• 대한기계학회:학술대회논문집
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• 대한기계학회 2002년도 학술대회지
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• pp.9-10
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• 2002

Human circulatory system between heart and tissue is not directly connected in normal condition but mandatory to go through the capillary system in order to fulfill its physiologic aim to deliver oxygen and nutrients, etc. to the tissue and retrieve used blood together with waste products from the tissue properly. When abnormal connection between arterial and venous system (AV fistula), these two circulatory systems respond differently to the hemodynamic impact of this abnormal connection between high pressure (artery) and low pressure (vein) system. Depending upon the location and/or degree (e.g. size and flow) of fistulous condition, each circulatory system exerts different compensatory hemodynamic response to this newly developed abnormal inter-relationship between two systems in order to minimize its hemodynamic impact to own system of different hemodynamic characteristics. Pump action of the heart can assist the failing arterial system directly to maintain arterial circulation against newly established low peripheral resistance by the AV fistula during the compensation period, while it affects venous system in negative way with increased venous loading. However, the negative impact of increased heart action to the venous system is partly compensated by the lymphatic system which is the third circulatory system to assist venous system independently with different hemodynamics. The lymphatic system with own unique Iymphodynamics based on peristaltic circulation from low resistance to high resistance condition, also increases its circulation to assist the compensation of overloaded venous system. Once these compensation mechanisms should fail to fight to newly established hemodynamic condition due to this abnormal AV connection, each system start to show different physiologic ${\underline{de}compensation}$ including heart and lymphatic system. The vicious cycle of decompensation between arterial and vein, two circulatory system affecting each other by mutually negative way steadily progresses to show series of hemodynamic change throughout entire circulation system altogether including heart. Clinical outcome of AV fistula from the compensated status to decompensated status is closely affected by various biological and mechanical factors to make the hemodynmic status more complicated. Proper understanding of these crucial biomechanical factors iii particular on hemodyanmic point of view is mandatory for the advanced assessment of biomechanical impact of AV fistula, since this new advanced concept of AY fistula based on blomechanical information will be able to improve clinical control of the complicated AV fistula, either congenital or acquired.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2010년도 정기총회 및 춘계학술발표회
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• pp.18-18
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• 2010

Glucosinolates(GSLs) are major secondary products($\beta$-thioglucoside N-hydroxysulfates) containing sulfates that are found mainly in Cruciferae family such as cabbage, broccoli, radish, turnip, kale, mustard and rapeseed as the important crops in agronomic and economic aspects. Especially, isothiocyanates(ITCs) have been shown to inhibit carcinogenesis with regulation cancer cell development followed by regulating target enzymes, inducing cell cycle arrest and apoptosis against various human cancer cell lines. Total desulfo(DS)-GSLs of nine type in 210 Korean leaf mustard accessions were isolated and confirmed using electrospray ionization mass spectrometric(ESI-MS/MS) method and DS-GSLs powerful library maked from several reference data. The isolated individual DS-GSLs were identified by removed $\beta$-D-glucopyranose residue ($C_6H_{11}O_5$, MW 163) from MS/MS data. Among them sinigrin(41.7%), glucoiberverin(21.7%) and gluconasturtiin(12.6%) were major components, Especially, despite gluconapin was minor component, accession K046197-1 and K046197-2 showed higher content of 4.11 and 3.31 mg/g(DW), respectively. The total GSLs contents in 210 accessions were ranged from 5.3 to 23.2 mg/g(DW) with a mean value of 13.0 mg/g(DW). As a result of principal component analysis(PCA), the individual GSLs loading plots were composed of three groups and components belonged to each group showed correlationship in quantitative pattern.

• 한국강구조학회 논문집
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• 제27권3호
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• pp.261-271
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• 2015

철골 중심 가새 골조는 최소의 물량으로 건물의 횡력에 대한 저항력을 확보할 수 있는 매우 효과적인 시스템이다. 본 논문에서는 기 설치된 H형 가새를 무 용접 냉간 성형보강재로 보강하여 휨-좌굴을 억제하고 인장력과 압축력에 동일한 강도를 확보하는 보강안에 대한 연구를 진행하였다. 역 V형 가새 골조에 설치된 H형가 새의 보강방안으로 선행연구의 보강재를 약축 보강형으로 변경하여 보강방안을 제시하고 부재실험, 부재변수해석, 골조실험을 통해 구조성능을 평가하였다. 보강된 가새는 AISC기준을 만족하였다. 이를 통해 보강으로 골조내 가새의 불 균형력에 의한 보의 파괴가 방지될 것으로 기대된다.

