• Journal of the Society of Cosmetic Scientists of Korea
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• v.34 no.4
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• pp.303-309
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• 2008

Deficiency of collagen regeneration, denaturalization of elastic fibers, and promotion of reactive oxygen species formation are important factors for deterioration of skin function. They induce wrinckle formation and decrease skin elasticity. Vitamin C and its derivatives have been used as cosmetic ingredients for anti-aging effects but their chemical instability has been a major problem. In an attempt to develop a novel anti-aging agent with a improved stability and bioactivity, the anti-wrinkle effect of 3-O-cetyl-L-ascorbic acid (VCCE), a new vitamin C derivative, was investigated in this study. VCCE increased procollagen type-1 synthesis in a dose-dependent manner (149% at 0.002%) in cultured fiboroblasts. Its potent anti-wrinkle effect was confirmed in vivo by analyzing human skin replica by a visiometer and the PRIMOS system. It did not cause any irritation in human patch test. Taken together, our findings suggest that the VCCE has potential benefits applicable to cosmetics for anti-wrinkle effects.

• Korean Chemical Engineering Research
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• v.46 no.2
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• pp.227-232
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• 2008

In this research, organic extracts from roots of platycodon grandiflorum was tested to see the possibility for cosmetic natural surfactant. Interfacial properties of extracts of Platycodon grandiflorum was checked for interfacial tension, forming force, dispersion force, emulsion force, emulsion activity, and emulsion stability. At 0.005 wt% concentration, the interfacial tension against the caster oil was 11.5 dyn/cm which was lower than that of Tween 40 and quillaja bark. Extracts of Platycodon grandiflorum showed excellent emulsification activity and stability for cosmetic oils such as olive oil, soybean oil, and canola oil. In patch test using 2-5% of the extract and glycerin, the extract showed mild skin irritation. From the experiment, the extracts of platycodon grandiflorum root showed good interfacial properties as a cosmetic agent with minor skin irritation.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.42 no.3
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• pp.279-284
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• 2016

In this study, facial hair weakening ability of urea and anti-oxidants for shaving was investigated. The hair weakening ability and cross-section increase of hair depends on concentration of urea. The results showed that urea affects swelling of hair and this is related to the hair weakening ability. Anti-oxidants showed outstanding weakening ability despite of their low concentrations by breaking disulfide bond in facial hair. To evaluate the suitability of urea and anti-oxidants for facial cosmetic products, in vitro safety tests were proceeded. The results showed that urea and glutathione were safe for face. As a result, urea and glutathione were safe and outstanding as hair weakening agent for cosmetic shaving products.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.36 no.1
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• pp.65-69
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• 2010

Collagen is the most abundant animal protein in mammals, accounting for about 30 % of all proteins. It is present in connective tissue and contributes to the structural framework of most organs. The tripeptide (glycineproline-hydroxyproline) with the INCI name Tripeptide-29 is main component of collagen type I. The palmitoyl tripeptide (palmitoyl-glycine-proline-hydroxyproline) with the INCI name Paimitoyi Tripeptide-29 is a synthetic material that was designed as a topical agent to stimulate collagen production. We synthesized the palmitoyl tripeptide as a potential anti-wrinkle compound. This compound has been characterized using HPLC. This compound proved, through in vitro tests, to stimulate collagen production and fibroblast proliferation. These results were very promising, so human studies were subsequently performed. We investigated the skin improvement effect of the palrnitoyl tripeptide on human skin by using non-invasive instruments. We measured physiological effects such as skin wrinkles and elasticity after volunteers applied the cosmetic products for 8 weeks. We observed significant improvement in skin wrinkles and elasticity after use of the cosmetic products for 8 weeks. We concluded that the palmitoyl tripeptide had an anti-aging effect on human facial skin.

• Journal of the Korean Applied Science and Technology
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• v.32 no.4
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• pp.781-788
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• 2015

In this study, the antioxidative effects of 50% ethanol extract, ethylacetate fraction and aglycone fraction obtained from dried whole plant of Solanum nigrum L. were investigated. The free radical scavenging activities ($FSC_{50}$) were $215.46{\mu}g/mL$, $42.43{\mu}g/mL$ and $52.28{\mu}g/mL$, respectively. Reactive oxygen species (ROS) scavenging activities ($OSC_{50}$) in $Fe^{3+}-EDTA/H_2O_2$ system were $25.25{\mu}g/mL$, $7.05{\mu}g/mL$ and $6.25{\mu}g/mL$, respectively. 50% ethanol extract and aglycone fraction showed the cellular protective effect against $^1O_2$ induced cellular damage of rabbit erythrocytes at $5{\sim}25{\mu}g/mL$, but not at high concentrations. These results indicated that S. nigrum extract/fractions could be used as an antioxidative agent. However, it could induce cellular damage at high concentrations. In conclusion, a special caution is required to use S. nigrum extracts as a cosmetic ingredient.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.47 no.4
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• pp.281-287
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• 2021

