• 한국생산제조학회지
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• 제8권4호
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• pp.19-28
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• 1999

In order to control thermal deformation of the machine origin of machine tools a empirical model and a compensation system have been developed, Prior to empirical modeling the volumetric error considering shape errors and joint errors of slides is formulated through the homogeneous transformation matrix (HTM) and kinematic chain. Simulation results of the HTM method show that the thermal error of the machine origin is more critical than position-dependent errors. In order to make a stable and effective software error compensation system the GMDH (Group Method of Data Handling) models are constructed to estimate the thermal deformation of the machine origin by measuring deformation data and temperature data. A test bar and gap sensors are used to measure the deformation data. In order to compensate the estimated error the work origin shift method is developed by implementing a digital I/O interface board between a CNC controller and an IBM PC. The method shifts the work origin as much as the amounts which are calculated by the pre-established thermal error model. The experiment results for a vertical machining center show that the thermal deformation of the machine origin is reduced within $\pm$5$mu extrm{m}$.

• Ocean and Polar Research
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• 제34권3호
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• pp.275-286
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• 2012

Over the last 20 years there have been more than 3000 peer-reviewed papers relating to climate change and biodiversity published, and still the numbers are increasing. However, most studies focused on the impacts of climate change at population or community levels, and the results invariably reveal that there has been, or will be, a negative effect on the structure and pattern of biodiversity. Moreover, the climate change models and statistical analyses used to test the impacts are only newly developed, and the analyses or predictions can often be misled. In this review, I ask why an individual's life history is considered in the study how climate change affects biodiversity, and what ecological factors are impacted by climate change. Using evidence from a range of species, I demonstrate that diverse life history traits, such as early growth rate, migration/foraging behaviour and lifespan, can be shifted by climate change at individual level. Particularly I discuss that the optimal decision under unknown circumstance (climate change) would be the reduction of the ecological fitness at individual level, and hence, a shift in the balance of the ecosystem could be affected without having a critical impact on any one species. To conclude, I summarize the links between climate changes, ecological decision in life history, the revised consequence at individual level, and discuss how the finely-balanced relationship affects biodiversity and population structure.

• Reproductive and Developmental Biology
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• 제33권3호
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• pp.163-169
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• 2009

Many biological systems are regulated by an intricate set of feedback loops that oscillate with a circadian rhythm of roughly 24 h. This circadian clock mediates an increase in body temperature, heart rate, blood pressure, and cortisol secretion early in the day. Recent studies have shown changes in the amplitude of the circadian clock in the hearts and livers of streptozotocin (STZ)-treated rats. It is therefore important to examine the relationships between circadian clock genes and growth factors and their effects on diabetic phenomena in animal models as well as in human patients. In this study, we sought to determine whether diurnal variation in organ development and the regulation of metabolism, including growth and development during the juvenile period in rats, exists as a mechanism for anticipating and responding to the environment. Also, we examined the relationship between changes in growth factor expression in the liver and clock-controlled protein synthesis and turnover, which are important in cellular growth. Specifically, we assessed the expression patterns of several clock genes, including Per1, Per2, Clock, Bmal1, Cry1 and Cry2 and growth factors such as insulin-like growth factor (IGF)-1 and -2 and transforming growth factor (TGF)-${\beta}1$ in rats with STZ-induced diabetes. Growth factor and clock gene expression in the liver at 1 week post-induction was clearly increased compared to the level in control rats. In contrast, the expression patterns of the genes were similar to those observed after 5 weeks in the STZ-treated rats. The increase in gene expression is likely a compensatory change in response to the obstruction of insulin function during the initial phase of induction. However, as the period of induction was extended, the expression of the compensatory genes decreased to the control level. This is likely the result of decreased insulin secretion due to the destruction of beta cells in the pancreas by STZ.

