• Journal of the Computational Structural Engineering Institute of Korea
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• v.18 no.4 s.70
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• pp.417-426
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• 2005

Recent days composite bridge dock is gaining attraction due to many advantages such as light weight, high strength, corrosion resistance, and high durability. In this study, composite deck models of hat, box and triangular section type wore fabricated with VARTM Process. For these models, three point flexural tests wore carried out both in strong and weak axis. The experimental results were compared with each other to determine efficient section profile. It has been demonstrated that composite sandwich deck has strong potentials to be used as bridge deck in the new construction and rehabilitation works.

• Special Issue of the Society of Naval Architects of Korea
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• 2006.09a
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• pp.89-96
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• 2006

The objective of this paper is to find out a reasonable method for docking analysis of ships. The characteristics of reaction force distribution under docking condition are investigated by carrying out parametric study. To assess the allowable reaction force on keel block from structural strength point of view, two kinds of structural assessment methods are proposed in accordance with expected collapse pattern. In order to verify the proposed method, linear buckling and elasto-plastic large deflection analyses of typical double bottom structure are carried out and the results are compared.

• Journal of the Society of Naval Architects of Korea
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• v.45 no.1
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• pp.93-100
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• 2008

There are two ways of conventional thermal distortion analysis. One is the thermal elasto-plastic analysis and the other is the equivalent forces method based on inherent strain. The former needs exorbitant analysis time, while the latter cannot obtain results of stress field and it needs much time consumption with loads modeling on curved plates. Such faults in two methods have made difficulties in thermal distortion analysis of a large structure like ship hull. In order to solve them, new kind of thermal distortion analysis method was developed. We devised that the inherent strains was used as direct input factors in forms of boundary conditions. It was embodied by using thermal expansion coefficient in commercial code. We used the pre-calculated inherent strain as thermal expansion coefficient, and endowed nodes with imaginary temperatures. This method was already adopted at hull block welding distortion analysis which was considered as impossible, and gave productive results such as reduction of work time in the dry dock.

• YAKHAK HOEJI
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• v.49 no.5
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• pp.428-436
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• 2005

DNA topoisomerase I(TOP1) helps the control of DNA replication, transcription and recombination by assist­ing breaking and rejoining of DNA double strand. Camptothecin (CPT) and its derivative, topotecan, are known to inhibit TOP1 by intercalating into TOP1-DNA complex. Recently various non-CPT intercalators are synthesized for a new class of TOP1 inhibitors. In this study, six compounds isolated from Poria cocos were investigated for their interaction with TOP1­DNA complex using the flexible docking program, FlexiDock. The binding modes were analyzed and compared with the TOP1 inhibition activities. The compounds that showed potent activity were intercalated between the + 1/-1 base pairs of DNA, located near the active site phosphotyrosine723 and formed hydrogen bonds with active site residues. On the other hand, compounds with no activity were not docked at all. The binding modes were well correlated with the inhibition activity, suggesting the possibility that potent inhibitors can be designed from the information presented by the docking study.

• Journal of Korean Society of Water and Wastewater
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• v.25 no.3
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• pp.399-405
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• 2011

In a desalination technology using RO membranes, chemical cleaning makes damage for membrane surface and membrane life be shortened. In this research cleaning technology using direct osmosis (DO) was introduced to apply it under the condition of high pH and high concentration of feed. When the high concentration of feed is injected to the concentrate side after release of operating pressure, then backward flow occurred from treated water toward concentrated for osmotic pressure. This flow reduces fouling on the membrane surface. Namely, flux of DO was monitored under pH 3, 5, 10 and 12 conditions at feed concentrations of NaCl 40,000 mg/L, 120,000 mg/L and 160,000 mg/L. As a result, DO flux in pH 12 increased about 21% than pH 3. DO cleaning was performed under the concentrate NaCl 160,000 mg/L of pH 12 during 20 minutes. Three kinds of synthetic feed water were used as concentrates. They consisted of organic, inorganic and seawater; chemicals of SiO2 (200 mg/L), humic acid (50 mg/L) sodium alginate (50 mg/L) and seawater. As a result, fluxes were recovered to 17% in organic fouling, 15% in inorganic fouling and 14% of seawater fouling after cleaning using DO under the condition of concentrate NaCl 160,000 mg/L of pH 12.

