microarray-based analysis to investigate changes in miRNA expression in insulin-deprived HCN cells as an in vitro model for cognitive impairment. miR-150-3p, miR-323-5p, and miR-370-3p, which increased significantly over time following insulin withdrawal, induced pronounced mitochondrial fission and dysfunction, ultimately leading to HCN cell death. These miRNAs collectively targeted the mitochondrial fusion protein OPA1, with miR-150-3p also targeting MFN2. Data-driven analyses of the hippocampi and brains of human subjects revealed significant reductions in OPA1 and MFN2 in patients with Alzheimer's disease (AD). Our results indicate that miR-150-3p, miR-323-5p, and miR-370-3p contribute to deficits in hippocampal neurogenesis by modulating mitochondrial dynamics. Our findings provide novel insight into the intricate connections between miRNA and mitochondrial dynamics, shedding light on their potential involvement in conditions characterized by deficits in hippocampal neurogenesis, such as AD.

• Journal of the Korea Society of Computer and Information
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• v.29 no.7
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• pp.159-167
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• 2024

This study analyzed the survey data of 162 rescuers working in G Special Self-Governing Province to find out the effect of the transactional and transformational leadership of 119 rescuer leaders on life satisfaction. As a result of analysis through multiple regression analysis, it was found that the life satisfaction of 119 rescuers was greatly influenced by the leadership style of their leaders. It has been confirmed that transformational and transactional leadership are not independent of each other, and that the appropriate balance of these two leadership approaches has a positive effect on the life satisfaction and organizational life of the rescuers. Therefore, the 119 rescuers' team leaders should create an environment in which transformational and transactional leadership can be balanced. Specifically, transformational leadership should be exercised through individualized consideration, intellectual stimulation, and inspirational motivation, while at the same time improving transactional leadership by establishing a reward system based on performance. Through this, it is expected that the quality of rescue service at the site will be improved by increasing the life satisfaction of 119 rescuers and laying the foundation for them to demonstrate their potential capabilities. The findings of this study provide practical implications for improving the quality of life and organizational performance of 119 rescuers.

• Industry Promotion Research
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• v.9 no.1
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• pp.89-101
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• 2024

The purpose of this study is to examine the relationship between parental/parental attachment and career indecision among college students, and to examine the goodness of fit and influence of variables in a model that assumes that socially imposed perfectionism has an influence on the relationship between parental/parental attachment and career indecision. It's about verification. For this purpose, an online survey was conducted by randomly sampling 250 college students attending 4-year institutions across the country, and data analysis was conducted using a three-stage regression method using SPSS Win 25.0. The analysis results are as follows. First, psychological attachment to parents appears to have a negative effect on career indecision, confirming that the more a stable attachment relationship with parents is formed, the less difficulties in career decision-making. Second, the mediating effect of socially imposed perfectionism was confirmed in the relationship between psychological attachment to parents and career indecision. This shows that the more stable the psychological attachment to the father and mother is formed, the lower the level of socially imposed perfectionism and career indecision. Based on these research results, implications for career counseling practice and follow-up research were discussed.

• Information Systems Review
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• v.19 no.4
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• pp.87-110
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• 2017

Analyzing and finding the risk factors in information technology (IT) projects have been discussed because risk management is an important issue in IT project management. This study obtained the risk factor checklists with priorities, analyzed the causal relationship of risk factors, and determined their influences on IT project management. However, only few studies systematically classified IT project risk factors in terms of risk exposure. These studies considered both the probability of occurrence and the degree of risk simultaneously. The present study determined 53 IT project risk factors on the basis of literature and expert group discussions. Additionally, this study presented clustering analysis based on the data of 140 project managers. The IT project risk factor classification framework was divided into four areas (HIHF, HILF, LIHF, and LILF). The present results can be used to help IT project managers establish effective risk management strategies and reduce IT project failures. This study also provides academic implication because it considers both the probability of occurrence and the degree of influence of risk factors.