• Toxicological Research
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• 제34권1호
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• pp.7-12
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• 2018

Laboratory animal models have been developed to investigate preventive or therapeutic effect of medicinal products, or occurrence or progression mechanism of atopic dermatitis (AD), a pruritic and persistent inflammatory skin disease. The murine model with immunologic phenomena resembling human AD was introduced, which demonstrated skewedness toward predominance of type-2 helper T cell reactivity and pathophysiological changes similar as human AD following 2,4-dinitrochlorobenzene (DNCB) sensitization and challenge. Molecular mechanism on the DNCB-mediated AD was further evaluated. Skin tissues were collected from mice treated with DNCB, and each tissue was equally divided into two sections; one for protein and the other for mRNA analysis. Expression of filaggrin, an important protein for keratinocyte integrity, was evaluated through SDS-PAGE. Level of mRNA expression for cytokines was determined through semi-quantitative reverse transcriptase polymerase chain reaction. Expression of filaggrin protein was significantly enhanced in the mice treated with DNCB compared with the vehicle (acetone : olive oil = 4 : 1 mixture) treatment group or the normal group without any treatment. Level of tumor necrosis factor-alpha and interleukin-18 mRNA expression, cytokines involved in activity of type-1 helper T ($T_H1$) cell, was significantly downregulated in the AD group compared with other control groups. These results suggest that suppression of $T_H1$ cell-mediated immune response could be reflected into the skin tissue of mice treated with DNCB for AD induction, and disturbance of keratinocyte integrity might evoke a compensatory mechanism.

• Psychiatry investigation
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• 제15권11호
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• pp.1079-1086
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• 2018

Objective The pathophysiology of social anxiety disorder (SAD) is not yet well understood, but previous research has suggested that oxytocin is associated with social behavior and may play a role in human anxiety states and anxiety-related traits. The aim of this study was to investigate the possible relationship between social anxiety symptoms and plasma oxytocin levels. Methods Twenty-three male patients with SAD and 28 healthy male controls participated in this study. All participants were assessed using the Mini International Neuropsychiatric Interview (MINI) and the Liebowitz Social Anxiety Scale (LSAS). Multivariate regression analysis was performed to identify associations between plasma oxytocin levels and SAD. Results In multiple regression models, after controlling for age and years of education, we found that higher oxytocin levels were significantly associated with higher total LSAS scores ($R^2=0.157$, coefficient=0.145, 95% CI=-0.0005-0.291, p=0.051) and fear subscale scores ($R^2=0.134$, coefficient=0.083, 95% CI=0.007-0.159, p=0.034) in the SAD group. Conclusion In this study, increased plasma oxytocin levels were associated with higher social anxiety symptoms among SAD patients, but not among controls. This might be because among SAD patients, higher oxytocin (OT) secretion is an insufficient compensatory attempt to reduce social anxiety symptoms.

• Parasites, Hosts and Diseases
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• 제30권3호
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• pp.177-182
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• 1992

Saimiri 원숭이 21마리와 Aotus 원숭이 12마리에게 Plasmedium falciparum Indochina CDC-1충주(원숭이 순응 충주)를 접종시킨 후 3주간 혈소판과 혈액치를 경시적으로 관찰하였던 바, 이들 원숭이 (Saimiri sciureus boliviensis와 Aotus nancymai karyotype-1)는 접종 14일 후에 최고의 기생률, 호중구감소증, 임파구증가증 그리고 심한 혈색소혈증과 섬유소원의 퇴행성 산물(FDP's)치의 증가를 수반한 섬한 혈소판 감소성 빈혈증이 관찰되었다. Aotus에 있어서는 평균혈색소량(MCH)과 평균혈구용적(MCV)치의 감소와 기생률의 증가를 가져왔으나, Saimiri에 있어서는 기생률이 상승함에 따라서 이들 혈액치는 유의적 차이로 상승하는 결과를 가져왔다. 일반적으로 이들 두 원숭이에 있어서 혈소판의 감소 증세와 최고 기생률을 14잎 째 나타낸 후 곧 정상 혈액치로 회복되는 소견이 관찰된다. 특히 혈소판의 변화에 있어서 Aotus 원숭이는 다른 혈액치의 변화 그리고 기생률과 깊 은 상관관계를 갖고 있었으나, Saimiri에 있어서는 상관관계를 유지하지 못하였다. 결론적으로 말라리아 연구시 Aotus 원숭이가 Saimiri 원숭이 보다 우수한 품종임과 말라리아 진단과정에 있어서 혈소판의 회복률과 재생은 말라리아의 감염시기 판정에 유용한 자료로서 활용될 수 있음을 관찰하였으며, 말라리아 병원성 판정에 대한 실험에 있어서 이들 두 종류 원숭이의 혈액치 변화 특이성을 보고하는 바이다.

