• 생물정신의학
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• 제12권1호
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• pp.68-72
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• 2005

Object:Nicotine dependence is the most common substance abuse disorder. One of the characteristics of nicotine dependence is craving. Regional activation of the brain induced by craving for nicotine was evaluated by using functional magnetic resonance imaging to investigate neuroanatomical site of smoking craving. Method:A smoker who satisfied DSM-IV criteria for nicotine dependence and a non smoker was studied. MRI data were acquired on a 1.5T Magnetom Vision Plus with a head volume coil. Two sets of visual stimuli were presented to subjects in a random manner. One was the film scenes of inducing smoking craving and the other was neutral stimuli not related to smoking. There were two fMRI sessions before and after smoking or sham smoking. Data were analyzed using SPM99. Results:fMRI showed significant activated area in anterior cingulate and medial frontal lobes in the smoker during smoking craving. Right dorsolateral prefrontal cortex and parietal lobes were activated in the control during visual stimulation before smoking. After smoking, there was no brain activation during visual stimulation in both of smoker and non smoker. Conclusion:Metabolic activity of the anterior cingulate and medial frontal lobes increased during craving for smoking. This result suggests that fMRI may be a valuable tool in the identification of neurobiological process of craving.

• 산업융합연구
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• 제22권2호
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• pp.127-134
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• 2024

본 연구는 혈액투석 기간 동안 경험하는 혈액투석 환자의 음식 갈망 현상을 깊이 있게 이해하기 위함이다. 참여자는 일개 의료기관으로부터 말기신부전 진단을 받고 혈액투석 치료를 받는 성인 환자 7인을 임의로 선정하였다. 수집된 자료는 현상학적 분석방법으로 분석하였다. 분석결과 10개 주제와 5개의 주제 모음과 2개의 범주로 구조화할 수 있었다. 두 범주는 '인지적 영역에서의 갈망경험', '정서적 영역에서의 갈망경험'이었으며 '갈증으로 물과 수분이 많은 음식을 찾게 됨', '제한된 음식으로 종일 음식 생각이 남', '항상 허기지고 배고픔', '매시간 식욕을 유발하는 상황에 맞닥뜨림', '식사 조절 실패로 부정적인 정서를 경험함'의 5가지 주제 모음이 포함되었다. 그동안 연구되지 않았던 혈액투석 환자의 관점에서 음식 갈망을 조명한 본 연구결과는 혈액투석 환자의 식욕조절과 수분 제한 및 식이요법 이행에 대한 이해를 증진하고 환자에게 맞는 식이요법 교육과 간호 중재를 적용할 때 혈액투석 환자의 음식 갈망 속성을 이해하고 그 정도에 맞춰 최적화된 맞춤형 교육이 이루어질 수 있도록 해야 할 것이다.

• 임상간호연구
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• 제23권3호
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• pp.398-406
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• 2017

Purpose: The purpose of this study was to evaluate food carving among hemodialysis patients and to identify factors affecting the food carving. Methods: A descriptive correlational study was conducted. Data were collected from 129 patients receiving hemodialysis between March 15 and April 15, 2017. Measurement instruments included the general food craving questionnaire trait, the center for epidemiological studies-depression scale, and stress response inventory-modified form. The statistical analysis included t-test, analysis of variance, pearson correlation analysis, and stepwise multiple regression analysis. Results: Mean food craving score was $53.00{\pm}12.36$. Food craving was higher in patients younger than 40 years (F=4.36 p=.006) and having occupation (t=2.18 p=.031). Patients receiving hemodialysis demonstrated higher levels of depression ($21.37{\pm}9.62$) and stress ($39.68{\pm}15.95$). Factors influencing food craving were depression (${\beta}=.52$, p<.001), stress (${\beta}=.65$, p<.001), and age 50~59 years old (${\beta}=-.28$, p=.001) and 60~69 years old (${\beta}=-.19$, p=.026), which accounted for 25.6% of total variance. Conclusion: Food craving among hemodialysis patients was influenced by patients' depression, stress and age. Assessment and management of depression and stress needs to be incorporated as a nursing strategy for dietary management for hemodialysis patients.

