• 대한의생명과학회지
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• 제15권1호
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• pp.1-8
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• 2009

Human genomic DNA is continuously attacked by oxygen radicals originated from cellular metabolic processes and numerous environmental carcinogens. 2-deoxyribonolactone (dL) is a major type of oxidized abasic (AP) lesion implicated in DNA strand scission, mutagenesis, and formation of covalent DNA-protein crosslink (DPC) with DNA polymerase (Pol) ${\beta}$. We show here that human DNA polymerase (Pol)${\iota}$ and mitochondrial $Pol{\gamma}$ give rise to stable DNA-protein crosslink (DPC) formation that is specifically mediated by dL lesion. $Pol{\gamma}$ mediates DPC formation at the incised dL residue by its 5'-deoxyribose-5-phosphate (dRP) lyase activity, while $Pol{\gamma}$ cross links with dL thorough its intrinsic dRP lyase and AP lyase activities. Reactivity in forming dL-mediated DPC was significantly higher with $Pol{\gamma}$ than with $Pol{\iota}$. DPC formation by $Pol{\gamma}$, however, can be reduced by an accessory factor of $Pol{\gamma}$ holoenzyme that may attenuate deleterious effects of crosslink adducts on mitochondrial DNA. Comparative kinetic analysis of DPC formation showed that the rate of DPC formation with either $Pol{\iota}$ or $Pol{\gamma}$ was lower than that with $Pol{\beta}$. These results revealed that the activity of catalytic lyase in DNA polymerases determine the efficiency of DPC formation with dL damages. Irreversible crosslink formation of such DNA polymerases by dL lesions may result in a prolonged strand scission and a suicide of DNA repair proteins, both of which could pose a threat to the genetic and structural integrity of DNA.

• 한국의학물리학회지:의학물리
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• 제29권4호
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• pp.157-163
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• 2018

Plans converted using dose-volume-histogram-based plan conversion (DPC) were evaluated by comparing them to the original plans. Changes in the dose volumetric (DV) parameters of five volumetric modulated arc therapy (VMAT) plans for head and neck (HN) cancer and five VMAT plans for prostate cancer were analyzed. For the HN plans, the homogeneity indices (HIs) of the three planning target volumes (PTV) increased by 0.03, 0.02, and 0.03, respectively, after DPC. The maximum doses to the PTVs increased by 1.20, 1.87, and 0.92 Gy, respectively, after DPC. The maximum doses to the optic chiasm, optic nerves, spinal cord, brain stem, lenses, and parotid glands increased after DPC by approximately 4.39, 3.62, 7.55, 7.96, 1.77, and 6.40 Gy, respectively. For the prostate plans after DPC, the HIs for the primary and boost PTVs increased by 0.05 and 0.03, respectively, and the maximum doses to each PTV increased by 1.84 and 0.19 Gy, respectively. After DPC, the mean doses to the rectum and femoral heads increased by approximately 6.19 and 2.79 Gy, respectively, and those to the bladder decreased by 0.20 Gy when summing the primary and boost plans. Because clinically unacceptable changes were sometimes observed after DPC, plans converted by DPC should be carefully reviewed before actual patient treatment.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2012년도 춘계 종합학술대회 논문집
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• pp.29-30
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• 2012

하드웨어 기술이 빠르게 성장함에 따라 임베디드 시스템의 발전이 가속화 되고 있다. 이러한 임베디드 시스템 상에서 논리적이고 신뢰성 있는 처리를 지원해 주기 위해 실시간 운영체제를 도입하게 되었다. 이러한 실시간 운영체제의 인터럽트 처리는 더 높은 우선순위의 인터럽트 서비스 루틴 수행에 의해 현재 발생한 인터럽트가 마스킹 되어 인터럽트 지연시간이 길어질 수 있다. 이러한 경우 시간결정성이 보장되지 않아 실시간성이 저해 된다. 범용 운영체제인 윈도우즈 운영체제의 경우 DPC(Deferred Procesure Call)라는 메커니즘을 이용하여 인터럽트 지연시간을 줄이는데, DPC란 인터럽트에서 보다 덜 중요한 부분을 지연처리호출로 처리하도록 하여 인터럽트의 지연시간을 줄이는 방식으로 이러한 DPC 메커니즘을 국산 실시간 운영체제인 CNU_RTOS상에서 HISR(High Level Interrupt Service Routine)을 이용하여 구현하였다. 본 논문에서는 CNU_RTOS상에서 HISR을 이용하여 구현된 DPC기법을 이용한 인터럽트의 처리 시간과 일반 인터럽트의 처리시간을 비교하여 측정하고 분석한다.

• Journal of Power Electronics
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• 제13권6호
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• pp.1000-1007
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• 2013

This paper proposes a sliding-mode-based direct power control (DPC) method in a three-phase boost rectifier without the use of a voltage sensor. This sliding-mode-based DPC is used to improve transient-state response characteristics. This DPC can eliminate voltage sensors by calculating a voltage using a sensorless method, thus considerably reducing cost. This DPC first presents an effective algorithm that does not significantly affect the previous performance and does not need a voltage sensor. Thereafter, the effectiveness of the algorithm is verified by simulations and experiments.

