• Journal of Korean Society of Industrial and Systems Engineering
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• v.22 no.50
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• pp.231-241
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• 1999

Recent market competition forces the price to be determined in the design stage so that the design would meet the target price of the product. However, most commercial PDM(Product Data Management) systems currently in use lack such a cost estimation function. In this paper, we propose detailed structure and functions of a new approach to estimate the cost of new products using integrated BOM in PDM. Such system will reduce the total life cycle cost of the products to be designed.

• Proceedings of the Safety Management and Science Conference
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• 2004.05a
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• pp.277-281
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• 2004

The establishment and application of risk management system is one of the current issues in world-wide leading companies. Poor risk management might bring large-scale accident in construction industry by its features(large scale, diversity). Standardization system and standard for risk should be managed timely. In this paper, we do comparative analysis of standardization systems and standards concerned on risk, so thus present basic data for safety reinforcement and risk zero in the construction life cycle process.

• IE interfaces
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• v.10 no.3
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• pp.109-116
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• 1997

Document management system is a tool, based on the document life cycle concept, for structured management of various documents within an organization. In this paper, we address a development process of document management system based on SGML. We have developed a document management system which can support a variety of types in documents such as informal data, HTML, CGI and so on. Using the developed system, users can access documents in the system through an internet browser, and also add or modify existing documents.

• International conference on construction engineering and project management
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• 2007.03a
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• pp.417-423
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• 2007

This paper describes how using the XPS Document technologies of Windows Vista support and enhances interactions with the structural design and construction process. It illustrates the document workflows and the document life cycle in a typical construction base knowledge system. It provides engineers and decision makers and implementers with information about this new technology and how they can apply it to their design and construction models. The paper also highlights opportunities for the new format of data exchange in the recent efforts to develop National Management System Standards for Transportation Applications to benefit from these emerging technologies.

• Biomolecules & Therapeutics
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• v.21 no.2
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• pp.114-120
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• 2013

Most patients with mutant B-Raf melanomas respond to inhibitors of oncogenic B-Raf but resistance eventually emerges. To better understand the mechanisms that determine the long-term responses of mutant B-Raf melanoma cells to B-Raf inhibitor, we used chronic selection to establish B-Raf (V600E) melanoma clones with acquired resistance to the new oncogenic B-Raf inhibitor UI-152. Whereas the parental A375P cells were highly sensitive to UI-152 ($IC_{50}$ < $0.5{\mu}M$), the resistant sub-line (A375P/Mdr) displayed strong resistance to UI-152 ($IC_{50}$ < $20{\mu}M$). Immunofluorescence analysis indicated the absence of an increase in the levels of P-glycoprotein multidrug resistance (MDR) transporter in A375P/Mdr cells, suggesting that resistance was not attributable to P-glycoprotein overexpression. In UI-152-sensitive A375P cells, the anti-proliferative activity of UI-152 appeared to be due to cell-cycle arrest at $G_0/G_1$ with the induction of apoptosis. However, we found that A375P/Mdr cells were resistant to the apoptosis induced by UI-152. Interestingly, UI-152 preferentially induced autophagy in A375P/Mdr cells but not in A375P cells, as determined by GFP-LC3 puncta/cell counts. Further, autophagy inhibition with 3-methyladenine (3-MA) partially augmented growth inhibition of A375P/Mdr cells by UI-152, which implies that a high level of autophagy may protect UI-152-treated cells from undergoing growth inhibition. Together, our data implicate high rates of autophagy as a key mechanism of acquired resistance to the oncogenic B-Raf inhibitor, in support of clinical studies in which combination therapy with autophagy targeted drugs is being designed to overcome resistance.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.12
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• pp.5121-5126
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• 2016