• 전기전자학회논문지
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• 제14권1호
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• pp.8-16
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• 2010

본 논문에서는 CCD 이미지 처리를 위한 최대 15MS/s의 속도의 중저속 아날로그-프론트 엔드(analog-front end, AFE)에서 사용될 수 있는 연속근사 ADC(Successive Approximation ADC, SA-ADC)의 설계를 제안한다. 파이프라인 ADC와 달리 SA-ADC는 동작주파수의 변화에 따른 전력소모의 스케일링(scaling) 효과가 크므로 저속에서 중속에 이르는 넓은 범위의 가변 데이터 처리 속도의 응용에 매우 효과적이다. 제안하는 설계는 입력 신호의 샘플링 동작을 내부 DAC(sub-DAC)로부터 따로 분리한 후, 커패시터 커플링을 통해 차동 결합함으로써 신호경로에 이르는 부하를 크게 줄이는 "차동 커패시터 커플링 기법"의 도입, 연속근사의 기법적 측면에서 signed 구조를 활용하여 데이터 변환주기 이전에 홀드된 입력신호로부터 미리 MSB(sign bit)를 결정함으로써 1사이클의 변환주기를 절약하고 내부 DAC의 하드웨어를 1비트 줄이는 구조와 같은 특징을 갖고 있다. 본 설계는 3.3V $0.35{\mu}m$ CMOS 공정으로써 설계하고 Spectre 시뮬레이션을 이용하여 그 특성을 분석함으로써 CCD 아날로그 프론트-엔드에 적용될 수 있음을 입증하였다.

• 한국환경보건학회지
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• 제24권2호
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• pp.9-19
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• 1998

Laboratory experiments were carried out to investigate the performance of anaerobic sequencing batch reactor(ASBR) for digestion of a municipal sludge. Each cycle of the ASBR comprised feeding, two-or three-day reaction, one-day thickening, and withdrawal. The reactors were operated at an HRT of 10days and 5days with an equivalent organic loading rate of 0.8-1.54 gVS/l/d, 1.81-3.56 gVS/l/d at 35$\circ$C, respectively. Solids accumulation was remarkable in the ASBR during start-up period, and directly affected by settleable solids in the feed sludge. Floatation thickening occured in the ASBRs, and Solids profiles at the end of thickening step dramatically changed at solid-liquid interface. Slight difference in solids concentrations was observed within thickened sludge bed. Efficiencies through floatation thickening were comparable to that of additional thickening of the completely mixed control reactor. Average solids concentrations in the ASBRs were 2.2-2.6 times higher than that in the control throughout the total operation period. The dehydrogenase activity had a strong correlation with the solids concentration. Organics removals based on clarified effluent of the ASBRs were consistently above 86%. Remarkable increase in equivalent gas production of 27-52% was observed at the ASBRs compared with the control though the control and ASBRs showed similiar effluent quality. Thus, digestion of a municipal sludge was possible using the ASBR in spite of high concentration of solids in the sludge.

• Journal of Nutrition and Health
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• 제32권1호
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• pp.50-63
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• 1999

This study was conducted with 20 female gymnasts and 23 age-matched controls to examine the relationship of diet, menstrual function and bone mineral density (BMD). The results obtained are summarized as follows : Energy intake of gymnasts was 968.9$\pm$421.4kcal, and energy expenditure was 2091.4$\pm$361kcal showing negative energy balance(-1,122.5$\pm$534.6kcal). The average intakes of calcium, iron, vitamin A, thiamin, riboflavin and niacin did not meet the Recommended Dietary Allowances for their age groups. Mean age at menarche in gymnasts is 15.8$\pm$1.2 years compared with 11.8$\pm$2.8 years in age-matched controls. The profile of estradiol, progesterone, and luteinizing hormone was lower than age-matched controls but not significant. Athletic amenorrheic gymnasts(n=12) have the menstrual irregularity(n=10) and amenorrhea(n=2). A number of variables as such nutritional deficiency in diet, negative energy blasnce and hypogonadotropic hormonal status were included. The bone mineral density (BMD) of female gymnasts were significantly higher than controls for the lumbar neck(p<0.001), trochanter(p<0.01), and Ward's triangle(p<0.001), but there were no significant differences for the lumbar spine and forearm. The lumbar spine BMD had a positive correlation with age and lean body weight. The femoral neck BMD was significantly associated with age, group and lean body mass. The trochanter BMD had significant relationship with group, body mass index, energy expenditure and follicular stimulating hormone. Ward's triangle BMD were related to body mass index and follicular stimulating hormone. The significant association was deterced between forearm BMD and age and lean body weight. The major finding of this investigation is that the BMD of gymnasts were higher than age-matched controls despite the fact that gymnasts as a group had inadequate dietary calcium and a higher propensity to have an interruption of their menstrual cycle. These data indicate that grymnsts involved in sports producing significant impact loading on the skeleton had greater femoral neck, trochanter and Ward's triangle bone density than age-matched controls.