In this study, we analyzed the cosmetic applicability of extract from snow tea, native to Lijiang, Yunnan-province, China. After confirming the species as N. grossedentata through DNA analysis of Lijiang snow tea, experiments were conducted using representative tea, green tea, and a representative control group for each efficacy analysis. Both teas were extracted using 70% (v/v) ethanol aqueous solution. The polyphenol content in the Lijiang snow tea extract (gallic acid equivalent, 23.9 ± 3.2 mg/mL) was higher than that in green tea extract (16.4 ± 2.3 mg/mL). In contrast, the antioxidant (Radical scavenging, IC₅₀ 104 ㎍/mL), tyrosinase enzyme inhibitory (whitening agent, IC₅₀ 40.7 ㎍/mL), and Escherichia coli growth inhibitory (preservative) activities (IC₅₀ 2.85 mg/mL) were analyzed based on the solid content in the extract, and it was confirmed that the activities of Lijiang snow tea extract were superior to those of green tea extract (radical scavenging, IC₅₀ 234 ㎍/mL. It also showed similar efficacy to previously used active substances such as antioxidants (vitamin C, IC₅₀ 108 ㎍/mL), whitening agents (vitamin C, IC₅₀ 80㎍/mL), and preservatives (methylparaben, IC₅₀ 4.35 mg/mL). However, green tea was found to be better in collagenase inhibition activity (anti-wrinkle). Through this study, the cosmetic application potential of Lijiang snow tea is high.

• Journal of the Korean Applied Science and Technology
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• v.23 no.1
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• pp.92-97
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• 2006

In this paper, magenta coupler was prepared by the reaction of 1-(2,4,6-Trichlorophenyl)-3-(5-amino-2-chloroanilino)-5-pyrazolone with 2,4-di-tert-pentyl-phenoxy butanoyl chloride in the presence of pyridine. The product was identified by using various analytical tools such as melting point, elemental analyzer, IR spectrophotometer, UV-Vis spectrophotometer and GC-mass spectrometer. The reaction of magenta coupler with CD-3 (color development agent) was shown magenta color.

• Journal of the Korean Applied Science and Technology
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• v.29 no.1
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• pp.116-121
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• 2012

In this paper, yellow coupler was prepared by the reaction of ${\alpha}$-pivaloyl- 2-chloro-5-aminoacetaniline hydrogen chloride with 1-hexadecane sulfonyl chloride in the presence of pyridine. The product was identified by using various analytical tools such as melting poin elemental analyzer, IR spectrophotometer, UV-Vis spectrophotometer, mass spectrometer. The reaction of yellow coupler with CD-3(color development agent) was shown yellow color.

• Proceedings of the Korean Society of Toxicology Conference
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• 2003.10b
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• pp.131-131
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• 2003

Benzophenone is an UV-absorbing agent that has been used in industry and medicine for more than 30 years. Its twelve derivatives, designated benzophenone-1 through benzophenone-12, are widely used today in cosmetic products as a photostabilizer, a sunscreen in lotions, and hair sprays to protect the skin and hair from UV irradiation.(omitted)

• The Korean Journal of Physiology and Pharmacology
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• v.22 no.1
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• pp.53-61
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• 2018

Ethyl linoleate is an unsaturated fatty acid used in many cosmetics for its various attributes, such as antibacterial and anti-inflammatory properties and clinically proven to be an effective anti-acne agent. In this study, we investigated the effect of ethyl linoleate on the melanogenesis and the mechanism underlying its action on melanogenesis in B16F10 murine melanoma cells. Our results revealed that ethyl linoleate significantly inhibited melanin content and intracellular tyrosinase activity in ${\alpha}$-MSH-induced B16F10 cells, but it did not directly inhibit activity of mushroom tyrosinase. Ethyl linoleate inhibited the expression of microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase related protein 1 (TRP1) in governing melanin pigment synthesis. We observed that ethyl linoleate inhibited phosphorylation of Akt and glycogen synthase kinase $3{\beta}$ ($GSK3{\beta}$) and reduced the level of ${\beta}-catenin$, suggesting that ethyl linoleate inhibits melanogenesis through $Akt/GSK3{\beta}/{\beta}-catenin$ signal pathway. Therefore, we propose that ethyl linoleate may be useful as a safe whitening agent in cosmetic and a potential therapeutic agent for reducing skin hyperpigmentation in clinics.