• Advances in Traditional Medicine
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• 제2권2호
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• pp.119-124
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• 2002

Cigarette smoking contributes to lung cancer, cardiovascular diseases, oral diseases, etc. In desire to reduce their risk of disease, many cigarette smokers have tried to quit smoking. Sensory aspects of cigarette smoke are important for providing smoking satisfaction. Previously it was reported that citric acid aerosol significantly reduced craving for cigarettes and enhances smoking reduction and cessation. In this study, we tested whether a newly combined product Ciga-X, an aerosol for cessation aid, had toxicity in human embryonic lung fibroblast (MRC-9). The inhibitory effect of Ciga-X on cytotoxicity induced by cigarette smoke extract (CSE) or nicotine was examined in MRC-9, and craving for cigarettes and smorkers satisfaction after using Ciga-X was estimated. Ciga-X did not affect cell viability and had no toxicity in MRC-9. Ciga-X significantly inhibited not only CSE-induced cytotoxicity but also nicotine-induced cytotoxicity in MRC-9. One hundred and forty smokers rated the satisfaction for Ciga-X aerosol and craving reduction for cigarettes after using Ciga-X. The percentage of over 5 rating was 71.0% and 50.0% of subjects in satisfaction test for Ciga-X compared to their own brand and in craving reduction for cigarette, respectively. Besides, craving reduction for cigarette was highly correlated with the duration of smoking. Subjects have smoked under 10 years were more reduced in craving for cigarettes after using Ciga-X as compared to over 10 years (p=0.049). These results suggest that Ciga-X may be effective in promoting smoking abstinence with the reduction of CSE- or nicotine-induced human lung fibroblasts cytotoxicity.

• 감성과학
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• 제10권4호
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• pp.603-611
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• 2007

남용 약물에 대한 갈망은 중독적인 행동을 지속하는 데 있어 중요하다. 갈망은 강화적이거나 보상적인 약물을 복용하고자 하는 강한 욕구와 관련된 다차원적인 현상으로 여겨진다. 본 연구에서는 알코올 사용 장애자와 정상인이 알코올 관련 자극(소량의 술을 마시기, 알코올 관련 시각 자극)에 노출되었을 때 갈망에 대한 심리적인 반응의 차이를 밝히고자 하였다. 알코올 관련 시각 자극을 개발하기 위하여 Normative Appetitive Picture System(NAPS)과 1차 집단 심리 실험을 통하여 알코올 자극을 선정하고 자극의 적합성과 효과성을 검증하여 자극을 최종 개발하였다. 본 실험을 위해 알코올 사용 장애를 가진 9명의 남녀 대학생(남:8명)과 9명의 비의존 남녀 대학생(남:8명)을 선정하였다. 실험참여자는 5cc 정도의 알코올을 복용하고, 알코올 자극, 음료 자극, 통제 자극(흐릿하게 변형된 알코올 자극)과 고정점 자극(십자가 기호)에 무선적으로 노출되었으며, 각 종류의 자극이 제시되고 나면 마우스를 이용하여 심리적 갈망 수준을 보고하였다. 심리반응 결과, 강박음주갈망척도, 음주 전, 음주 후 알코올 갈망에서 두 집단 간 유의한 차이가 나타났다. 알코올 사용 장애 집단은 알코올 자극을 포함한 모든 자극에서 정상인 집단보다 높은 알코올 갈망 수준을 나타내었다. 결론적으로 알코올 사용 장애자는 알코올 자극에 의해 유발된 심리적 갈망이 정상인과 다른 것으로 나타났다.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 2002년도 추계학술대회 논문집
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• pp.187-192
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• 2002

Research has shown that many smokers experience an increase in the desire to smoke when exposed to smoking-related cues. Cue exposure treatment (CET) refers to the manualized, repeated exposure to smoking-related cues, aimed at the reducing cue reactivity by extinction. In this study, we constructed a virtual reality system for evoking a desire of nicotine, which was based on the results of a Questionnaire of Nicotine-craving. And we investigated the effectiveness of the virtual reality system as compared to classical device (pictures). As a result, we reached the conclusion that virtual reality elicits more craving symptoms than the classical devices.

• 한국통신학회논문지
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• 제31권6A호
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• pp.617-626
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• 2006

본 논문에서는 OFDMA 시스템 하향 링크에서 섹터 Throughput을 향상시키기 위하여, 모든 사용자의 채널 상태를 고려하여 동적 채널 할당을 진행하는 ASA(Aggressive Subchannel Allocation) 알고리즘을 제안한다. 그리고 제안한 알고리즘을 섹터 별 Frequency Reuse Factor 가 1인 2-tier 환경 하에서 Round Robin, ACG(Amplitude Craving Greedy), RCG(Rate Craving Greedy) 그리고 GPF(General Proportional Fair) 알고리즘과 함께 모의실험을 통하여 각 알고리즘의 성능을 분석한다. 그 결과 본 논문에서 제안한 ASA 알고리즘이 Round Robin 보다는 58 %, ACG 보다는 190 %, RCG 보다는 130 % 그리고 GPF보다는 8.5 % 높은 Sector Throughput을 보인다.