• Current Optics and Photonics
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• 제7권5호
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• pp.537-544
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• 2023

Differential phase contrast (DPC) microscopy, a central quantitative phase imaging (QPI) technique in cell biology, facilitates label-free, real-time monitoring of intrinsic optical phase variations in biological samples. The existing DPC imaging theory, while important for QPI, is grounded in paraxial diffraction theory. However, this theory lacks accuracy when applied to high numerical aperture (NA) systems that are vital for high-resolution cellular studies. To tackle this limitation, we have, for the first time, formulated a nonparaxial DPC imaging equation with a transmission cross-coefficient (TCC) for high NA DPC microscopy. Our theoretical framework incorporates the apodization of the high NA objective lens, nonparaxial light propagation, and the angular distribution of source intensity or detector sensitivity. Thus, our TCC model deviates significantly from traditional paraxial TCCs, influenced by both NA and the angular variation of illumination or detection. Our nonparaxial imaging theory could enhance phase retrieval accuracy in QPI based on high NA DPC imaging.

• 한국정보과학회논문지:시스템및이론
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• 제33권10호
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• pp.789-796
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• 2006

그래프 G의 비쌍형 다대다 k-서로소인 경로 커버(k-DPC)는 k개의 서로 다른 소스 정점과 싱크 정점을 연결하며 그래프에 있는 모든 정점을 지나는 k개의 서로소인 경로 집합을 말한다 여기서 한 소스는 임의의 한 싱크와 짝지어질 수 있다. 이 논문에서는 하이퍼큐브형 상호연결망의 한 부류인 제한된 HL-그래프에서 비쌍형 다대다 DPC를 고려하여, 고장인 요소(정점이나 에지)의 수가 f 이하인 모든 m차원 제한된 HL-그래프$(m{\geq}3)$는 $f+k{\leq}m-2$을 만족하는 임의의 $f{\geq}0,\;k{\geq}1$에 대하여 비쌍형 다대다 k-DPC를 가짐을 보인다.

• 대한화학회지
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• 제18권6호
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• pp.430-436
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• 1974

여러 pH에서 1,1-dicyano-2-p-dimethylaminophenyl-2-chloroethylene(DPC)의 가수분해 속도상수를 측정하고 넓은 pH 범위에서 잘 맞는 반응 속도로식을 구하였다. 이 식에 의하면 넓은 pH 범위에서 DPC에 대한 가수분해 반응메카니즘을 잘 설명할 수 있다. pH3이하와 7.5이상에서는 속도상수는 hydronium ion과 hydroxide ion 농도에 각각 비례한다. 또 pH 3∼7.5 사이에서는 물, hydronium ion 과 hydroxide ion이 DPC의 가수 분해에 촉매 역활을 함을 알았다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제15권4호
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• pp.1342-1359
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• 2021

The data deduplication technique identifies the duplicates and minimizes the redundant storage data in the backup server. The chunk level deduplication plays a significant role in detecting the appropriate chunk boundaries, which solves the challenges such as minimum throughput and maximum chunk size variance in the data stream. To provide the solution, we propose a new chunking algorithm called Dynamic Prime Chunking (DPC). The main goal of DPC is to dynamically change the window size within the prime value based on the minimum and maximum chunk size. According to the result, DPC provides high throughput and avoid significant chunk variance in the deduplication system. The implementation and experimental evaluation have been performed on the multimedia and operating system datasets. DPC has been compared with existing algorithms such as Rabin, TTTD, MAXP, and AE. Chunk Count, Chunking time, throughput, processing time, Bytes Saved per Second (BSPS) and Deduplication Elimination Ratio (DER) are the performance metrics analyzed in our work. Based on the analysis of the results, it is found that throughput and BSPS have improved. Firstly, DPC quantitatively improves throughput performance by more than 21% than AE. Secondly, BSPS increases a maximum of 11% than the existing AE algorithm. Due to the above reason, our algorithm minimizes the total processing time and achieves higher deduplication efficiency compared with the existing Content Defined Chunking (CDC) algorithms.

• 대한화학회지
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• 제52권5호
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• pp.461-467
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• 2008

• Journal of international Conference on Electrical Machines and Systems
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• 제3권2호
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• pp.169-175
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• 2014

This paper presents an improved direct power control (DPC) strategy for grid-connected voltage source inverter (VSI) under unbalanced and harmonic grid voltage conditions. Based on the mathematic model of VSI with the negative sequence, 5th and 7th harmonic voltage components consideration, a PI controller is used in the proposed DPC strategy to achieve the average output power regulation. Furthermore, vector PI controller with the resonant frequency tuned at the two times and six times grid fundamental frequency is adopted to regulate both negative and harmonic components, and then two alternative targets of the balanced/sinusoidal current and smooth active/reactive output power can be achieved. Finally, simulation results based on MATLAB validate the availability of the proposed DPC strategy.