Objective: To investigate the impact of chemotherapy on quality of life (QoL) among breast cancer patients and to evaluate the relationship with age, cancer stage and presence of any comorbidity. Methods: A prospective study was conducted among breast cancer patients receiving chemotherapy in Hospital Melaka from 1st January 2014 to 31st July 2014. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) was given to patients to fill in prior chemotherapy (baseline) and after the third cycle of chemotherapy. Socio-demographic and clinical data were collected and analyzed using SPSS version 20. Result: Respondents were 32 female patients [mean age (SD): 49.7(9.93) years]. They reported a significant lower global health status (P < 0.01) and significant higher symptoms of nausea and vomiting (P < 0.01), loss of appetite (P = 0.028) and diarrhea (P = 0.026) after the third cycle of chemotherapy as compared to baseline. Compare to, this study showed significant better emotional functioning (P < 0.01) and social functioning (P < 0.01) than the EORTC QLQ-C30 Reference Values 2008 for breast cancer cases. Under symptom scales higher scores were noted for appetite loss (P = 0.017), nausea and vomiting (P < 0.01). Age, stage and comorbidity had no clear associations with global health status in our patients (P > 0.05). Conclusion: Chemotherapy did reduce the QoL of breast cancer patients. Management of chemotherapy-induced loss of appetite, diarrhea, nausea and vomiting should be improved for a better outcome.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.4
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• pp.263-272
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• 2021

This study investigated the oral health knowledge and educational needs of adults by life cycle. We aimed to provide basic data for developing oral health education plans for well -aging. The survey was conducted online and through mobiles by Gallup Korea during February 2021. A total of 319 adults over the age of 19 were surveyed. The study aimed at investigating the general characteristics, the quality of life-related to oral health, knowledge of oral health, and the need for well-aging education. The PASW Statistics ver 18.0 statistical program was used for data analysis. The analysis of the data suggests that prevention was the highest priority among all age groups. Furthermore, there was a difference in the perceived educational need among different age groups. The cause of the youth, the treatment of the middle-aged and the elderly were significantly related to oral and systemic disease. The need for education related to oral diseases was ranked in the order of aches, bad breath, periodontal diseases, and tooth discoloration. For information, the subjects reached out to the internet, dental and medical institutions, and public health centers. The teaching methods experienced by those surveyed included lectures combined with experience, videos, and expert lectures. We believe that this study can be used to develop an education plan that reflects the needs of the subjects when conducting life cycle education for well-aging.

• Journal of the Korea Safety Management & Science
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• v.2 no.3
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• pp.129-140
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• 2000

Nowadays the role of information systems is getting more and more increased according to the development of information technology. In order to manage complex, various and huge data, it is vital to construct efficient information system. For this effective information system, data have properly to be stored, encoded and represented when needed. This paper presents equipment management information system using wireless application protocol. This system enables us to have remote control of data searching and data management. Also, through the technique of data mining, database resulted from this system can be utilized into expectation and analysis about life-cycle, characteristic, and failure time of equipment, pattern recognition of users, and state of movement, etc.

• KIPS Transactions on Software and Data Engineering
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• v.5 no.3
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• pp.117-124
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• 2016

The demands for additional functionalities and improvements in performance of software increase over time. In particular, increases in software complexity and requirements for quality control attributed to continued maintenance lead to the deterioration of software quality and raises in software life cycle costs. In order to prevent this, software operators have to conduct timely redevelopment of the software. However, the scope of previous studies on timely redevelopment of software is limited to enterprises. We, in this study, suggest a model to derive the optimal cycle for the redevelopment of governmental agency software using Renewal process and discuss its correlation with previous studies.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2011.05a
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• pp.27-30
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• 2011

Analysis data of basics which are used for LCC(Life Cycle Cost) analysis of buildings and maintenance plan, are demanded to secure according as replacement cycle of repairs of apartment houses has come. However, investigation techniques and systems for investigating condition of deterioration of apartment houses, have not been made yet in Korea. For this reason, this study was wanted to make investigation techniques and systems, so the process for maintenance of apartment houses was researched and the required quality and deterioration factors of interior/exterior materials were investigated. As a result Check-List for investigating condition of deterioration, was made. if this is used during a nonscheduled, a routine, a regular and a urgency check, the methodical investigation will be achieved. Furthermore, if this is used for maintenance of apartment houses, it will be helped to select the repair cycle and the long-term repair plan.