• Journal of Practical Agriculture & Fisheries Research
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• v.26 no.1
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• pp.22-29
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• 2024

In this study, we summarized the definition of smart vegetable seedling production technology, analysis of smart seedling production system, a hardware and software configuration model for smart seedling production system, research and development trends in smart seedling production system, and proposed future research and development plans for smart seedling production technology. Smart vegetable seedling production is a data-based seedling production, management, and distribution system that utilizes 4th Industrial Revolution technology to improve seedling productivity and quality. The production of vegetable seedlings using smart seedling production technology can be efficiently managed by collecting, analyzing, and managing information on seedlings, environment, and tasks at each stage of production by linking with the smart seedling integrated management system. However, there is still a lack of standardization of seedling standards and quality for each vegetable crop to establish smart seeding production technology, as well as development of smart seedling production element technology, which requires national wide R&D support.

• Nuclear Engineering and Technology
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• v.55 no.11
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• pp.4274-4281
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• 2023

Blanket is of vital importance for engineering application of the fusion reactor. Nuclear heat deposition in materials is the main heat source in blanket structure. In this paper, the three-dimensional method for thermal-hydraulics/neutronics coupling analysis is developed and applied for the full-scale module of the helium-cooled ceramic breeder tritium breeding blanket (HCCB TBB) designed for China Fusion Engineering Test Reactor (CFETR). The explicit coupling scheme is used to support data transfer for coupling analysis based on cell-to-cell mapping method. The coupling algorithm is realized by the user-defined function compiled in Fluent. The three-dimensional model is established, and then the coupling analysis is performed using the paralleled Coupling Analysis of Thermal-hydraulics and Neutronics Interface Code (CATNIC). The results reveal the relatively small influence of the coupling analysis compared to the traditional method using the radial fitting function of internal heat source. However, the coupling analysis method is quite important considering the nonuniform distribution of the neutron wall loading (NWL) along the poloidal direction. Finally, the structure optimization of the blanket is carried out using the coupling method to satisfy the thermal requirement of all materials. The nonlinear effect between thermal-hydraulics and neutronics is found during the blanket structure optimization, and the tritium production performance is slightly reduced after optimization. Such an adverse effect should be thoroughly evaluated in the future work.

• Journal of Korean Society for Quality Management
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• v.51 no.4
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• pp.531-550
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• 2023

Purpose: The unique nature of life-and-death healthcare services sets them apart from other service industries. While many studies exist on the relationship between healthcare services and customer satisfaction, most of them focus on mildly ill patients, ignoring the differences between critically ill and non-seriously ill patients. This study discusses the actual quality of healthcare services for patients who are facing life-threatening illnesses and are on life support, as well as their right to protection and dignity. Methods: The survey conducted to 149 patients with the four major illnesses: cancer, heart disease, brain disease and rare and incurable disease, those who have experiences with senior general hospitals. Results: The basic statistics of this study are adequate to represent the four major critical illnesses, and the reliability and validity of this study's hypotheses, which were measured by multiple items, were analyzed, and the internal consistency was judged to be high. In addition, it was found that the convergent validity was good and the discriminant validity was also secured. When examining the goodness of fit of the hypotheses, the SRMR, which is the standardized root mean square of residuals that measures the difference between the covariance matrix of the data variables and the theoretical covariance matrix structure of the model, met the optimal criteria. Conclusion: The academic implications of this study are differentiated from other studies by moving away from evaluating the quality of healthcare services for mildly ill patients and focusing on the rights and dignity of patients with life-threatening illnesses in four senior general hospitals. In terms of academic implications, this study enriches the depth of related studies by demonstrating the right to protection and dignity as a factor of patient-centeredness based on physical environment quality, interaction quality, and outcome quality, which are presented as sub-factors of healthcare quality. We found that the three quality factors classified by Brady and Cronin (2001) are optimized for healthcare quality assessment and management, and that the results of patients' interaction quality assessment can be used to provide a comprehensive quality rating for hospitals. Health and human rights are inextricably linked, so assessing the degree to which rights and dignity are protected can be a superior and more comprehensive measurement tool than traditional health level measures for healthcare organizations. Practical implications: Improving the quality of the physical environment and the quality of outcomes is an important challenge for hospital managers who attract patients with life and death conditions, but given the scale and economics of time, money, and human inputs, improving the quality of interactions and defining them as performance indicators in hospital quality management is an efficient way to create maximum value in the short term.

