• IMMUNE NETWORK
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• v.21 no.4
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• pp.30.1-30.12
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• 2021

High expression of mitofusin-2 (MFN2), a mitochondrial fusion protein, has been frequently associated with poor prognosis of patients with cervical cancer. Here, we aimed to identify the function of MFN2 in cervical cancer to understand its influence on disease prognosis. To this end, from cervical adenocarcinoma, we performed an MTT assay and quantitative RT-PCR (qRT-PCR) analysis to assess the effects of MFN2 on the proliferation and of HeLa cells. Then, colony-formation ability and tumorigenesis were evaluated using a tumor xenograft mouse model. The migration ability related to MFN2 was also measured using a wound healing assay. Consequently, epithelial-mesenchymal transition (EMT) of MFN2-knockdowned HeLa cells originating from adenocarcinoma. markers related to MFN2 were assessed by qRT-PCR. Clinical data were analyzed using cBioPortal and The Cancer Genome Atlas. We found that MFN2 knockdown reduced the proliferation, colony formation ability, migration, and in vivo tumorigenesis of HeLa cells. Primarily, migration of MFN2-knockdowned HeLa cells decreased through the suppression of EMT. Thus, we concluded that MFN2 facilitates cancer progression and in vivo tumorigenesis in HeLa cells. These findings suggest that MFN2 could be a novel target to regulate the EMT program and tumorigenic potential in HeLa cells and might serve as a therapeutic target for cervical cancer. Taken together, this study is expected to contribute to the treatment of patients with cervical cancer.

• Journal of the Korea institute for structural maintenance and inspection
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• v.23 no.7
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• pp.66-71
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• 2019

In this paper, a study was conducted on the method of using GPR data to predict rebar thickness inside a facility. As shown in the cases of poor construction, such as the use of rebars below the domestic standard and the construction of reinforcement, information on rebar thickness can be found to be essential for precision safety diagnosis of structures. For this purpose, the B-scan data of GPR was obtained by gradually increasing the diameter of rebars by making specimen. Because the B-scan data of GPR is less visible, the data was converted into the heatmap image data through migration to increase the intuition of the data. In order to compare the results of application of commonly used B-scan data and heatmap data to CNN, this study extracted areas for rebars from B-scan and heatmap data respectively to build training and validation data, and applied CNN to the deployed data. As a result, better results were obtained for the heatmap data when compared with the B-scan data. This confirms that if GPR heatmap data are used, rebar thickness can be predicted with higher accuracy than when B-scan data is used, and the possibility of predicting rebar thickness inside a facility is verified.

• 한국지구물리탐사학회:학술대회논문집
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• 2009.05a
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• pp.67-71
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• 2009

The high resolution seismic data processing essentially requires the latest data processing technology with a system which enables to calculate the large volume of input/output and computing of data. Nowadays, there is a high foreign dependency on the data processing and QC. In this research, The test processing had been carried out to deduce the best suited software by evaluating functionality, usability and user environment. And several attempts are made to select the most appropriated specification of hardware in order to maximize the software efficiency. The results showed that more numbers of multiple and noise were eliminated in existing prestack time migration sections, which effectively enhanced the resolution.

• Geophysics and Geophysical Exploration
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• v.5 no.3
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• pp.178-184
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• 2002

For economy and convenience, seismic refraction survey is widely used in surveying for large civil engineering work. The purpose of this study is to obtain the numerical responses of various models using Kirchhoff migration, and to analyze its application to the real data processing. Synthetic traveltime curve was calculated by vidale's algorithm, and various models such as 2 or 3 layer model and irregular topography model are tested to simulate the response of real structure. In order to compare the effect of initial velocity model, true velocity models, inversion results by tomography, smooth velocity models are used as an initial guess. The responses of model data show that the algorithm of this study is more sensitive to initial velocity model than the reflection survey, so choosing a suitable initial velocity model will be the most important thing in real data processing.

• Journal of Radiation Protection and Research
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• v.44 no.4
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• pp.128-148
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• 2019

Massive environmental monitoring has been conducted continuously since the Fukushima Daiichi Nuclear Power accident in March of 2011 by different monitoring methods that have different features together with migration studies of radiocesium in diverse environments. These results have clarified the characteristics of radiological environments and their temporal change around the Fukushima site. At three months after the accident, multiple radionuclides including radiostrontium and plutonium were detected in many locations; and it was confirmed that radiocesium was most important from the viewpoint of long-term exposure. Radiation levels around the Fukushima site have decreased greatly over time. The decreasing trend was found to change variously according to local conditions. The air dose rates in environments related to human living have decreased faster than expected from radioactive decay by a factor of 2-3 on average; those in pure forest have decreased more closely to physical decay. The main causes of air dose rate reduction were judged to be radioactive decay, movement of radiocesium in vertical and horizontal directions, and decontamination. Land-use categories and human activities have significantly affected the reduction tendency. Difference in the air dose rate reduction trends can be explained qualitatively according to the knowledge obtained in radiocesium migration studies; whereas, the quantitative explanation for individual sites is an important future challenge. The ecological half-lives of air dose rates have been evaluated by several researchers, and a short-term half-life within 1 year was commonly observed in the studies. An empirical model for predicting air dose rate distribution was developed based on statistical analysis of an extensive car-borne survey dataset, which enabled the prediction with confidence intervals. Different types of contamination maps were integrated to better quantify the spatial data. The obtained data were used for extended studies such as for identifying the main reactor that caused the contamination of arbitrary regions and developing standard procedures for environmental measurement and sampling. Annual external exposure doses for residents who intended to return to their homes were estimated as within a few millisieverts. Different forms of environmental data and knowledge have been provided for wide spectrum of people. Diverse aspects of lessons learned from the Fukushima accident, including practical ones, must be passed on to future generations.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.9 no.12
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• pp.4759-4775
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• 2015