• Journal of Institute of Control, Robotics and Systems
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• v.13 no.1
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• pp.65-71
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• 2007

Adjustable autonomy architecture provides various ways for a human operator to participate as a member of a human-robot team in improving the performance of the team by resolving issues that the robots cannot deal with or performing tasks that the robots alone would unable to do. According to the level of involvement of the human operator, the robots have to adjust their level of autonomy and, in consequence, the operation mode of the overall system shifts. This paper deals with the implementation issues of seamless switching when the level of autonomy of the human-robot team shifts from one level to another. Especially, we focus on developing reliable methods for monitoring the task progress and maximizing the system flexibility by coping with the detailed differences between humans and robots in their characteristics of motions and their choices of positions, paths, and sequences of sub-goals to achieve a given task. To test and motivate the proposed methods, we have assembled three heterogeneous robots which work together to dock both ends of a suspended beam into stanchions.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.6
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• pp.2883-2888
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• 2016

Background: Breast cancer (BC) is a serious lifestyle disease. There are several prognostic biomarkers like nuclear receptors whose over-expression is associated with BC characteristics. These biomarkers can be blocked by compounds with anti-cancer potential but selection must be made on the basis of no adverse side effects. This study is focused on finding of compounds from a plant source garlic. Materials and Methods: Twenty compounds from garlic and five targets considered involved in BC were retrieved from Pubchem database and Protein Data Bank respectively. They were docked using Accelrys Discovery Studio (DS) 4.0. The compounds which showed interaction were checked for drug likeliness. Results: Docking studies and ADMET evaluation revealed twelve compounds to be active against the targets. All the compounds displayed highly negative dock scores which indicated good interactions. Conclusions: The results of this study should help researchers and scientists in the pharmaceutical field to identify drugs based on garlic.

• Proceedings of the KWS Conference
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• 2009.11a
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• pp.50-50
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• 2009

본 연구에서는 차체 부품의 경량소재 대체에 따른 Panel Assembly Rear Seat Back 부품 제작에 최신 저입열 미그용접공정을 적용한 TWB(Tailor Welded Blank) 공정기술을 확보하기 위해 최적 용접조건 도출에 관한 연구를 진행하였다. 용접 후 성형이 이뤄지는 제조공정의 특성 상 성형강도에 중점을 둔 실험을 진행하였으며, 이를 위해 각 와이어에 따른 용접부의 기계/금속학적 특성이 평가되었다. 대상 시편은 6천계열 열처리형 합금이며, 두께는 각각 1.6t, 1.4t로 이를 맞대기 용접 후 그 특성을 평가하였다. 용접은 저입열 GMA용접 공법 중 하나인 CMT 용접법(Cold Metal Transfer)을 사용하였으며, 평가 대상 와이어로는 4043, 4047, 5183 및 5356이 사용되었다. 특성평가는 마크로 및 마이크로 조직, 경도, 인장강도, 기공 및 결함, 성형강도 등에 대해 이뤄졌으며, 희석된 와이어의 조성이 용접부 특성에 미치는 영향에 대해서도 검토되었다. 실험 결과, 5천계열 와이어가 성형강도에 비교적 더 강인한 결과를 나타냈으며 성형강도는 용접조건 및 초기 갭에 대한 영향은 받았으나, 비드형상과 강도간의 연관성은 찾을 수 없었다. 이에 따라 TWB 적용을 위한 와이어로는 5356이 가장 우수한 것으로 판명되었다.

• Journal of the Korean Society for Precision Engineering
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• v.23 no.7 s.184
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• pp.130-137
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• 2006

TFT-LCD(Thin Film Transistor Liquid Crystal Display) module is representative commercial product of FPD(Flat Panel Display). Thickness of TFT-LCD module is very thin. It is adopted for major display unit for IT devices such as Cellular Phone, Camcorder, Digital camera and etc. Due to the harsh user environment of mobile IT devices, it requires complicated structure and tight assembly. And user requirements for the mechanical functionalities of TFT-LCD module become more strict. However, TFT-LCD module is normally weak to high level transient mechanical shock. Since it uses thin crystallized panel. Therefore, anti-shock performance is classified as one of the most important design specifications. Traditionally, the product reliability against mechanical shock is confirmed by empirical method in the design-prototype-drop/impact test-redesign paradigm. The method is time-consuming and expensive process. It lacks scientific insight and quantitative evaluation. In this article, a systematic design evaluation of TFT-LCD module for mobile IT devices is presented with combinations of FEA and testing to support the optimal shock proof display design procedure.

• Explosives and Blasting
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• v.33 no.2
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• pp.25-39
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• 2015

The common underwater rock removal methods involve underwater blasting and crane's chisel dropping impact method. From an environmental point of view, these methods cause ground vibrations and underwater noise. At the site for this study, a method of dropping heavyweight chisel is selected to remove the underwater bedrock near the ferry rack in the course of improving the cargo handling ability of the loading dock. A prediction formula for the vibration was obtained based on the measurement and evaluation of the vibrations caused by the chisel dropping impacts during the test droppings. The prediction formula was successfully applied to the main construction for securing the stability of the structure.