• Korean Journal of Environmental Biology
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• v.42 no.2
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• pp.193-206
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• 2024

This study aimed to quantify changes in forest cover and carbon storage of Korean Peninsular during the last two decades by integrating field measurement, satellite remote sensing, and modeling approaches. Our analysis based on 30-m Landsat data revealed that the forested area in Korean Peninsular had diminished significantly by 478,334 ha during the period of 2000-2019, with South Korea and North Korea contributing 51.3% (245,725 ha) and 48.6% (232,610 ha) of the total change, respectively. This comparable pattern of forest loss in both South Korea and North Korea was likely due to reduced forest deforestation and degradation in North Korea and active forest management activity in South Korea. Time series of above ground biomass (AGB) in the Korean Peninsula showed that South and North Korean forests increased their total AGB by 146.4Tg C (AGB at 2020=357.9Tg C) and 140.3Tg C (AGB at 2020=417.4Tg C), respectively, during the last two decades. This could be translated into net AGB increases in South and North Korean forests from 34.8 and 29.4 Mg C ha^-1 C to 58.9(+24.1) and 44.2(+14.8) Mg C ha^-1, respectively. It indicates that South Korean forests are more productive during the study period. Thus, they have sequestered more carbon. Our approaches and results can provide useful information for quantifying national scale forest cover and carbon dynamics. Our results can be utilized for supporting forest restoration planning in North Korea

• Industry Promotion Research
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• v.9 no.3
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• pp.295-309
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• 2024

With the implementation of the Northeast Revitalization Strategy, the tourism industry in Heilongjiang Province had an increasingly greater impact on regional economic development. Based on the tourism panel data of Heilongjiang Province from 2005 to 2021, this paper used DEA-BCC and Malmquist Index to analyze the static and dynamic changes of the tourism industry.The results of the study were as follows: (1) Static: The OE value reached strong DEA effectiveness in 2010, 2013, and 2019, indicated that tourism resources had been fully utilized. The SE value changed dramatically between 0.354 and 1, and the PTE value approached 1. OE was mainly affected by SE changes. (2) Dynamic: The total factor productivity (TFP) was overall greater than 1 and grew at an average annual rate of 13.8%. The variation in TFP was primarily influenced by the index of technological progress, indicated that the tourism industry in Heilongjiang Province made full use of technology for resource development, with a relatively high level of development efficiency. Therefore, the future focus of Heilongjiang Province's tourism industry will be on adjustments in industrial scale, technological innovation, and policy optimization.

• Journal of Preventive Medicine and Public Health
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• v.57 no.4
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• pp.327-338
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• 2024

Objectives: Estimating the number of deaths caused by smoking is crucial for developing and evaluating tobacco control and smoking cessation policies. This study aimed to determine smoking-attributable mortality (SAM) in Korea in 2020. Methods: Four large-scale cohorts from Korea were analyzed. A Cox proportional-hazards model was used to determine the hazard ratios (HRs) of smoking-related death. By conducting a meta-analysis of these HRs, the pooled HRs of smoking-related death for 41 diseases were estimated. Population-attributable fractions (PAFs) were calculated based on the smoking prevalence for 1995 in conjunction with the pooled HRs. Subsequently, SAM was derived using the PAF and the number of deaths recorded for each disease in 2020. Results: The pooled HR for all-cause mortality attributable to smoking was 1.73 for current men smokers (95% confidence interval [CI], 1.53 to 1.95) and 1.63 for current women smokers (95% CI, 1.37 to 1.94). Smoking accounted for 33.2% of all-cause deaths in men and 4.6% in women. Additionally, it was a factor in 71.8% of men lung cancer deaths and 11.9% of women lung cancer deaths. In 2020, smoking was responsible for 53 930 men deaths and 6283 women deaths, totaling 60 213 deaths. Conclusions: Cigarette smoking was responsible for a significant number of deaths in Korea in 2020. Monitoring the impact and societal burden of smoking is essential for effective tobacco control and harm prevention policies.