The reduction of power consumption in large-scale datacenters is highly-dependent on the use of virtualization to consolidate multiple workloads. However, these consolidation strategies must also take into account additional important parameters such as performance, reliability, and profitability. Resolving these conflicting goals is often the major challenge encountered in the design of optimization strategies for cloud data centers. In this paper, we put forward a data center monitoring strategy which dynamically alters its approach depending on the cloud system's current state. Results show that our proposed scheme outperformed strategies which only focus on a single metric such as SLA-Awareness and Energy Efficiency.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.16
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• pp.6543-6546
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• 2014

MicroRNAs (miRNAs) act as critical regulators of genes involved in many biological processes. Aberrant alteration of miRNAs have been found in many cancers, including gastric cancer (GC), but the molecular mechanisms are not well understood. Herein, we investigated the role of miR-124 in GC. We found that its expression was significantly reduced in both GC tissue samples and cell lines. Forced expression of miR-124 suppressed GC cell proliferation, migration, and invasion. Furthermore, the Rho-associated protein kinase (ROCK1) was identified as a direct target of miR-124 in GC cells. Finally, silencing of ROCK1 showed similar effects as miR-124 overexpression, while supplementation of ROCK1 remarkably restored the cell growth and invasion inhibited by miR-124. Together, our data demonstrate that miR-124 acts as a tumor suppressor by targeting ROCK1, and posit miR-124 as a novel strategy for GC treatment.

• Nutrition Research and Practice
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• v.9 no.3
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• pp.304-312
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• 2015

BACKGROUND/OBJECTIVES: International students face dissimilar food environments, which could lead to changes in dietary behaviors and anthropometric characteristics between before and after migration. We sought to examine the risk factors, including dietary behaviors, acculturation, and demographic characteristics, related to overweight subjects residing in South Korea. SUBJECTS/METHODS: We conducted a cross-sectional study, collecting data from 142 Chinese international students (63 males, 79 females) in 2013. RESULTS: The mean age of the subjects was 25.4 years, and almost half of them immigrated to South Korea to earn a master's degree or doctoral degree (n = 70, 49.3%). Chinese international students showed an increase in skipping meals and eating speed, but a decrease in the frequency of fruit and vegetable consumption in South Korea compared to when they lived in China. We found a statistically significant increase in weight (69.4 ${\rightarrow}$ 73.9 kg) and BMI (22.4 ${\rightarrow}$ $23.8kg/m^2$) for male subjects (P < 0.001) but no change for female subjects. We also found that overweight subjects were more likely to be highly acculturated and male compared with normal-weight subjects. CONCLUSION: Among Chinese international students living in South Korea, male and more highly acculturated subjects are more vulnerable to weight gain. This study provides useful information to design tailored nutrition intervention programs for Chinese international students.

• KSBB Journal
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• v.27 no.5
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• pp.295-300
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• 2012

Matured dendritic cells (DCs) begin migration with their release from the bone marrow (BM) into the blood and subsequent traffic into peripheral lymphoid and non-lymphoid tissues. Throughout this long movement, migrating DCs must apply specialized skills to reach their target destination. Non-invasive in vivo cell-tracking techniques are necessary to advance immune cell-based therapies. In this study, we used a DiD cell-tracking solution for in vivo dendritic cell tracking in naive mice. We tracked DiD (non-invasive fluorescence dye)-labeled mature dendritic cells using the Near Infrared (NIR) imaging system in normal mice. We examined the immunophenotype of DiD-labeled cells compared with non-labelled mature DCs, and obtained time-serial images of NIR-DC trafficking after mouse footpad injection. In conclusion, we confirmed that DiD-labeled DCs migrated into the popliteal lymph node 24 h after the footpad injection. Here, these data suggested that the cell tracking system with the stable fluorescence dye DiD was useful as a cell tracking tool to advance dendritic cell-based immunotherapy.

• Journal of the Korean institute of surface engineering
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• v.29 no.6
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• pp.753-759
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• 1996

The artificial construction of well-defined low-dimensional (low-D) quantum structures, such as quantum wire (QWR) still attracts attention of many researchers due to their applications in room-temperature optoelectronic devices. In this work, the migration enhanced epitaxial growth (MEE) and the analysis of InAs/ AlAs QWR are reported. On the vicinal semi-insulating InP substrate of $3^o$ tilted cut from (100) surface towards (010) direction, InAs/ AlAs QWR superlattices have been successfully grown by MEE with the introduction of growth interruption at each shutter operation of MBE cell. The in-situ RHEED analyses show that MEE gives superior step-flow growth (SFG) and sharper interface formation over a conventional MBE growth. We have grown 4 samples in series varying the growth temperature. The QWR samples are analyzed by photoluminescence (PL) and atomic force microscopy (AFM). From the AFM images, we can get the definitely resolved 1-D structures. This structure is believed to be due to the MEE method and its separation is better than any other data from others. We are now studying the dependence of the structure on the growth temperature.