Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Changes of Appetite and Eating Behavior in Bipolar Disorder Patients : Measurement with General-Food Craving Questionnaire-Trait and the Drug-Related Eating Behavior Questionnaire

양극성 장애 환자에서 나타나는 식욕 및 섭식 행동의 특성 : 일반적 음식갈망-특질척도(G-FCQ-T)와 약물 관련 섭식행동 설문지(DR-EBQ)를 이용한 평가

  • Lee, Sunny (Department of Psychiatry, Seoul Metropolitan Eunpyeong Hospital) ;
  • Ryu, Seung-Hyong (Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Ko, Hyo-Jung (Department of Psychiatry, Seoul Metropolitan Eunpyeong Hospital) ;
  • Hong, Kyung-Sue (Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Nam, Hee-Jung (Department of Psychiatry, Seoul Metropolitan Eunpyeong Hospital)
  • 이선이 (서울특별시 은평병원 정신과) ;
  • 류승형 (성균관대학교 의과대학 삼성서울병원 정신과학교실) ;
  • 고효정 (서울특별시 은평병원 정신과) ;
  • 홍경수 (성균관대학교 의과대학 삼성서울병원 정신과학교실) ;
  • 남희정 (서울특별시 은평병원 정신과)
  • Received : 2011.07.29
  • Accepted : 2011.08.25
  • Published : 2011.11.30
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Abstract

Objectives In the current study, we quantitatively estimated changes in appetite and eating behavior of bipolar disorder patients during the pharmacotherapy. We also investigated their contribution to the weight gain and their association with specific food-craving characteristics of the patients. Methods Subjects included forty-one bipolar disorder patients and fifty-six controls. Currently sustained natures of food craving were assessed using the General-Food Craving Questionnaire-Trait (G-FCQ-T) and changes in appetite and eating behavior were measured using the Drug-Related Eating Behavior Questionnaire (DR-EBQ). Results Compared to the control group, the patients' group showed significantly higher body mass index (t=2.028, p=0.045). The patients' group had significantly higher 'Preoccupation with food' factor score of G-FCQ-T (p=0.016) than that of the control group. Hierarchical multiple regression analysis showed that only 'preoccupation with food' factor independently predicted psychotropic medication-induced appetite change. Conclusions Appetite change while receiving psychotropic medication seems to be related to the weight-gain and associated with craving natures of 'preoccupation with food' in bipolar disorder. Appetite and/or eating behavioral changes measured by G-FCQ-T and DR-EBQ could be regarded as an important mediating factor in future studies exploring biological mechanisms of weight gain related with pharmacotherapy for bipolar disorder.

Keywords

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