• 한국학교ㆍ지역보건교육학회지
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• 제23권4호
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• pp.63-79
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• 2022

Objectives: The purpose of this study is to reveal the phenomenological meaning and experience of alcohol craving experienced by alcoholics through qualitative research. Methods: From November 8, 2020 to October 10, 2022, in-depth interviews were conducted with four recovering alcoholics within two years of a single week who were diagnosed with alcoholism in the past and had been hospitalized for alcoholism problems. The data were analyzed using phenomenological qualitative research methods. Results: The alcohol craving experienced by alcoholics worked in connection with the life of alcoholics. Alcohol intensity was not entirely determined by external factors, but varied by the individual's internal state and circumstances surrounding the individual, and cravings were found to be classified into when control and intervention were possible. Also, the power to neutralize alcohol cravings was a warm 'self-compassion' mind. Conclusion: This study presented a new perspective on alcohol craving, and based on this perspective, the necessity of developing an alcohol addiction prevention program and a recurrence prevention program was presented. In addition, the basis for emphasizing the necessity of complete abstinence in health education services for preventing alcohol and preventing recurrence in the community was presented.

• 생물정신의학
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• 제18권4호
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• pp.245-253
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• 2011

Objectives In the current study, we quantitatively estimated changes in appetite and eating behavior of bipolar disorder patients during the pharmacotherapy. We also investigated their contribution to the weight gain and their association with specific food-craving characteristics of the patients. Methods Subjects included forty-one bipolar disorder patients and fifty-six controls. Currently sustained natures of food craving were assessed using the General-Food Craving Questionnaire-Trait (G-FCQ-T) and changes in appetite and eating behavior were measured using the Drug-Related Eating Behavior Questionnaire (DR-EBQ). Results Compared to the control group, the patients' group showed significantly higher body mass index (t=2.028, p=0.045). The patients' group had significantly higher 'Preoccupation with food' factor score of G-FCQ-T (p=0.016) than that of the control group. Hierarchical multiple regression analysis showed that only 'preoccupation with food' factor independently predicted psychotropic medication-induced appetite change. Conclusions Appetite change while receiving psychotropic medication seems to be related to the weight-gain and associated with craving natures of 'preoccupation with food' in bipolar disorder. Appetite and/or eating behavioral changes measured by G-FCQ-T and DR-EBQ could be regarded as an important mediating factor in future studies exploring biological mechanisms of weight gain related with pharmacotherapy for bipolar disorder.

• 동의신경정신과학회지
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• 제18권2호
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• pp.75-88
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• 2007

Objective : This study was designed to test the anti-craving effect of Gigaltang(extracts of Oriental medicinal herbs ; Hovenia dulcis and Puerariae flos) in C57BL/6 mice. Anti-craving effect was substituted by alcohol intake amount of C57BL/6 mice. Method : 60 C57BL/6 mice was randomized into vehicle(water) group and Gigaltang group. Only 39(vehicle group(21) and Gigaltang group(18)) was eligible for this study, and 21 C57BL/6 mice was dropped out. The procedure was composed of 5 days of adjustment period and 32 days of alcohol exposure and withdrawal period with limited access paradigm and 10 days of treatment period. Alcohol was offered only for 2 hours a day from 2 to 4PM and water was offered for 22 hours left. Food was offered for 24 hours a day. 1140mg/Kg/day of Gigaltang was administrated to 18 mice of Gigaltang group for 10 days whereas water to 21 mice of vehicle group. The amount of alcohol intake, water intake, food intake, body weight were measured every other day. Result : There weren't significant differences in 2 hours of alcohol intake, 22 hours of water intake, 24 hours of food intake and body weight for ten days between Gigaltang and vehicle group. Conclusion : Anti-craving effect of Gigaltang on C57BL/6 mice wasn't verified. To verify the anti-craving effect, further study with advanced animal model, various dose of Gigaltang and diverse period of drug administration should be taken.