• Environmental Analysis Health and Toxicology
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• 제25권4호
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• pp.295-306
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• 2010

Objectives : This study was undertaken to examine the metabolomic changes due to gender and diurnal variation at sampling time and to identify an appropriate time point for urine sampling in epidemiologic studies using metabolomic profiles. Methods : Urine samples were collected twice a day (morning and afternoon) from 20 healthy Korean adults after fasting for 8 hours. The metabolomic assay was investigated using $^1H$ NMR spectroscopy coupled with the principal components analysis (PCA) and partial least squares discriminant analysis (PLS-DA). The metabolites responsible for differentiation between groups were identified through the loading plot of PLS-DA and quantified using Chenomx NMR Suite with a 600 MHz library. Results : Metabolites responsible for differentiation in gender and sampling time were creatinine, trimethyl anine oxide (TMAO), hippurate, mannitol, citrate and acetoacetate. Dimethylamine showed difference only as a factor of diurnal time. The level of creatinine was higher in men compared to women, and the levels of citrate, TMAO, hippurate, mannitol, and acetoacetate were higher in women compared to men. The levels of creatinine, TMAO, hippurate, dimethylamine and mannitol were higher in the morning rather than the afternoon while those of citrate and acetoacetate were higher in the afternoon rather than the morning. Conclusions : Since urinary metabolomic profiles varied by gender and diurnal cycle, urine sampling should be performed at the same time point for all participants in epidemiologic studies using metabolomic profiles.

• 한국정밀공학회지
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• 제23권2호
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• pp.199-206
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• 2006

Automatic grease lubricator is equipment that provides adequate amount of fresh grease constantly to the shaft and the bearings of machines. It minimizes the friction heat and reduces the friction loss of machines to the least. This research is to develop automatic grease lubricator by gear driven mechanism with controlled operation time. The ultimate design of this equipment is to lubricate an adequate amount of grease by a simple switch clicking according to the advanced set cycle. The backlash of the gear was minimized to increase the output power. To increase the power of gear mechanism, the binding frequency and the thickness of the coil were changed. To control the rotating cycles of the main shaft according to its set numbers, different resistance and chips were used to design the circuit to controls electrical signals with pulse. The body of the lubricator was analyzed by stress analysis with different constructed angle. The stress analysis for differing loading pressures applied to the exterior body of grease lubricator due to the setup angle, was found that the maximum stress was distributed over the outlet part where the grease lubricator suddenly narrowed contracts. Digital mock-up was analyzed and the rapid prototyping(RP) trial products were tested with PCB circuit and grease. The evaluation of the outlet capacity for RP trial products was conducted, because the friction caused by the outlet on the wall surface was an important factor in the operation of the equipment. Finally, the finishing process was applied to decrease the roughness of the surface to a comparable level and was able to test the performance examination for the product.

• 방사성폐기물학회지
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• 제14권2호
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• pp.123-134
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• 2016

최근 국내에서는 월성 1호기 및 고리 1호기를 포함하여 운영 중인 원자력발전소가 노후화함에 따라 원전 해체에 대한 관심이 많이 증대되고 있다. 이와 관련하여 월성 1호기의 계속운전이 최근 결정되었으며, 고리 1호기의 경우 2017년 6월 영구정지하기로 결정되었다. 이에 본 논문에서는 상업용 원자로로서는 국내 최초로 해체가 예정된 고리 1호기에 대해, 원자로 압력용기 자체의 해체로 인해 발생하는 방사성폐기물 최종 처분량을 원자로 압력용기 절단 방법 및 방사성폐기물 처분용기를 고려하여 산정하였다. 처분용기를 고려한 방사성폐기물 처분량을 산정한 결과 원자로 압력용기 몸통 부위보다는 반구 형태의 헤드 부분을 작게 절단할수록 최종 처분량이 감소하는 것으로 예측되었다. 또한 경주 방폐장의 200 L 및 320 L 드럼 처분용 처분용기의 경우 무게 제한으로 인해 적재효율이 좋지 못한 것으로 나타났다.

• 한국자동차공학회논문집
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• 제13권2호
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• pp.1-9
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• 2005

An end beam is one of the most important structural members supporting uncovered freight under in-service loading. In general, it needs to endure over 25 years. However fatigue fracture has occurred at dynamic stress concentration location of the end beam because user's specifications demanded high speed and vehicle manufacturer made the uncovered freight car with comparatively low strength and stiffness. For durability analysis, finite element analysis is performed to evaluate the problem of uncovered freight structure and local strain. The uncovered freight car was operated on actual problematic railroad line to measure dynamic stress versus time history on the critical part from which a crack is initiated often. Rainflow cycle counting method was used to estimate fatigue damage at dangerous area under operating condition. Therefore, this study shows that analytical fatigue life at the end beam can be predicted on the basis of S-N curve and structure analysis and has a fairly good correlation with experimental fatigue life.