• 대한약침학회지
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• 제19권2호
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• pp.163-166
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• 2016

Objectives: Quercetin is a flavonoid and an important dietary constituent of fruits and vegetables. In recent years, several pharmacological activities of quercetin, such as its neuroprotective activity and, more specifically, its anti-convulsant effects in animal models of epilepsy, have been reported. This study evaluated the role of quercetin pretreatment on gene expression of ${\gamma}$-amino butyric acid type A ($GABA_A$) receptor beta subunits in kainic acid (KA)-induced seizures in mice. Methods: The animals were divided into four groups: one saline group, one group in which seizures were induced by using KA (10 mg/kg) without quercetin pretreatment and two groups pretreated with quercetin (50 and 100 mg/kg) prior to seizures being induced by using KA. Next, the messenger ribonucleic acid (mRNA) levels of the $GABA_A$ receptor ${\beta}$ subunits in the hippocampus of each animal were assessed at 2 hours and 7 days after KA administration. Quantitative real-time polymerase chain reaction (RT-PCR) assay was used to detect mRNA content in hippocampal tissues. Results: Pretreatments with quercetin at doses of 50 and 100 mg/kg prevented significant increases in the mRNA levels of the ${\beta}_1$ and the ${\beta}_3$ subunits of the $GABA_A$ receptor at 2 hours after KA injection. Pretreatment with quercetin (100 mg/kg) significantly inhibited ${\beta}_1$ and ${\beta}_3$ gene expression in the hippocampus at 7 days after KA injection. But, this inhibitory effect of quercetin at 50 mg/kg on the mRNA levels of the ${\beta}_3$ subunit of the $GABA_A$ receptor was not observed at 7 days after KA administration. Conclusion: These results suggest that quercetin (100 mg/kg) modulates the expression of the $GABA_A$ receptor ${\beta}_1$ and ${\beta}_3$ subunits in the KA model of epilepsy, most likely to prevent compensatory responses. This may be related to the narrow therapeutic dose range for the anticonvulsant activities of quercetin.

• 산업경영시스템학회지
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• 제40권3호
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• pp.59-65
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• 2017

The purpose of this study is to investigate the factors and effects of job stress of construction workers on construction accidents and turnover intention in order to improve the field work environment of construction industry which shows higher industrial accidents than other industries. To this end, research models and hypotheses were established based on previous research, and the questionnaire was distributed to 10 construction companies in Daejeon, Sejong, and Chungcheong provinces. The 301 data collected were performed statistical analysis such as basic statistical analysis, factor analysis, reliability analysis, correlation analysis, regression analysis, and logistic regression analysis using the statistical package (IBM SPSS 22). The results of this study are summarized as follows. First, job stress has a significant effect on accident occurrence. Among the sub-factors of job stress, there was positive (+) influence on work culture and relationship conflict between peers, and organizational system had negative influence. Job demands, compensation incompetence, and job instability were not statistically significant. Therefore, it is necessary to concentrate on the factors of work culture, organizational system, and relationship conflict in the construction site. Second, job stress has positive effect on turnover intention. Job stress, inadequacy of compensation, and work culture were positively related to turnover intention. Third, job demands have a slightly greater impact than compensatory inadequacies. The factors that make the job turnover more important are the excessive job burdens such as respect, internal motivation, responsibility rather than expectation non-conformity, time pressure, increase of work load. Therefore, in order to reduce the turnover intention of the construction worker, it is necessary to pay attention to improvement of the job requirement. Fourth, the worker's job stress could overcome by exercise and fatigue elimination, work environment management, and self-opening for others. It is necessary to establish a work environment management system for counseling and intimacy formation to open up the exercise and fatigue relief program of the workers at the construction site and to open themselves between the workers and the supervisors.

• 한국수자원학회논문집
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• 제43권8호
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• pp.681-694
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• 2010

본 연구에서는 경제성분석에 의한 강변저류지의 최적위치 선정기법을 제안하였다. 강변저류지 설치에 소요되는 비용을 크게 건설비용과 토지매입비용으로 나누어 산정하였으며, 강변저류지 설치로 인해 발생하는 이익을 홍수피해저감액과 습지설치로 인한 연간이득으로 구분하여 산정하였다. 홍수량-홍수피해액 관계를 간접적으로 도출하는 방안을 제시하였으며, 강변저류지의 습지활용 시에 발생하는 이익은 인공습지의 가치평가기법을 도입하여 평가하였다. 경제성평가 기법으로는 편익-비용분석을 적용하였으며, 안성천 유역의 13개 후보강변저류지에 대한 경제성평가를 수행하였다. 또한 강변저류지의 최적 위치와 규모를 결정하기 위해 홍수저감효과를 이용한 기존의 모형을 보완하여, 경제성평가기법을 이용한 의사결정기법을 제안하였다. 제안된 의사결정기법을 안성천유역의 13개 후보강변저류지를 대상으로 적용하였으며, 기존에 홍수저감효과만을 이용한 모형의 결과와 비교분석하였다. 그 결과 홍수저감량만을 고려한 기존의 결과와 비교할 때 보다 높은 경제성을 제공할 수 있는 최적조합선정이 가능하였고, 경제성을 고려하는 것이 보다 실질적인 의사결정의 기준으로 사용될 수 있다는 것으로 나타났다.

• 한국사회복지학
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• 제57권3호
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• pp.51-72
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• 2005

본 연구의 목적은 여성의 경제참여 증가에 따른 무급가사노동의 분담정도를 설명하고 있는 세 가지 가설을 한국 상황에서 실증적으로 검증해 보는 것이다. 이 세 가지 가설이란 기혼여성이 취업할 경우 남성배우자가 적극적으로 가사노동을 분담한다는 협조적 적응 가설, 남성배우자의 가사노동분담이 이루어지지 않아 근로기혼여성은 유급과 무급의 이중적인 노동부담에 처하게 된다는 이중노동부담 가설, 그리고 어느 한 시점에서 근로기혼여성의 이중노동부담이 나타나는 것은 사실이나 그 정도는 세대간에 달라질 수 있으며, 장기적인 추세를 관찰하면 맞벌이 남성의 가사노동분담도 역시 증가해 왔다는 적응 지체가설이다. 이상의 세 가설을 검증하기 위한 핵심 독립변수로 성별, 연령, 맞벌이 여부가, 종속변수로는 총 노동시간과 무급가사노동시간이 설정되었고, 분석자료는 1999년 통계청의 생활시간조사 원자료가 이용되었다. 연구결과, 근로기혼여성은 남성배우자에 비하여 하루 평균 100분 이상을 더 일하고 있었으며, 한국 남성들의 가사노동시간은 23-25분 정도로 여성의 5-10% 수준에 불과하여, 무급가사 노동의 분담수준이 매우 낮았음을 알 수 있었다. 또, 남성의 무급가사노동시간의 변이를 설명하기 위한 독립변수로 설정되었던 맞벌이 여부나 연령의 통계적 유의성은 찾아볼 수 없었다. 따라서, 한국의 상황에서는 협조적 적응 가설은 물론 세대간의 행위차이를 가정한 적응지체 가설도 채택될 수 없었으며, 이중노동부담가설이 근로기혼여성의 현실을 가장 잘 설명하는 것으로 분석되었다. 이러한 연구결과를 바탕으로, 본 연구는 취업여성의 이중노동부담을 경감시킬 수 있는 사회복지서비스 제도의 확충, 보살핌노동에 대한 보상체계 등을 제안하였으며, 시간자료를 이용한 후속연구의 방향을 제시하였다.